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Daniela Weiskopf: SARS-CoV-2 specific adaptive immune responses after infection and vaccination

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  • Daniela Weiskopf: SARS-CoV-2 specific adaptive immune responses after infection and vaccination

    59:34

    This week's speaker is Daniela Weiskopf, a research assistant professor at La Jolla Institute for Immunology.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE:

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  • Dr. Daniela Weiskopf and Dr. Alessandro Sette Lab Meeting of La Jolla Institute of Immunology

    1:3:50

    Watch our Global COVID Lab Meeting with Dr. Daniela Weiskopf who speaks about Adaptive Immune Responses to SARS-COV-2 and Common Cold Coronaviruses and Dr. Alessandro Sette who talks about T-cell Responses to SARS-CoV-2 Variants of Concern.

    Dr. Weiskopf is Research Assistant Professor a the La Jolla Institute for Immunology and Dr. Alessandro Sette Division Head of the La Jolla Institute for Immunology .


    Learn more about the Human Vaccines Project Global COVID Lab Meeting and see upcoming events here:

    #COVID19​​​​​​​ #research​​​​​​​ #webinar​​​​​​​ #interferons​​​​​​​ #vaccines​​​​​​​ #globalcovidlabmeeting​​​​​​​ #covidvaccineinitiative​​​​​​​

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  • Shane Crotty: Adaptive Immunity and Immune Memory to SARS-CoV-2 after COVID-19

    1:25:48

    This week's speaker is Shane Crotty, a professor at the Center for Infectious Disease and Vaccine Research at La Jolla Institute for Immunology.

    Crotty's team studies immunity against infectious diseases and investigates how the immune system remembers infections and vaccines. He is the author of Ahead of the Curve, a biography of scientist and Nobel laureate David Baltimore, published in 2001. He earned his BS in biology and writing from MIT and his PhD in molecular biology/virology from UCSF.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE: janelia.org/scienceofcovid19

  • Nina Le Bert: SARS-CoV-2 specific T cell Immunity in COVID 19, SARS and Uninfected Controls

    9:59

    Dr. Nina Le Bert from Duke NUS, discusses her recent involvement in the study of SARS-CoV-2 specific T cell immunity, specifically looking at the induction and persistence of T cells using an overlapping peptide library of specific proteins in SARS-CoV-2 to test convalescent patients' IFN-gamma responses to these peptides. Using a cohort of individuals who were infected and recovered in 2003 with SARS, and a similar approach of overlapping peptides from SARS-CoV, she is able to show there are still persistent ex vivo T cell responses. Importantly, she also highlights the cross reactivity of NP peptides from SARS-CoV and SARS-CoV-2.

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  • Alessandro Sette: Adaptive Immune Responses to SARS-CoV-2

    1:3:30

    This week's speaker is Alessandro Sette, a professor at the Center for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology.

    Sette has devoted more than 35 years of study towards understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. His lab is defining in chemical terms the specific structures (epitopes) that the immune system recognizes, and uses this knowledge to measure and understand immune responses. The lab’s approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE: janelia.org/scienceofcovid19

  • Webinar: T Cells: A New Hope for Lasting Protection against SARS-CoV-2

    1:28:41

    Many immunologists are looking at T cells to understand the potential for lasting immunity to SARS-CoV-2. In this webinar, Drs. Alessandro Sette and Shane Crotty of La Jolla Institute for Immunology present their latest findings in T cell function following SARS-CoV-2 infection and the implications for vaccine development and lasting immune memory.

    Topics covered:
    1. CD4+ and CD8+ T cell recognition of SARS-CoV-2 sequences in unexposed individuals and potential cross-reactivity with common cold coronaviruses
    2. Implications of the T cell response against SARS-CoV-2 for vaccine design and viral escape
    3. How the nature of the acute immune response correlates with COVID-19 severity
    4. Factors affecting COVID-19 immune response duration and memory

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  • T Cells: A New Hope for Lasting Protection Against SARS-CoV-2

    1:27:11

    Many immunologists are looking at T cells to understand the potential for lasting immunity to SARS-CoV-2. In this webinar from The Scientist, Alessandro Sette and Shane Crotty will present the latest findings in T cell function following SARS-CoV-2 infection and the implications for vaccine development and lasting immune memory.

    Topics to be covered

    - CD4+ and CD8+ T cell recognition of SARS-CoV-2 sequences in unexposed individuals and potential cross-reactivity with common cold coronaviruses
    - Implications of the T cell response against SARS-CoV-2 for vaccine design and viral escape
    - How the nature of the acute immune response correlates with COVID-19 severity
    - Factors affecting COVID-19 immune response duration and memory

  • Alessandro Sette: Study of adaptive responses to SARS CoV2

    29:52

    In this presentation, Dr. Sette provides evidence that there are robust CD4+ and CD8+ T cell responses detected in uncomplicated SARS-CoV-2 convalescent cases; that reactivity is reproducibly detected in non-exposed subjects; specific CD4 and CD8 T cells targets in COVID-19 patients were identified; in acute and severe infection it appears that the speed of the adaptive response is key to protective immunity; that T cell responses are durable over at least 8 months and that there is negligible impact of SARS-CoV-2 variants on T cell responses.

