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TWiV 736: Rhapsody in T with Alessandro Sette

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  • TWiV 734: Weiss hath no furin like a virus scorned

    2:11:49

    Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
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  • x
  • TWiV 814: COVID-19 clinical update #83 with Dr. Daniel Griffin

    50:14

    In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID.

    Show notes at

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    •This Week in Parasitism
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    •Urban Agriculture
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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    I do not run ads on our work as it is disruptive to learning. We depend on your support.

    If you would like to support our work, go over to
    ———————————————————————
    #microbe #viruses #coronavirus #pandemic
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  • x
  • Alessandro Sette: Adaptive Immune Responses to SARS-CoV-2

    1:3:30

    This week's speaker is Alessandro Sette, a professor at the Center for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology.

    Sette has devoted more than 35 years of study towards understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. His lab is defining in chemical terms the specific structures (epitopes) that the immune system recognizes, and uses this knowledge to measure and understand immune responses. The lab’s approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology.

    Organized by Janelia's Sarada Viswanathan and Loren Looger, the Science of COVID-19 seminar series brings in outside experts, covers papers and preprints, and highlights local efforts in testing, production, and analysis.

    LEARN MORE: janelia.org/scienceofcovid19

  • TWiV 729: A floret of spikes with Matt Frieman

    1:58:20

    Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.

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    •This Week in Parasitism
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    •Urban Agriculture
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    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
    ———————————————————————
    #microbe #viruses #coronavirus #pandemic
    ———————————————————————

  • x
  • TWiV 776: Yes! We have no pangolins

    1:49:24

    TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida.

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    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
    •Immune
    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    I do not run ads on our work as it is disruptive to learning. We depend on your support.

    If you would like to support our work, go over to
    ———————————————————————
    #microbe #viruses #coronavirus #pandemic
    ———————————————————————

  • Virology Lectures 2021 #25 - Therapeutic Viruses

    1:9:33

    It seems fitting that for the last lecture of this virology course that we explore the use of viruses to treat or prevent human disease. Basic virology research has provided a fundamental understanding about viral genomes, replication, and interaction with the host that together with clinical research has created the growing field of therapeutic virology. In this lecture we describe different viruses used for gene therapy, how they are produced, and examples of their use for vaccines, monogenic gene therapy, and viral oncotherapy.

    Access lecture slides and readings at

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    ——————————— OUR OTHER PODCASTS ———————————
    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded multiple days a week.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
    ———————————————————————
    #virology #viruses #coronavirus #pandemic
    ———————————————————————

  • x
  • TWiV 745: Gorilla COVID with Nadine Lamberski

    1:48:47

    Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.

    Show notes at

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    •Virology Blog:
    •This Week in Virology
    •Virus Watch
    •Principles of Virology textbook

    ——————————— OUR OTHER PODCASTS ———————————
    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
    •Immune
    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    If you would like to support our work, go over to
    ———————————————————————
    #microbe #viruses #coronavirus #pandemic
    ———————————————————————

  • Alessandro Sette: Study of adaptive responses to SARS CoV2

    29:52

    In this presentation, Dr. Sette provides evidence that there are robust CD4+ and CD8+ T cell responses detected in uncomplicated SARS-CoV-2 convalescent cases; that reactivity is reproducibly detected in non-exposed subjects; specific CD4 and CD8 T cells targets in COVID-19 patients were identified; in acute and severe infection it appears that the speed of the adaptive response is key to protective immunity; that T cell responses are durable over at least 8 months and that there is negligible impact of SARS-CoV-2 variants on T cell responses.

