This website uses cookies to ensure you get the best experience on our website. Learn more

Galit Altar: Systems Serology to Assess SARS-CoV-2-specific Placental Antibody Transfer

x
  • Dr. Galit Alter: Using Systems Serology to Define Antibody Responses to SARS-CoV-2

    1:7:10

    Watch the full Global COVID Lab Meeting with Dr. Galit Alter, Professor of Medicine at the Ragon Institute of MGH, MIT, and Harvard. Her research is focused on the development of systems biology tools to define the correlates of immunity against infectious diseases that ravage the globe. Her work points to unexpected mechanisms of protection against HIV, malaria, and tuberculosis has led to the development of novel diagnostics to monitor chronic infections/diseases. Hear Dr. Alter discuss how this work is now being applied to the development of novel classes of COVID-19 therapeutics.Learn more about the Human Vaccines Project Global COVID Lab Meeting and see upcoming events here:

  • x
  • Immune History and SARS-CoV-2 Antibody Responses: Lessons Learned from Influenza Viruses”

    1:12:55

    Scott Hensley, Associate Professor of Microbiology at the UPenn's Perelman School of Medicine

    Abstract: SARS-CoV-2 has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans have been previously exposed to other antigenically distinct common seasonal human coronaviruses before the COVID-19 pandemic. In this seminar, Hensley will describe how previous coronavirus exposures potentially impact immune responses and susceptibility to SARS-CoV-2. He will also discuss how immune history impacts susceptibility to pandemic influenza viruses and speculate that similar mechanisms may be applicable to the current COVID-19 pandemic.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE: janelia.org/scienceofcovid19

  • x
  • Alessandro Sette: Adaptive Immune Responses to SARS-CoV-2

    1:3:30

    This week's speaker is Alessandro Sette, a professor at the Center for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology.

    Sette has devoted more than 35 years of study towards understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. His lab is defining in chemical terms the specific structures (epitopes) that the immune system recognizes, and uses this knowledge to measure and understand immune responses. The lab’s approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE: janelia.org/scienceofcovid19

  • Dr. Pamela Bjorkman: Neutralizing Antibodies Against Coronaviruses

    59:12

    Watch our Global COVID Lab Meeting with Pamela Bjorkman, Ph.D., who talks about: Neutralizing Antibodies Against Coronaviruses.

    Dr. Bjorkman is the David Baltimore Professor of Biology and Biological Engineering and a Merkin Institute Professor at Caltech. She received a BA in Chemistry from the University of Oregon and a PhD in Biochemistry from Harvard. As a graduate student and postdoctoral fellow with Don Wiley, she solved the first 3-D structure of a major histocompatibility complex molecule, HLA-A2. Dr. Bjorkman is a member of the US National Academy of Sciences, the American Academy of Arts and Sciences, the American Philosophical Society, and an elected Fellow of AAAS. She received the William B. Coley Award for Distinguished Research in Immunology, the James R. Klinenberg Science Award, the Gairdner Foundation International Award, the Paul Ehrlich and Ludwig Darmstaedter Award, the Max Planck Research Award, the Rose Payne Distinguished Scientist Award, an NIH Director’s Pioneer Award, and was a L'OREAL-UNESCO Women in Science Laureate. Dr. Bjorkman’s lab studies the structural basis of the host immune response to HIV-1 and other viruses, including SARS-CoV-2.

    Learn more about the Human Vaccines Project Global COVID Lab Meeting and see upcoming events here:

    #COVID19​​​​​​​ #research​​​​​​​ #webinar​​​​​​​ #interferons​​​​​​​ #vaccines​​​​​​​ #globalcovidlabmeeting​​​​​​​ #covidvaccineinitiative​​​​​​​

  • x
  • “Systemic inflammation and other unexpected surprises in the host response to SARS-CoV-2”.