    Alessandro Sette has devoted more than 35 years in biotech and academia to understanding and measuring immune responses, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. Dr. Sette’s laboratory is the world leader in the study of the specific structures, called epitopes, that the immune system recognizes. Dr. Sette has overseen the design and curation efforts of the national Immune Epitope Database (IEDB), a freely available, widely used bioinformatics resource. The IEDB catalogs all epitopes for humans and experimental animals for allergens, infectious diseases, autoantigens and transplants, and includes epitope prediction tools to accelerate immunology research around the world. Dr. Sette’s lab uses knowledge of epitopes to define the hallmarks of a beneficial immune response associated with effective vaccines, as opposed to immune responses that are ineffective or that cause harm. The laboratory’s infectious disease interests include SARS CoV2, dengue, Zika Chikungunya, herpesviruses, poxviruses, lassa fever, HIV and hepatitis viruses, and bacterial pathogens such as tuberculosis and bordetella pertussis. Our investigations outside infectious disease include allergic asthma and Parkinson’s disease.
    Dr. Sette is a Doctor in Biological Sciences from the University of Rome and did postdoctoral work at the National Jewish Center for Immunology and Respiratory Medicine in Denver, Colorado. In 1988, Dr. Sette joined the newly founded company Cytel, in La Jolla, and was also appointed adjunct assistant professor at The Scripps Research Institute. He founded Epimmune in 1997, where he served both as Vice President of Research and Chief Scientific Officer until 2002, when he joined LJI as Head of the Division of Vaccine Discovery. He also heads the Center for Infectious Disease at LJI.

  • Prof. Shane Crotty: T cell responses to SARS-CoV-2

    1:2:25

    In this Global COVID Lab Meeting, Prof. Shane Crotty of the La Jolla Institute for Immunology discusses T cell-responses to SARS-CoV-2 and the implications for vaccine development. His team was involved in a recent study that shows SARS-CoV-2-infected people harbor T cells that target the virus—and may help them recover.

    Learn more about the Human Vaccines Project Global COVID Lab Meeting and see upcoming events here:

    #Covid19 #CovidVaccineIniative #Vaccines #HumanVaccinesProject #Webinar

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  • Galit Altar: Systems Serology to Assess SARS-CoV-2-specific Placental Antibody Transfer

    1:22:29

    This week's speaker is Galit Alter, a professor of medicine at Harvard Medical School and a group leader at the Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard.

    Abstract: SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. The Alter Lab has used their unique systems serology antibody profiling approach to characterize the Fc-profile of influenza-, pertussis-, and SARS-CoV-2-specific antibodies transferred across the placenta. Influenza- and pertussis-specific antibodies were actively transferred. However, SARS-CoV-2-specific antibody transfer was significantly reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity were lower than in maternal plasma. This effect was only observed in third trimester infection. SARS-CoV-2-specific transfer was linked to altered SARS-CoV-2-antibody glycosylation profiles and was partially rescued by infection-induced increases in IgG and increased FCGR3A placental expression. These results point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE: janelia.org/scienceofcovid19

  • T Cells: A New Hope for Lasting Protection against SARS-CoV-2

    1:28:41

    Many immunologists are looking at T cells to understand the potential for lasting immunity to SARS-CoV-2. In this webinar from The Scientist, Alessandro Sette and Shane Crotty will present the latest findings in T cell function following SARS-CoV-2 infection and the implications for vaccine development and lasting immune memory.

  • Dr. Petter Brodin: Systems-level blood immunomonitoring study of SARS-CoV-2 patients

    58:41

    Watch our Global COVID Lab Meeting with Petter Brodin, M.D., Ph.D., Associate Professor of Immunology at Karolinska Institutet.
    Dr. Brodin’s team is aiming to understand the human immune system variation in health and disease, and understand the factors that shape human immune systems. The team is interested in defining better metrics of immune system health and develop methods for better immune system analyses in human patients. As a physician at the department of pediatrics at the Karolinska University Hospital, Dr. Brodin has a particular interest in understanding when and how human immune systems are shaped early in life, and the influences by environmental exposures such as the microbiome, infections, vaccines, nutritional components etc in this process.

    Learn more about the Human Vaccines Project Global COVID Lab Meeting and see upcoming events here:

    #COVID19​​​​​ #research​​​​​ #webinar​​​​​ #interferons​​​​​ #vaccines​​​​​ #globalcovidlabmeeting​​​​​ #covidvaccineinitiative​​​​​

  • The-Scientist Webinar: T Cells A New Hope for Lasting Protection against SARS CoV 2

    1:28:41

    Many immunologists are looking at T cells to understand the potential for lasting immunity to SARS-CoV-2. In this webinar from The Scientist, Alessandro Sette and Shane Crotty will present the latest findings in T cell function following SARS-CoV-2 infection and the implications for vaccine development and lasting immune memory.

    Topics to be covered

    · CD4+ and CD8+ T cell recognition of SARS-CoV-2 sequences in unexposed individuals and potential cross-reactivity with common cold coronaviruses

    · Implications of the T cell response against SARS-CoV-2 for vaccine design and viral escape

    · How the nature of the acute immune response correlates with COVID-19 severity

    · Factors affecting COVID-19 immune response duration and memory

  • TWiV 657: Shane Crotty on SARS-CoV-2 immunity

    2:14:55

    Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.

    Show notes at

    Become a patron of TWiV at

  • COVID Variants vs. Coronavirus Vaccines + Immunity

    54:25

    Renowned virologist Shane Crotty, PhD joins us again to address the most important COVID-19 questions: Should people who’ve been vaccinated or had COVID-19 continue to wear masks and physically distance? How will each vaccine hold up to the SARS-CoV-2 variants? What does the research say about people who’ve already had COVID-19 who get a vaccine? How long will immunity last for the vaccines or COVID-19 infection?

    Shane Crotty is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Prof. Crotty also has an academic appointment with the University of California San Diago. See his full bio here:
    Prof. Crotty on Twitter:

    Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com

    (This video was recorded on March 23, 2021)

    Just to clarify at 8:40 in the video: Prof. Crotty is describing a theoretical person when he says I myself am comfortable getting infected... He hasn't had COVID, and doesn't have that opinion. He was explaining one end of the spectrum of level of concern for individuals.