    Alessandro Sette has devoted more than 35 years in biotech and academia to understanding and measuring immune responses, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. Dr. Sette’s laboratory is the world leader in the study of the specific structures, called epitopes, that the immune system recognizes. Dr. Sette has overseen the design and curation efforts of the national Immune Epitope Database (IEDB), a freely available, widely used bioinformatics resource. The IEDB catalogs all epitopes for humans and experimental animals for allergens, infectious diseases, autoantigens and transplants, and includes epitope prediction tools to accelerate immunology research around the world. Dr. Sette’s lab uses knowledge of epitopes to define the hallmarks of a beneficial immune response associated with effective vaccines, as opposed to immune responses that are ineffective or that cause harm. The laboratory’s infectious disease interests include SARS CoV2, dengue, Zika Chikungunya, herpesviruses, poxviruses, lassa fever, HIV and hepatitis viruses, and bacterial pathogens such as tuberculosis and bordetella pertussis. Our investigations outside infectious disease include allergic asthma and Parkinson’s disease.
    Dr. Sette is a Doctor in Biological Sciences from the University of Rome and did postdoctoral work at the National Jewish Center for Immunology and Respiratory Medicine in Denver, Colorado. In 1988, Dr. Sette joined the newly founded company Cytel, in La Jolla, and was also appointed adjunct assistant professor at The Scripps Research Institute. He founded Epimmune in 1997, where he served both as Vice President of Research and Chief Scientific Officer until 2002, when he joined LJI as Head of the Division of Vaccine Discovery. He also heads the Center for Infectious Disease at LJI.

  • TWiV Special: Coronavirus update with Mark Denison, MD

    52:53

    Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.

  • x
  • Virology Lectures 2021 #22 - Emerging Viruses

    1:8:15

    Emerging virus refers to a newly discovered virus or viral disease. In this lecture we discuss the anthropogenic factors that drive virus emergence, the four types of virus-host interactions, and descriptions of specific emerging virus infections including those caused by poliovirus, Nipah and Hendra viruses, Ebolavirus, and the coronaviruses SARS-CoV-1, MERS-CoV, and SARS-CoV-2.

    Access lecture slides and readings at

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    •This Week in Virology
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    ——————————— OUR OTHER PODCASTS ———————————
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    •This Week in Evolution
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    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded multiple days a week.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
    ———————————————————————
    #virology #viruses #coronavirus #pandemic
    ———————————————————————

  • Virology Lectures 2021 #19 - Vaccines

    1:2:16

    A year after the onset of the COVID-19 pandemic, multiple vaccines have been designed, manufactured and tested, a remarkable display of scientific and clinical ingenuity. Vaccines are a safe way to prevent viral infections and will end this pandemic. In this lecture we discuss examples of how different types of vaccines work, including inactivated vaccines, subunit vaccines, and replication competent, infectious vaccines. These concepts are illustrated using vaccines for poliovirus, influenza virus, hepatitis B virus, human papillomavirus, yellow fever virus, and dengue virus. We also discuss some of the many vaccines that are ini development or have been authorized for COVID-19.

    Access lecture slides and readings at

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    ——————————— MORE VIROLOGY ———————————
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    •Virology Blog:
    •This Week in Virology
    •Virus Watch
    •Principles of Virology textbook

    ——————————— OUR OTHER PODCASTS ———————————
    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
    •Immune
    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded multiple days a week.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
    ———————————————————————
    #virology #viruses #coronavirus #pandemic
    ———————————————————————

  • Leading Internal Medicine Specialist Dr Pratit Samdani will answer questions on the Covid Vaccine

    1:3:08

    Topic - Leading Internal Medicine Specialist Dr Pratit Samdani will answer questions on the Covid Vaccine - the Need to take the Vaccine, Space between 1st and 2nd Dose & the After-Care. Confirmation

    About Dr Pratit Samdani:

    Dr Pratit Samdani is an awardwinning doctor with specialisation in Internal Medicine. He has experience in General Medicine Ward, Emergency, Casualty, HIV, Isotope, Diabetes, Nephrology, Neurology, Infectious Diseases & OPD. He has vast experience in training and teaching graduate and postgraduate students. He is Honorary Professor of Medicine and Head Of Medicine unit at the GT and Sir JJ Hospitals in Mumbai. He is Consultant Physician, Intensivist and Head of the Department of Intensive Care at the Breach Candy Hospital. He is also Consultant Physician at the Jaslok, Saifee and Bhatia Hospitals in Mumbai.

    ---------------------------------------------------------------------------------------------------------------------
    About Seniors Today:

    Senior citizens make up an increasing percentage of the population. One in every 10 Indians is a senior citizen, and this percentage is increasing, bringing its own challenges. Seniors can often feel lonely or confused because of health problems, or being separated from family.