    1:18:05

    Dr. Benjamin tenOever is the Fishberg Professor of Medicine, Icahn Scholar and Professor of Microbiology, and Director, Virus Engineering Center for Therapeutics and Research (VECToR) at the Icahn School of Medicine at Mount Sinai. He holds a PhD in medicine from McGill University and completed his postdoctoral training in molecular biology at Harvard University.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

  • Galit Altar: Systems Serology to Assess SARS-CoV-2-specific Placental Antibody Transfer

    1:22:29

    This week's speaker is Galit Alter, a professor of medicine at Harvard Medical School and a group leader at the Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard.

    Abstract: SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. The Alter Lab has used their unique systems serology antibody profiling approach to characterize the Fc-profile of influenza-, pertussis-, and SARS-CoV-2-specific antibodies transferred across the placenta. Influenza- and pertussis-specific antibodies were actively transferred. However, SARS-CoV-2-specific antibody transfer was significantly reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity were lower than in maternal plasma. This effect was only observed in third trimester infection. SARS-CoV-2-specific transfer was linked to altered SARS-CoV-2-antibody glycosylation profiles and was partially rescued by infection-induced increases in IgG and increased FCGR3A placental expression. These results point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE: janelia.org/scienceofcovid19

  • x
  • Conference 2021 Day 1 | Dr. Galit Alter

    59:44

    Title: Systems serology to define correlates of immunity to SARS-CoV-2

    Website:
    LinkedIn:
    Instagram:
    Facebook:

  • Virtual Hall: Dr. Galit Alter

    49:56

    Dr. Galit Alter spoke to students as part of a Virtual Hall on Thursday, September 17, 2020. Her lecture served as a follow-up to the previous week's lecture from Dr. Nahid Bhadelia. Dr. Alter focused her presentation on immunity response to infectious disease, the history of vaccines and inoculation, and the progress being made on a Coronavirus vaccine.

    Dr. Alter is a Professor of Medicine at Harvard Medical School and a Group Leader at the Ragon Institute of MGH, MIT and Harvard. Dr. Alter’s work focuses on the development of systems biology tools to define the correlates of immunity against infectious diseases that ravage the globe.

  • Humoral Immune Response

    45:44

    Galit Alter, Ph.D., talks about her work using systems serology to explore antibody responses to SARS-CoV-2 during ASGCT's COVID-19 Symposium.

  • x
  • Research Contributing to Successful COVID-19 Vaccine Development

    1:53

    Galit Alter, PhD, is a principal investigator at the Ragon Institute of Massachusetts General Hospital, MIT and Harvard, and Samana Cay MGH Research Scholar. Her research has informed the battle against CoV-2—has been important for developing the critical insights into the antibody mechanisms that are essential to induce through vaccination to ultimately control and clear the infection. Her work has also helped inform strategies to evaluate vaccines more effectively to ensure that the most effective antibody responses are elicited against the virus.

    Advances in Motion provides health care professionals with information about the latest breakthroughs, research and clinical advances from Massachusetts General Hospital.
    Subscribe:

  • Developing COVID-19 Diagnostics By Understanding Antibody Protection

    2:28

    Galit Alter, PhD, principal investigator at the Ragon Institute of Massachusetts General Hospital, MIT and Harvard, and Samana Cay MGH Research Scholar. Early on in the COVID-19 pandemic, her research looked at early responses to SARS-CoV-2 infection at hospital admission to see whether or not they could predict if someone was going to handle the disease well and survive. This research has allowed for the development of diagnostic platforms that can help in managing patient care, helping to inform which patients may require closer attention or more intense medical interventions.

    Advances in Motion provides health care professionals with information about the latest breakthroughs, research and clinical advances from Massachusetts General Hospital.
    Subscribe:

  • SARS-CoV-2 Virus and Antibody Transmission Between Mothers and Neonates

    9:25

    What do we know about the transmission of the SARS-CoV-2 virus and antibodies from expectant mothers to their children? Massachusetts General Hospital researchers Andrea Edlow, MD, MSc, Drucilla Roberts, MD, Galit Alter, PhD, and Anjali Kaimal, MD, discuss the findings of their recent study.



