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Rheumatoid Arthritis Animation

  • Rheumatoid Arthritis Animation


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    This 3D medical animation gives a brief overview of the anatomy and physiology of a typical synovial joint, explains what arthritis is and how rheumatoid arthritis effects a joint. The animation goes on to show the common treatment options for rheumatoid arthritis.


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  • Rheumatoid Arthritis Mode of Action Animation


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    The 3d animation film shows rheumatoid arthritis as a chronic and debilitating disease caused by a defect in one or many of the body's own defense mechanisms. The underlying chronic inflammation results when the immune system and its specialized cells that normally work to protect the body from foreign invaders start to attack normal tissues. The film explains the mode of action of a monoclonal antibody.

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  • Rheumatoid arthritis Animation - Etiology, Signs and Symptoms, Pathology, Diagnosis, and Treatment


    Rheumatoid arthritis Animation - Etiology, Signs and Symptoms, Pathology, Diagnosis, and Treatment

    Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder characterized by joint pain, swelling, and synovial destruction. RA predominantly affects middle-aged women. The condition can also cause various extra-articular manifestations such as rheumatoid nodules and pulmonary fibrosis. Diagnosis is mainly based on clinical features (e.g., morning stiffness, symmetrical joint swelling) and laboratory tests (e.g., anti-CCP). X-ray findings (e.g., soft tissue swelling or joint space narrowing) occur late in the disease and are therefore not typically used for diagnosis. Early intervention with disease-modifying antirheumatic drugs (DMARDs) plays a decisive role in successful treatment. RA is not curable, but early effective treatment may help offset severe complications (e.g., permanent damage to the affected joints).

    #rheumatoidarthritistreatment #rheumatoidarthritispathology #rheumatoidarthritis #pathology #usmle #usmlestep1 #mbbs #pathologyvideos #uworld #medicalanimation #nationalexittest #nationalexitexam #pathologyanimations

  • Immunology of the rheumatoid joint


    Rheumatoid arthritis is an inflammatory disease that mainly affects the joints in which the body's immune system attacks its own tissues. This animation produced by Nature Reviews Immunology and Nature Reviews Rheumatology guides us through the immune pathways involved in the disease, from the first signs of self-reactive immune cells to joint damage and other symptoms, and highlights opportunities for new treatments.

    Nature Reviews Immunology ( and Nature Reviews Rheumatology ( have full responsibility for all editorial content. This content is editorially independent of sponsors.

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  • Rheumatoid arthritis - causes, symptoms, diagnosis, treatment, pathology


    What is rheumatoid arthritis? Rheumatoid arthritis is an autoimmune condition where the immune system attacks the joints.

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    Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.

  • What is Rheumatoid Arthritis? | RA Awareness Day 2017



    The 2nd of February is Rheumatoid Arthritis Awareness Day and 3D4Medical made a video explaining more about the condition.

    #anatomy #NervousSystem #medtech #doctor #medstudent #3D #physiology #CompleteAnatomy

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  • Osteoarthritis | Nucleus Health


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    This 3D medical animation gives a brief overview of the anatomy and physiology of a typical synovial joint, what arthritis is and how osteoarthritis affects a joint. The animation goes on to show common treatment options for osteoarthritis.


  • Psoriatic Arthritis - 3D Medical Animation


    This video was produced by Amerra for Paradigm Medical Communications, LLC as part of a CME-credit earning, web monograph offered through their website:

    For more information about custom 3D animation, please visit Amerra at or call 1-888-9AMERRA.

  • Rheumatoid Arthritis Pathophysiology


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  • Stages of Knee Osteoarthritis


    In this video we discuss the stages of knee osteoarthritis.

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  • Rheumatoid Arthritis | autoimmune disorder | Pathophysiology, risk factors ,treatment.


    Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels.

    An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body's tissues.

  • Shoulder Arthritis Narrated Animation.