    Seniors Today will be a leading provider of trustworthy health information, empowering readers with practical strategies to improve their physical, mental and emotional well-being. Our content is written in friendly, jargon-free language that provides real-life contexts around complex information, helping readers take important decisions about their health and also making new friends.

    We hope to find a new way of thinking about seniors. We know people can be creative and vital, no matter what their age. Comprising first-class editorial, beautiful photography and award-winning design, our pages are filled with distinctive content that is intelligent, timely and pertinent.

    Each edition of Seniors Today will contain feature-length articles and columns on topics such as travel, entertainment, shopping, dining, health and wellness, and much more. We will continue to expand, providing our readers with information that matters to them. In the coming months, we will have a lot more content, and information you could use.

    Pls give us a missed call at 7406469469 for a free membership to the Seniors club

    Website:
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    #Vaccine
    #Covid-19
    #SeniorsToday

  • TWiV 594: Coronavirus update – Shelter in place

    1:52:25

    A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.

  • Virology Lectures 2021 #21 - Evolution

    1:5:25

    Viral evolution, the change of a viral population in the face of selection pressures, occurs faster than in other organisms because viruses produce so many progeny harboring many genome mutations. In this lecture we consider the four main drivers of viral evolution: large numbers of progeny, mutation, selection, and quasispecies effects. We discuss selection by the immune system and how it gives rise to antigenic drift and antigenic shift in the context of influenza viruses and SARS-CoV-2. We conclude by a review of the origins of viruses in the pre-cellular world and why all viruses emerge not de novo, but from existing viruses.

    Access lecture slides and readings at

    Become a patron of MicrobeTV at microbe.tv/contribute

    ——————————— CONNECT ———————————
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    Our Podcasts:
    Contribute:

    ——————————— MORE VIROLOGY ———————————
    •My Virology Course
    •Virology Blog:
    •This Week in Virology
    •Virus Watch
    •Principles of Virology textbook

    ——————————— OUR OTHER PODCASTS ———————————
    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
    •Immune
    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded multiple days a week.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
    ———————————————————————
    #virology #viruses #coronavirus #pandemic
    ———————————————————————

  • Covid-19 Vaccine Immunity and the Impact of Variants

    47:02

    As the delta variant becomes the dominant strain of the Covid-19 pandemic, scientists are working to understand the role variants will play in future surges of Covid-19, the efficacy of current vaccines, and how long immunity will last. Dr. Shane Crotty,, virologist and professor in the Center for Infectious Disease and Vaccine Research at the La Jolla Institute for Immunology (LJI), provides insights on the progress of Covid-19 vaccine immunity research for current U.S. Covid-19 vaccines (Pfizer, Moderna, Janssen/Johnson & Johnson), and critical emerging questions, such as the impact of the delta variant on the efficacy of current Covid-19 vaccines.

  • Virology Lectures 2021 #18 - Transformation and Oncogenesis

    1:8:25

    About 20% of human cancers are associated with virus infections, but viruses do not directly cause cancer. Rather virus infection may make cells immortal, placing them on the road to cancer. In this lecture we review the discovery of RNA and DNA tumor viruses and how an understanding of how they transform cells led to an understanding of how cell growth is controlled. It all began with a chicken!

    Access lecture slides and readings at

    Become a patron of MicrobeTV at microbe.tv/contribute

    ——————————— CONNECT ———————————
    ???? Subscribe to this channel!
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    Twitter: @profvrr
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    Our Podcasts:
    Contribute:

    ——————————— MORE VIROLOGY ———————————
    •My Virology Course
    •Virology Blog:
    •This Week in Virology
    •Virus Watch
    •Principles of Virology textbook

    ——————————— OUR OTHER PODCASTS ———————————
    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
    •Immune
    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded multiple days a week.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
    ———————————————————————
    #virology #viruses #coronavirus #pandemic
    ———————————————————————

  • COVID Variants vs. Coronavirus Vaccines + Immunity

    54:25

    Renowned virologist Shane Crotty, PhD joins us again to address the most important COVID-19 questions: Should people who’ve been vaccinated or had COVID-19 continue to wear masks and physically distance? How will each vaccine hold up to the SARS-CoV-2 variants? What does the research say about people who’ve already had COVID-19 who get a vaccine? How long will immunity last for the vaccines or COVID-19 infection?