    TOPICS DISCUSSED IN THIS VIDEO INCLUDE:

    0:00 Intro
    0:46 Heated exchange between Dr. Fauci and Senator Rand Paul
    1:00 How long does immunity last for those who’ve had COVID-19?
    3:31 How antibody levels and T cells drop over time
    4:03 Dr. Fauci: Difference between in vitro and real-world studies
    4:36 Population-based studies about COVID 19 immunity against reinfection
    6:22 Huge variability from person to person for post coronavirus immunity
    8:20 Policy decision: individual vs. community goals during a pandemic
    9:03 Very rare for hospitalization from COVID-19 reinfection
    9:34 Avoiding COVID-19 infection and transmission potential
    10:12 Should mask-wearing continue for those who’ve had COVID-19?
    12:23 If I’ve had COVID-19, shouldn’t my vaccine dose go to someone else?
    13:39 Vaccines are eliciting more immunity than natural infection
    14:02 Is natural immunity always better than a vaccine?
    20:05 If you’ve had COVID-19, when should you get vaccinated? Both doses?
    22:07 How are variants “game changers” for vaccines and natural infections?
    24:53 Can’t I stop wearing masks and distancing after a vaccine or having COVID?
    26:14 Variants of concern: B.1.1.7 (UK) and B.1.351 (S. Africa) details and implications
    30:57 South Africa Variant escaping immunity: AstraZeneca Vaccine data
    32:28 Isn't preventing COVID 19 hospitalizations and deaths the primary goal?
    35:25 Will we need updated coronavirus vaccines?
    36:38 Johnson and Johnson vaccine versus the variants
    37:57 Preventing transmission to prevent SARS CoV 2 mutation opportunities
    38:40 Coronavirus antibodies vs T Cells and other parts of the immune system
    39:54 Replication and asymptomatic spread of COVID-19 vs. Pneumonia
    42:53 Vaccine incentives and Senator Rand Paul's perspective
    45:35 Looking ahead, SARS-CoV-2 vs Influenza, Will we need annual vaccinations?
    52:20 Current research and goals for Prof. Shane Crotty

    PREVIOUS MEDCRAM DISCUSSIONS WITH PROF. CROTTY :
    (Dec 16, 2020)
    (January 5, 2021)

    REFERENCES:

    Crotty's Research Published in Science |

    Variant Tracker |

    Denmark Research in the Lancet |

    UK SIREN study:

    Research from Qatar |

    UK Research in NEJM |

    Qatar:

    Congressional Hearing 3/8/21: exchange with Dr. Fauci and Rand Paul: (PBS News Hour) and (CNBC)


    THE MEDCRAM WEBSITE:

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    All coronavirus updates are at MedCram.com ad-free (including more on RNA vaccines, COVID variants, South African Variant, Johnson and Johnson vaccine for COVID 19, and more):


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    Video Produced by Kyle Allred


    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #Coronavirus #COVID19UK

  • COVID 19 Vaccine Deep Dive: Safety, Immunity, RNA Production,

    34:29

    Professor Shane Crotty, PhD joins MedCram to answer a series of COVID vaccine questions including what are the chances of long-term side effects? How safe is RNA vaccine (i.e. Pfizer / BioNTech and Moderna Vaccines) technology? How long does mRNA from a vaccine stay in our cells? What else goes in vaccines? How long does immunity last? Why are T-Cells so important? Why does Pfizer's vaccine need to stay SO cold?

    Shane Crotty, PhD is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Professor Crotty also has an academic appointment with the University of California San Diego. See his full bio here:
    Professor Crotty on Twitter:

    Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com

    See our new interview with Prof. Crotty on how virus mutations (UK variant and S. African variant) may be impacting COVID-19 transmission and vaccine efficacy.

    Research referenced in this video from Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science:

    New York Times article highlighting Prof. Shane Crotty's research:

    00:00 Introducing Prof. Shane Crotty's Research
    0:35 How long does COVID-19 immune memory last?
    0:57 The three primary aspects of immune memory: antibodies, killer T cells, and helper T cells
    2:25 The anatomy (protein makeup) of SARS-CoV-2
    3:02 Why is spike protein the primary target?
    5:17 Could a mutation allow SARS-CoV-2 to infect without spike protein?
    7:02 Utilizing lipid nanoparticles to deliver mRNA and the role of RNA normally
    9:52 What human cells does an RNA vaccine go into?
    10:36 How long does mRNA from a vaccine stay in human cells?
    11:44 What else goes in vaccines besides mRNA and lipid nanoparticles? Any preservatives or adjuvants?
    12:30 Why are adjuvants used in many vaccines?
    14:08 Protein production from mRNA
    15:00 Why utilize the extra step of mRNA to code for protein antigens?
    17:28 Are mRNA vaccines the future of vaccine development?
    19:18 Any chance for mRNA to enter our cells' nucleus?
    20:55 The immune response to a coronavirus vaccine
    23:17 Expected symptoms from immune response to a vaccine vs. vaccine side effects
    25:50 Should people who've had COVID-19 get vaccinated?
    27:27 Immunity from COVID vaccine vs. a natural infection
    28:30 Why does the Pfizer vaccine need to be stored so cold?
    29:04 What would you say to a family member who is nervous about a rushed vaccine and RNA technology?
    32:37 What about the possibility of long term side effects from RNA vaccines?
    33:30 What's next for Shane Crotty's research team?

    (This video was recorded on December 16, 2020).

