This website uses cookies to ensure you get the best experience on our website. Learn more

Second Vitamin D clinical trial, positive results

x
  • Second Vitamin D clinical trial, positive results

    21:15

    Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)




    It has been observed that vitamin D-deficient individuals
    have increased COVID-19 risk and mortality

    Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA 2020;323:1824–36. doi: 10.1001/jama.2020.6019

    The role of vitamin D in the prevention of coronavirus disease infection and mortality.

    Aging Clin Exp Res 2020;32:1195–8. doi: 10.1007/s40520-020-01570-8

    Association of vitamin D status and other clinical characteristics with COVID-19 test results.

    JAMA Netw Open 2020;3:e2019722. (Published 3 Sep 2020).doi: 10.1001/jamanetworkopen.2020.19722

    Immunomodulatory role and protective effect of vitamin D against other viral infections

    Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;15:356:i6583. doi: 10.1136/bmj.i6583

    An intervention study with calcifediol noticed a reduction in requirement for intensive care among hospitalised patients for COVID19

    Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study.

    J Steroid Biochem Mol Biol 2020;203:105751. doi: 10.1016/j.jsbmb.2020.105751

    50 patients treated with calcifediol, one required admission to the ICU (2%), no deaths

    26 untreated patients, 13 required admission (50 %) to the ICU, 2 deaths

    Immune-modulatory effect of vitamin D is likely to be observed at 25(OH)D levels, which are considered higher than that required for its skeletal effects

    Vitamin D to prevent COVID-19: recommendations for the design of clinical trials. Febs J2020;287:3689–92. doi: 10.1111/febs.15534

    Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults.

    BMC Res Notes 2012;5:575. doi: 10.1186/1756-0500-5-575

    Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection.

    PLoS One 2020;15:e0239799.doi: 10.1371/journal.pone.0239799

    Aim



    Effect of high dose, oral cholecalciferol supplementation on SARS-CoV-2 viral clearance

    First cholecalciferol intervention study for asymptomatic and mildly symptomatic SARS-CoV-2 positive individuals


    Design

    Randomised, placebo-controlled.

    Participants

    Asymptomatic or mildly symptomatic SARS-CoV-2

    RNA positive vitamin D deficient (25(OH) D less than 20 ng/ml)

    Calcifediol, calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3

    Pre intervention baseline serum 25(OH) D

    Intervention group, 8.6 ng/ml

    Control group, 9.54 ng/ml (p=0.730)

    10 out of 16 patients could achieve 25(OH)D more than 50 ng/ml by
    day-7

    Another two by day-14

    Outcome measure

    Proportion of patients with SARS-CoV-2 RNA negative before day-21

    Change in inflammatory markers

    Intervention group (n=16)

    60 000 IU of cholecalciferol (oral nano-liquid droplets) for 7 days

    Therapeutic target 25(OH)D more than 50 ng/ml

    Cholecalciferol supplementation was continued for those with 25(OH)D less than 50 ng/ml

    Fibrinogen levels significantly decreased with cholecalciferol supplementation

    10 (62.5%) participants became SARS-CoV-2 RNA negative

    Control group (n=24)

    Placebo

    5 (20.8%) participants became SARS-CoV-2 RNA negative (p less than 0.018)

    Both groups

    Patients requiring invasive ventilation or with significant comorbidities were excluded

    25(OH)D levels were assessed at day 7

    Regular measurements of: SARS-CoV-2 RNA, fibrinogen, D-dimer, procalcitonin, CRP, ferritin

    Improvements

    Calcifediol would have been better

    Little and often for prevention

  • x
  • Vitamin D, First clinical trial

    27:43



    About 42% of the US population is vitamin D deficient

    82% in black people

    70% in Hispanics

    Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results, (JAMA Open, 3rd September, Chicago)



    Cohort study of 489

    Patients who had a vitamin D level measured in the year before COVID-19
    testing

    Relative risk of testing positive for COVID-19 was 1.77 times

    First clinical trial on vitamin D and COVID

    Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study (Spain, Journal of steroid biochemistry and molecular biology)



    Objective

    Vitamin D decreases Acute Respiratory Distress Syndrome

    Effect of calcifediol treatment

    Calcifediol can rapidly increase serum 25OHD concentration

    25-hydroxyvitamin D

    Intensive Care Unit Admission and Mortality

    Spanish patients hospitalized for COVID-19.

    Design

    Parallel pilot, randomized, double-masked clinical trial

    Setting

    Reina Sofia University Hospital, Córdoba, Spain

    Participants

    76 consecutive patients hospitalized with COVID-19 infection

    Clinical picture of acute respiratory infection

    Confirmed by a radiographic pattern of viral pneumonia

    Positive SARS-CoV-2 PCR

    Procedures

    All hospitalized patients received as best available therapy

    Hydroxychloroquine and azithromycin

    Allocated at a 2 calcifediol:1

    Oral calcifediol (0.532 mg), or not

    Oral calcifediol (0.266 mg) on day 3 and 7

    Then weekly until discharge

    End points, ICU admission and deaths.

    Results

    50 patients treated with calcifediol

    One required admission to the ICU (2%),

    Of 26 untreated patients, 13 required admission (50%)

    p  less than 0.001

    Of the patients treated with calcifediol, none died, and all were discharged, without complications

    Of the patients not treated, 2 died

    Conclusion

    Calcifediol seems to be able to reduce severity of the disease

    Larger trials with groups properly matched will be required to show a definitive answer

    Rationale, activation of the vitamin D receptor (VDR) signalling pathway

    Reduced ARDS

    Cytokine/chemokine storm

    Regulating the renin angiotensin system

    Modulating neutrophil activity

    Maintaining the integrity of the pulmonary epithelial barrier

    Stimulating epithelial repair

    Tapering down the increased coagulability


    Ventilate

    Don't abdicate
    Dilute that virus
    So you stay great
    Ventilate
    Don't complicate,
    Complain or whine
    You'll acclimate
    Contemplate
    When you congregate
    Does the air here circulate
    Instigate, Nominate
    Educate, Motivate
    I hope this message will resonate
    That when we populate
    Instead of isolate
    Ventilate
    Don't abdicate
    Dilute that virus
    So you stay great

  • x
  • Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus

    1:24

    Professor Roger Seheult, MD explains the important role Vitamin D may have in the prevention and treatment of COVID-19. Dr. Seheult is the lead professor at
    Dr. Seheult illustrates how Vitamin D works, summarizes the best available data and clinical trials on vitamin D, and discusses vitamin D dosage recommendations.

    Roger Seheult, MD is Co-Founder of MedCram and an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine. He is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, & Sleep Medicine

    Interviewer: Kyle Allred, Producer & Co-Founder of MedCram.com

    REFERENCES:

    The National Human Activity Pattern Survey (NHAPS)... (J. of Exposure A. and Env. Epidem.) |

    Aging decreases the capacity of human skin to produce vitamin D3 (The J. of Clin. Invest.) |

    Racial differences in the relationship between vitamin D... (Osteoporosis Int.) |

    Decreased bioavailability of vitamin D in obesity (The American J of Clin. Nutrition) |

    Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases ... (Nutrients) |

    Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis... (BMJ) |

    Randomized trial of vitamin D supplementation to prevent seasonal influenza A... (The American J.of Clin. Nutrition) |

    Vitamin D and SARS-CoV-2 infection... (Irish J. of Med. Sci.) |

    Factors associated with COVID-19-related death... (Nature) |

    Editorial: low population mortality from COVID-19 ... (Alimentary Pharm. & Therap.) |

    The role of vitamin D in the prevention of coronavirus ... (Aging Clin. & Exper. Res.) |

    25-Hydroxyvitamin D Concentrations Are Lower in Patients with ... SARS-CoV-2 (Nutrients) |

    Vitamin D deficiency in COVID-19: Mixing up cause and consequence (Metabolism) |

    Low plasma 25(OH) vitamin D level... increased risk of COVID-19... (The FEBS J.) |

    The link between vitamin D deficiency and Covid-19... |

    SARS-CoV-2 positivity rates... with circulating 25-hydroxyvitamin D levels (PLOS One) |

    Vitamin D status and outcomes for... COVID-19 (Post. Med. J.) |

    Vitamin D Deficiency and Outcome of COVID-19... (Nutrients) |

    “Effect of calcifediol treatment...” (J. of Steroid Bio. Molec. Bio.) |

    Vitamin D and survival in COVID-19 patients... (J. of Steroid Bio. Molec. Bio.) |

    Effect of Vitamin D3 ... vs Placebo on Hospital Length of Stay...: A Multicenter, Double-blind, RCT |

    Short term, high-dose vitamin D... for COVID-19 disease: RCT [SHADE study] (Postgrad. Med. Journal) |

    Association of Vitamin D Status... With COVID-19 Test Results (JAMA Network Open) |

    Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (JCEM) |

    Vitamin D Fortification of Fluid Milk ... A Review (Nutrients) |

    Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients... (Scientific Reports from the Journal Nature) |

    MEDCRAM.COM

    Visit us for videos on over 60 medical topics and CME / CEs for clinicians:
    All coronavirus updates are at MedCram.com (COVID-19 developments, cholecalciferol, vitamin d benefits, vitamin D biochemistry, vitamin B12 etc.)

    Media contact:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #VitaminD

  • Does Supplemental Vitamin D Help Prevent Covid-19?

    5:25

    Ah, Vitamin D, back again. We’ve made our case on how unnecessary Vitamin D supplements are for outcomes like diabetes, cardiovascular and musculoskeletal health, and overall mortality. But what about its effect on viral infections like Covid-19? Can it reduce symptom severity, or perhaps even reduce your odds of becoming infected in the first place?

    Sources:









    Related HCT episodes:
    Acetaminophen, Risk-Taking, and Covid-19:

    Be sure to check out our podcast!


    Other Healthcare Triage Links:
    1. Support the channel on Patreon:
    2. Check out our Facebook page:
    3. We still have merchandise available at
    4. Aaron's book The Bad Food Bible: How and Why to Eat Sinfully is available wherever books are sold, such as Amazon:

    Credits:
    Aaron Carroll -- Writer
    Meredith Danko – Social Media
    Tiffany Doherty -- Writer and Script Editor
    John Green -- Executive Producer
    Stan Muller -- Director, Producer
    Mark Olsen – Art Director, Producer

    Images and Footage
    Storyblocks/Made360
    Storyblocks/glowonconcept
    Storyblocks/kk5hy
    iStock.com/Geber86
    iStock.com/blackdovfx
    iStock.com/damircudic
    iStock.com/PeopleImages
    iStock.com/Martin Wahlborg
    iStock.com/Helin Loik-Tomson

    #healthcaretriage #covid-19 #vitaminD

  • x
  • New Study - Vitamin D High Dose and COVID-19

    44:53

    New Study - Vitamin D High Dose and COVID-19

    More lectures on drbeen.com

    Looking to support my educational work? Donate here:



    2% of the patients taking high dose calcifediol were admitted to ICU.
    50% of the patients not taking calcifediol were admitted to ICU.

    Effect of calcifidiol (25(OH)D) on severity and disease progress of COVID-19


    Effect of vitamin D receptor activation


    Vitamin D deficiency in the US population


    Obesity and vitamin d deficiency. A study of their relationship


    What is cholecalciferol?


    What is calcifediol?


    Active Vitamin D synthesis pathway


    Should you always take calcium and vitamin K2 with vitamin D?