    Shane Crotty is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Prof. Crotty also has an academic appointment with the University of California San Diago. See his full bio here:
    Prof. Crotty on Twitter:

    Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com

    (This video was recorded on March 23, 2021)

    Just to clarify at 8:40 in the video: Prof. Crotty is describing a theoretical person when he says I myself am comfortable getting infected... He hasn't had COVID, and doesn't have that opinion. He was explaining one end of the spectrum of level of concern for individuals.

    TOPICS DISCUSSED IN THIS VIDEO INCLUDE:

    0:00 Intro
    0:46 Heated exchange between Dr. Fauci and Senator Rand Paul
    1:00 How long does immunity last for those who’ve had COVID-19?
    3:31 How antibody levels and T cells drop over time
    4:03 Dr. Fauci: Difference between in vitro and real-world studies
    4:36 Population-based studies about COVID 19 immunity against reinfection
    6:22 Huge variability from person to person for post coronavirus immunity
    8:20 Policy decision: individual vs. community goals during a pandemic
    9:03 Very rare for hospitalization from COVID-19 reinfection
    9:34 Avoiding COVID-19 infection and transmission potential
    10:12 Should mask-wearing continue for those who’ve had COVID-19?
    12:23 If I’ve had COVID-19, shouldn’t my vaccine dose go to someone else?
    13:39 Vaccines are eliciting more immunity than natural infection
    14:02 Is natural immunity always better than a vaccine?
    20:05 If you’ve had COVID-19, when should you get vaccinated? Both doses?
    22:07 How are variants “game changers” for vaccines and natural infections?
    24:53 Can’t I stop wearing masks and distancing after a vaccine or having COVID?
    26:14 Variants of concern: B.1.1.7 (UK) and B.1.351 (S. Africa) details and implications
    30:57 South Africa Variant escaping immunity: AstraZeneca Vaccine data
    32:28 Isn't preventing COVID 19 hospitalizations and deaths the primary goal?
    35:25 Will we need updated coronavirus vaccines?
    36:38 Johnson and Johnson vaccine versus the variants
    37:57 Preventing transmission to prevent SARS CoV 2 mutation opportunities
    38:40 Coronavirus antibodies vs T Cells and other parts of the immune system
    39:54 Replication and asymptomatic spread of COVID-19 vs. Pneumonia
    42:53 Vaccine incentives and Senator Rand Paul's perspective
    45:35 Looking ahead, SARS-CoV-2 vs Influenza, Will we need annual vaccinations?
    52:20 Current research and goals for Prof. Shane Crotty

    PREVIOUS MEDCRAM DISCUSSIONS WITH PROF. CROTTY :
    (Dec 16, 2020)
    (January 5, 2021)

    REFERENCES:

    Crotty's Research Published in Science |

    Variant Tracker |

    Denmark Research in the Lancet |

    UK SIREN study:

    Research from Qatar |

    UK Research in NEJM |

    Qatar:

    Congressional Hearing 3/8/21: exchange with Dr. Fauci and Rand Paul: (PBS News Hour) and (CNBC)


    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:

    All coronavirus updates are at MedCram.com ad-free (including more on RNA vaccines, COVID variants, South African Variant, Johnson and Johnson vaccine for COVID 19, and more):


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    Video Produced by Kyle Allred


    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #Coronavirus #COVID19UK

  • TWiV 736: Rhapsody in T with Alessandro Sette

    2:3:41

    Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.

    Show notes at

    Become a patron of TWiV at microbe.tv/contribute

    ——————————— CONNECT ———————————
    ???? Subscribe!
    Instagram: @profvrr and @microbe.tv
    Twitter: @profvrr
    Facebook:
    Our Podcasts:
    Contribute:

    ——————————— MORE VIROLOGY ———————————
    •My Virology Course
    •Virology Blog:
    •This Week in Virology
    •Virus Watch
    •Principles of Virology textbook

    ——————————— OUR OTHER PODCASTS ———————————
    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
    •Immune
    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

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  • TWiV 789: Does delta mean a change?

    1:49:00

    TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease.

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  • Coronavirus Updates: Live from the Laboratory with Alessandro Sette, Dr. Biol. Sci.