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    PREVIOUS / RECENT MEDCRAM COVID-19 INTERVIEWS:

    Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2) with Professor Roger Seheult, MD

    At Home COVID 19 Antigen Testing and Vaccine Update with Professor Michael Mina, MD

    All coronavirus updates are at MedCram.com ad-free (including more videos on the Pfizer vaccine, Moderna vaccines, BioNTech vaccine, vaccine side effects, COVID 19 vaccine mechanism, AstraZeneca Oxford coronavirus vaccine, side effects of COVID 19 vaccine, COVID 19 treatments, and more):

    We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website and CME for clinicians.


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    Video Produced by Kyle Allred

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    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #Coronavaccine

  • Coronavirus Updates: Live from the Laboratory with Shane Crotty, Ph.D.

    1:11:14

    On April 20, 2020, vaccine design and infectious disease expert Shane Crotty, Ph.D. shared his research efforts and observations from the field regarding the coronavirus and COVID-19. Institute leadership and experts President & CSO Mitchell Kronenberg, Ph.D., Executive Vice President & COO Stephen S. Wilson, Ph.D., and Chairman of the Board Eric V. Zwisler also provided their insights during the virtual discussion. The presentation concluded with a Q&A, with questions from webinar participants.

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  • Simplifying COVID Immunology, One Metaphor at a Time | Medicine and the Machine

    38:12

    With tales of Post-it Notes and fire trucks, Shane Crotty explains COVID immunology and vaccine responses for scientists and nonscientists alike.

  • Coronavirus Updates: Live from the Laboratory with Alessandro Sette, Dr. Biol. Sci.

    1:47

    On May 13, 2020, one of the world's most cited researchers and immunology expert Alessandro 'Alex' Sette, Dr. Biol. Sci. shared his research efforts and observations from the field regarding the coronavirus and COVID-19. Institute leadership and experts President & CSO Mitchell Kronenberg, Ph.D. and Executive Vice President & COO Stephen S. Wilson, Ph.D. also provided their insights during the virtual discussion. The presentation concluded with a Q&A, with questions from webinar participants.

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  • Immunity and Vaccines for COVID 19 vs Cancer

    52:18

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  • Covid-19 Vaccine Immunity and the Impact of Variants

    47:02

    As the delta variant becomes the dominant strain of the Covid-19 pandemic, scientists are working to understand the role variants will play in future surges of Covid-19, the efficacy of current vaccines, and how long immunity will last. Dr. Shane Crotty,, virologist and professor in the Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology (LJI), provides insights on the progress of Covid-19 vaccine immunity research for current U.S. Covid-19 vaccines (Pfizer, Moderna, Janssen/Johnson & Johnson), and critical emerging questions, such as the impact of the delta variant on the efficacy of current Covid-19 vaccines.

  • COVID-19: Clinical Labs in the Media Spotlight with Dr. Katherine Wu and Dr. Susan Butler-Wu

    44:27

    The COVID-19 pandemic has brought more media attention to clinical laboratories than at any time in recent history. Today we’ll talk about media coverage of diagnostic testing for COVID-19 with two experts. Some of the questions we’ll discuss include:

    • How has the media coverage of tests for COVID-19 affected the public’s view of these tests?
    • What is the role of social media in talking about testing for COVID-19?
    • How do reporters covering COVID-19 testing work with clinical microbiologists to get the story right?

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  • What are viral vector vaccines and how do they work?

    1:40

    Viral vector vaccines use a modified version of a virus (the vector) to deliver genetic instructions to the body’s cells. The vector can’t cause disease but is recognised as ‘foreign’ triggering an immune response. Should the body be exposed to the virus in the future, it has already learnt how to recognise and defend against it.



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  • Friday Morning Medical Update: Kids and COVID Vaccines Plus: Answering Community Questions

    38:46

    The University of Kansas Health System reports another decrease in the numbers of COVID patients today. 32 with the active virus are being treated, down from 35 yesterday. Only five of them are vaccinated. 11 patients are in the ICU, down from 13 yesterday, but none are vaccinated. Nine are on ventilators, the same as yesterday, also none vaccinated. 38 other patients are still hospitalized because of COVID but are out of the acute infection phase, up from 37 yesterday. That’s a total of 70 patients, down from 72 yesterday
    On today’s Morning Medical Update, we took a closer look at kids and COVID and when the vaccine might be available for them. Also, a surprising survey about whether parents will get their children vaccinated when it’s available. We also answered community questions we didn’t have time for earlier this week.
    Joining Dana Hawkinson, MD, medical director of Infection Prevention and Control at The University of Kansas Health System was Dr. Amol Purandare {pooh-run-the-ray}, Infectious Diseases physician at Children's Mercy. He says children now account for one in five new cases of COVID, with 14 hospitalized at Children’s Mercy. His hospital was involved in the clinical trial of a vaccine for kids, and he expects it will be available in the next couple of months after the FDA examines the data. The doctors reacted to a Kaiser Family Foundation survey of parents showing only 26 percent will take their children to be vaccinated as soon as it’s available. 40 percent will wait and see how it’s working, nine percent will only get the vaccine for their kids if it’s required and 25 percent will not get their children vaccinated. Dr. Purandare was surprised, and said, “You would think with everything going on we would expect a lot of families to jump to get the vaccine.” He believes that hesitancy doesn’t make sense as the vaccine for kids, which is about a third the dose of adults, has proven safe and effective in the trials. He says contrary to the survey, the parents he sees in clinics are more interested in getting their kids vaccinated as soon as possible. The doctors also discussed data showing the total preventable costs for treating hospitalized COVID patients has skyrocketed in the last three months to $5.7 billion.
    Here are the community questions in the order the panel addressed them, followed by the short answer. The time code for the question is in parentheses. See the video for their full answers and comments.
    • (16:35) An NPR model suggested no winter surge this year as children continue to get vaccinated in the next couple of months. Your thoughts? It’s possible, but doctors wouldn’t be surprised if there was a surge because of all the variants out there.
    • (17:25) Have any children died of COVID in the U.S.? Social media posts that say there is no risk of death in children are simply not true. Children have died all over the country, six in Missouri and one just this week in Kansas.
    • (19:05) Is there any verified data proving that vaccination decreases transmissibility? Information comes out on a daily basis, but early data shows that it does.
    • (20:30) What's the best type of mask for young kids? Something that fits well and is comfortable. It must snugly cover the nose and mouth.
    • (21:30) What role do kid vaccination rates play in getting through this pandemic quicker? The sooner we can get kids vaccinated the quicker we’ll keep the disease from spreading.
    • (22:10) I’ve heard a lot of people who test positive for COVID only experience GI symptoms. Is it possible to not have any upper respiratory symptoms and be COVID positive? It’s possible but not common. Most COVID patients also experience at least a runny nose or scratchy throat.
    • (24:00) When will the health system begin offering the newly-approved third Pfizer booster? Putting the process in place right now. Should be ready by Monday.
    • (25:00) Since we’ve had the vaccine out for nine months, what is the data showing for immunity of those who have been vaccinated all this time, knowing we’ve had some breakthrough infections? The vaccines are still extremely effective. There is no need to rush out and get a third shot unless it’s medically necessary.
    • (26:35) What recommendations do you have for schools about masking at each level of schooling? All age groups should be wearing a mask, especially those not vaccinated.
    • (27:15) My adult daughter has type one diabetes, which is well controlled. She works in a preschool. Should she get the booster? CDC recommendations are vague, saying only that those in a preschool setting “may” receive a booster. The diabetes could put her into a higher risk category.
    • (29:15) Can someone have a positive COVID test beyond the active disease period? If so for how long? Yes, it’s possible. PCR testing is very sensitive, and a person could test positive for weeks.