    Song: Ikson - New Day (Vlog No Copyright Music)
    Music provided by Vlog No Copyright Music.
    Video Link:

  • Researchers Explain! The Immune System

    15:12

    Ever wondered how your body fights off germs? Listen to some of the Ragon's immunologists - that's scientists who study the immune system! - explain how the immune system works to fight bad germs that can make you sick. Galit Alter makes a special appearance a the end to talk about how vaccines can help your immune system power up to fight diseases like COVID-19.

    This video was made by Vicky Roy, technologist in Galit Alter's lab, as part of the 2021 Cambridge Science Festival, with support from the Alter lab and the Ragon Institute. Follow the Cambridge Science Festival 2021 on #30daysofscience

  • CAHR2015 - Basic Sciences Plenary

    46:17

    Systems Serology to Profile Protective Immunity Against HIV

    Presenter: Dr. Galit Alter
    Associate Professor of Medicine; Director, Ragon Institute Imaging Core; Director, Harvard Center for Aids Research Immunology Core, Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

  • Decoding Covid, June 15: Coronavirus immunity and Approaches to Vaccine Development

    1:9:22

    Galit Alter, PhD
    Ragon Institute

  • ESCMID Websymposium: COVID-19 Diagnostics

    2:2:13

    ESCMID president, Maurizio Sanguinetti and ECCMID Programme Director, Jacob Moran-Gilad, host the first in a new series of 5 open-access websymposia dedicated to the COVID-19 pandemic. They are joined by 4 experts in the field of diagnostics to create the programme outlined below.

    Gilbert Greub: Molecular diagnostics for COVID in the vaccine era
    Mario Plebani: COVID serology - before, during and after vaccination
    Bali Pulendran: Laboratory assessment of SARS-CoV2 immunity
    Sharon Peacock: Tracking SARS-CoV2 variants through large scale genomics

    The live event took place on February 16, 2021.

    Be sure to follow ESCMID Social media to learn about future events.

    Other ESCMID Links:
    ECCMID:
    ​​Twitter:
    Facebook:

    ​​LinkedIn:

  • Immunological profiling using multiple model systems to understand SARS CoV 2 infection

    51:47

    Presented By:
    Dr. Claudio Fenizia
    Premnath Rajakannu

    Speaker Biography:
    Dr. Fenizia is an Assistant Professor in General Pathology and a member of the PhD School in Molecular and Translational Medicine at the University of Milan. A trained molecular immunologist, Dr. Fenizia has over 15 years of experience in basic and translational laboratory research and has published over 40 research papers in peer-reviewed scientific journals. At the Department of Biomedical and Clinical Sciences, University of Milan, his research work focuses on the immunological and genetic correlations of protection involved in several chronic pathologies, including transplant-related diseases and viral infections such as HIV-1 and SARS-CoV-2 infection. As an educator and communicator, Dr. Fenizia has over 12 years of teaching experience at medical and nursing school at the University of Milan.
    Dr. Rajakannu is an application scientist for protein and RNA biomarker assays at Thermo Fisher Scientific. He received his Ph.D degree from University hospital Lausanne, Switzerland specializing in cancer and immunology research. As an application scientist, Dr. Rajakannu's work in focused on scientific support for the Invitrogen multiplex assays, ProcartaPlex and QuantiGene Plex, assisting researcher with experimental planning, testing, assay optimization and data analysis. Dr. Rajakannu also serves as a liaison between external scientific collaborators and Thermo Fisher Scientific R&D, helping with successful product development and testing.

    Webinar:
    Immunological profiling using multiple model systems to understand SARS-CoV-2 infection

    Webinar Abstract:
    Since the current SARS-CoV-2 outbreak, there has been an urgent need to define the immune response and understand the relevant immunological mechanisms underlying the progression of the disease. In this webinar, we will present data from multiple model systems used to analyze the antiviral response against SARS-CoV-2 utilizing a direct-from-sample transcriptional profiling technology. Specifically, we will discuss the use of a multiplexing/multiparametric panel in studying the RNA targets relevant to respiratory virus infection biology including the immune response, viral infection process, cytokine storm. Part 1 of the webinar will focus on the infection biology of various SARS-CoV-2 isolates in comparison to influenza AB infection, using in vitro and mouse infection models. In part 2 of the webinar, we will present findings from clinically relevant models such as human lung biopsies, and an ex-vivo viral exposure human PBMCs in the context of SARS-CoV-2 infection. Finally, we present our observations on the characterization of immune response in a cohort of SARS-CoV-2 infected women postpartum. Taken together these investigations of the immunological profile triggered by SARS-CoV-2 infection provides a better understanding of disease progression.