    1:47

    On May 13, 2020, one of the world's most cited researchers and immunology expert Alessandro 'Alex' Sette, Dr. Biol. Sci. shared his research efforts and observations from the field regarding the coronavirus and COVID-19. Institute leadership and experts President & CSO Mitchell Kronenberg, Ph.D. and Executive Vice President & COO Stephen S. Wilson, Ph.D. also provided their insights during the virtual discussion. The presentation concluded with a Q&A, with questions from webinar participants.

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  • TWiV 779: Evolving boosterism

    1:41:24

    TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA.

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  • TWiV 777: SARS-CoV-2 fitness with Ron Fouchier

    1:38:55

    Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants.

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    I’m Vincent Racaniello, Earth’s Virology Professor.

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  • Alessandro Sette - Pre-existing immunity is detected in many non-exposed individuals

    2:18

    Dr Sette is a leader in the field of T cell epitope-MHC interactions, beginning with his contribution to the discovery of the biological function of MHC in the mid 80s to mid 90s. From those studies he and his collaborators further developed the notion that different MHCs have distinct binding specificities that can be used to predict epitopes. The Sette group also discovered and characterized how MHC variants can be grouped according to broad common functional specificities (MHC supertypes), greatly facilitating epitope classification, characterization and understanding the basic rules of epitope-MHC interactions. At the same time, several studies have outlined the fine specificity of different closely related alleles, in some cases clearly associated with predisposition to disease resistance or susceptibility.

  • TWiV 735: COVID-19 clinical update #55 with Dr. Daniel Griffin

    38:54

    In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.

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    I’m Vincent Racaniello, Earth’s Virology Professor.

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  • Alessandro Sette - Common cold coronaviruses: Antibodies prevalence, reinfection and immune response

    3:49

    Dr Sette is a leader in the field of T cell epitope-MHC interactions, beginning with his contribution to the discovery of the biological function of MHC in the mid 80s to mid 90s. From those studies he and his collaborators further developed the notion that different MHCs have distinct binding specificities that can be used to predict epitopes. The Sette group also discovered and characterized how MHC variants can be grouped according to broad common functional specificities (MHC supertypes), greatly facilitating epitope classification, characterization and understanding the basic rules of epitope-MHC interactions. At the same time, several studies have outlined the fine specificity of different closely related alleles, in some cases clearly associated with predisposition to disease resistance or susceptibility.

  • TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin

    34:57

    In COVID-19 clinical update #56, Daniel Griffin notes increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

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    New videos are uploaded every Thursday and Sunday mornings.

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  • TWiV 786: You make mucus and you move it

    1:45:10

    TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19.

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

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  • TWiV 741: COVID-19 clinical update #57 with Dr. Daniel Griffin

    42:34

    In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

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  • TWiV 720: With vaccines, Offit is on it

    2:1:37

    Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.

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  • TWiV 732: Citizen science with Forest Rohwer and Maria-Isabel Rojas

    1:52:57

    Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis.

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  • lemon Weight Loss 1Kg In 2 Days How to extract 100% Natural Medicinal

    10:26

    Lemon Benefits.
    Lemons Improve Vitamin C Levels
    Lemons provide 64% of the daily value of Vitamin C in a 100g serving. A water-soluble vitamin and potent antioxidant, Vitamin C helps the body form and preserve connective tissue, as well as bones, blood vessels, and skin. All varieties of lemons have around the same amounts of nutrients. The lemon’s main right to fame is its high vitamin C content.

    So how much Vitamin C can you get from one lemon?

    30.7 milligrams! Which is about 34-40 percent of the recommended daily allowance for men and women. Fascinatingly, the skin of this fruit contains nearly double this quantity. Vitamin C functions as an antioxidant and plays a key role in your body’s immune function.

    2. Lemons Can Decrease Blood Cholesterol
    Lemons contain pectin fiber, a soluble dietary fiber essential for colon health. In human digestion, pectin binds to cholesterol in the gastrointestinal tract and decelerates glucose absorption by trapping carbohydrates. Consumption of pectin has been shown to decrease blood cholesterol levels. The mechanism seems to be an upsurge of viscidness in the intestinal tract, leading to a reduced absorption of cholesterol from bile or food.

    What does pectin do in the large intestine and colon?