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    Voice by: Qudsi Baker.
    ©Alila Medical Media. All rights reserved.
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    All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
    The main joint of the shoulder, commonly referred to as THE shoulder joint, is the joint between the head of the humerus - the upper arm bone, and the glenoid cavity of the scapula -the shoulder blade. This is a ball-and-socket type of joint.
    Shoulder arthritis refers to loss of cartilage on the surface of the humeral head and the glenoid of the shoulder joint. The two bones rub against each other and produce pain, stiffness and difficulty moving an arm.
    Types of shoulder arthritis include:
    Osteoarthritis - also called degenerative joint disease - is the wear and tear condition of the joint, commonly due to old age. Osteoarthritis is characterized by loss of cartilage, bone spurring and NO major inflammation.
    Rheumatoid arthritis – is a result of inflammation of the synovium - the membrane that encloses the joint. Inflammation brings in the cells of the immune system, whose inflammatory chemicals damage and destroy the joint. It is not clear how rheumatoid arthritis starts but genetic predisposition together with infection of the joint are likely to be among the causes.
    Rotator cuff arthropathy or cuff tear arthropathy is shoulder arthritis AS A RESULT and IN A SETTING of rotator cuff tears. Rotator cuff muscles hold the ball and the socket together and prevent the humeral head from moving out of the socket when the person raises an arm. In people with torn rotator cuff, the head of the humerus moves upwards and rub onto the acromion. This causes damages to the covering cartilage and eventually arthritis. Combination of cuff tear and arthritis is a devastating condition that seriously impairs functions of the shoulder joint.
    Post-traumatic arthritis – is arthritis that develops after physical injury to the joint.
    Chondrolysis - sudden loss of cartilage that happens occasionally after a shoulder surgery, commonly seen in association with infusion of local anesthetics into the joint for pain management.

  • Gout


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    This 3D medical animation created by Nucleus Medical Media describes the cause of gout and various side effects of gout. Illustrated within are the different physiological conditions that cause or are caused by gout. Also described are related topics such as purines role in gout, uric acid production and removal from the body, hyperuricemia, dehydration, and tophus formation.


  • Novel Treatments for Rheumatoid Arthritis


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    Animation reviews the novel therapies available for the treatment of rheumatoid arthritis.

  • What is Rheumatoid Arthritis?


    Animated Video explaining Rheumatoid Arthritis, How it occurs?, What are it's different symptoms?, how will you investigate it and its management. A project of Free Medical Education​.

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    Let's make Medical Education Universal, Free, State of the Art and Available to every human being to enable best medical facilities for every human being.

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    Imagine A World in which Every Medical Student & Every Doctor can have access to State of the Art Animations/illustrations explaining Entire Medical Course for FREE.
    Imagine, how dramatically it will improve quality of medical education for millions of healthcare givers.
    Imagine, how dramatically it will improve the Quality of healthcare provided by these healthcare givers to billions of human beings.
    Together we can achieve this dream.
    Let's make Medical Education Universal, Free, State of the Art and Available to every human being to enable best medical facility for every human being.
    Using state of the art animation videos we would create videos that will help every medical student get the best possible resource for easily grasping and understanding all medical concepts.
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  • Rheumatoid Arthritis - Mayo Clinic


    Pain, swelling and stiffness in your joints. All are symptoms of rheumatoid arthritis. But because these symptoms come and go, the condition can sometimes be tricky to diagnose. And it's important to get the right diagnosis because starting treatment early can make a difference.

  • Rheumatoid Arthritis of the hand - Everything You Need To Know - Dr. Nabil Ebraheim