    Cathelicidins

  • Vitamin D studies confirm correlations

    26:58

    Vitamin D

    UK biobank



    Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank (29th January, 2021)



    The American Journal of Clinical Nutrition

    Background

    Vitamin D supplementation, lower risk of acute respiratory tract infection

    Emerging evidence, vitamin D insufficiency is related to a higher risk of coronavirus infection and disease

    Objectives

    To investigate the prospective association between habitual use of vitamin D supplements and risk of COVID- 19 infection

    Associations according to levels of circulating and genetically predicted vitamin D

    Methods

    N = 8,297 adults

    Records of COVID-19 test results from UK Biobank

    16 March 2020 to 29 June 2020

    Results

    Of the 8,297 adults, 1,374 (16.6%) tested positive

    Vit D users, n = 363

    Non-vit D users, n = 7,934

    Unadjusted model

    OR 0.78 (p = 0.105)

    Adjustment for covariates

    Age, sex, race, origin (outpatient or inpatient), blood-type, years of education, TDI, smoking, moderate drinking, physical activity, healthy diet score, use of any other supplements

    Inverse association emerged

    Between habitual use of vitamin D supplements and risk of COVID-19 infection

    OR, 0.66, (P = 0.038)

    Habitual use of vitamin D supplements was significantly associated with a 34% lower risk of COVID-19 infection

    No association with baseline blood vitamin D levels and risk of COVID-19 infection

    Associations between the risk of COVID-19 infection and habitual use of other individual supplements

    Vitamin A, vitamin B, vitamin C, vitamin E, folic acid, a
    multivitamin,

    Calcium, zinc, iron, selenium, glucosamine, fish
    Oil

    Vitamin D Deficiency and Outcome of COVID-19 Patients

    Medical University Hospital Heidelberg, (September 2020)



    Identification of modifiable prognostic factors may help to improve outcomes

    N = 185, diagnosed and treated in Heidelberg

    Median Vitamin D level was 16.6 ng/ml

    Associations of vitamin D status with disease severity and survival

    Vitamin D status assessed at first presentation

    Deficient

    25-hydroxyvitamin D (Calcifediol)
    level less than 12 ng/mL ( less than 30 nM)

    N = 41 (22%)

    Median IL-6 levels at hospitalization were significantly higher

    70.5 versus 29.7 pg/mL

    Insufficiency

    Less than 20 ng/mL (less than 50 nM)

    N = 118 (64%)

    Higher levels

    N = 26

    Median Vitamin D level was significantly lower in the inpatient versus the outpatient subgroup

    Results

    Median observation period of 66 days

    93 (50%) patients required hospitalization

    28 patients required ventilation

    Including 16 deaths

    Adjusting for age, sex, comorbidities

    Deficiency was associated with higher risk of ventilation and death

    Mechanical ventilation

    HR 6.12

    p less than 0.001

    Death

    HR 14.73

    p less than 0.001

    Other hazard ratios

    Male, 1.69 2.5

    Over 60, 3.2 7.7

    Comorbidity, 2.7 5.3

    Need for interventional studies

    Cholecalciferol

    Calcifediol

    Active form of vitamin D3, 1, 25-dihydroxyvitamin D3 (1,25D3), calcitriol, is
    pluripotent hormone and important modulator of both innate and adaptive immunity

  • x
  • Dosage For Vitamin D, K2, and Calcium

    36:46

    Doses For Vitamin D, K2, and Calcium
    More lectures on drbeen.com

    Looking to support my educational work? Donate here:


    The correct RDA is 8,800 IU per day for vitamin D (according to this article)


    Coimbra Protocol for high dose vitamin D



    4 ounces of cooked salmon contains approximately 600 IU of vitamin D


    Ergocalciferol



    Cholecalciferol or Calcifediol in the Management of Vitamin D Deficiency


    How to adjust the vitamin D dose for overweight or obese persons?
    The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteers

    How much K2, vitamin D, and vitamin A to take together?
    Are You Taking Vitamin K2 With Your Vitamin D? - Murray Avenue Apothecary - Blog




    How much calcium to add?
    Vitamin D and calcium supplements: Take them or leave them? - Harvard Health

    Are You Taking Too Many Calcium Supplements? – Health Essentials from Cleveland Clinic


    Who should receive calcitriol?
    calcitriol (vitamin D3) oral/injection | Michigan Medicine

  • Vitamin D, blood levels

    30:46

    Vitamin D tests used in this video

    Your personalised vitamins




    Single test, £39.99

    Year plan, 2 tests and vitamin D supplies to titrate, £75

    BetterYou test

    £32.95




    Vitamin D into the body

    D3 (cholecalciferol), sun, animals or supplement

    D2 (ergocalciferol), plants, supplements

    Pathway

    In the skin

    Vitamin D, cholecalciferol, synthesised in the skin

    In the liver

    Converted to its major circulating form, 25-hydroxyvitamin D (25(OH)D)

    Calcifediol

    In the kidneys

    Converted into 1,25-dihydroxyvitamin D3, or calcitriol, the principal active hormonal form of vitamin D

    Vitamin D in the blood

    25 hydroxy vitamin D

    25-hydroxyvitamin D (25OHD)

    Calcifediol

    Circulating concentration of 25OHD is the accepted biomarker for vitamin D status




    Many experts recommend a level between 20 and 40 ng/mL (50 to 100 nmol/L)

    Others recommend a level between 30 and 50 ng/mL (75 to 125 nmol/L)

    Some say higher




    Serum concentrations, units

    Nanograms per milliliter (ng/mL)

    (1000 ng = 1 microgram)

    Nanomoles per liter (nmol/L)

    1 ng/mL is equal to 2.5 nmol/L

    Supplements

    Micrograms

    International units

    400 IU = 10 mcg

    1,000 IU = 25 mcg

    2,000 IU = 50 mcg

    4,000 IU = 100 mcg


    How much to take in Winter?



    Do not take more than 100 micrograms (4,000 IU) of vitamin D a day (11 years to adults)

    Children aged 1 to 10 years should not have more than 50 micrograms (2,000 IU) a day.

    Infants under 12 months should not have more than 25 micrograms (1,000 IU) a day.



    Prostate cancer



    Colon cancer



    Breast cancer



    Multiple sclerosis



    Heart disease



    Immunity



    Autoimmunity



    Diabetes




    Chronic pain and sleep



    Depression



    Cytokine storm



    COVID

  • A NEW STUDY On Vitamin D

    34:45

    More lectures on DrBeen.COM

    Looking to support my educational work? Donate here:


    A very creative study published on April 30th 2020
    “We show that the risk of severe COVID-19 cases among patients with severe Vit D deficiency is 17.3% while the equivalent figure for patients with normal Vit D levels is 14.6% (a reduction of 15.6%)”

    Looking to support my work? Donate here


    The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients



    C-reactive protein



    The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918–1919 influenza pandemic in the United States



    Vitamin D and the Immune System



    Association of C-reactive protein and vitamin D deficiency with cardiovascular disease: A nationwide cross-sectional study from National Health and Nutrition Examination Survey 2007 to 2008.



    Association of C‐reactive protein and vitamin D deficiency with cardiovascular disease: A nationwide cross‐sectional study from National Health and Nutrition Examination Survey 2007 to 2008

  • x
  • Vitamin D Toxicity Rare in People Who Take Supplements, Mayo Clinic Researchers Report

    6:36

    Over the past decade, numerous studies have shown that many Americans have low vitamin D levels and as a result, vitamin D supplement use has climbed in recent years. Vitamin D has been shown to boost bone health and it may play a role in preventing diabetes, cancer, cardiovascular disease and other illnesses. In light of the increased use of vitamin D supplements, Mayo Clinic researchers set out to learn more about the health of those with high vitamin D levels. They found that toxic levels are actually rare.
    Their study appears in the May issue of Mayo Clinic Proceedings. For more information, see the Mayo Clinic News Network:

  • Vitamin D & COVID-19 Prevention Expert Q&A

    28:46

    New research indicates that vitamin D may protect against COVID-19, especially in Black people. UChicago Medicine researchers discuss the importance of adequate vitamin D in preventing disease, and how you can participate in a clinical research trial.

    Introduction (0:00)
    Why is vitamin D important? (1:32)
    How do we get Vitamin D? (3:30)
    Is skin color a factor in getting vitamin D (5:43)
    What is the relationship between COVID and Vitamin D? (7:28)
    What research is being done between vitamin D and race? (9:23)
    Do I need to be a patient of UChicago Medicine or Roche to participate in a study? (13:24)
    What are the best sources for Vitamin D? (14:21)
    If somebody had their COVID-19 vaccine, should they still take Vitamin D? (18:11)
    Can you take too much vitamin D? (19:13)
    Can people with high Vitamin D have low antibodies? (20:53)
    Is a Vitamin D lamp effective? (22:31)
    Does Vitamin D need to be combined with other vitamins like K to be effective? (23:30)
    Do I have to decrease my Vitamin D3 in order to go on your low dose study? (24:22)
    What do people need to know about your study? (26:00)

  • What Vitamin D Level Reduces The Risk of Death From COVID-19? A New Study From Boston University

    22:37

    What Vit-D Level Reduces The Risk of Death From COVID-19? A New Study From Boston University

    More lectures on drbeen.com

    Looking to support my educational work? Donate here:


    Start your free trial - no credit card needed:



    Vitamin D Study shows tremendous positive results for COVID-19





    In summary the researchers from Boston University recommend keeping your vitamin D levels at or above 40 ng/mL.

    Every 4 ng/mL increase in vitamin D level reduces the risk of seasonal infections by 7%.

  • Vitamins D and K2

    40:22

    Download my two educational text books for free using this link:

    Hard copy of the Physiology Notes text book on ebay,

    Hard copy of the Pathophysiology text book,

    Latest on Vitamin D


    Basically, consider 400 units (10 mcg) per day

    But, NHS mid Essex



    Routine screening of vitamin D levels and prescribing of Vitamin D is not advisable.

    Both clinical symptoms and risk factors must be present before measuring Vitamin D levels (25OHD).

    As yet there is no clear evidence to prove the risks from non-symptomatic Vitamin D deficiency.

    Adults

    Vitamin D levels less than 30nmol/L (12ng / ml)

    Oral capsules, 40,000 units (1,000 mcg or 1 mg) colecalciferol weekly for 7 weeks

    (400 units per day = 2,800 units per week)

    Vitamin D levels 30 – 50 nmol/L (12 – 20 ng / ml)

    Buy your own, 400 units per day

    Vitamin D levels more than 50 nmol/L (20 ng / ml)

    Buy your own, consider, 400 units per day

    Vitamin K1

    Phylloquinone

    Involved in blood coagulation (1929)

    Found in plant foods like leafy greens

    Vitamin K2







    Menaquinones

    Mostly bacterial origin

    Animal-based and fermented foods

    Adult vitamin K Adequate Intakes, 90 -120 mcg

    Fermented foods

    Sauerkraut

    Natto

    High fat dairy from grass fed cows

    Eggs

    Animal organs

    Gut bacteria

    Antibiotics

    Vitamin K might play a role, osteoporosis and coronary heart disease

    Vitamin K-dependent proteins



    Vitamin K2 supplements may improve bone and heart health, while vitamin K1 has no significant benefits



    Promotes bone calcification

    Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women



    May prevent tissue calcification

    Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats



    Vitamin K2 (MK-4) reduced blood vessel calcification whereas vitamin K1 did not



    Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study



    K2 may help with dental health



    Especially with vitamin D



    Links with liver cancer



    Links with preventing advanced prostate cancer

    Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)



    Synergistic effect with vitamin D

    Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy



    Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice



    Determine the concentrations of 25-OH-vitamin D at which the risk of hypercalcemia

    N = 25,567

    Hypervitaminosis D was defined at serum 25-OH-vitamin D more than160 nmol/L (64 ng / ml)

    Results:

    382 samples were identified as the first record of hypervitaminosis D

    39 presented hypercalcemia (10.2%)

    Some had 25-OH-vitamin D levels between 161 and 375 nmol/L.

    (most subjects presented hypercalcemia at serum concentrations of 25-OH-vitamin D less than 375 nmol/L, 150 ng / ml)

    In 15 subjects, hypercalcemia could be directly attributed to vitamin D

    In no case, serum calcium achieved concentrations considered as critical values (more than13 mg/dl).

    Conclusion

    Hypercalcemia due to vitamin D represented less than 4% of the total hypervitaminosis D detected

    Less than 0.1% of the tests performed.

    Healthline



    No strong evidence proves that moderate amounts of vitamin D are harmful without an adequate intake of vitamin K. However, research is ongoing, and the picture might become clearer in the near future.

  • Two Studies About Vitamin C and Vitamin D

    29:16

    Two Studies About Vitamin C and Vitamin D

    More lectures on drbeen.com

    Looking to support my educational work? Donate here:


    Start your free trial - no credit card needed:



    Understand a little bit about the p value. p value greater than 0.05 means insignificant result. We think you will love this blog post about the p value.


    Dr. Paul Marik’s small study about the role of vitamin C


    Another small and possibly poor study about vitamin C. Still, discussing for educational purposes.



    #drbeen #koolbeens #COVID-19

  • Is 10,000 IUs of Vitamin D3 Safe to Take?

    5:52

    DR. BERG'S D3 & K2 VITAMIN ➜ ➜

    Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey. Call 1-540-299-1556 with your questions about Keto, Intermittent Fasting or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 am to 10 pm EST. Saturday & Sunday from 9 am to 6 pm EST. USA Only.

    . . NEW KETO RECIPES CHANNEL:

    How much is too much vitamin D3? Find out.

    DATA:











    Timestamps
    0:00 Vitamin D
    0:32 Studies on vitamin D
    1:06 It takes longer than you think to fix a vitamin D deficiency
    1:30 Various things that can prevent vitamin D absorption
    4:05 Vitamin D dosage
    4:23 Vitamin D toxicity

    Today we’re going to talk about how long to take vitamin D and vitamin D dosage. There seems to be a lot of confusion around vitamin D3 that I want to help clear up. Most people take 600 IUs to 2,000 IUs of vitamin D3, and they think that’s enough. But is it?