    Microorganisms damage pectin and release short-chain fatty acids that have positive effects on health.

    3. Lemons Can Alkalize Our pH
    The 2.2 pH of lemons helps to alkalinize our own pH, due in part to the huge levels of citric acid. Outside the body, lemon juice is acid.

    What happens inside the body though, when lemon juice has been completely absorbed and its minerals are distanced in the bloodstream?

    The result is alkalizing and therefore increases the pH of body tissue!

    4. Lemon Boosts Liver Function

    4. Lemon Boosts Metabolism
    With about 47 grams per liter, lemons are a major source of citric acid, a key part of the Krebs cycle essential for metabolic function.
    The bitterness of the lemon is also helpful for production of bile, as it stimulates the liver and gall bladder. A diet heavy in fat and animal based foods places extra stress on liver function and impairs the smooth flow of bile, which is vital for optimal digestion.

    A glass of lemon water in the a.m. is a straightforward method to stimulate the liver and promote bile flow which in turn aids in digestion. Lemon water also sometimes helps resolve indigestion symptoms by stimulating healthy stomach function.

    7. Lemons Can Help Digestion
    Lemons contain numerous phytochemicals, including polyphenols which are micronutrients full of antioxidants. Polyphenols are micronutrients that we get through certain plant-based foods. They’re packed with antioxidants and potential health benefits.

    What can polyphenols help with specifically?

    Digestion issues, weight management problems, diabetes, neurodegenerative illness, and circulatory illnesses, to name a few.

    8. May Help Treat Acne
    Lemons also contain terpenes which produce the invigorating aroma we often associate with lemons! It comes as no shock that lemon is a favorite essential oil. It is extensively valued for its clean odor, but has many healing qualities as well. It improves attentiveness, aids in digestion and eases symptoms of acne and stiffness.

    9. Decreases Digestive Irritation
    It contain tannins, astringents responsible for the dry, pucker feel we get in our mouths after consumption. Natural astringents contain strong anti-inflammatory properties that can be used to decrease digestive system irritation while also improving digestion and inhibiting diarrhoea.

    10 Relieves Symptoms Associated with Pathogenic Bacteria
    Lemons are powerfully antibacterial, that prevent the growth of pathogenic bacteria that cause infections and disease such as malaria, diphtheria, and typhoid
    The bioflavonoids in lemons prevent internal haemorrhage in The Journal of Nutrition, a team of Harvard University researchers inspected the diets and blood vessel function of over 30,000 females.

    The scientists found that women who frequently consumed sources of bioflavonoids had better markers of healthy blood vessel function compared to persons who did not. Women who consumed at least two servings of citrus fruits a day showed 20 percent lower levels of endothelial stress-linked biomarkers and a significant improvement in markers of blood vessel function compared to those who did not frequently eat citrus fruits.

    It deliver a strong mixture of both vitamin C and citrus bioflavonoids, which work together to deliver powerful benefits for supporting healthy blood vessels.

    12. Helps Improve Eye Health
    Rutin, found in it help to maintain eye health and reduce symptoms of eye problems. It’s no secret that Rutin has many health benefits when it comes to regulating blood flow. Seeing as smooth blood flow to the retina of the eye is an important part of strong and sharp vision, Rutin can help stop blood vessel illnesses in the eyes.

    13. Helps Improve Cancer Treatment

  • TWiV 755: COVID-19 clinical update #62 with Dr. Daniel Griffin

    41:28

    In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality.

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  • TWiV 754: Tuesday two: SARS-CoV-2 and TLR2

    1:39:34

    TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

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  • TWiV 749: COVID-19 clinical update #60 with Dr. Daniel Griffin

    40:06

    In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae.

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

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  • TWiV 744: COVID-19 clinical update #58 with Dr. Daniel Griffin

    45:08

    In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask.

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    If you would like to support our work, go over to
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  • TWiV 705: Rocky Mountain COVID with Emily Travanty

    1:51:49

    Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01.

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    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

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  • TWiV 296: The real Batman, Linfa Wang

    1:6:27

    Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa Wang about his work on bats and bat viruses.

  • TWiV 770: COVID-19 clinical update #67 with Dr. Daniel Griffin

    39:25

    In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.

    Show notes at

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    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    I do not run ads on our work as it is disruptive to learning. We depend on your support.