    Dr. Ebraheim’s educational animated video describes the condition of rheumatoid arthritis, the etiology, signs and symptoms, the diagnostic tests and indications, and the treatment options and prognosis.
    Rheumatoid Arthritis involves the synovium of the joints. The condition of rheumatoid arthritis will result in deformities. Rheumatoid Arthritis occurs in females more than males. There may be a hereditary component with Rheumatoid Arthritis. Rheumatoid Arthritis has spontaneous remissions and exacerbations. The disease can have a systemic nature.
    Pain and stiffness of joints especially in the morning (morning stiffness). Rheumatoid Arthritis is typically polyarticular, bilateral and symmetrical and most commonly affects the hands and feet.
    x-rays show periarticular erosions at the time of diagnosis. Osteopenia and minimal osteophyte formation favor the diagnosis of rheumatoid arthritis.
    Rheumatoid Arthritis is an autoimmune disease. The disease has two components: immunological reaction. Increased degradative enzymes. The IgM (Rheumatoid factor) is produced by the plasma cell as ana antibody to the native IgG, which is altered in RA. 70% of patient with RA have rheumatoid factor positive. Leucocytes are attracted to the immune complex forming deposits over the inflammatory surface of the synovium. These leucocytes ingest fibrin and immune complex and is called the Rheumatoid cells. The leucocytes release lysosomal enzymes that cause acute inflammatory response and tissue necrosis as well as inflammatory mediators ( IL-1, IL-6, TNF alpha). The chondrocytes respond to stimulation by TNF- alpha, IL-1 and other inflammatory mediators causing cells to become activated and secrete more metalloproteinases which lead to cartilage damage. The synovium becomes hypertrophied (pannus), showing intimal hyperplasia and infiltration by plasma cells and lymphocytes.
    Stages of Rheumatoid Arthritis
    Early: acute: hot swollen tender joints (synovitis)
    •MCP swelling
    •Wrist swelling
    •Flexor sheath synovitis
    Complicated: digital vasculitis, ecchymosis, skin atrophy, nodules.
    •Swelling of MCP joints
    •Lateral slippage of extensor tendon ruptures
    •Ulnar deviation of fingers
    •Xrays show destruction of MCP with subluxation, ulnar deviation and wrist destruction.
    •Finger deformities: Mallet, boutonniere, Swan neck
    The thumb is also involved. These changes occur due to proliferation, inflammation and hypertrophy of the synovium. Involvement of the distal radioulnar joint is usually associated with rupture of the extensor digiti minimi.
    Rheumatoid nodules
    25% of patients with RA will have subcutaneous nodules on extensor surfaces of elbow and forearm. Nodules are often multiple and seen along the ulnar margin of the forearm or pulp of the digits. Vasculitis is more common in patients with SC nodules, it is strongly seropositive disease (aggressive) with less favorable prognosis.
    •Synovitis: splint and medical treatment
    •Joint space narrowing, bone erosions and osteopenia: synovectomy.
    •Joint destruction/fixed deformity/ loss of hand function: surgery based on condition
    Before operating on RA patients, x-ray of the cervical spine is needed because the patient may have subluxation of C1-C2.
    Metacarpophalangeal joint arthroplasty of the fingers usually results in decreased extensor lag and improvement of the ulnar drift.

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  • Rheumatoid Arthritis Of The Hand - Everything You Need To Know - Dr. Nabil Ebraheim


    Dr. Ebraheim’s educational animated video describes rheumatoid arthritis of the wrist.

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  • Mechanism of Action of JAK Inhibitors


    This animation discusses the mechanism of action of JAK inhibitors.
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  • Rheumatology...Joint fluid analysis


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    ►????‍????????Antibiotics Lectures: ... Check out my brand new Electrolytes course at and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Joint fluid aspiration (arthrocentesis) can help diagnose a variety of rheumatological diseases via synovial fluid analysis.
    The doctor taps the joint and aspires the synovial fluid, then send it to the laboratory for examination.
    The lab comments on the fluid's color, aspect (clarity), consistency, viscosity, WBC count, RBC count, glucose,...etc.
    The normal synovial fluid is colorless, clear, thin, stringy, possesses an intermediate viscosity, has a WBC count of fewer than 200 cells/mm3, free of RBCs, bacteria, fungi or viruses.
    The glucose level in the synovial fluid should -- normally-- be slightly lower than that of the plasma.
    In this video, we discuss the joint fluid analysis of osteoarthritis, rheumatoid arthritis, gout, sjögren syndrome, systemic lupus erythematosus, as well as septic arthritis.