    Earn PACE Credits:
    1. Make sure you're a registered member of LabRoots (
    2. Watch the webinar on the LabRoots Website (
    3. Click Here to get your PACE credits (Expiration date – MAY 27, 2023): (

    LabRoots on Social:
    Facebook:
    Twitter:
    LinkedIn:
    Instagram:
    Pinterest:
    SnapChat: labroots_inc

  • Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

    4:14

    Ragon Steering Committee Member Dan Barouch, of Beth Israel Deaconess Medical Center led a team that developed a COVID-19 vaccine which proved promising in primate trials. Dan, Group Leaders Galit Alter and Aaron Schmidt, and Director Bruce Walker speak on the paper and what it's like to work against a pandemic.

  • Covid Testing in a Vaccinated Population: Needed or Obsolete? - Highlights

    3:38

    Highlights of a Panel discussion with Galit Alter, Ian Law, Lisa Regan and Kathrin Röschel, moderated by Johannes Frühauf. Presented by GABA and GABC, supported by the German Consulates of Boston and San Francisco.

    The full version is available here:

  • How your immune system responds to COVID-19 - Get Real Health

    24:03

    Dr. Galit Alter chats with host Dr. Chana Davis about why COVID-19 infections can be either deadly or invisible - and why age, health, and obesity matter so much. Dr. Alter, a leading immunologist, sheds light on how our immune response to viral infection shapes our fate.

    Their conversation gets into the science behind these questions: Why do kids tend to escape COVID-19 infection with little to no symptoms? Why are older adults at such high risk of severe disease? What is the biology beneath the other key COVID-19 risk factors (e.g. obesity, hypertension, immunocompromised state)? How does COVID-19 compare to other viruses?

    The conversation closes with a discussion of boosting the immune system and what we should all be doing to protect ourselves.

    This episode is part one of a two part conversation. The second segment, on vaccine development, will be coming out later this month.

    Galit Alter, PhD is a Professor of Medicine at the Ragon Institute of MGH, MIT, and Harvard where she studies the immune response to viral infections, and how to use this knowledge to improve vaccines. She is also co-Director of Harvard's Center for AIDS Research (CFAR). Dr. Alter received her PhD in experimental medicine from McGill University.

    This interview was recorded on October 2, 2020.

    ---

    Get Real Health provides science-based insights so that you can make smart, healthy choices. Dr. Chana Davis (PhD, Stanford genetics) interviews leading experts who share practical, science-based advice and bust common myths and misconceptions. Show topics span food (nutrition, toxicology, weight loss), exercise, infectious diseases (microbiome, COVID-19), public health (vaccines), and mental wellbeing.

    Access more of Dr. Davis' work:
    Website:
    Instagram: @fueledbyscience
    Facebook: @fueledbyscience
    Twitter: @fueledbyscience

  • x
  • SARS CoV2 Round-Robin: From Variants to Long-Haulers and More - 3/2/2021

    56:34

    SARS CoV2 Round-Robin: From Variants to Long-Haulers and more | Specialist Panel | 3/2/2021
    Slides and Session Resources:
    Recordings are not eligible for continuing education credit.
    Visit us at

  • CRRG Webinar: Immune interactions and SARS-CoV-2 Evolution

    1:14:40

    Immune interactions and SARS-CoV-2 Evolution

    Speaker: Benjamin Greenbaum, Memorial Sloan Kettering Cancer Center
    Moderator: Nicolas Vabret, Mt. Sinai

    Topics covered during this webinar:
    - Host-virus interactions that drive the deterministic aspect of virus evolution.
    - Understanding the pathology of infectious disease.
    - Viral genomics at short and long-time evolutionary scales that can be used to understand which features most impact a virus in ways that can inform antiviral therapies.
    - Review of approaches to quantifying how the immune system interacts with SARS-CoV-2.
    - Which processes are likely most relevant to COVID-19 pathogenesis and treatment.