    About 75% of the population is deficient in vitamin D. I believe vitamin D is the most important fat-soluble vitamin—especially for the immune system.

    Studies on vitamin D:

    1. In the first study, the group took 1,000-2,000 IUs of vitamin D 1-2 times per week for 1 month and did not increase their vitamin D levels at all.

    2. In the second study, the group to 1,000-2,000 IUs of vitamin D, and it took 4 months to elevate their vitamin D.

    3. In the third study, it took 3 months to achieve the normal level of vitamin D by taking 1,600 IUs of vitamin D.

    • It takes a lot longer than you think to fix a vitamin D deficiency.
    • There are various things that prevent the absorption of vitamin D.

    Various things that can prevent the absorption of vitamin D:

    • Gut damage
    • Age
    • Skin pigment
    • Subcutaneous fat
    • Sun exposure
    • Metabolic issues
    • Season
    • Polymorphism
    • Chronic infection

    Vitamin D dosage:
    • You may want to consider taking 10,000 IUs of vitamin D per day for maintenance, but you may want to take more if there is an autoimmune issue involved.

    You would have to consume something like 100,000-200,000 IUs of vitamin D for months or years to create complications. The biggest complication of vitamin D toxicity could be hypercalcemia.

    Still, to help minimize the risk of hypercalcemia, you could drink 2.5 liters of water per day. You could also simply avoid consuming calcium in supplements as well as cheese.

    Dr. Eric Berg DC Bio:
    Dr. Berg, age 56, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg’s Nutritionals. He no longer practices, but focuses on health education through social media.

    DR. BERG'S SHOP:

    Follow us on FACEBOOK: fb.me/DrEricBerg

    Send a Message to his team: m.me/DrEricBerg

    ABOUT DR. BERG:

    Disclaimer:
    Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

    Thanks for watching! This is why it may be necessary to take at least 10,000 IUs of vitamin D3 per day.

  • Vitamin D deficiency Treatment, Vitamin D3, How To Get Sunlight For Vitamin D Recovery- Must Do It

    6:27

    Best Way to Get Vitamin D from Sunlight, How to Recover Vitamin D deficiency in This Lock Down.

    In this video Dr. Varun Wasil (MPT ORTHOPAEDICS) From Sukoon Physical Therapy, Jalandhar, explained How to get sunlight to recover vitamin D deficiency to protect from osteoporosis, Vitamin D is essential for bones and muscles. We can Take enough Vitamin D in this time of lock down.

    Must Watch:
    Importance of vitamin D in Hindi | Reasons of vitamin D deficiency, Vitamin D3, Cholecalciferol


    He also explained these points in this video:
    Vitamin d deficiency, vitamin d deficiency treatment, vitamin d3, vitamin d3 deficiency symptoms, vitamin d, sunshine vitamin, cholecalciferol vitamin d3, osteoporosis vitamin d, role of vitamin d


    #vitamind #osteoporosis #sunlight #lockdown #vitaminddeficiency #vitamind3 #sukoonphysicaltherapy

  • COVID-19 and Vitamin D | Association Between Vitamin D Deficiency and COVID-19

    1:2:02

    Ninja Nerds,
    #COVID #VitaminD #coronavirus
    In this lecture, Zach Murphy, PA-C will present on the association between Vitamin D levels and COVID-19. We will be presenting on all of the current evidence that is available on the association between Vitamin D deficiency and COVID-19. Please scroll down to the bottom of our description box to review all of our references on the association between Vitamin D deficiency and COVID-19. Please enjoy this lecture and be sure to check out all of our social media pages and ways to donate below!

    Join this channel to get access to perks:


    Support us by purchasing apparel and donating to our GoFundMe or Patreon!

    --Become a Patron of ours and receive the final, high resolution photo of the lecture!

    APPAREL |
    Amazon |
    Teespring | teespring.com/stores/ninja-nerd

    DONATE
    PATREON |
    PAYPAL |

    SOCIAL MEDIA

    FACEBOOK |

    INSTAGRAM |

    TWITTER |
    @NinjaNerdSci

    REFERENCES
    1) Decreased Vitamin D associated with increased mortality in hospitalized COVID-19 patient's.
    2) Decreased Vitamin D associated with increased ventilation requirements in COVID-19 patient's.
    a)
    b)
    c)
    d)
    e)
    f)

    3) Decreased Vitamin D associated with increased SARS-CoV-2 positive PCR's.
    a)
    b)
    c)
    d)

    4) Decreased Vitamin D is associated with increased CRP, fibrinogen, and D-dimer levels in COVID-19 patient's.
    a)
    b)

    5) Decreased Vitamin D is associated with decreased clearance of SARS-CoV-2.
    a)
    b)
    c)
    d)

    6) Decreased Vitamin D is associated in elderly, African Americans, hispanics, and obesity.
    a)
    b)
    c)

    7) Decreased Vitamin D is associated with worsening of conditions such as CHF, CAD, DM, and HTN.
    a)
    b)
    c)
    d)

    8) Vitamin D has been shown to be effective against viral respiratory tract infections.
    a)

    Vitamin D Dosage:


    Vitamin D Toxicity:

    Vitamin D Immunology:
    a. Cathelicidins:

    b. Beta Defensins:

    c. Vitamin D and Cytokines:


    d. Vitamin D Metabolic Pathway: Lehninger's Principles of Biochemistry Textbook

  • Does VITAMIN D Protect Against COVID-19? | Doctor ER

    4:52

    Does VITAMIN D Protect Against COVID-19? | Doctor ER. Vitamin D and COVID 19: Board-Certified Emergency Medicine Physician, Dr. Jordan Wagner explains the latest COVID news and the important role vitamin D may have in the prevention and treatment of coronavirus. What is the link between COVID-19 and vitamin D? Vitamin D deficiency has been associated with rickets, however, 120 health, science, and medical experts from the United States and Europe say there is scientific evidence that vitamin D reduces infections, hospitalizations, and deaths during the COVID-19 pandemic. Can I take any vitamins or supplements to prevent COVID-19? Is vitamin D important for the immune system? What is the best way to reduce the spread of COVID-19? The role of vitamin D in preventing viral infections, including COVID-19, is gaining attention as more studies are released. A new study that looked at 216 people with COVID-19 found that 80% did not have adequate levels of vitamin D (vitamin D3) in their blood. Doctor Jordan Wagner is always sharing his experience coping with the COVID-19 pandemic and what he's learned first hand treating COVID-19 patients. If you have any medical questions, COVID-19 questions, or even a funny quarantine vlog, send it my way! Thanks so much for watching. Stay healthy, my friends!

    OTHER VIDEOS ABOUT VITAMIN D AND COVID-19:

    @MedCram - Medical Lectures Explained CLEARLY - Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)


    @Doctor Mike Hansen - COVID 19: Should you take Vitamin C and Vitamin D to fight COVID


    @Doctor Mike - Doctor Reacts To Simpsons Medical Scenes


    @The Daily Show with Trevor Noah - The Best of Michael Kosta in the Field | The Daily Social Distancing Show


    @TODAY - Officials Fear ‘Surge’ In COVID-19 Cases After Christmas | TODAY


    @Doctor Mike Hansen - Vitamin D for SEVERE Covid 19? (And other final 2020 Thoughts)


    ???? SUBSCRIBE for new videos every week! ▶

    FOLLOW ME HERE:
    Facebook ▶
    Instagram ▶
    Twitter ▶
    TikTok ▶
    Contact email ▶ doctorerwagz@gmail.com

    Doctor ER Dr. Jordan Wagner, DO

    #COVID19 #VitaminD #DoctorJordanWagner

    Coronavirus Disease 2019 (COVID-19) | CDC


    Coronavirus disease (COVID-19) - World Health Organization (WHO)


    Coronavirus Disease 2019 (COVID-19) | coronavirus.gov


    Coronavirus (COVID-19) Response | FEMA.gov


    Coronavirus Disease 2019 (COVID-19) | FDA


    Vitamin D and SARS-CoV-2 infection—evolution of evidence supporting clinical practice and policy development | Irish Journal of Medical Science


    The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality | Aging Clinical & Experimental Research


    25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2 |
    Nutrients


    The link between vitamin D deficiency and Covid-19 in a large population


    Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study) | Postgraduate Medical Journal


    ** WARNING** If you feel like you are actually experiencing a real-life medical emergency, immediately stop watching and call 9-11 or contact a medical professional. The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace an appointment with your own personal doctor/mental health professional!

  • 8 Signs Your Body Is Begging for Vitamin D

    8:21

    What are the signs of vitamin D deficiency? Vitamin D greatly influences the systems of our body from ensuring calcium supply to our bones to strengthening our immune system. We normally get this vitamin from foods, supplements, and the sun’s rays, but when something goes wrong and we face vitamin D deficiency, our body systems may break.


    For example, sweating that seems a little excessive or not brought on by anything particularly obvious, however, can be a sign that you’re lacking vitamin D. So what other signs show a deficiency, how serious is the problem, and what can you do to get more of it? Here at Bright Side, we’ve studied the most common symptoms of low vitamin D levels and we want to tell you what we’ve found.

    TIMESTAMPS:
    You sweat excessively 1:01
    Your bones often ache 1:35
    You have muscle pain 2:11
    You get sick all the time 2:47
    You can’t seem to stay energized 3:26
    When you get cuts or bruises, they take forever to heal 4:03
    You notice more hair falling out of your head than usual 4:52
    You can’t shake the feeling of sadness 5:25
    What can you do to get more of vitamin D? 6:26

    #vitamind #vitamindeficiency #lackofvitamins

    Preview photo credit:

    FORT MEADE, Md. Sweat drips down the face of a U.S. Army Reserve Soldier from the 200th Military Police Command during a Spin class as part of a Performance Triad program organized by the command and hosted on Fort Meade, Maryland, May 9, 2017. The three-week fitness program took place from May 5-25 to help Soldiers who had either failed the Army Physical Fitness Test or had been on the Army Body Fat Composition program. The camp focused on the triad of overall health: physical fitness, nutrition and sleep, by providing education and personalized coaching to Soldiers in all three of those phases of life and more: By Master Sgt. Michel Sauret/U.S. Army Reserve,
    Animation is created by Bright Side.

    Music by Epidemic Sound

    SUMMARY:
    - Without vitamin D, your bones can’t absorb the necessary amount of calcium to create healthy bone tissue, causing a weakening of the bones known as osteomalacia.
    - In addition to aching bones and muscles, a lack of vitamin D can cause chronic pain throughout the entire body. This debilitating condition is known as fibromyalgia, and it makes life a living nightmare for those who suffer from it!
    - Suffering from your 4th or 5th virus this year? It may be because a lack of vitamin D is causing your immune system to work poorly.
    - It’s 4 pm and you feel like you have two bricks as eyelids and barely have the strength to get up from your desk. Sound familiar? There could be quite a few reasons for this feeling. But it can also be due to a lack of vitamin D.
    - Does it seem like your small wounds and injuries take longer to heal than everyone else’s? But this kind of slow healing can also be because of a lack of (say it with me) vitamin D!
    - The average person loses anywhere from 50 to 100 hairs from their head every day. But if you suffer from a lack of vitamin D, you can lose way more than that, at least enough to notice that something’s definitely not right.
    - According to Psychology Today, vitamin D is the only vitamin that is also a hormone. In studies on the relationship between vitamin D and depression, scientists discovered traces of the vitamin on cells found in the regions where depression resides.
    - Vitamin D can be attained by spending time outside. According to The Arthritis Foundation, spending 10-15 minutes in the sun every other day or so can help replenish your vitamin D levels. Even sitting by an open window can help give you more vitamin D!

    Subscribe to Bright Side :

    ----------------------------------------------------------------------------------------
    Our Social Media:

    Facebook:
    Instagram:

    5-Minute Crafts Youtube:

    ----------------------------------------------------------------------------------------
    For more videos and articles visit:

  • Vitamin D Toxicity | Causes, Pathophysiology, Symptoms, Diagnosis, Treatment

    13:08

    Vitamin D Toxicity (Hypervitaminosis D) | Causes, Pathophysiology, Symptoms, Diagnosis, Treatment

    ***NOTE: I forgot to mention that in the diagnosis of Hypervitaminosis D, it is important to not only measure calcium (which will be high), vitamin D (which will also be high), but also to measure PTH (which will be LOW).***

    Vitamin D Toxicity (Hypervitaminosis D) is a condition involving excessively high levels of vitamin D from either exogenous dietary sources or as produced from granulomatous conditions or lymphoma. Vitamin D Toxicity leads to hypercalcemia, which causes many of the symptoms observed in Vitamin D Toxicity. In this lesson, we also discuss how Vitamin D Toxicity is diagnosed and treated.