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  • Rheumatoid Arthritis - Signs & Symptoms | Johns Hopkins Medicine


    The onset of Rheumatoid Arthritis is very gradual. Often the symptoms are worse in the morning and improve as the day goes on. Because of inflammation, many patents experience restlessness at night and can have flu-like fatigue, fevers, and aches. In this video, Dr. Uzma Haque, a physician at the Johns Hopkins Arthritis Center, discusses the signs and symptoms of Rheumatoid Arthritis.

  • Cataract Surgery


    UPDATE 2011: A newer version of this animation is now available! You can watch it here:

    - This 3D medical animation depicts the phacoemulsification and extracapsular removal of a cataract (cloudy lens), and the placement of an artificial lens.

    The lens of the eye is responsible for focusing images onto the back of the eye. It is normally transparent. As a normal part of aging, the lens begins to cloud and causes a gradual, painless loss in vision. Cataract removal is most often performed to better examine the back of the eye when monitoring for damage from certain diseases such as diabetes or glaucoma and to improve vision. There are two main types of cataract removal. The large majority of cataract surgeries are performed using the phacoemulsification technique. During the phacoemulsification technique an ultrasound probe breaks the cloudy lens into tiny fragments. The fragments are vacuumed out through a tiny incision. An intraocular lens implant is then inserted to replace the natural lens that was removed. Because the incision is tiny, stitches are often not necessary and visual improvement is usually noted relatively soon after surgery. During the extracapsular technique the cataract is removed as one entire piece. This requires a larger incision and stitches. An intraocular lens implant (artificial lens) is inserted to replace the natural lens that was removed. Recovery is usually slower, due to the larger incision. The stitches sometimes need to be removed, which is usually done in the office. After both procedures, the surgeon usually places a patch over the eye.


  • Hydroxychloroquine - Pharmacology, mechanism of action, indication, side effects


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    Hydroxychloroquine (plaquenil) is an old antimalarial agent that has immunomodulatory effects widely used in SLE, in which it decreases mortality and the likelihood of developing lupus nephritis, a very common complication of SLE. It works by inhibiting the processing effects of peptide antigens and their assembly into major histocompatibility complex by antigen presenting cells.

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  • Torn Knee Meniscus Repair


    This 3D medical animation of torn knee meniscus repair begins with an orientation of the knee joint, the medial and lateral meniscus, and the free-floating cartilage in the joint space. Prior to surgery, the joint is prepared by filling it with fluid. Afterwards and arthroscope and a surgical tool are inserted to visualize and repair the torn meniscal cartilage, respectively.

    #meniscus #knee #tornmeniscus #KneeArthroscopy #Meniscectomy #arthroscopy

  • COPD I Nucleus Health


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    This video, created by Nucleus Medical Media, explains the causes, symptoms, and treatments for chronic obstructive pulmonary disease (COPD). The differences between normal and damaged lung anatomy are outlined. This animation also details the development of emphysema and chronic bronchitis, which are the main conditions that cause COPD. Treatments, such as medication and surgery, are outlined.


  • Rheumatoid Arthritis - CIMS Hospital


    एक विशिष्ट साइनोवीयल जाइंट (जोड़) की एनाटॉमी (शरीर रचना) और फिजियोलॉजी (शरीर क्रिया विज्ञान), यहाँ चित्रित किया गया है, और आर्थराइटिस (गठिया) क्या है और रह्युमेटोइड आर्थराइटिस एक जोड़ को कैसे प्रभावित करता है, यह यहाँ समझाया गया है। रह्युमेटोइड आर्थराइटिस के लिए उपचार के सामान्य विकल्पों को यहाँ दिखाया गया है।
    सिम्स ऑर्थोपेडिक्स। (