  • Webinar - SARS-CoV-2 and assisted reproduction in 2021

    1:38:50

    A webinar (12 May 2021) addressing the currently relevant issues regarding COVID-19, being vaccination, vertical transmission, patient support and adaptation of services.

  • Biology of SARS-CoV2 & COVID-19

    1:12:17

    Dr. Jamie Newman and Dr. Patrick Hindmarsh, members of the Louisiana Tech University School of Biological Sciences, will moderate the event. Dr. Barbara Osborne, Professor of Veterinary and Animal Sciences at UMass Amherst will share research on the immune system and its response to SARS-CoV2 and Dr. Gordon Love (Louisiana Tech University class of 1973), Professor of Pathology at LSU School of Medicine in New Orleans will share his findings related to COVID-19 pathology and the tissue damage sustained by those suffering from the disease.

  • 10/28/20 - Jesse Bloom Seminar

    52:44

    The evolutionary potential of the SARS-CoV-2 Spike protein

  • Landscape of the SARS-CoV-2 Vaccines | 1-8-2021

    1:37

    Benjamin Israelow, MD, Ph.D

  • Reproductive Immunology - Dr. Gil Mor, M.D., Ph.D.

    1:00

  • Experts Panel Dental Community 20210216 2359 1

    1:2:11

  • COVID-19 vaccines: Will they work? When will they come? - Get Real Health

    28:33

    Dr. Galit Alter chats with host Dr. Chana Davis about what we can expect from a COVID-19 vaccine, and when they will become available.

    Dr. Alter is a leading immunologist who studies how we can use our knowledge of the immune system to improve vaccines.

    This episode of Get Real Health dives into many of the questions surrounding COVID-19 vaccine development. How effective will COVID-19 vaccines be? How long will they protect us? How will their safety be ensured? What types of vaccines are leading the pack? When will they be ready? While there are no simple answers, Dr. Alter sheds light on what the experts are predicting, and why.

    This episode is the second part of a two part conversation. The first segment, on the immune response to COVID-19 was released on October 8, 2020.

    Galit Alter, PhD is a Professor of Medicine at the Ragon Institute of MGH, MIT, and Harvard and co-Director of Harvard's Center for AIDS Research (CFAR). Dr. Alter received her PhD in experimental medicine from McGill University.

    This interview was recorded on October 2, 2020.

    ---

    Get Real Health provides science-based insights so that you can make smart, healthy choices. Dr. Chana Davis (PhD, Stanford genetics) interviews leading experts who share practical, science-based advice and bust common myths and misconceptions. Show topics span food (nutrition, toxicology, weight loss), exercise, infectious diseases (microbiome, COVID-19), public health (vaccines), and mental wellbeing.

    Access more of Dr. Davis' work:
    Website:
    Instagram: @fueledbyscience
    Facebook: @fueledbyscience
    Twitter: @fueledbyscience

  • Aaron Ring: Diverse Functional Autoantibodies in Patients with COVID-19

    1:14:05

    This week's speaker is Aaron Ring, an assistant professor of immunobiology at Yale School of Medicine.

    Aaron joined the faculty of the Yale Department of Immunobiology in 2016 as the Robert T. McCluskey Yale Scholar. The focus of his research is to understand and manipulate the activity of immune receptors using precision immunopharmacology and systems immunology.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE:

  • COVID, Thrombosis, and the Research: Steering into the Storm with Full Sails

    1:32:19

    This program addressed the unique cardiovascular (CV) risks and challenges that patients face when recovering from COVID-19, with a particular focus on thrombotic illnesses. The epidemiology, pathophysiology, and prevention of CV complications in COVID-19 was discussed, and the program concluded with a case series exploring key clinical dilemmas in COVID-19-associated thrombosis.