    I hope you find this lesson helpful! If you do, please consider liking this video, and subscribing to the channel!
    REFERENCES:
    Vitamin D Toxicity (StatPearls)


    Please donate to help support this channel (and get ACCESS TO EXCLUSIVE VIDEOS) ➜

    *Subscribe for more free medical lessons*

    -------------------------------------------------------------------------------------------------------------

    EXCLAIMER: The content used in this lesson is used in accordance with Fair Use laws and is intended for educational purposes only.

    **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

    Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

    -------------------------------------------------------------------------------------------------------------
    For books and more information on these topics


    Check out the best tool to help grow your YouTube channel (it’s helped me!)


    Follow me on Twitter! ➜
    Come join me on Facebook! ➜
    -------------------------------------------------------------------------------------------------------------

    Check out some of my other lessons.

    Medical Terminology - The Basics - Lesson 1:


    Infectious Disease Playlist


    Dermatology Playlist


    Pharmacology Playlist


    Hematology Playlist


    Rheumatology Playlist


    Endocrinology Playlist


    Nephrology Playlist


    ---------------------------------------------------------------------------------------

    *Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

  • x
  • Vitamin D3 and Calcitriol | All About Vitamin D

    13:28

    Vitamin D3 (Cholecalciferol) and Vitamin D2 (Ergocalciferol) and Calcitriol | All About Vitamin D

    What are all of these things?
    They refer to the various forms of Vitamin D in our bodies or in the food we eat. For example, vitamin D3 is also known as cholecalciferol; this is the form made naturally by the body in response to sunlight. Vitamin D2 is also known as Ergocalciferol and comes from plants. Vitamin D supplements come in the form of either Vitamin D3 or Vitamin D2. Calcitriol, or 1,25-dihydroxy vitamin D if you prefer, is the active form of vitamin D in our body. When sunlight contains ultraviolet B (UVB) radiation, and when it hits your skin cells, it turns 7-dehydrocholesterol into vitamin D3, meaning cholecalciferol. Vitamin D3, in turn, binds to vitamin D-binding protein (VDBP) and is transported to the liver, where it gets converted to calcidiol, aka 25-hydroxyvitamin D.

    Calcidiol is the storage form of vitamin D in the body. Calcidiol is later converted to the active form of vitamin D in the body, meaning calcitriol, or 1,25-dihydroxy vitamin D. This conversion of calcidiol into calcitriol mainly occurs in the kidney. But it also takes place in different tissues and cells of the immune system, such as lymph nodes and alveolar macrophages. And not only in alveolar macrophages but the alveoli themselves.

    Vitamin D3 is only found naturally in a few different food sources, mainly fatty fish, like cod, swordfish, tuna, and salmon. Milk doesn’t naturally contain vitamin D3, but it has been fortified with it for almost 100 years now. But other dairy products made from milk like cheese and ice cream aren’t typically fortified with vitamin D and contain only small amounts. So to meet the RDA of 800 IU, older adults would have to drink about 4 cups of fortified milk per day. Vitamin D3 mainly comes from sunlight, though, not food. But the skin’s production of vitamin D depends on several factors, only some of which you have control.

    Depending on the season, where you live, where you travel, the time of day, the clothing you wear, and the umbrella you use, all of these factors determine how much UVB light hits your skin. The sun’s rays are most direct between 10 a.m. and 3 p.m. However, the farther you live from the equator, the less UVB radiation you receive. People who live north of about 37° latitude can’t make any vitamin D from sunlight from November to March, even if they spend all day outside bare naked. Why is this the case? During the winter months, the earth tilts away from the sun, ultimately leading to fewer sun rays hitting the earth. Having darker skin means less UVB absorption, which means less vitamin D3 production. Also, as we age, our bodies become less efficient at converting UVB light into vitamin D3. This is why older people and darker skin people are more prone to have lower vitamin D levels. Many older people have reduced exposure to sunlight for different reasons and may not be getting enough vitamin D in their diet to make matters worse.

    Vitamin D signals the intestines to absorb calcium into the bloodstream.
    This happens even if you have enough calcium in your diet. Besides strengthening bones, vitamin D helps reduce fractures in the elderly by preventing muscle deterioration and reducing the chances of falling.

    The official definition of a vitamin deficiency means that specific health problems arise due to not having enough of a specific nutrient. True vitamin D deficiency in children causes rickets, a bone disease where the legs become bowed. This is rare in the United States. Vitamin D deficiency in adults can lead to osteomalacia and osteoporosis, leading to bone fractures. So what if you don’t have deficiency per se, but you have less-than-ideal levels of a specific vitamin? Well, this can increase your risk of various health issues, even though they are not solely responsible for these problems. This is what we call “Insufficiency.”

    Most medical societies consider someone with vitamin D insufficiency if their level is between 12 to 20 ng/mL (30 to 50 nmol/L), and Vitamin D deficiency is less than 12 ng/mL (30 nmol/L). Most experts consider normal levels to be above 20 and less than 50 ng/ml. Most people in the United States have values around 20 ng/ml.

    But having too high levels can cause other health issues. In one study, levels above 32 ng/ml resulted in people getting less quality sleep. The risk of vitamin D toxicity typically occurs at levels over 100 ng/mL in adults who also ingest substantial calcium amounts. Vitamin D toxicity, whether it's from vitamin D3 or vitamin D2, generally occurs after inappropriate use of vitamin D. It’s essential to avoid excess vitamin D in pregnancy because that can cause calcium levels to rise to the point of causing seizures in the mother and developmental problems in the baby.

    Doctor Mike Hansen, MD
    Internal Medicine | Pulmonary Disease | Critical Care Medicine
    Website:

    #vitamind #d3

  • Can Supplements Prevent and Treat COVID 19 | Vitamin D, Vitamin C, and Zinc

    7:37

    Can supplements prevent or treat COVID 19? I review current data on Vitamin C, Zinc, and Vitamin D. Unfortunately for two of these, data is lacking in supporting their use for prevention or treatment. Vitamin D however does show some potential. More studies are needed before making any definitive claims however.

    In full disclosure, I do take vitamin C and Vitamin D daily. They can't hurt right? As long as you don't take too much that is.

    Studies mentioned in this video:

    Vitamin C:
    Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection
    The COVID A to Z Randomized Clinical Trial -

    Zinc:
    Low zinc levels at clinical admission associates with poor outcomes in COVID-19 -

    Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection
    The COVID A to Z Randomized Clinical Trial -

    Vitamin D:
    Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study -

    Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study -

    No significant association between vitamin D and COVID-19. A retrospective study from a northern Italian hospital -

    Is there a link between vitamin D status, SARS‐CoV‐2 infection risk and COVID‐19 severity? -

    Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy -

    Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results -

    Vitamin D concentrations and COVID-19 infection in UK Biobank -

    0:00 Intro
    1:00 Vitamin C and Zinc
    3:20 Vitamin D
    5:45 Supplement Dose

    ------------------------------------
    WEBSITE:
    FACEBOOK:
    INSTAGRAM:
    TWITTER:

    This video is for educational purposes only. It is not intended to diagnose or treat any condition in any way. Always consult a medical professional for matters concerning your personal health.

    #covid19 #supplementsforCOVID #vitaminsforCOVID

  • Should you take vitamin D for Coronavirus? Which? investigates

    5:14

    Experts agree vitamin D is the one vitamin we should be taking, but can it prevent you catching Coronavirus and help your body fight it?

    In this video we cover how vitamin D works and the dosage you should take, and Which? video reporter Lucia Ariano speaks with Martin Hewison, Professor of Endocrinology at the University of Birmingham and specialist in vitamin D research to find out how vitamin D can help you fight colds, flu and Covid-19.

    Chapters
    00:00 What is vitamin D and how does it help your immune system?
    01:37 Does vitamin D protect against coronavirus?
    02:52 How much vitamin D should you take?
    04:23 Do you need to take anything else with vitamin D?

    Read more:

    Subscribe to make sure you never miss out on our reviews and advice:


    Looking for the latest product reviews and advice? You're in the right place. Which? has been championing the cause for consumers since 1957, asking probing questions of businesses and manufacturers, and pursuing the answers that put you in the driving seat.

    Reviews You Can Trust
    Which? has more than 1.3m members and supporters, making us the largest independent consumer body in the UK. Our commitment to providing unbiased advice to consumers is at the heart of everything we do. So from choosing a TV, mobile phone, new car, or holiday, to managing your personal financial needs, we’re always on your side.

    Completely Independent
    The unique thing about Which? is that we are completely independent. This means we work entirely on behalf of you – so you can rest assured that you're getting the very best advice available. Which? works for you reviewing products and services, so that you make the best purchase decisions for your needs.

    For more expert advice visit:


    Follow us on Twitter:


    Join the discussion on Facebook:

  • Vitamin D: How Much Vitamin D Should I Take A Day

    18:22

    Vitamin D: How Much Vitamin D Should I Take A Day

    COVID 19 cytokine storms increase mortality. If vitamin D plays a role in decreasing pro-inflammatory cytokines, this video explores how vitamin D deficiency increases the susceptibility for a COVID 19 patient developing cytokine storms?

    Vitamin D is a fat-soluble vitamin that plays a role in calcium absorption, bone health, and immune function. Vitamin D comes in two forms: vitamin D3, which we get from sunlight and animal products, and vitamin D2 through our diet like milk, fish, and fortified cereals. Vitamin D supplements can come in either vitamin D2 or D3. While some experts have suggested that vitamin D3 is more potent and absorbed better, either type is ok if it takes general health.

    Vitamin D2 mainly comes from fortified foods like breakfast cereals, milk, and other dairy items. Vitamin D3 is made by your own body when UVB light from the sun penetrates 7-dehydrocholesterol in the skin. Vitamin D3 is also found in some foods, including eggs and fatty fish, such as salmon, tuna, and mackerel. Both Vitamin D2 and D3 are then bound to a carrier protein called vitamin D binding protein (DBP) and then metabolized in the liver into calcifediol, also called 25-hydroxyvitamin D. When your doctor orders lab tests to check your vitamin D levels, they are measuring your 25-hydroxyvitamin D levels.

    Vitamin D status is significantly associated with clinical outcomes. The results suggest that an increase in serum 25 hydroxyvitamin D level in the body could either improve clinical outcomes or mitigate worst (severe to critical) outcomes. In contrast, a decrease in serum 25 hydroxyvitamin D level in the body could worsen the clinical outcomes of COVID 19 patients. In conclusion, this study provides substantial information to clinicians and health policy-makers. Vitamin D supplementation could possibly improve the clinical outcomes of patients infected with COVID 19.

    Dr. Yo
    Website:
    Facebook Page:
    Instagram Account:
    Please Subscribe to My Channel and Push the Bell Icon:


    #vitamind #vitamind3 #covid19

  • Vitamin D, Large scale studies

    27:14

    Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study (Federation of European Biochemical Societies Journal)



    Vitamin D deficiency is a worldwide pandemic

    To evaluate associations of plasma 25(OH)D levels with the likelihood of coronavirus disease infection and hospitalization

    N = 7, 807

    February 1st to April 30th, 2020

    Participants had one previous blood test for the plasma 25(OH)D level

    Suboptimal’ or ‘low’ plasma 25(OH)D. Below 30 ng/mL

    Sufficiency more than 30 ng/ml. (75 nmol/L)

    Insufficiency, 20 – 29 ng/ml

    Deficiency less than 20 ng/ml (50 nmol/L)

    7, 807 individuals

    Risk by age and sex were as expected

    Obesity not significantly associated with increased risk for COVID‐19 infection or hospitalization

    Sufficient vitamin D levels

    7, 025 tested negative

    Low vitamin D levels

    782 tested positive

    Increased likelihood of COVID‐19 infection
    Odds ratio (OR) of 1.45

    Increased likelihood of hospitalisation
    OR of 1.95

    We concluded that low plasma 25(OH)D levels appear to be an independent risk factor for COVID‐19 infection and hospitalization.