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    ३५० बेड वाली, यानि कि ३५० मरीजों को एक साथ संभाल सके वैसी, मल्टी सुपर स्पेशियालिटी (अनेक प्रकार के रोगों / स्वास्थ्य परिस्थितियों के निदान, देखभाल और उपचार प्रदान करने वाली अस्पताल), ऐसी सिम्स (CIMS) हॉस्पिटल (अस्पताल), अहमदाबाद (गुजरात) के सबसे अच्छे अस्पतालों मेंसे एक है, जोकि विभिन्न प्रकार के निदान और उपचार सेवाओं को प्रदान करता है।
    वैश्विक स्वास्थ्य देखभाल के उच्चतम मानकों की सेवाएँ प्रदान करने वाली, सिम्स हॉस्पिटल को, भारत भर में उच्च गुणवत्ता वाली स्वास्थ्य सेवा और मरीजों की सुरक्षा प्रदान करने के लिए, जेसीआई (JCI) – जाइंट कमिशन इंटरनेशनल (यूएसए), एनएबीएच (NABH) (नेशनल एक्रेडिटेशन बोर्ड फॉर हॉस्पिटल एंड हेल्थकेर प्रोवाइडर्स) और एनएबीएल (NABL) (नेशनल एक्रेडिटेशन बोर्ड फॉर टेस्टिंग एंड केलिब्रेशन लेबोरेटरीज़) की मान्यता प्राप्त है।
    दो पर्याप्त रूप से विशाल जगह वाली और अद्यतन और अत्याधुनिक में फैली हुई – सिम्स पूर्व और सिम्स पश्चिम – सिम्स हॉस्पिटल, सबसे अनुभवी डॉक्टर, नवीनतम प्रौद्योगिकी (टेक्निक) और उत्कृष्ट बुनियादी ढांचे (मरीजों की देखभाल के लिए जरूरी बुनियादी ढांचे के प्रबंधन) का मिश्रण प्रदान करता है , जो यह सुनिश्चित करता है कि मरीजों को विश्व स्तर की देखभाल और उपचार मिले।
    इस अस्पताल ने, अपने मरीजों को, मानवीय और दयालु देखभाल प्रदान करने की संस्कृति विकसित की है।
    यदि आपको यह वीडियो को पसंद है, तो हमारे अधिक शैक्षिक वीडियो प्राप्त करने के लिए कृपया हमारे चैनल सबस्क्राइब करें (चेनल की सदस्यता लें) और कृपया इसे अपने मित्रों एवं परिवारजनो के साथ साझा करें।

    Medical Animation Copyright© 2017 Nucleus Medical Media, All rights reserved

  • Methotrexate - Pharmacology


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    Methotrexate is a first line treatment for RA and other autoimmune diseases. It is an immunosuppressant meaning it suppresses the immune system. Methotrexate is a folic analog and works by inhibiting dihydrofolate reductase. Dihydrofolate reductase is an important enzyme in the synthesis of nucleotides.

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  • Craniotomy and Craniectomy


    - This 3D medical animation depicts two operations, called craniotomy and craniectomy, in which the skull is opened to access the brain. The normal anatomy of the skull and tissues surrounding the brain are shown, including arteries and veins. The animation lists the common reasons for these procedures, and briefly introduces intracranial pressure.

    Video ID: ANH13109


    Your doctor may recommend a craniotomy or a craniectomy procedure to treat a number of different brain diseases, injuries, or conditions.

    Your skull is made of bone and serves as a hard, protective covering for your brain. Just inside your skull, three layers of tissue, called meninges, surround your brain. The thick, outermost layer is the dura mater. The middle tissue layer is the arachnoid mater and the innermost layer is the pia mater. Between the arachnoid mater and the pia mater is the subarachnoid space, which contains blood vessels and a clear fluid called cerebrospinal fluid. Blood vessels, called bridging veins, connect the surface of your brain with the dura mater. Other blood vessels, called cerebral arteries, bring blood to your brain.