    --Contents of this video-----------------
    0:00 - Introduction
    1:34 - A Public Health Challenge: The Burden of Venous and Arterial Thrombosis in COVID-19
    18:30 - Mechanisms and Histopathology of Thrombosis in COVID-19
    33:56 - Recognizing the Hazard of Cardiovascular Complications in COVID-19
    49:05 - Prevention of Thrombosis in COVID-19: Navigating the Trials and Guidance Documents
    1:13:37 - Cases: Clinical Dilemmas in Patients with COVID-19 and Thrombosis

  • JoCo on the Go, episode #80: Lingering COVID-19 symptoms

    17:45

    On JoCo on the Go, episode #80, host Theresa Freed shares her story of getting COVID-19 and the continued struggle to fully recovery. Hear from a local doctor about how common it is for residents to experience lingering effects from the virus and the help that is available to overcome issues such as loss of taste and smell, extreme fatigue, brain fog, cardiac issues, problems in the lungs and more.

  • COVID-19: Message from Founder & CEO Tim Springer

    2:58

    Free Accessibility Help for COVID-19 Digital Communications & Resources

    Level Access CEO Tim Springer discusses why digital accessibility is more important than ever now, and free resources available to help you ensure your website, mobile app, and other communications are accessible.

    Resources available at
    - Pro bono consultation offer for COVID-19 resources
    - Quick fixes for improve accessibility ASAP
    - On-Demand webinars and other learning resources
    - Free testing tools

    Also check out our industry-specific resource pages:
    - Banking and Financial Services:
    Healthcare:
    Education:

  • Keynote session on COVID-19 | #ESCAIDE2020

    1:37:38

    First plenary session of ESCAIDE 2020 on COVID-19, moderated by Mike Catchpole (ECDC) & Magdalena Rosińska (National Institute of Public Health - National Institute of Hygiene, Poland.

    Speakers:
    - George Fu Gao - China CDC;
    - Andrea Ammon - ECDC;
    - Maria van Kerkhove - WHO.

    Learn more about ESCAIDE: escaide.eu
    Visit ECDC website: ecdc.europa.eu

  • Anatomy of Covid - The Respiratory System & Beyond | NI Science Festival

    42:53

    Since the global pandemic cause by the Coronavirus SARS-CoV-2, most people know about the main symptoms of the infection and how it is transmitted from person to person. We know about the cough, loss of taste and smell, feelings of tiredness, and high fever. We know about hand washing and mask wearing.

    What might be less well understood is how the virus gets into our bodies to cause infection, or how some people become so unwell, needing intensive care. How does the virus enter our lungs, and what happens to the body when the immune system spirals out of control?

    This session looks at the body’s anatomy to explain some of these issues in simple terms.

  • Lecture 10a: Mucosal Immunology

    26:44

    UCSD Extension School: Applied Immunology (BIOL-40371)
    Summer Quarter 2021
    This lecture summarizes specialized immune responses that are localized at mucosal surfaces, and how they work to both promote rapid responses to infectious pathogens while maintaining mucosal tolerance to commensal microbes and food antigens.

    All figures are either from Janeway's Immunobiology (9th ed.) where noted, or my own original figures.

  • Rare Genetic Variants May Predispose to Severe COVID-19

    8:11

    Dr. Alex Hoischen, Radboud University, discussed his published results on genomic variants found in families with severe COVID-19. In two families with severely ill brothers, mutations were found in the Toll Like Receptor 7 gene (TLR7), which affects the production of interferons, signaling molecules used to control the immune response. Several other studies have since made similar findings in other genes of the TLR family. Dr. Hoischen discussed how individual patients each may carry individually rare variants, that are collectively common and point to important pathways involved in the disease. His interest in the consortium is based on his understanding that larger SVs have a greater chance to be rare and disruptive, and genome-wide studies have lacked so far in their assessment.

  • Why COVID-19 Matters to Communities of Color

    48:44

    Why COVID-19 Matters to Communities of Color:

    A panel with public health experts discussing inequity and the pandemic’s disproportionate impact on communities of color

  • Arnaud Marchant - Immunobiology of Maternal Immunization

    28:02

    Arnaud Marchant (Université Libre de Bruxelles) delivers a talk at the Human Vaccines Project's 2018 conference, the Future of Vaccine Development, June 27, 2019, at the University of Southern California in Los Angeles, Calif.