    The link between vitamin D deficiency and Covid-19 in a large population



    52, 405 infected patients

    524, 050 controls

    Greater incidence of COVID-19 with lower vitamin D levels

    Highest infection prevalence with lowest vitamin D levels

    A significant protective effect in those who had supplemented over the previous 4 months

    Joint Guidance on Vitamin D in the Era of COVID-19 from the ASBMR, AACE, Endocrine Society, ECTS, NOF, and IOF



    Spend at least 15-30 minutes with direct sun exposure each day

    Most older and younger adults can safely take 400-1000 IU daily

    Vitamin-D and COVID-19: do deficient risk a poorer outcome? (Lancet)



    Comparing data across nations, mortality from COVID-19 is clearly higher in some countries than in others

    Relative vitamin D status of populations

    Vitamin D supplementation could be especially important for older people

    Functions

    Calcium and phosphate balance

    Affecting bone growth and turnover

    Low vitamin D status

    Associated with increased susceptibility to infectious disease

    Notably, upper respiratory tract infections

    Treating the lowest levels gives most percentage benefit

    Vitamin D and COVID-19

    Virus emerged and started its spread in the northern hemisphere at the end of 2019

    When levels of 25-hydroxyvitamin D are lowest

    COVID-19 mortality was significantly associated with vitamin D status in different populations

    Nordic countries, widespread fortification of foods

    Italy and Spain, prevalence of vitamin D deficiency, surprisingly common

    Black and minority ethnic people

    UK, more than four times more likely to die from COVID-19

    In COVID

    Vitamin D supports production of antimicrobial peptides in the respiratory epithelium

    Might help to reduce the inflammatory response

    Vitamin D is known to interact angiotensin- converting enzyme 2

    SARS-CoV-2 down regulates expression of ACE2

    Vitamin D promotes expression of this gene

    Rose Anne Kenny

    Trinity College Dublin

    Lead investigator of the Irish Longitudinal Study on Ageing

    The circumstantial evidence is very strong

    we don’t have randomised controlled trial evidence, but how long do you want to wait in the context of such a crisis?

    We know vitamin D is important for musculoskeletal function, so people should be taking it anyway

    Vitamin D supplements should normally be given to care home residents unless there is an extremely good reason not to do so.

    Adrian Martineau

    Queen Mary University of London

    At best vitamin D deficiency will only be one of many factors involved in determining outcome of COVID-19

    but it’s a problem that could be corrected safely and cheaply

    there is no downside to speak of, and good reason to think there might be a benefit

    Vitamin D dose

    IU mcg
    400 10mcg
    800 20mcg
    1,000 25mcg
    2,000 50mcg
    4,000 100mcg

  • Coronavirus Pandemic Update 74: Vitamin D & COVID 19; Academic Censorship

    8:54

    COVID-19 Update 74 with Roger Seheult, MD. All coronavirus updates available free at our website
    In this video, Dr. Seheult reviews a new article from the Lancet discusses the potential benefit and role of Vitamin D in preventing and reducing the severity of COVID-19. The censorship of academic discussion about studies and peer-reviewed journal articles has become an area of significant concern for medical professionals and those seeking evidence-based information during a pandemic. Dr. Seheult shares his opinion on this type of censorship, and also shares resources for dental professionals preparing to open their practices. (This video was recorded on May 22, 2020)
    -------------------------------------------

    Links referenced in this video:

    Johns Hopkins Tracker -

    Worldometer

    Lancet Article on Vitamin D -

    TILDA Study -

    Australian Dental Association -

    ADA Center for Professional Success -

    CNN -

    60 Minutes -

    -------------------------------------------

    Some previous videos from this series (visit MedCram.com for the full series):
    - Coronavirus Pandemic Update 73: Relapse, Reinfections, & Re-Positives - The Likely Explanation
    - Coronavirus Pandemic Update 72: Dentists; Diabetes; Sensitivity of COVID-19 Antibody Tests:
    - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine +
    Azithromycin:
    - Coronavirus Pandemic Update 70: Glutathione Deficiency, Oxidative Stress, and COVID 19
    - Coronavirus Pandemic Update 69: NAC Supplementation and COVID-19 (N-Acetylcysteine)
    - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19:
    - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor
    - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19
    - Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors)
    - Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update
    - Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?
    - Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)?
    - Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress
    - Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19?
    - Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
    - Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID 19 (V/Q vs Shunt vs Diffusion)
    - Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?

    All coronavirus updates are at MedCram.com (including a discussion of that data for coronavirus UK, coronavirus NYC, COVID 19 testing and reinfections) and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.).

    -------------------------------------------

    Speaker: Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

    MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

    Media Contact: customers@medcram.com
    Media contact info:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #FOAMed

  • Dr. Roger Seheult: COVID-19 Question & Answer - Live - June 14, 2020

    1:39

    Dr. Roger Seheult will respond to COVID-19 questions from the week in addition to new questions that are received during the live-stream.

    Join us at for the full video library and CME / CEUs for clinicians.

    Speakers:
    Roger Seheult, MD
    Co-Founder and Lead Instructor at
    Board Certified in Internal Medicine, Pulmonary, Critical Care, and Sleep Medicine
    Associate Clinical Professor at the University of California, Riverside School of Medicine

    Kyle Allred, PA
    Co-Founder and Producer at
    Conference Director

    00:00 Introduction
    00:50 Update from the hospital ICU
    02:07 is there plenty of PPE (Personal Protective Equipment)?
    04:15 You showed us last week Fructose can increase your risk, so should people be cutting back on fruit?
    08:55 What is the role of systemic steroids and/budesonide nebulizer in COVID patients especially early in the disease?
    12:20 For a 65-year-old, is age in and of itself enough to increase my risk?
    13:20 If i have to seek covid19 treatment: can i shop around to different doctors or hospitals, asking them about their ideas for treatment? Or is the typical hospital doctor going to be totally restricted to hospital policy set by the administrators and/or the insurance companies?
    19:40 is the SARS-COV2 virus getting weaker now?
    21:40 have treatments become more targeted/efficient/efficacious?
    23:59 Much information has emerged about those who were never hospitalized but remain sick for two, three months. Do you have thoughts about this demographic? Is this an active infection?
    25:58 My husband has just tested positive, but i am negative. How could this happen? What should we both do?
    27:39 NAC (N-acetylcysteine): side effects? pros and cons?
    31:06 thoughts on the dosing of NAC?
    31:41 what are your thoughts about the vaccine attempts, especially with the inability to find a vaccine in the first sars outbreak?
    35:00 have you seen any correlation between blood type and disease strength?
    36:53 is there enough convalescent plasma at your hospital?
    39:22 what treatment are you enthusiastic about at your hospital?
    [proning]
    44:45 at the hospital, is there any equipment to help in proning position?
    46:12 a role for proning at home?
    47:56 what are the dangers for people who need to be on steroids like prednisone or dexamethasone. What are the pros and cons of chronic steroids?
    52:25 why aren't we treating earlier?
    56:09 thoughts on treatment with tocilizumab (IL6 inhibitor)?
    57:20 is there any indication as to how long anti-bodies will last? If it turns out they only last for 6 months, what does it mean going forward?
    59:45 any parting words before we sign off?

    Quick links to some recent COVID 19 updates:
    Coronavirus Pandemic Update 83: High Fructose, Vitamin D, & Oxidative Stress in COVID-19:
    - Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D
    - Coronavirus Pandemic Update 81: New Data on Hydroxychloroquine Side Effects & Prevention of COVID-19
    - Coronavirus Pandemic Update 80: COVID-19 Retractions & Data (Hydroxychloroquine, ACE Inhibitors):
    - Coronavirus Pandemic Update 79: COVID-19 Vaccines to Keep an Eye On - mRNA, Antigen, Others:
    - Coronavirus Pandemic Update 78: Mask Controversy; Vaccine Update for COVID-19
    - Coronavirus Pandemic Update 77: Remdesivir Update; COVID-19 in Mexico
    - Coronavirus Pandemic Update 76: Antibody Testing False Positives in COVID-19:
    - Coronavirus Pandemic Update 75: COVID-19 Lung Autopsies - New Data:
    - Coronavirus Pandemic Update 74: Vitamin D & COVID 19; Academic Censorship:
    - Coronavirus Pandemic Update 73: Relapse, Reinfections, & Re-Positives - The Likely Explanation:
    - Coronavirus Pandemic Update 72: Dentists; Diabetes; Sensitivity of COVID-19 Antibody Tests:
    - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine + Azithromycin:
    - Coronavirus Pandemic Update 70: Glutathione Deficiency, Oxidative Stress, and COVID 19:
    - Coronavirus Pandemic Update 69: NAC Supplementation and COVID-19 (N-Acetylcysteine):
    - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19:
    - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor:
    - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19:

  • Vitamin D Pills Are Useless

    21:59

    Today we take a dive into the current research on Vitamin D pills. Should Vitamin D be taken for lifestyle-related diseases like cancer, heart disease, diabetes, etc.? There's a lot of wrong and outdated information out there. Let's talk about it.

    UPDATE 2: Major long-awaited randomized controlled trial on Vit D pills show they have NO EFFECT on Cancer or Heart Disease:

    UPDATE: New research of 500,000 individuals show Vitamin D levels have nothing to do with bone health:


    UPDATE: Read this article exposing the profit-driven scheme to push Vitamin D pills, which experts admit are not only useless, but could increase risk of death:



    Info referenced in video:

    My daughters' book, The Clear Skin Diet:


    Dr. Greger's video: Should Vitamin D Be Taken to Prevent Falls in Elderly?


    US Preventive Task Force Recommends Against Vit D for seniors


    US Preventive Task Force Recommends Against Vit D for cancer


    Dr. Greger's video: Will You Live Longer if you Take Vitamin D Pills?


    Meta-Analysis: Vitamin D supplementation for prevention of mortality in adults


    Dr. Greger's video: Do Vitamin D Supplements Reduce the Risk of Dying from Cancer?


    Vitamin D supplements and cancer incidence and mortality: a meta-analysis


    Comment on Comment on: ‘Vitamin D supplements and cancer incidence and mortality: a meta-analysis'


    Author's response to Comment:


    USPS Task Force Cancer - Vit D Recommendations


    AICR Vitamin D Supplements


    Dr. McDougall's position on Vitamin D


    Recommendations against use of Vit D of American Cancer Society:







    ❤ ☀ °‧°‧☆ ☾ O U R S T O R E ☽ ☆‧°‧°☀ ❤
    The Store:

    ▬▬▬▬▬▬▬▬▬ஜ۩۞ F O L L O W ۞۩ஜ▬▬▬▬▬▬▬▬
    ☪ Instagram: 'vegsource' or
    → Personal Questions:
    ۞ Facebook:
    Twitter:

    ◂ ◃ ☀ °‧°‧☆ W E B S I T E ☆‧°‧°☀ ▹ ► ▻

  • Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention

    12:41

    Coronavirus (COVID-19) Update 30 with pulmonologist Dr. Seheult of

    Topics include a variety of growing international coronavirus epidemics including Australia, Norway, Iceland, Iran, Italy, Poland, India, Belgium, South Korea, Canada, and the United States (Los Angeles). Dr. Seheult also discusses compelling evidence about the possible role of Vitamin D (in proper dosage) in fighting acute respiratory infections like COVID-19.

    PLEASE NOTE: This video was recorded on March 4, 2020. Our more recent COVID-19 updates can be accessed free at our website or here on YouTube:

    We've produced each COVID-19 video with the best information we could access at the time of recording. Naturally, some videos will contain information that has become outdated or replaced by better information or research.

    That said, we believe each video contains concepts that have enduring value and reviewing how the response to COVID-19 has progressed over time may be of interest to you as well.


    Previous videos from this series:

    - Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran:

    - Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate:

    - Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases:

    - Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic?

    - Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends:

    - Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms:

    - Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats:

    - Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing:

    - Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?:

    - Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins:

    - Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials:

    - Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips:

    - Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19):

    - Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19):

    - Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19)

    - Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks:

    - Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada:

    - Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV:

    - Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine):

    - Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV):

    - Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate:

    - How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

    -----------------------------------------------------------
    LINKS for references from this video:

















    -----------------------------------------------------------

    Speaker: Roger Seheult, MD
    Produced by Kyle Allred, PA

    Note: MedCram medical videos are for medical education and exam preparation, and not intended to replace recommendations by your doctor.
    #Coronavirus #COVID19 #SARSCoV2

  • Does Vitamin D boost immunity and protect against COVID-19?

    30:49

    Vitamin D deficiency has been linked to a range of health issues, but can healthy people really benefit from supplementing their vitamin D intake?

    Prof. Tim Spector and Dr. John Campbell discuss the merits and misconceptions of the so-called 'sunshine vitamin' and explore it's role in a healthy immune system - including whether science supports claims vitamin D supplements may protect against COVID-19.

    For the website visit:

    For more localised data visit:

    The app is available to download from:
    The Apple App Store:
    Google Play:

    If you need subtitles, please click the option for subtitles at the bottom right of the video

  • Vitamin D and COVID-19 || Could Vitamin D Help with COVID-19

    29:03

  • COVID-19 and Aspirin

    32:24

    Aspirin
    Aspirin has antithrombotic, anti-inflammatory, analgesic, and anti-pyretic effects.