  • Coronavirus Updates: Live from the Laboratory with Dr. Mitch Kronenberg

    58:06

    LJI President and Chief Scientific Officer, Mitchell Kronenberg, presents his perspectives regarding the scientific progress made over the past 6 months and where he anticipates science can take us as we strive to overcome this elusive virus.

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  • March 31, 2021- MassCPR Scientific Symposium: COVID-19 Vaccines and Pathogenesis

    57:52

    Introduction: Galit Alter, PhD (MGH, Ragon Institute) and Dan Barouch, MD, PhD (BIDMC, Ragon Institute)

    Moderna RNA vaccine: Andrea Carfi, PhD (Moderna)
    J&J Ad26 vaccine: Katy Stephenson, MD, MPH (HMS, BIDMC)

    SARS-CoV-2 pathogenesis: Nir Hacohen, PhD (MGH)

    Animal models of COVID-19: Amanda Martinot, PhD, MPH, DVM, BS, DACVP

    (Tufts Cummings School of Veterinary Medicine)


    SARS-CoV-2 variants: Pardis Sabeti, MD, DPhil (Harvard University, HSPH)

  • What Weve Learned One Year In: A Live from the Lab COVID-19 Discussion

    1:7:04

    On February 9, 2021, La Jolla Institute for Immunology’s Executive Vice President & Chief Operating Officer, Stephen Wilson, Ph.D. and immunology expert Alba Grifoni, Ph.D. of the Sette Laboratory synthesized what has been learned about COVID-19 in the past year as the SARS-CoV-2 puzzle has been untangled through significant advances in immunology research, much of which is being accomplished at the Institute. They also highlighted what laboratories are looking at next as the fight against the pandemic continues.

    Institute leadership and experts President & CSO Mitchell Kronenberg, Ph.D. and Chairman of Board of Directors Eric V. Zwisler also provided their insights during the virtual discussion. The presentation concluded with a Q&A, with questions from participants.

    La Jolla Institute for Immunology is committed to keeping the community up to speed on its COVID-19 related research developments. The Institute's Live from the Lab webinar series allows viewers to virtually go behind the scenes as scientists and leadership address how the immune system responds to the most pressing global health challenges facing society.

    Additional information on current research efforts underway can be found at lji.org/covid-19.

    __________________________________________

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  • In-Depth: La Jolla Institute takes comprehensive look at COVID-19 immunity

    3:53

    Researchers at the La Jolla Institute for Immunology are working to come up with a definitive look at how long COVID-19 immunity lasts from vaccines and natural infection.

  • Dr. Douglas Nixon: COVID-19 – Can Old Vaccines Have New Tricks?

    57:54

    Watch our Global COVID Lab Meeting with Douglas F. Nixon, M.D., Ph.D., who talks about: COVID-19 – Can Old Vaccines Have New Tricks?