  • COVID-19 Update: Feb. 18, 2021

    46:37

    Doctors discuss COVID-19 infection rate among expectant moms and what they advise patients about getting the vaccine and avoiding the virus. Also, hear from an expectant mom on why she got the COVID-19 vaccine.

  • A&P2_Respiratory System

    1:9:21

  • MERIT CoVID 19 Webinar Day 24 April 23rd 2020

    1:27:06

    This Daily Meeting & Webinar is a Physicians Collaborative between APPNA MERIT and Pakistani institutions to discuss updates and lessons learned daily for treatment of acute care or inpatient management of hospitalized patients with Coronavirus infections.

    Topic: Obstetric Concerns in Covid.
    Speaker:
    Noormahal Kabani
    Pulmonary /Critical Care / Sleep Consultant
    Houston Texas

    APPNA Leadership:
    1. Dr. Naheed Usmani, MD (President, APPNA)
    2. Dr. Shahid Rafiq, MD (Chair, APPNA MERIT)
    3. Danish Bhatti, MD FAAN (Co-Chair APPNA MERIT)

    Register yourself using below link:

    After registering, you will receive a confirmation email containing information about joining the webinar.

    All information related to merit covid-19 webinars is now available on our website:


    Some questions and comments by participants in this webinar:
    1. Question for Epidemiological measures stand point- Does anyone believe that advising an all at the same time( simultaneous) lock down approach at a global level would have worked out well in beating this disease out.? I am extrapolating this based on ' Richochet effect ' observed in pandemics where the infection keeps on bouncing back and forth oblivious to the territorial divides and especially when the durability and longevity of protective antibody response is not ironclad.
    2. Question on prospective treatment armamentarium- A non peer reviewed article in ChemRxiv (chemarchive) suggest in vitro high viral load clearance with Ivermectin. Do we have any clinical trial or extended use or compassionate use report of this drug in US experience.?
    3. Question about neurological aspect of COVID-19. There were few case reports on neurological manifestation of COVID-19 patients like dizziness, syncopy etc in US. Could this disease cause a serious condition like 'acute necrotizing encephalopathy' known to be attributed to other viral infections e.g influenza? If so how much could be the neurological burden of this virus in terms of presentation?
    4. Somebody said that steroids should not be used in the fitst place while having initial phases of COVID when viruses are in the upper respiratory tract since it bolsters infections . The question is an what an asthmatic will do whose on inhaled or systemic steroids , since the use is so vital for him ?
    5. How high should be Ig G of donors of convalsecent plasma
    6. Does pregnancy outcome varied by trimester of presentation
    Is delayed cord clamping still appropriate in a patient who has suspected or confirmed COVID-19?
    7. Any precautions for new born and new mother post delivery and post discharge?
    those asymptomatic. are they checked for covid 19 prior to discharge?
    8. when do you get the convalescent serum? after 2 negative 1 week apart or more - will antibodies be elevated by then?
    9. Do you use covid score for screening to decide if to be placed in covid floor
    10. For Fetal maturation between 27-33 weeks what should be dose of corticosteroids?

  • Immunoglobulin crossing placenta / Ig G / Image based learning / Basic Immunology

    3:05

  • Special issues: COVID-19 Infection and Thrombosis

    27:08

    #COVID-19 #Thrombosis #Venous_Thromboembolism #Saudi_Society_Blood_Disorders

  • Ragon Institute 10 Year Video

    3:16

    On February 4, 2009, the presidents of the Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT) and Harvard University – Peter L. Slavin, MD; Susan Hockfield, PhD; and Drew G. Faust, PhD; respectively – and special guests Phillip T. and Susan M. Ragon gathered at the Charles Hotel to announce creation of the Ragon Institute of MGH, MIT and Harvard.

    Formed to find new ways of preventing and curing human disease through harnessing the power of the immune system, the Ragon Institute brings scientists and clinicians together with engineers using the latest technologies in an interdisciplinary effort to better understand how the body fights infections. That understanding will ultimately be applied against a wide range of infectious diseases and cancers, with an initial focus on the need for an effective vaccine against AIDS.