    Inside your skull, normal brain function requires a delicate balance of pressure between the blood in your blood vessels, the cerebrospinal fluid that surrounds your brain, and your brain tissue. This is called normal intracranial pressure. Increased intracranial pressure may result from: brain tumors, head injuries, problems with your blood vessels, or infections in your brain or spinal cord. These conditions put pressure on your brain and may cause it to swell or change shape inside your skull, which can lead to serious brain injury.

    Your doctor may recommend a craniotomy to remove: abnormal brain tissue, such as a brain tumor, a sample of tissue by biopsy, a blood clot, called a hematoma, excess cerebrospinal fluid, or pus from an infection, called an abscess.

    A craniotomy may also be done to: relieve brain swelling,
    stop bleeding, called a hemorrhage, repair abnormal blood vessels, repair skull fractures, or repair damaged meninges.

    Finally, a craniotomy may also be done to: treat brain conditions, such as epilepsy, deliver medication to your brain, or implant a medical device, such as a deep brain stimulator.

    The most common reason for a craniotomy is to remove a brain tumor.

  • Disease-modifying antirheumatic drugs Part 3 - Pharmacology



    DMARDs work to suppress the body's overactive immune and/or inflammatory systems. They take effect over weeks or months and are not designed to provide immediate relief of symptoms.

    Other medicines, such as pain relievers, nonsteroidal antiinflammatory drugs (eg, ibuprofen or naproxen), and, sometimes, prednisone, are given to provide faster relief of ongoing symptoms. DMARDs are often used in combination with these medications to reduce the total amount of medication needed and to prevent damage to joints.

    DISEASE-MODIFYING ANTIRHEUMATIC DRUGS — The choice of DMARD depends on a number of factors, including the stage and severity of the joint condition, the balance between possible side effects and expected benefits, and patient preference. Before treatment begins, the patient and clinician should discuss the benefits and risks of each type of therapy, including possible side effects and toxicities, dosing schedule, monitoring frequency, and expected results. Certain screening tests, including blood tests for past exposure to certain infections, may be needed before starting some of these medications.

    In some cases, one DMARD is used. In others, more than one medication may be recommended. Sometimes a patient must try different medicines or combinations to find one that works best and that has the fewest side effects. A patient who does not respond completely to a single DMARD may be given a combination of DMARDs, such as methotrexate plus another medication.

    The most common DMARDs are methotrexate, sulfasalazine, hydroxychloroquine, and leflunomide. Less frequently used medications include gold salts, azathioprine, and cyclosporine.

  • Scoliosis | Scoliosis Surgery | Nucleus Health


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    This 3D medical animation shows the normal anatomy and movement of the spine, and how scoliosis affects the spine. The animation shows stabilization of the condition through bracing. It also shows posterior spinal fusion with instrumentation and bone grafting to correct the spinal curvature of scoliosis.


  • Chloroquine & Hydroxychloroquine | Mechanism of Action, Targets , Adverse Effects


    Chloroquine & Hydroxychloroquine | Mechanism of Action, Targets (Malaria, Viruses), Adverse Effects
    In this lesson, we discuss the medications known as chloroquine and hydroxychloroquine, including how they are administered, metabolized and excreted, along with their mechanism of action, microbial targets (including protozoa and viruses), and possible adverse effects of their use.

    I hope you find this lesson helpful! If you do, please consider liking, subscribing and clicking the notification bell to help support this channel and stay up-to-date on future lessons :)


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    ****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

    **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

    Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.


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  • Rheumatoid Arthritis of the Knee Animation


    To continue viewing, click here:

    The skeletal system provides the framework for the body and protects the internal organs. Joints exist where two bones meet to allow movement and flexibility of the skeleton. They are complex structures that contain many types of tissue. Ligaments surround the joints in order to provide support to the joints and prevent dislocation and injury.

    Please visit for more medical topics!!

  • What is rheumatoid arthritis?


    Rheumatoid arthritis is a condition that can cause pain, swelling and stiffness in joints.