    Dr. Nixon graduated with a Bachelor of Science from University College London in 1981 with First Class Honors, and received his medical degree from Westminster Hospital Medical School, London in 1984. He then went on to train as a pathologist and clinical virologist at the University of Oxford and received his Master’s degree in 1991 and his PhD in Immunology in 1992. During his time at Oxford, he made substantial contributions to the understanding of the newly emerged Human Immunodeficiency Virus (HIV). He spent the following two years at a biotechnology company in New York working on HIV vaccine development, before joining the Aaron Diamond AIDS Research Centre at the Rockefeller University, first as a postdoctoral fellow, and subsequently as an assistant professor, to investigate how antiviral T cells function in pediatric HIV infection. In recognition of several important contributions to HIV/AIDS research he made while there, he was awarded the Elisabeth Glaser Scientist Award in 2000. That same year he joined the Gladstone Institute of Virology and Immunology in San Francisco as an Associate Professor. In 2006, he accepted the appointment of Professor of Medicine at the University of California, San Francisco (UCSF), and as Associate Chief of the Division of Experimental Medicine at UCSF. From 2013 -2018 he was recruited to the George Washington University as Chair and Walter G. Ross Professor (with tenure) of the Department of Microbiology, Immunology and Tropical Medicine. He is currently Professor of Immunology in Medicine at the Weill Cornell Medical College in New York City. A scientist and educator, he has actively pursued immunovirology research for more than 28 years, with his studies spanning from clinical research and human immunology, to basic virology, vaccine development and molecular biology. Among his accomplishments, Nixon has gained recognition for publishing the first identification of an HIV specific cytotoxic T cell (CTL) epitope. He has published more than 250 articles in peer-reviewed journals, including first-or-senior author publications in Nature, PNAS, Journal of Clinical Investigation, PLoS Pathogens, and holds several patents. He has served on multiple study section and grant review panels, and has mentored more than 50 students, postdocs and fellows. He is the past Chair of the NIH’s AIDS Vaccine Research Subcommittee. Dr. Nixon is currently the Principal Investigator of the NIH’s Martin Delaney collaboratory for HIV Cure Grant, “BELIEVE”.

    Learn more about the Human Vaccines Project Global COVID Lab Meeting and see upcoming events here:

    #COVID19​​​​​​​ #research​​​​​​​ #webinar​​​​​​​ #interferons​​​​​​​ #vaccines​​​​​​​ #globalcovidlabmeeting​​​​​​​ #covidvaccineinitiative​​​​​​​

  • Nearly 80% of Oklahomans have some form of immunity to COVID-19, official says

    1:30

    Nearly 80% of Oklahomans have some form of immunity to COVID-19, official says

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  • Thursday Morning Medical Update: Coast to Coast Bike Ride to Cure Cancer

    32:09

    Slightly lower numbers of COVID patients at The University of Kansas Health System today. 35 with the active virus are being treated, down from 40 yesterday. 13 patients are in the ICU, down from 14 yesterday. Nine are on ventilators, the same as yesterday. 37 other patients are still hospitalized because of COVID but are out of the acute infection phase, up from 35 yesterday. That’s a total of 72 patients, the same as yesterday. HaysMed reports a total of 10 patients, eight active and two recovering.
    On today’s Morning Medical Update, we reported live from Arrowhead Stadium on a passionate group of bike riders traveling coast to coast to find a cure for cancer.
    A very dedicated group of bike riders peddled their way to Arrowhead Stadium today, after having ridden all the way from Denver. They are employees of Bristol Myers Squibb and are participating in one leg of the Coast 2 Coast 4 Cancer Ride to raise money for the V Foundation for Cancer Research. Another group took off from the stadium headed for Indianapolis on the next leg of the journey. We met two of the riders, Christy Williams and Todd Franklin, both riding for family members who died from cancer. Christy herself is a cancer survivor. Each rider had to raise at least $5,000, with every dollar going to cancer research. This year’s riders raised $1.5 million. Christy said it was very emotional seeing her family waiting for her at the finish line and Todd said the memory of his father, brother and wife kept him going for the grueling ride. Both said they can’t wait to try some of the famous Kansas City Bar-B-Que before heading back to Colorado.
    Roy Jensen, MD, vice chancellor and director of The University of Kansas Cancer Center, explained how the V Foundation has funded some of the cancer center’s younger researchers, especially in their efforts to develop immunotherapy treatments, in which a patient’s own re-engineered cells are used to fight their cancer. He said it’s a special year, marking the 50th anniversary of the Cancer Research Act, and is grateful to have the bike ride back after missing last year due to the pandemic.
    Dana Hawkinson, MD, medical director of Infection Prevention and Control at The University of Kansas Health System, said news of a Kansas middle school student dying from COVID is a tragedy that didn’t have to happen. He says masking in schools is vital for keeping students safe and says a vaccine for those under 12 may be approved next month. He noted only 10 to 15 percent of people who get the virus will need to seek medical treatment and explained how to tell when it’s time to do so. He advises getting tested if you even suspect you have COVID. He added that no vaccine is 100 percent effective at stopping disease, but the COVID vaccines are effective enough to keep you from getting seriously ill, going to the hospital, and dying. He discussed booster shots and reminded us that right now they are recommended for those who are immunocompromised. He urges everyone to seek out sources of truth, not just active misinformation campaigns, which he says are “completely false, uninformed opinions not informed by the science, by the reality of the situation.”
    Friday, September 24 at 8:00 a.m. is the next Morning Medical Update. We’ll take a closer look at kids and COVID and have the latest on the vaccine and whether parents will get their children vaccinated when it’s available. We’ll also answer community questions we didn’t have time for earlier this week.

  • Why Declining Antibodies Don’t Spell Disaster for Long-Lasting COVID-19 Immunity

    1:00



    Dr. Daniela Weiskopf discusses the study.

    Credit: Jenna Hambrick, La Jolla Institute for Immunology

  • Type 2 immunity: learning from helminths by Dr. Judith Allen

    54:58

    GLOBAL IMMUNOTALK insert 09-29-21

  • Live from the Laboratory with Cecilia Lindestam Arlehamn, Ph.D. and Alessandro Sette, Dr. Biol. Sci.