    Follow the Ragon Institute:
    Twitter: @ragoninstitute
    Facebook:
    Linkedin:

  • Tim Springer - Canada Gairnder Laureate Lecture

    38:20

    Learn more about Tim Springer and Gairdner here:

    #Gairdner2019

  • Breathing in COVID-19 | UCL Medical Sciences Public Lecture

    57:27

    A recording of a talk and Q&A with UCL's Professor Joanna Porter, Head of Undergraduate Respiratory Teaching at UCLH, on Breathing in COVID-19: The short and long term impacts of COVID-19 on our lungs.

    COVID-19 is impacting all of us across the world. In this lecture and Q&A, we talked more about COVID-19 and the new variants, initial timelines of infection, how it hijacks the body to spread to others, and the effect it has on the lungs. We also took a look at how our body’s immune system may worsen lung inflammation and how the lung recovers from infection and returns to normal.

    About the speaker
    Professor Joanna Porter heads the NHS National Interstitial Lung Disease (ILD) service at UCLH and is a Professor in Respiratory Medicine at UCL. Joanna is one of the founding members, and Medical Director of Breathing Matters Charity. She is the UCL/H BRC clinical academic lead for the NIHR translational research collaboration, heads the leukocyte trafficking laboratory at UCL and is Head of Undergraduate Respiratory Teaching at UCLH.

  • Keystone Symposia HIV Panel Discussion

    21:59

    2014 HIV Panel Discussion
    A panel discussion on March 11, 2014 on the topic of “HIV/AIDS: Strategies for an Endgame” that took place at the joint Keystone Symposia meetings on “HIV Vaccines: Adaptive Immunity and Beyond” and “HIV Pathogenesis – Virus vs. Host” in Banff, Alberta, Canada.

    This was a follow-up discussion to Keystone Symposia’s live webcast on the topic that took place December 13, 2013.

    Link:

    ____

    Participants are, left to right:

    Dr. David L. Woodland, Chief Scientific Officer of Keystone Symposia;

    Dr. Carl W. Dieffenbach, Director of the Division of AIDS, NIAID, NIH;

    Galit Alter, Associate Professor, Ragon Institute of MGH, MIT and Harvard;

    David M. Margolis, Professor of Medicine, University of North Carolina at Chapel Hill;

    Magdalena E. Sobieszczyk, Assistant Professor of Clinical Medicine, Columbia University;

    Myron S. Cohen, Associate Vice Chancellor, University of North Carolina at Chapel Hill;

    Thomas C. Quinn, Associate Director of International Research and Professor, NIAID, NIH and Johns Hopkins University;

    Peter A. Anton, Professor of Medicine, David Geffen School of Medicine at UCLA.

    ____

    Copyright Keystone Symposia, 2015. All rights reserved.

    About Keystone Symposia:
    Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.




    Visit our website:


    For more videos:


    Follow us on Twitter:


    Like us on Facebook:


    Link to us on LinkedIn:



    Outro music:
    Slider by Blue Dot Sessions (

  • FcRn Therapies 2021 Conference Humanized Cytokine Models

    20:04

    Humanized mouse models to access the in vivo efficacy of antibody therapeutics

    Speaker:
    Jenna Frame, PhD,
    Senior Scientist, Scientific Communication at Biocytogen Boston Corp

  • COVID Vaccines and Variants March 2021

    1:9:16

    A Ragon Institute Webinar given for Susan Ragon and friends about COVID-19 vaccines and variants of concern, featuring Galit Alter, Dan Barouch and Bruce Walker. The video deals with how viruses like SARS-CoV-2 hijack cells to make new viruses, and mutate in the process to make new viruses that evade host immunity. The video highlights the J&J single shot vaccine that was developed by Dan Barouch, a founding member of the Ragon Institute, with help from Galit Alter at the Ragon. And it highlights the transformative power of philanthropy in science from people like Terry and Susan Ragon, Mark and Lisa Schwartz and many others.

Menu