    Aspirin plus Vitamin D trial for COVID-19
    The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations (LEAD COVID-19)


    Aspirin


    Leukotrienes and allergies

  • Coronavirus Mutations and COVID 19 Vaccine Implications with Shane Crotty, PhD

    39:47

    Professor Shane Crotty, Ph.D. explains recent coronavirus mutations and how they might impact COVID 19 vaccines and transmission. COVID-19 research of Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science:

    Prof. Shane Crotty is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Prof. Crotty also has an academic appointment with the University of California San Diago. See his full bio here:
    Prof. Crotty on Twitter:

    Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com


    TOPICS DISCUSSED IN THIS VIDEO INCLUDE:

    0:00 Intro
    0:08 SARS-CoV-2 / COVID 19 mutations (UK variant etc.) and implications for COVID-19 vaccines
    10:58 How to test if coronavirus variants can escape immunity
    12:28 How have mutations made this virus more transmissible?
    17:44 Could mutations make vaccines less than 50% effective?
    24:15 Possible changes to vaccine schedules (one dose, half dose)?
    35:34 Could alternate COVID-19 vaccine schedule make mutations more likely?
    38:29 What is next for Prof. Crotty and his team?

    (This video was recorded on January 5, 2021)

    PREVIOUS DISCUSSION WITH PROF. CROTTY (Dec 16, 2020):


    REFERENCES:

    Viral mutations may cause another ‘very, very bad’ COVID-19 wave, scientists warn (Science) |

    Vaccine Tracker (Bloomberg) |

    FDA Statement on Following the Auth. Dosing Schedules for COVID-19 Vaccines |

    S-variant SARS-CoV-2 is assoc. with sig. higher viral loads in samples tested by ThermoFisher TaqPath RT-QPCR (MedRxiv) |

    Human Leukocyte Antigen (HLA) System |

    UK reports new variant, termed VUI 202012/01 (GISAID)

    Covid-19 in South Africa: Scientists seek to understand new variant (BBC) |

    Mutation Allows Coronavirus to Infect More Cells. Scientists Urge Caution (NY Times) |

    The UK is delaying second vaccine shots and it’s proving controversial (CNBC)

    The receptor binding domain of the SARS-CoV-2 (News Medical Life Sciences) |

    NY Times article highlighting Prof. Shane Crotty's research:


    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


    SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


    Get notified of new videos by hitting the bell icon!


    PREVIOUS / RECENT MEDCRAM COVID-19 INTERVIEWS:

    Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2) with Professor Roger Seheult, MD

    At Home COVID 19 Antigen Testing and Vaccine Update with Professor Michael Mina, MD

    All coronavirus updates are at MedCram.com ad-free (including more on RNA vaccines, BioNTech vaccine, vaccine side effects, AstraZeneca Oxford coronavirus vaccine, side effects of COVID 19 vaccine, new strain of coronavirus, and more):

    We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website and CME for clinicians.


    MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

    MedCram offers group discounts for students and a variety of medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


    MEDIA CONTACT:

    Media Contact: customers@medcram.com
    Media contact info:

    Video Produced by Kyle Allred

    FOLLOW US ON SOCIAL MEDIA:





    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #Coronavaccine

  • Medical exemptions and Ivermectin

    26:19

    Friendly Pharmacy 5:
    Videos:
    • Vitamin D & Immunity:
    • Oxford/AstraZeneca Vaccine:
    • COVID-19 VACCINE Q&A PART 1: Ingredients, Speed of Production, mRNA:

    • Interval between vaccine doses stretched up to 4 months:
    • Health Canada Epidemiology summary:
    • COVID-19 CANADA Vaccine Production:
    • COVID-19 Vaccines in Canada:
    IVERMECTIN:
    • US National Library of Medicine:
    • Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID‐19:

  • When NOT to Take Extra Vitamin D

    4:46

    Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey. Call 1-540-299-1556 with your questions about Keto, Intermittent Fasting or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 am to 10 pm EST. Saturday & Sunday from 9 am to 6 pm EST. USA Only.

    . . Join my FREE 30-Day Low-Carb, No-Cheat Challenge Here!

    Vitamin D can be very beneficial for most people. But, there are certain cases when you should NOT take vitamin D. 

    For more info on health-related topics, go here:

    Download Keto Essentials


    Timestamps
    0:15 Vitamin D as the most important nutrient 
    0:43 The side effect of too much vitamin D
    2:12 When not to take vitamin D #1 
    2:46 When not to take vitamin D #2
    3:13 When not to take vitamin D #3
    3:34 When not to take vitamin D #4
    3:43 When not to take vitamin D #5
    4:00 When not to take vitamin D #6
    4:05 When not to take vitamin D #7

    I’ve done many different videos on the importance of vitamin D. But, there is always an exception to the rule. In this video, we’re going to talk about when not to take vitamin D.

    In my opinion, vitamin D is the most important nutrient. There are many different benefits of vitamin D for your health. It’s almost impossible to get enough vitamin D through the diet, and people aren’t outside as much anymore to get it from the sun. It’s common for people to have a vitamin D deficiency. But, in rare cases, you may need to avoid taking vitamin D.

    The main side effect of taking too much vitamin D:

    • Hypercalcemia, which is too much calcium in the blood. 

    Symptoms of hypercalcemia:

    • Kidney stones 
    • Bone pain 
    • Excessive urination
    • Muscle weakness
    • Depression 
    • Anxiety 

    When not to take vitamin D:

    1. Sarcoidosis
    2. Primary hyperparathyroidism 
    3. Familial hypocalciuric hypercalcemia 
    4. Lithium 
    5. Diuretics (hydrochlorothiazide)
    6. Certain cancers
    7. Hyperthyroid

    Dr. Eric Berg DC Bio:
    Dr. Berg, 56 years of age is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of The New Body Type Guide and other books published by KB Publishing. He has taught students nutrition as an adjunct professor at Howard University. He no longer practices, but focuses on health education through social media.

    DR. BERG'S SHOP:

    Follow us on FACEBOOK: fb.me/DrEricBerg

    Send a Message to his team: m.me/DrEricBerg

    ABOUT DR. BERG:

    Disclaimer:
    Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

  • Dangers of vitamin B12 deficiency

    7:48

    Vitamin B12 deficiency can occur in all kinds of individuals. It may be of particular concern if you are following a vegan or vegetarian diet, or taking medications that reduce your absorption ability of vitamins. This video looks at what exactly a vitamin B12 deficiency can lead to and the ways in which you can obtain vitamin B12 through your diet or by taking B12 supplements.

    This video was created by Demystifying Medicine students Dhruvika Joshi, Prabhjot Khabra, Minahil Jabeen and Vanessa Lombardo.

    Copyright McMaster University 2017

    References:

    1. Bruins Slot, W., Merkus, F. W., Deventer, S. J. H. V., & Tytgat, G. N. (1997). Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology, 113, 430-433.

    2. Daily Intake. (2017). Canadian Food Inspection Agency. Retrieved 30 October 2017, from

    3. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B b6 s, folate, vitamin B b12 s, pantothenic acid, biotin, and choline. (1998) (pp. 306-356). Washington, D.C.

    4. Ermens, A., Vlasveld, L., & Lindemans, J. (2003). Significance of elevated cobalamin (vitamin B12) levels in blood. Clinical Biochemistry,36(8), 585-590. doi:10.1016/j.clinbiochem.2003.08.004

    5. Ganeson, S., Thanawala, N., & Hussain, N. (2013). Vitamin B12 deficiency: a treatable cause of developmental delay in infancy. J Paediatric Child Health, 49(4): E348-349. doi: 10.1111/jpc.12158

    6. Gropper SS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism: Fourth Edition. Boston, MA: Wadsworth (2004).

    7. Hashim, O. H., & Adnan, N. A. (1994). Coenzyme, cofactor and prosthetic group — Ambiguous biochemical jargon. Biochemical Education,22(2), 93-94. doi:10.1016/0307-4412(94)90088-4

    8. Hvas, A., & Nexo, E. (2006). Diagnosis and treatment of vitamin B12 deficiency. An update. Haematologica, 91(11), 1506-1512.

    9. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. (1998). Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academies Press (US).

    10. Kwong, J. C., Carr, D., Dhalla, I. A., Tom-Kun, D., & Upshur, R. E. (2005). Oral vitamin B 12 therapy in the primary care setting: a qualitative and quantitative study of patient perspectives. BMC family practice, 6(1), 8.

    11. . Langan, R. C., & Goodbred, A. J. (2017). Vitamin B 12 Deficiency: Recognition and Management. American Family Physician, 96(6).

    12.. Miller, A., Korem, M., Almog, R., & Galboiz, Y. (2005). Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Journal of the Neurological Sciences,233(1-2), 93-97. doi:10.1016/j.jns.2005.03.009

    13. Møllehave, L. T., Skaaby, T., Simonsen, K. S., Thuesen, B. H., Mortensen, E. L., Sandholt, C. H., ... & Linneberg, A. (2017). Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies. European Journal of Clinical Nutrition, 71(9), 1054-1060.

    14. National Heart, Lung, and Blood Institute (2011). What are the signs and symptoms of pernicious anemia? Retrieved from

    15. Niculescu, M., & Zeisel, S. (2002). Diet, Methyl Donors and DNA Methylation: Interactions between Dietary Folate, Methionine and Choline. The Journal of Nutrition,132, 2333-2335.

    16. Oh, R., & Brown, D. (2003). Vitamin B12 Deficiency. American Family Physician, 67(5), 979-986. Retrieved from

    17. Osimani, A., Berger, A., Friedman, J., Porat-Katz, B. S., & Abarbanel, J. M. (2005). Neuropsychology of vitamin B₁₂ deficiency in elderly dementia patients and control subjects. Journal of geriatric psychiatry and neurology, 18(1), 33-38.

    18. Vogiatzoglou, A., Smith, A. D., Nurk, E., Berstad, P., Drevon, C. A., Ueland, P. M., ... & Refsum, H. (2009). Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. The American journal of clinical nutrition, 89(4), 1078-1087.

    19. Whitney, E., Rolfes, S., Hammond, G., & Piche, L. (2011). Understanding Nutrition (1st ed., pp. 332-334). Toronto: Nelson Education Ltd.

  • Coronavirus Update 116: Pfizer COVID 19 Vaccine Explained

    22:32

    Professor Roger Seheult, MD discusses the Pfizer / Biontech COVID-19 mRNA vaccine: How it works and what we know about the safety and efficacy at this time.

    No mRNA vaccine has ever been approved by the FDA, but Pfizer and BioNTech hope to receive emergency approval based on preliminary data from their ongoing vaccine trial.

    This two-dose vaccine regimen has limitations including the need for -70 C refrigeration and many questions remain:
    Will the vaccine prevent transmission and asymptomatic spread?
    How long will immunity last?
    Will “90% effective” hold up to peer-review and additional data when it is gathered?

    (This video was recorded on November 12, 2020).

    Dr. Seheult is the co-founder and lead instructor at


    LINKS / REFERENCES:

    Johns Hopkins Tracker |

    Worldometer |

    COVID-19 vaccine tracker (RAPS) |

    Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates (NEJM) |

    A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates (bioRxiv) |

    Pfizer and BioNTech Announce Vaccine Candidate Against COVID-19 Achieved Success in First Interim Analysis from Phase 3 Study (BioNTech) |

    Why mRNA represents a disruptive new drug class {BioNTech) |


    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


    SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


    Get notified of new videos by hitting the bell icon:


    RECENT PREVIOUS COVID-19 UPDATES:

    Please visit MedCram.com for the full series:
    - Coronavirus Update 115: Convalescent Plasma vs Monoclonal Antibodies for COVID 19 Treatment
    - Coronavirus Update 114: COVID 19 Death Rate Drops; NAC (N acetylcysteine) Data
    - Coronavirus Update 113: Remdesivir May Not Work for COVID 19
    - Coronavirus Update 112: Linoleic Acid; Vaccines; UK COVID 19 Data
    - Coronavirus Update 111: Masks; New Vitamin D Data and COVID 19; NAC
    - Coronavirus Pandemic Update 110: Trump's Risk Factors and COVID-19 Prognosis; Interferon
    - Coronavirus Pandemic Update 109: New Data From Europe As COVID 19 Infections Rise
    - Coronavirus Pandemic Update 108: High Risk COVID 19 Behaviors; Cases Rise in Europe
    - Coronavirus Pandemic Update 107: Monoclonal Antibodies for COVID 19 Treatment and Prevention?
    - Coronavirus Pandemic Update 105: FDA Authorized Treatments; COVID 19 Vaccine Update
    - Coronavirus Pandemic Update 103: Convalescent Plasma Treatment & the FDA; College Campuses Close

    All coronavirus updates are at MedCram.com (including monoclonal antibody treatment vs convalescent plasma treatment, COVID vaccine, COVID 19 prevention, Pfizer vaccine, Biontech, coronavirus vaccine, COVID 19 treatments, COVID-19 vaccine updates, and more).
    We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website.


    MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

    MedCram offers group discounts for students and a variety of medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


    MEDIA CONTACT:

    Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
    Associate Professor at the University of California, Riverside School of Medicine

    Media Contact: customers@medcram.com
    Media contact info:

    Video Produced by Kyle Allred

    FOLLOW US ON SOCIAL MEDIA:






    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2

  • Vitamin D deficiency in the UK

    28:46

    1st October, Vitamin D, news and science


    16th September, Vitamin D and pandemic science


    12th September, Vitamin D, Large scale studies


    6th September, Vitamin D, Frist clinical trial


    27th July, Vitamin D, Science


    20th June, Vitamin D hits the media


    10th June, Vitamin D update


    18th May, Dr Shelton, Part 1, Reports from New Zealand


    21st May, Dr Shelton, Part 2, Vitamin D


    10th May, Vitamin D dose


    15th April, Vitamin D and Immunity, Lots of evidence


    9th March, Vitamin D and immunity


    There is not enough evidence that vitamin D supplements protect people against Covid-19, an expert panel says.



    Institute for Health and Care Excellence

    Public Health England

    Scientific Advisory Committee on Nutrition

    More research needed

    Insufficient evidence

    Advised to take a daily supplement this winter to keep bones and muscles healthy

    10 micrograms (400 international units)

    Nobel prize, 1928, Adolf Windaus

    Dr Paul Chrisp

    We are continuing to monitor evidence as it is published and will review and update the guidance if necessary

    Determinants of vitamin D deficiency in the UK (Clinical Nutrition)

    University of South Australia (16th December)







    Using UK Biobank data



    Severe vitamin D deficiency remains an issue throughout the UK

    Cross-ethnic analyses on the prevalence and determinants of vitamin D deficiency

    25(OH)D equal to or less than 25 nmol/L Calcifediol

    10 ng/ml

    Data from 440,581 UK Biobank participants

    415,903 identified as White European

    7,880 Asian

    7,602 Black African

    1,383 Chinese

    6,473 of mixed ancestry

    Prevalence of vitamin D deficiency

    Asian ancestry

    57.2% in winter or spring

    50.8% in summer or autumn

    Black African ancestry

    38.5% in winter and spring

    30.8% in summer or autumn

    Mixed ancestry

    36.5% in winter and spring

    22.5% in summer or autumn

    Chinese ancestry

    33.1% in winter and spring

    20.7% in summer or autumn

    White European ancestry

    17.5% in winter and spring

    5.9% in summer or autumn

    Participants with higher socioeconomic deprivation

    More likely to have 25(OH)D deficiency compared to less deprived participants (P = less than 1 × 10 −300)

    This pattern was more apparent among those of White European ancestry

    Regular consumption of oily fish was associated with reduced odds of vitamin D deficiency across all ethnicities

    Asians are less likely to eat fish or use vitamin D supplements compared to other ethnicities

    Outdoor-time in summer was less effective for Black Africans than White Europeans

    Other risk factors

    Living further north

    Indoor employment

    Computer time and games

    Professor Elina Hypponen (SA)

    The severity of vitamin D deficiency is concerning

    especially with the high rates of COVID-19 infections in Europe and elsewhere in the northern hemisphere this winter

    Clinical trials have shown that vitamin D supplements are beneficial in the prevention of respiratory infections and even mortality

    Vitamin D is not expensive and the doses which have shown the greatest benefits are those that we can all acquire over the counter from the local pharmacy

    Given the COVID-19 pandemic, now is really the time for all who may be affected to take action

  • Arthritis and COVID-19: Vaccines, Access and What’s Next | Arthritis Talks

    59:22

    It has been one year since the COVID-19 pandemic took hold and there have been profound changes since that time, including how healthcare has evolved for people with arthritis.
    In this Arthritis Talks, rheumatologist Dr. Vandana Ahluwalia and pharmacist Dr. Alan Low look back at what we’ve learned over the past year and more importantly, looks forward to what we can expect in the months and years ahead. The webinar discusses:
    • If vaccination is right for you, and what you can expect as vaccine campaigns roll out
    • How COVID-19 treatments might impact the supply of certain arthritis drugs
    • What questions about arthritis and COVID-19 are still being studied

    Learn and watch more webinars at:

  • Sputnik V peer reviewed

    28:58

    Sputnik V (Gam-Covid-Vac)

    2 doses, 3 weeks apart

    Muscle injection

    Freezer storage

    Developing an alternative formulation that can be refrigerated

    Gamaleya Research Institute (Ministry of Health)

    Combination of two adenoviruses called Ad5 and Ad26

    August 11th President Putin announced approval

    Before phase 3 trials had started

    November, Russian government began offering Sputnik V within Russia

    Widespread hesitancy

    Phase 3, Russia, Belarus, UAE, Venezuela, India

    Gamaleya Institute joined forces in December with the AstraZeneca

    AstraZeneca / Gamaleya combination started Phase 1 trial on Dec. 24


    Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia



    Background

    A heterologous recombinant adenovirus

    Phase 2 results,

    showed a good safety profile and induced strong humoral and cellular immune responses

    Interim analysis of this phase 3 trial
    Methods

    Randomised, double-blind, placebo-controlled, phase 3 trial

    25 hospitals and polyclinics in Moscow

    Participants at least 18 years, with negative PCR and IgG and IgM tests

    Randomly assigned (3:1) to receive vaccine or placebo

    Two shots, 21 days apart

    First dose, rAd26

    Second dose, rAd5),

    Both vectors carrying the gene for the full-length SARS-CoV-2 glycoprotein S

    Outcome recorded 21 days after second shot (vaccine or placebo)

    Finding

    Sept 7 to Nov 24, 2020

    N = 21 977

    Randomly assigned

    Vaccine group, n = 16 501

    Placebo group, n = 5476

    N = 19 866 received two doses of vaccine or placebo and were included

    (2,144 participants older than 60 years, 1,611 in the vaccine group and 533 in the placebo group)

    Primary outcome analysis

    Included all participants who had received at least two doses at the time of database lock

    Vaccine group, n = 14,964

    16 (0·1%) confirmed COVID infections

    No cases of moderate or severe COVID-19 confirmed at least 21 days after dose 1

    Placebo group, n = 4,902

    62 (1·3%) confirmed COVID infections

    20 cases of moderate or severe COVID-19 confirmed at least 21 days after dose 1

    Efficacy

    91·6%

    Vaccine efficacy was 91·8 in participants older than 60 years

    Interim immunogenicity

    Vaccine group

    RBD-specific IgG detected in 336 (98%) of 342 samples

    Seroconversion rate of 98·25%

    Higher levels of interferon-gamma

    (secreted by activated T helper lymphocytes, T cytotoxic lymphocytes, B lymphocytes and NKs)

    Significantly higher levels of IFN-γ secretion upon antigen restimulation

    Placebo group

    RBD-specific IgG was detected in 17 (15%) of 114 samples

    Seroconversion rate of 14·91%

    (p less than 0·0001 vs the vaccine group)

    Adverse events

    Grade 1

    7485 [94·0%] of 7966 total events

    Serous adverse events

    Vaccine group


    45 (0·3%) of 16, 427

    Placebo group

    23 (0·4%) of 5435

    None were considered associated with vaccination

    Four deaths were reported during the study

    Vaccine group

    Three (less than 0·1%) of 16 427

    Placebo group

    One (less than 0·1%) of 5435

    None of which were considered related to the vaccine

    Interpretation

    This interim analysis of the phase 3 trial of Gam-COVID-Vac showed 91·6% efficacy against COVID-19 and was well tolerated in a large cohort

  • Hydroxychloroquine, evidence of efficacy

    36:46

    Belgium, not Dutch. Low-dose Hydroxychloroquine Therapy and Mortality in Hospitalized Patients with COVID-19: A Nationwide Observational Study of 8075 Participants (International Journal of Antimicrobial Agents, 24 August)



    Background

    Hydroxychloroquine (HCQ) has been largely used and investigated as therapy of COVID-19 , at total dose usually ranging from 2400 mg to 9600 mg.

    In Belgium, off-label use of low-dose HCQ (2400 mg in total over five days) was recommended for hospitalized patients with COVID-19.

    “low-dose” regimen of HCQ sulphate in monotherapy

    400mg twice on day 1

    200mg twice a day from day 2 to 5

    i.e. a total dose of 2400 mg

    Methods

    Multi-centric design

    Vast majority of Belgian hospitals

    Retrospective analysis

    In-hospital mortality in Belgium

    40 day follow up

    No difference in the baseline characteristics

    Groups

    HCQ alone and supportive care

    Supportive care only

    Adjusted for demographic and clinical features

    Results

    8075 patients with complete discharge data

    HCQ group, n = 4,542

    Deaths, 804, (17.7%)

    no-HCQ group, n = 3,533

    Deaths, 957 (27.1%)

    Multivariable analysis

    Mortality was lower in the HCQ group compared to the no-HCQ group

    Hazard ratio = 0.684

    Estimated direct-adjusted mortality at 40 days

    19.1% with HCQ alone

    26.5% with supportive care only

    Mortality in the HCQ group was reduced

    Both in patients diagnosed in less than 5 days and more than 5 days

    Conclusions

    Compared to supportive care only, low-dose HCQ monotherapy was independently associated with lower mortality in hospitalized patients with COVID-19 diagnosed and treated early or later after symptom onset.

    Other positive studies



    Risk Factors for Mortality in Patients with COVID-19 in New York City



    Hydroxychloroquine use was associated with decreased in-hospital mortality

    Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19



    treatment with hydroxychloroquine alone and in combination with azithromycin was associated with reduction in COVID-19 associated mortality


    Recovery Trial

    Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. 15 July 2020





    Hydroxychloroquine group, n = 1,561

    Usual care group, n = 3,155

    Patients allocated to hydroxychloroquine sulfate (200mg) received a loading dose of 4 tablets (800 mg) at zero and 6 hours, followed by 2 tablets (400 mg) starting at 12 hours after the initial dose and then every 12 hours for the next 9 days

    9,200 mg over 10 days

    Conclusion

    In patients hospitalized with COVID-19, hydroxychloroquine was not associated with reductions in 28-day mortality

    Was associated with an increased length of hospital stay and increased risk of progressing to invasive mechanical ventilation or death

    WHO-led SOLIDARITY



    9600 mg over 10 days

    Provided no benefit in hospitalized patients with COVID-19

    Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19 (NEJM23 July) Brazil



    METHODS

    55 hospitals, Brazil

    Randomized

    Open label

    Three-group

    Controlled

    Patients

    667 patients, 504 confirmed Covid-19

    Receiving no supplemental oxygen

    Or a maximum of 4 liters per minute

    1:1:1

    Standard care n = 229

    Standard care plus hydroxychloroquine (400 mg twice daily) n = 221

    Standard care plus hydroxychloroquine (400 mg twice daily) plus azithromycin (500 mg once
    daily for 7 days) n = 277

    RESULTS

    No difference in need for ventilation, deaths, thromboembolic complications, AKI

    Clinical status at 15 days

    As compared with standard care = 1

    Hydroxychloroquine alone, odds ratio, 1.21

    Hydroxychloroquine plus azithromycin, odds ratio, 0.99

    HCQ Group

    Prolongation of the corrected QT interval and

    Elevation of liver-enzyme levels

    CONCLUSIONS
    Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care.

  • Hemostasis: Lesson 4 - Tests

    25:22

    A review of the measurement and interpretation of platelet count, INR, PTT, fibrinogen, d-dimer, and the mixing study.

  • Coronavirus Update 125: Variants, Vaccine Uptake, Sinovac, Brazil, India, Israel

    15:01

    Professor Roger Seheult, MD of discusses the dramatic rise in COVID 19 in Brazil and India, Global Vaccine Update, The Sinovac CoronaVac Vaccine, and new research on coronavirus vaccine efficacy vs. variants in Israel, South Africa, and other locations. (This video was recorded on April 12, 2021).

    Roger Seheult, MD is the co-founder and lead professor at
    He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.