    59:34

    On October 13, 2020, Dr. Cecilia Lindestam Arlehamn and Dr. Alessandro Sette shared their latest research progress on the role of the immune system in Parkinson’s Disease and COVID-19, as well as, a possible unexpected link between the two diseases. Dr. Arlehamn discovered that autoimmunity plays a role in Parkinson’s disease when she found that the immune system's T cells target a protein called alpha-synuclein, which gathers into damaging clumps in dopamine-producing brain cells. In recognition of her pioneering work, the team around Dr. Arlehamn was recently awarded $3.5 million from Aligning Science Across Parkinson’s (ASAP) to expand this research in individuals at risk of Parkinson’s. Laboratory Principal Investigator Dr. Sette is the foremost global expert in studying and understanding the immune response, measuring immune activity, and developing disease intervention strategies against a range of diseases, from Parkinson's to SARS-CoV-2 to cancer and others. Institute leadership and experts President & CSO Mitchell Kronenberg, Ph.D. and Executive Vice President & COO Stephen S. Wilson, Ph.D. also provided their insights during the virtual discussion. Behind-the-scenes access previewing the Sette laboratory, where this work is underway, and the critical technology propelling this research was virtually provided to webinar participants. The presentation concluded with a Q&A, with questions from live participants.

    ___________________________________________

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  • Third Congress, 4-Scientific Session Two (Panel Discussion)& Closing

    50:17

    Third ISV COVID-19 Vaccines Virtual Congress
    Featuring: Shan Lu (ISV), Margaret Liu (ISV), Alessandro Sette (La Jolla Institute for Immunology), Michel Nussenzweig (The Rockefeller University), Neil Almond (NIBSC), Linda Klavinskis (ISV)

  • 2020 User Workshop – 1.7 – Using the IEDB-AR to Identify SARS-CoV-2 Candidates

    37:42

    Day 1, Session 7: A practical, research example of how the Immune Epitope Database and Analysis Resource can be used to identify candidates in SARS-CoV-2, presented by Dr. Alba Grifoni.
    Slides available for download on our website (

    Timestamps:
    02:40 - Searching for T and B cell epitopes for SARS-CoV
    03:35 - Mapping epitopes to the different SARS-CoV proteins
    05:01 - ImmunomeBrowser analysis tool to map epitopes on SARS-CoV-2 sequence
    06:33 - Linear B cell epitope prediction
    06:55 - Structure-based prediction
    10:55 - Applications of T cell epitopes
    15:05 - Q&A with Dr. Bjoern Peters and Dr. Alex Sette

    Event Background:
    Our team holds an annual user workshop (typically in October/November) to which we invite both those new to the IEDB as well as experienced users wanting to better understand and utilize this resource. The workshop is a great opportunity to learn about all the features of the IEDB database and tools, and to get hands-on individual support on how it can answer your research questions. For more information, contact us at iedb_workshop@lji.org or visit the informational webpage (

    This event was held November 5-6, 2020 virtually via Zoom Webinar due to the COVID-19 pandemic.

  • Nathan Grubaugh: Of Variants and Vaccines

    1:10:44

    This week's speaker is Nathan Grubaugh, an associate professor of epidemiology (microbial diseases) at the Yale School of Public Health.

    Grubaugh earned his PhD in microbiology from Colorado State University (focus on West Nile virus evolution), and was a postdoc at The Scripps Research Institute, studying the 2015-2017 Zika virus epidemic. Building on these experiences, the Grubaugh Lab uses genomics to determine the emergence risk and to track the spread of mosquito-borne viruses, like Zika, chikungunya, dengue, and West Nile.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE:

  • Live from the Lab with Sonia Sharma, Ph.D., presenting Building Better Cancer Immunotherapy

    58:30

    On June 8, 2021, LJI's Sonia Sharma, Ph.D., Associate Professor of the Institute's Center for Cancer Immunotherapy and Center for Autoimmunity and Inflammation, presented her novel research which is advancing more effective cancer immunotherapies. Dr. Sharma's work integrates cutting-edge genetics, biochemistry, and cell biology, as well as computational and translational approaches to define the key genetic mechanisms regulating cellular innate immunity, to determine how they impact human health and disease. In this Live from the Lab discussion, Dr. Sharma discussed some advances in therapies and she shared how her research with her colleagues in cancer immunotherapies supports the Institute's overarching goal – achieving Life Without Disease®.

    The webinar also featured the Institute's sequencing technology and expertise for the laboratory portion. The research highlighted in the webinar and the other research of the Institute's Center for Cancer Immunotherapy is at the forefront of exploring new and sometimes unexpected avenues for novel immune-based cancer treatments, as well as predicting and improving the effectiveness of existing immunotherapies.

    Expert insights during the virtual discussion were provided by Institute leadership including President & CSO Mitchell Kronenberg, Ph.D. and Professor Erica Ollmann Saphire, Ph.D., who was appointed President and CEO of LJI in March 2021. She will become the Institute’s fifth president when she formally begins her term on September 1, 2021. The presentation concluded with a Q&A, with questions from participants.

  • SARS-CoV-2 Impfung und zelluläre Immunität- Dr. Weiskopf

    40:27

    ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ WEITERE INFOS UND LINKS ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓

    Dr. Weiskopf beschreibt die Bedeutung des zellulären Immunsystems in der immunologischen Antwort auf eine COVID19-Erkrankung und eine SARS-CoV-2-Impfung.

  • Bay Area Impact webinar: Will Delta Derail Our Reopening?

    59:12

    Sutter Health Chief Quality and Safety Officer Dr. Bill Isenberg leads an informative and fascinating discussion with UCSF infectious and contagious disease expert Dr. Monica Gandhi and California Department of Public Health COVID Local Response Program Coordinator Dr. Caroline Kurtz on the science behind the fast-emerging and highly contagious delta variant, what it means for reopening and the importance of getting vaccinated and following other safety protocols.

  • Pioneering research: scientists united in global effort to combat Zika - Part 2

    44:38

  • COVID-19 Critical Care Training Forum: Episode 9

    1:9:24

    COVID-19 Critical Care Training Forum: Radiologic findings, immune responses and current controversies in COVID-19

    Dr. Lin presented a COVID-19 case followed by a presentation from Dr. Kligerman on radiologic findings in COVID-19 patients. Dr. McGuire provided an overview of recent updates and controversies in COVID care and Drs. Ramirez and Cho discussed immune responses in COVID patients. Hosted by Laura Crotty Alexander, MD.