    It is what is known as an auto-immune condition. This means that the immune system, which is the body’s natural self-defence system, gets confused and starts to attack your body’s healthy tissues. In rheumatoid arthritis, the main way it does this is with inflammation in your joints. If you have RA, you're not alone. It affects around 400,000 adults aged 16 and over in the UK. Find out more:
    Updated November 2019

  • Rheumatoid Arthritis - Pfizer - Cortical Studios / Glow Studio


    In the second phase of the rheumatology Pfizer project, together Cortical Studios and Glow Studio developed an animation illustrating the pathologic characteristics of rheumatoid arthritis and its possible treatments.

    Cortical Studios - Animation Illuminates Science


  • Rheumatoid arthritis - hybrid medical animations


  • Rheumatoid Arthritis pathology in 5 minutes


    Here is the narration exactly as it is in the video:
    Unfortunately, some genetic factors, bacterial or viral infection or smoking can induce mutation in the collagen II.
    This mutation results in replacement of arginine amino acid with citrulline amino acid.
    This little change has devastating lifelong sequences on the affected people.
    The antigen presenting cells APCs such as dendritic cells which patrol our tissues recognize this new mutated collagen.
    These antigen presenting cells have specific detecting molecules on their outer cell membranes called HLA molecules.
    Specific types of these HLA molecules which are HLA DR1 and HLA DR4 become confused and deal with the new collagen as foreign body.
    “phagocyte them now, phagocyte them now”
    As a result, the antigen presenting cells phagocyte this mutated collagen.

    After digesting the citrullinated collagens the APCs present some parts of the protein on their outer surface as foreign bodies
    On the other hand, T helper cells in our body work as security detectors who search all antigen presenting cells for any suspicious foreign molecules.
    Once T helper CD4+ cells meet HLA molecules connected to citrullinated collagen they become activated.
    This activation results in production and release of cytokines IL-2 which have autocrine effects as they come back to bind and activate their releasing T helper cells.
    IL-2 induces T helper cell proliferation into 2 new cellular lines, T helper 1 abbreviated as Th1 and T helper 2 cells abbreviated as Th2.
    The Th2 stimulate the production of various antibodies
    whereas Th1 are directed toward cell mediated immunity and later production of interferon gamma and IL-17.

    Now we will focus on antibody production
    Once Th2 binds to B cell it activates it.
    This activation results in sequence of B cell proliferations ended up with 2 new cell lines, Plasma cells and memory cells.
    Plasma cells produce various types of antibodies.
    Whereas memory cells keep records of all foreign antigens in our bodies and provide long lasting immunological memory.
    Now we will focus on the antibodies

    The first type of antibodies are the IgG antibodies with attack the cyclic citrullinated peptides abbreviated as CCP.
    The anti CCP antibodies are specific markers for diagnosis of rheumatoid arthritis.
    The second type of antibodies are the IgM antibodies which attack our IgG antibodies.
    So, they are antibodies against our antibodies.
    They are called rheumatoid factor and they are very common in the serum of patients with rheumatoid arthritis.
    Now both types of antibodies travel through blood to the joints, and even to other tissues.
    Remember rheumatoid arthritis is joint disease with systematic manifestations.
    Now let’s focus on joints, where antibody complexes accumulation activates phagocytes and complement system.
    The activated phagocytes will release inflammatory cytokines such as TNF alpha which play important role in mediating the inflammatory damage to the joints.
    They also secrete IL-1, IL-6.
    We have also IL-17 and interferon gamma produced by T cells.
    Additionally, complement enzymes activate the neutrophils in the joint synovial fluids.
    Cytokines stimulate synovial membrane proliferation and swelling which is a remarkable pathological sign of rheumatoid arthritis.
    Additionally, they activate osteoclast cells which induce bone erosions.
    Angiogenesis also stimulated by cytokines.
    Together cytokines released by activated macrophages and activated neutrophils induce the production of protease and collagenase enzymes which progressively erode and destroy the cartilage layer of the joints.
    Happy reading (or enjoy your reading, it is up to you Carla)
    Narration reading Carla Tordoff Gibson
    Pharmacology and Therapeutic department
    Kings College London KCL University

  • What Is Rheumatoid Arthritis?