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  • MENTAL ASPECT OF HIV

    12:04

    ROYALTY TELEVISION

  • আপনার যক্ষ্মা হয়েছে কিনা কিভাবে বুঝবেন? Tuberculosis: Symptoms & Causes | Rtv Helath Program

    3:24

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  • 2021 Region VII Conference-Sat

    2:29:01

  • TWiV 275: Virocentricity with Eugene Koonin

    2:9:42

    Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life.

  • COVID-19 Q&A with A&V Livestream 5/12/21

    1:33:43

    Virologists Amy Rosenfeld and Vincent Racaniello answer your COVID-19 questions (or any virus questions) on this livestream of 5/12/21.

  • IMCI PROCESS FOR CHILDREN 2 MONTHS TO 5 YEARS part 2

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  • Virology Lectures 2021 #20 - Antivirals

    1:2:36

    Antiviral drugs can stop an infection after it has started. In this lecture we discuss antiviral drug discovery, how some currently licensed compounds block different steps of the viral reproduction cycle, and the origin and mechanisms of drug resistance. You will also find out why hydroxychloroquine failed for treatment of COVID-19 and what other antivirals have been tested.

    Access lecture slides and readings at

    Become a patron of TWiV at microbe.tv/contribute

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    ——————————— MORE VIROLOGY ———————————
    •My Virology Course
    •Virology Blog:
    •This Week in Virology
    •Virus Watch
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    ——————————— OUR OTHER PODCASTS ———————————
    •This Week in Parasitism
    •This Week in Microbiology
    •Urban Agriculture
    •This Week in Evolution
    •Immune
    •This Week in Neuroscience

    – Who Am I? –

    I’m Vincent Racaniello, Earth’s Virology Professor.

    I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

    New videos are uploaded every Thursday and Sunday mornings.

    I don’t monetize my videos because it’s disruptive to learning. If you would like to support our work, go over to
    ———————————————————————
    #microbe #viruses #coronavirus #pandemic
    ———————————————————————

  • New antiviral drug in trials

    16:53

    Novel oral antiviral for SARS-CoV-2 progresses in Phase I trial, Protease inhibitor



    Background science

    Viral proteases are enzymes, endopeptidases

    Encoded by the genetic material (DNA or RNA) of viral pathogens

    Catalyze cleavage of specific peptide bonds in viral precursors

    These proteolytic events are essential for the completion of the viral infectious cycle

    Protease inhibitors, bind to a viral enzyme, called a protease

    Prevent the virus from replicating

    Protease inhibitors, used to treat HIV and hepatitis C

    Assess tolerability and safety of multiple ascending doses of PF-07321332

    Phase I study, healthy adults

    Randomised, double-blind, sponsor-open, placebo-controlled, single- and multiple-dose escalation study in healthy adults evaluating the safety, tolerability and pharmacokinetics of PF-07321332.

    Protease inhibitor, demonstrated potent in vitro antiviral activity against SARS-CoV-2 and other coronaviruses.

    Could be prescribed orally at the first sign of infection

    Pfizer also investigating an intravenously administered protease inhibitor, PF-07304814, in hospitalised patients with COVID-19.

    November??

  • ThinkEDU 2021 | Day 2 - Mental Health: The other pandemic | Vikram Patel

    37:07

    ThinkEDU 2021 | Day 2 - Mental Health: The other pandemic | Vikram Patel

  • Herbal Teas that Boost Immunity Spring Wellness Check

    7:04

    In this video I'll be sharing some of My Favorite Herbal Teas to help Naturally Boost Immunity and overall Wellness. For my returning viewers, if this video seems familiar that's because I posted a shorter version his winter, but realized after I uploaded that some of the footage was lost :( So I thought I'd go back and add that additional footage in, and re-share just in time for Spring Cold and Flu Season.
    I hope you all find these tips helpful!