    Moderator: Laura E. Crotty Alexander, MD, UCSD
    Discussants: Seth Kligerman, MD, UCSD; Josalyn Cho, MD, University of Iowa; Sydney Ramirez, MD, PhD, UCSD ID Fellow; Erica Lin, MD, UCSD PCC Fellow; Cameron McGuire, MD, UCSD PCC Fellow

  • Why Is My Serology Negative But I had Symptoms?

    34:36

    Please read and agree to the disclaimer before watching this video.
    . More lectures on DrBeen.com

    Looking to support my COVID-19 response effort? Donate here


    In some people, the symptoms of the disease are present, however, they have negative serology. We will discuss the possible causes.

    We will also discuss why the vaccines should have more than the S antigen only.


    Memory T Cells activate rapidly and proliferate on reexposure



    Antigen Recognition by T Cells


    Why is my serology negative?


    Vaccines should add more viral peptides in addition to the S proteins
    ...

    Disclaimer:
    This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
    Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
    Disclaimer:
    This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
    Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

  • Supplements For Immune System: 5 Supplements To Take Daily

    6:42

    Can supplements really boost your immune system? If yes, which are the most effective ones? And how should you take them?

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    --
    Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Your Inception Team, its employees, guests, and affiliates assume no liability for the application of the information discussed. We do not attempt to diagnose, treat, or prevent any diseases or illnesses.

  • 2019 User Workshop – 1.2 – How Data are Retrieved, Entered, and Organized

    17:53

    Day 1, Session 2: Describes where database content is acquired and how it is standardized.
    Slides available for download on our website (

    Timestamps:
    00:00 - About the actual data
    08:39 - Data structure; leveraging ontologies & external resources
    15:25 - Q & A

    Event Background:
    Our team holds an annual user workshop (typically in October/November) to which we invite both those new to the IEDB as well as experienced users wanting to better understand and utilize this resource. The workshop is a great opportunity to learn about all the features of the IEDB database and tools, and to get hands-on individual support on how it can answer your research questions. For more information, contact us at iedb_workshop@lji.org or visit the informational webpage (

    This event was held November 7-8, 2019 at the National Institute of Allergy and Infectious Diseases in Rockville, Maryland, USA.

  • What are T cells? Role of T-cells to fight off COVID19 explained, Current Affairs 2020 #UPSC2020

    8:54

    Click here to Download our Android APP to have access to 1000's of #Smart_Courses covering length and breadth of almost all competitive exams in India.

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  • CORONAVIRUS, INTERFERONS & INTERLEUKINS - Recent Research

    35:04

    Kendall shares some exciting research that's been recently completed, exploring the relationship between COVID-19, Interferon, and Interleukins. He also speaks about the drawbacks of the clinical trial approach to developing treatments.

    Papers referenced:

    Global virus outbreaks: Interferons as 1st responders
    Ben X. Wang, Eleanor N. Fish

    Interferon-α2b Treatment for COVID-19
    Qiong Zhou, Virginia Chen, Casey P. Shannon, Xiao-Shan Wei, Xuan Xiang, Xu Wang, Zi-Hao Wang1, Scott J. Tebbutt, Tobias R. Kollmann, and Eleanor N. Fish

    Targets of T Cell Responses to SARS-CoV-2
    Coronavirus in Humans with COVID-19 Disease and
    Unexposed Individuals
    Alba Grifoni, Daniela Weiskopf, Sydney I. Ramirez, Davey M. Smith,
    Shane Crotty, Alessandro Sette

    Further reading:






    ***

    Read more at Kendall’s website, keep up with his latest thoughts on Twitter, or grab a copy of his latest book, Molecular Immunity via the links below.





  • Conceptos Básicos de COVID-19 - Parte 2

    1:29:53

    Dr. Sebastián Hernández Botero
    Médico Microbiólogo

  • КОВИД-19: Вакцины аюулгүй байдал, РНХ нийлэгжил ба Дархлаа тогтох нь

    18:45

    Шинжлэх ухааны судалгааны ажлыг ГАРДАЖ хийсэн хүнээс өөрөөс нь сонсох, өөрөөр нь энгийнээр тайлбарлуулна гэдэг гайхалтай боломж биз дээ?

    2021 оны 2 сарын 5-нд “Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection” нэртэй судалгаа хэвлэгдэж, өнөөдрийг хүртэл тодорхойгүй байсан олон асуултанд хариулт өгсөн байна.  Калифорниагийн Их Сургуулийн доктор, La Jolla Дархлааны Институтын судлаач Shane Crotty дараах асуултуудад хариулжээ:

    - Мэдээллийн РНХ (мРНХ)-д суурилсан коронавирүсийн вакцинууд хэрхэн үйлчлдэг вэ?
    - мРНХ-д суурилсан вакцин (Pfizer-BioNTech, Moderna) хэр аюулгүй вэ?
    - ДНХ-д суурилсан вакцин (Sputnik, AstaZeneca, Johnson&Johnson) гэж юу вэ? Хэр аюулгүй вэ?
    - Вакцины дараах гаж нөлөө үүсэх боломжтой юу?
    - Вакцины дараах дархлааны хамгаалах тогтолцоо хэр удаан хадгалагдах вэ?


    Эх сурвалж:

  • 最近発表された新型コロナウイルスについての重要論文を読む

    50:38

    今回は、新型コロナウイルスについての理解を深めてくれた面白い論文を岡崎さんと読む予定です。

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