    Rheumatoid arthritis is the second most common type of arthritis and often affects the wrists, hands, knees, ankles, and feet. Find out how this disease damages your joints and makes it painful to move them.

  • Rheumatoid Arthritis and Interleukin 6 HD


    The role of interleukin-6 in Rheumatoid Arthritis, see more:

    Autoimmune diseases are a heterogenous group of incompletely understood disorders. The complex pathophysiology of these disorders is regulated in part by a network of different cytokines. Among these cytokines interleukin-6 (IL-6) is considered particularly important. Learn about the role of IL-6 in inflammation, and how it can contribute to rheumatoid arthritis and other autoimmune diseases.

    DISCLAIMER: This educational video was not developed nor is it copyrighted by this Channel.

  • Rheumatoid Arthritis


  • Rheumatoid Arthritis Pathway Animation HD


    Rheumatoid Arthritis physiopathology animation



    #medicine #pathology #mnemonics #medicalschool#dentistry#futuredoctor#nurse#nursing_school##nursing#usmle#usmlestep1#nbde1#nbde#nclex#mbbs#doctors#medicalstudentlife#medicalmneomonics#anatomyandphysiology#usmlestep2ck#medico#pharmacology#biology#muedicinestudent#medschoolprobs #medschoolproblems#pharmacylife #futuredoctor #futurenurse#paramedics #dentalstudent #medstudentlife#medical #doctor #medicalstudent#physicianassistant #doctors #becomingadoctor#medicalhumor #medicalmemes #medicalmeme#medicine

  • Rheumatoid arthritis


    The Animated Atlas of Rheumatoid Arthritis is a comprehensive collection of 61 animated videos and around 120 images pertaining to various aspects of disease development, progression and treatment. This Animated Atlas is an excellent reference and an invaluable resource for effective presentations and lectures.

  • all about RHEUMATOID ARTHRITIS | orthopaedic | animation by medicos Asterion


  • Juvenile Rheumatoid Arthritis mnemonic


    ????????Animated Mnemonics (Picmonic):

    - With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
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  • 3D Animation on Osteoarthritis


  • Rheumatoid Arthritis


    Rheumatoid Arthritis is an Animation video by Focus Medica Pvt. Ltd.
    For more information please visit
    Download the App from :
    Amazon -

  • What Is Rheumatoid Arthritis?


    To learn more about rheumatoid arthritis, please visit

    Rheumatoid arthritis is a type of chronic (ongoing) arthritis that occurs in joints on both sides of the body (for instance, both hands, wrists, and/or knees). Dr. Elaine Husni discusses symptoms, causes, management and treatment options.

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  • Carpal Tunnel


    UPDATE 4/10/15: Watch the updated version of this animation here:

    This 3D medical animation depicts carpal tunnel syndrome and carpal tunnel release. Carpal tunnel syndrome is a nerve disorder of the hand caused by compression of the median nerve. Two different types of carpal tunnel release are animated, an open carpal tunnel procedure and the endoscopic approach.

  • Pacemaker


    - A pacemaker is a small, battery--powered device made up of two parts, a pulse generator and the leads. This 3D medical animation provides an anatomical overview of the heart and demonstrates the steps involved in placing a pacemaker. The pulse generator of the pacemaker gives off impulses that cause the atria and/or ventricles to contract. It is positioned under the skin, below the collarbone on either side of the chest. The leads carry signals between the pulse generator and the heart in both directions. The surgeon will make a small incision beneath your collarbone. The pacemaker's leads will be inserted into the subclavian vein and then threaded toward the right side of your heart. Your surgeon will view x--ray images on a video screen to position the leads correctly.
    #Pacemaker #Heart #Cardiac
    CLINICIANS: Download Nucleus's iHeart Touch iPad app FREE for your practice:


  • Rheumatoid arthritis : Extra-articular manifestations


    ????????Animated Mnemonics (Picmonic):

    - With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
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