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    Health and Wellness, Antioxidant Rich, Vitamin C Boost, Tazo Lotus Blossom Green Tea, Organic Tea, Turmeric and Ginger Tea, Republic of Tea, Traditional Medicinals Dandelion Root Tea, Health Benefits of Tea, Holistic Wellness, Holistic Health, Natural Medicine, Holistic Healing, Herbs that heal, black tea, Herbalism, Herbal Medicine, All Natural, Heal Autoimmune Diseases, Lower Inflammation Naturally, fight illness naturally, stress management, anti aging tips, improve brain function, clear brain fog, weight loss, fat burning tips, hydration, hydrate your body, Medicinal Herbs, lower cholesterol, liver health, lower triglyceride levels, cure hormonal imbalance, all natural diuretic, reduce stress, calm the body, cure the body, cure chronic pain, ease your mind, cure anxiety, cure sleep depravation

  • COVID-19 Q&A with A&V Livestream 4/7/21

    1:30:29

    Virologists Amy Rosenfeld and Vincent Racaniello answer your COVID-19 questions (or any virus questions) on this livestream of 4/7/21.

  • 16/20 Human Health & Diseases – AIDS - Cause, Transmission, Pathogenicity, Prevention, Symptom

    36:08

    ----------------------------------------------------------------------------
    1/20 Human Health & Diseases - Introduction

    ----------------------------------------------------------------------------
    2A/20 Human Health & Diseases - Introduction Detailed - 1

    ----------------------------------------------------------------------------
    2B/20 Human Health & Diseases - Introduction Detailed - 2

    ----------------------------------------------------------------------------
    3/20 Human Health & Diseases - Etiology - Cause of Diseases

    ----------------------------------------------------------------------------
    4/20 Human Health & Diseases - Epidemiology (Spread of Diseases) & Disease Manifestations (Symptoms)

    ----------------------------------------------------------------------------
    5/20 Human Health & Diseases - Prophylaxis (Prevention of Diseases)

    ----------------------------------------------------------------------------
    6/20 Human Health & Diseases - Some Terms, Word-Roots, Important Names & Dates

    ----------------------------------------------------------------------------
    7/20 Human Health & Diseases - Typhoid, Pneumonia, Plague, TB, Leprosy, Cholera, Pertuasis, etc.

    ----------------------------------------------------------------------------
    8/20 Human Health & Diseases - Cold, Flu, Measles, Mumps, Smallpox, Chickenpox - Viral Diseases - 1

    ----------------------------------------------------------------------------
    9/20 Human Health & Diseases - Rabies, Polio, Dengue, Chikungunya & Hepatitis - Viral Diseases - 2

    ----------------------------------------------------------------------------
    10/20 Human Health & Diseases - Malaria & Life-Cycle of Malaria & Amoebiasis - Protozoan Diseases

    ----------------------------------------------------------------------------
    11/20 Human Health & Diseases - Ascariasis, Filariasis & Ringworm - Helminthic & Fungal Diseases

    ----------------------------------------------------------------------------
    12/20 Human Health & Diseases - Immunology & Types - Active & Passive Immunity

    ----------------------------------------------------------------------------
    13/20 Human Health & Disease - Type of Immune System AMIS (Antibody-Mediated) & CMIS (Cell-Mediated)

    ----------------------------------------------------------------------------
    14/20 Human Health & Diseases – Vaccination & Immunization – Lymphoid Organs – GALT, MALT, BALT etc.

    ----------------------------------------------------------------------------
    15/20 Human Health & Diseases – Disorders of Immune System – Hypersentivity/Allergy, SCID, Hashimoto

    ----------------------------------------------------------------------------
    16/20 Human Health & Diseases – AIDS - Cause, Transmission, Pathogenicity, Prevention, Symptom

    ----------------------------------------------------------------------------
    17/20 Human Health & Diseases – Cancer Biology - Cause, Mode of Action, Signals, Diagnosis, etc.

    ----------------------------------------------------------------------------
    18/20 Human Health & Diseases – Mental Health & Disorders; Tobacco Abuse and Addiction

    ----------------------------------------------------------------------------
    19/20 Human Health & Diseases – Drug Addiction & Types of Drugs - Cannabinoids, Opiates, etc.

    ----------------------------------------------------------------------------
    20/20 Human Health & Diseases – Alcoholism, Addiction of Alcohol and Side-Effects of Alcohol

    ----------------------------------------------------------------------------
    For More Lectures,
    Contact:
    Lect. Manoj Bansal
    9 8 8 8 6 6 6 3 6 3
    ----------------------------------------------------------------------------

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