    TOPICS IN THIS VIDEO INCLUDE:

    00:00 Updates on COVID-19 daily new cases and daily deaths around the world
    00:30 Brazil and India emerge as global “hotspots” for COVID-19
    03:09 International vaccination campaign tracker
    04:05 Mechanism of Sinovac’s COVID-19 vaccine developed in China
    06:42 Efficacy of Sinovac vaccine on different SARS-CoV-2 variants
    08:01 COVID-19 vaccination and infection rates in Chile
    08:50 Three countries to watch carefully: Brazil, India, and Chile
    09:27 Israel among highest in the world for COVID-19 vaccine coverage
    09:48 Is Pfizer vaccine becoming less effective against South African variant in Israel?
    12:39 Serious COVID-19 cases in Israel fall below 300 for first time since December
    13:13 Could low vaccination rate be responsible for high COVID-19 death rate in Brazil?
    14:15 What to do if COVID-19 cases are surging near you


    LINKS / REFERENCES:

    Coronavirus Update 121: Johnson and Johnson Vaccine - Efficacy and Safety vs. Pfizer & Moderna (MedCram) |

    If You Get COVID 19: Optimize Immune System (MedCram) |

    Coronavirus Update 119: Pfizer BioNTech COVID Vaccine (MedCram) |

    Coronavirus Update 118: AstraZeneca DNA COVID 19 Vaccine Explained (MedCram) |

    Coronavirus Update 117: Moderna vs. Pfizer COVID 19 Vaccine (MedCram) |

    Coronavirus Update 116: Pfizer COVID 19 Vaccine Explained (MedCram) |

    More Than 781 Million Shots Given: Covid-19 Tracker (Bloomberg) |

    How the Sinovac Vaccine Works (NYT) |

    Sinovac: Brazil results show Chinese vaccine 50.4% effective (BBC News) |

    Israeli data shows South African variant able to ‘break through’ Pfizer vaccine (The Times of Israel) |

    Pfizer Covid Vaccine Protects Against South African Variant, ‘Highly Effective’ Against Disease For Six Months, Updated Trial Data Shows (Forbes) |

    Pfizer and BioNTech Confirm High Efficacy and No Serious Safety Concerns... (Pfizer) |

    India bans remdesivir exports as COVID-19 cases surge (Aljazeera) |

    Chile Covid-19 vaccination drive adds to Sinovac efficacy data (S. China Morning Post) |

    Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals (medRxiv) |

    Covid-19: Why have deaths soared in Brazil? (BBC News) |

    All coronavirus updates are at MedCram.com (including more discussion on COVID variants, Sinovac, CoronaVac, COVID mutations, California variant, coronavirus variant, vaccine uptake, and more).


    SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


    Get notified of new videos by hitting the bell icon:


    MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

    MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


    MEDIA CONTACT:

    Media Contact: customers@medcram.com
    Media contact info:

    Video Produced by Kyle Allred


    FOLLOW US ON SOCIAL MEDIA:






    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #Coronavirus

  • Coronavirus Pandemic Update 93: Antibodies, Immunity, & Prevalence of COVID-19 - New Data from Spain

    15:32

    Data on the actual prevalence of COVID-19 has been limited due to a variety of factors including asymptomatic spread and testing limitations. Dr. Seheult of breaks down a new large study from Spain on the prevalence of SARS-CoV-2, antibody tests, demographics, and some big questions about COVID 19 immunity. (This video was recorded July 8, 2020).

    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


    SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


    Get notified of new videos by hitting the bell icon:


    LINKS / REFERENCES:

    The Lancet |

    JAMA |

    Nature Medicine |

    Johns Hopkins Tracker |

    Worldometer |


    PREVIOUS COVID-19 UPDATES:

    Please visit MedCram.com for the full series:
    - Coronavirus Pandemic Update 92: Blood Clots & COVID-19 - New Research & Potential Role of NAC
    - Coronavirus Pandemic Update 91: Remdesivir Pricing & Disparities in Drug Availability
    - Coronavirus Pandemic Update 90: Assess The Quality of COVID-19 Info With A Validated Research Tool
    - Coronavirus Pandemic Update 89: COVID 19 Infections Rising in Many States; Dexamethasone Cautions
    - Coronavirus Pandemic Update 88: Dexamethasone History & Mortality Benefit Data Released From UK
    - Coronavirus Pandemic Update 87: More on Dexamethasone; Do COVID-19 antibodies last?
    - Coronavirus Pandemic Update 86: COVID-19 Testing & Cases Increasing but Daily Deaths Decreasing
    - Coronavirus Pandemic Update 85: Dexamethasone and Key Questions to Ask if in The Hospital (Part 2)
    - Coronavirus Pandemic Update 84: Key Questions to Ask if in the Hospital for COVID-19 (Part 1 of 2)
    - Coronavirus Pandemic Update 83: High Fructose, Vitamin D, & Oxidative Stress in COVID-19
    - Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D
    - Coronavirus Pandemic Update 81: New Data on Hydroxychloroquine Side Effects & Prevention of COVID-19
    - Coronavirus Pandemic Update 80: COVID-19 Retractions & Data (Hydroxychloroquine, ACE Inhibitors)
    - Coronavirus Pandemic Update 79: COVID-19 Vaccines to Keep an Eye On - mRNA, Antigen, Others:
    - Coronavirus Pandemic Update 78: Mask Controversy; Vaccine Update for COVID-19
    - Coronavirus Pandemic Update 77: Remdesivir Update; COVID-19 in Mexico
    - Coronavirus Pandemic Update 76: Antibody Testing False Positives in COVID-19

    All coronavirus updates are at MedCram.com (including the diagnosis, prevention, treatment, vaccine developments, dexamethasone, remdesivir, SARS-CoV-2 antibody tests, coronavirus misinformation, infodemic, peer-reviewed research, and more).
    We offer many other medical topics (ECG Interpretation, thrombosis, pulmonary embolism, myocardial infarction, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at our website.


    MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

    MedCram offers group discounts for students and a variety of medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


    MEDIA CONTACT:

    Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
    Associate Professor at the University of California, Riverside School of Medicine

    Media Contact: customers@medcram.com
    Media contact info:


    FOLLOW US ON SOCIAL MEDIA:






    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #FOAMed

  • COVID 19 Vaccine Deep Dive: Safety, Immunity, RNA Production,

    34:29

    Professor Shane Crotty, PhD joins MedCram to answer a series of COVID vaccine questions including what are the chances of long-term side effects? How safe is RNA vaccine (i.e. Pfizer / BioNTech and Moderna Vaccines) technology? How long does mRNA from a vaccine stay in our cells? What else goes in vaccines? How long does immunity last? Why are T-Cells so important? Why does Pfizer's vaccine need to stay SO cold?

    Shane Crotty, PhD is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Professor Crotty also has an academic appointment with the University of California San Diego. See his full bio here:
    Professor Crotty on Twitter:

    Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com

    See our new interview with Prof. Crotty on how virus mutations (UK variant and S. African variant) may be impacting COVID-19 transmission and vaccine efficacy.

    Research referenced in this video from Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science:

    New York Times article highlighting Prof. Shane Crotty's research:

    00:00 Introducing Prof. Shane Crotty's Research
    0:35 How long does COVID-19 immune memory last?
    0:57 The three primary aspects of immune memory: antibodies, killer T cells, and helper T cells
    2:25 The anatomy (protein makeup) of SARS-CoV-2
    3:02 Why is spike protein the primary target?
    5:17 Could a mutation allow SARS-CoV-2 to infect without spike protein?
    7:02 Utilizing lipid nanoparticles to deliver mRNA and the role of RNA normally
    9:52 What human cells does an RNA vaccine go into?
    10:36 How long does mRNA from a vaccine stay in human cells?
    11:44 What else goes in vaccines besides mRNA and lipid nanoparticles? Any preservatives or adjuvants?
    12:30 Why are adjuvants used in many vaccines?
    14:08 Protein production from mRNA
    15:00 Why utilize the extra step of mRNA to code for protein antigens?
    17:28 Are mRNA vaccines the future of vaccine development?
    19:18 Any chance for mRNA to enter our cells' nucleus?
    20:55 The immune response to a coronavirus vaccine
    23:17 Expected symptoms from immune response to a vaccine vs. vaccine side effects
    25:50 Should people who've had COVID-19 get vaccinated?
    27:27 Immunity from COVID vaccine vs. a natural infection
    28:30 Why does the Pfizer vaccine need to be stored so cold?
    29:04 What would you say to a family member who is nervous about a rushed vaccine and RNA technology?
    32:37 What about the possibility of long term side effects from RNA vaccines?
    33:30 What's next for Shane Crotty's research team?

    (This video was recorded on December 16, 2020).

    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


    SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


    Get notified of new videos by hitting the bell icon!


    PREVIOUS / RECENT MEDCRAM COVID-19 INTERVIEWS:

    Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2) with Professor Roger Seheult, MD

    At Home COVID 19 Antigen Testing and Vaccine Update with Professor Michael Mina, MD

    All coronavirus updates are at MedCram.com ad-free (including more videos on the Pfizer vaccine, Moderna vaccines, BioNTech vaccine, vaccine side effects, COVID 19 vaccine mechanism, AstraZeneca Oxford coronavirus vaccine, side effects of COVID 19 vaccine, COVID 19 treatments, and more):

    We offer over 60 medical topics (ECG Interpretation, DKA, influenza, measles, mechanical ventilation, etc.) on our website and CME for clinicians.


    MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:

    MedCram offers group discounts for students and a variety of medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested.


    MEDIA CONTACT:

    Media Contact: customers@medcram.com
    Media contact info:

    Video Produced by Kyle Allred

    FOLLOW US ON SOCIAL MEDIA:






    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #Coronavaccine

  • Mouth Washes That Inactivate Coronaviruses

    25:01

    Mouth Washes That Inactivate Coronaviruses

    Study finds the SARS-COV-2 is inactivated by some of the oral rinsing products



    Study finds that some mouth washes and nasal rinses help reduce virus load by greater than 90%


    An article for the above study


    How to perform a nasal rinse


    A study in Malaysia finds rapid virus clearing in SARS-COV-2 patients


    Polyvidone



    #drbeen #koolbeens #COVID-19

  • Endocrinology - Calcium and Phosphate Regulation

    11:20

    Support me:
    ????️ Buy PDFs:
    ???? Patreon:
    ???? Buy shirts:

    Social media:
    ???? Instagram:
    ???? Twitter:
    ???? Facebook:

    Resources:
    ???? Books:
    ????️ Equipment: armandoh.org/armando-faigl

    You can send me mail:
    ???? PO BOX 166, Randwick NSW 2031, Australia

  • Vitamin-D, Second vaccine for Coronavirus?? | विटामिन डी - कोरोना वायरस की दूसरी वैक्सीन ?? |

    9:46

    In these difficult times of Corona virus pandemic one thing is clear by research and observation that Vaccination is the only and effective answer to this pandemic.
    in this episode of Doctor's Arena we tried bringing you all the evidence related with effectiveness of Vitamin-D which has now come up as Second Vaccine to Coronavirus.
    to know more about role of other Vitamins it is advised to see our this video

    For more authentic and reliable medical information of various diseases and health related topics follow us on....
    twitter
    Instagram
    Facebook

  • Coronavirus and Vitamin D: Correlation, Causation, and Confusion

    6:24

    As you're here on YouTube, you may want to watch How Social Media Hacks Your Brain --~--
    The “lifestyle vitamin” has burned us before. Is Vitamin D supplementation smart during the coronavirus pandemic?

    Get more medical news analysis at or

  • Vitamin D deficiency in acute respiratory distress syndrome | Dr Dhruv Parekh

    12:46

    Dr Dhruv Parekh explains his research on acute respiratory distress syndrome, or ARDS, and how it might be impacted by vitamin D deficiency. *Please see pinned comment for updates connected to coronavirus.*

    ARDS is a life-threatening condition characterised by widespread inflammation in the lungs. Around 1 in 5 people who develop ARDS will die. While vitamin D is traditionally associated with calcium regulation, it also is involved in a range of other processes, including regulating antimicrobial compounds and apoptosis. There is also a connection between worse outcomes in critically ill patients and vitamin D deficiency, although it's unclear if the deficiency is a cause or an effect of ARDS.

    Here, Dr Parekh explains his research investigating mechanisms behind the connection between ARDS and vitamin D deficiency, using animal experiments to investigate how vitamin D deficiency in mice affects response to infection, and how this might impact our future understanding of how ARDS is caused and may be treated.

    Dr Dhruv Parekh is a Clinical Lecturer in Respiratory Medicine at the University of Birmingham and an Honorary Consultant in Intensive (Critical) Care Medicine at University Hospital Birmingham.

    He gave this presentation, Vitamin D deficiency and bacterial load in a murine model of sepsis -induced lung injury, at the 2014 Academy of Medical Sciences Spring Meeting for Clinician Scientists in Training, which brought together 250 attendees from across the UK to discuss their research.

    For more information about the Academy's Spring Meeting for Clinician Scientists in Training, visit

    We are the independent body in the UK representing the diversity of medical science. Our mission is to advance biomedical and health research and its translation into benefits for society.

    Find the Academy of Medical Sciences online:
    Website:
    Twitter:
    Facebook:
    Instagram:

Shares

x

Check Also

Menu