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Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)

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  • Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus

    1:24

    Professor Roger Seheult, MD explains the important role Vitamin D may have in the prevention and treatment of COVID-19. Dr. Seheult illustrates how Vitamin D works, summarizes the best available data and clinical trials on vitamin D, and discusses vitamin D dosage recommendations.

    Roger Seheult, MD is the co-founder and lead professor at
    He is an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine
    Dr. Seheult is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine

    Interviewer: Kyle Allred, Producer and Co-Founder of MedCram.com

    REFERENCES:

    The National Human Activity Pattern Survey (NHAPS)... (J. of Exposure A. and Env. Epidem.) |

    Aging decreases the capacity of human skin to produce vitamin D3 (The J. of Clin. Invest.) |

    Racial differences in the relationship between vitamin D... (Osteoporosis Int.) |

    Decreased bioavailability of vitamin D in obesity (The American J of Clin. Nutrition) |

    Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases ... (Nutrients) |

    Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis... (BMJ) |

    Randomized trial of vitamin D supplementation to prevent seasonal influenza A... (The American J.of Clin. Nutrition) |

    Vitamin D and SARS-CoV-2 infection... (Irish J. of Med. Sci.) |

    Factors associated with COVID-19-related death... (Nature) |

    Editorial: low population mortality from COVID-19 ... (Alimentary Pharm. & Therap.) |

    The role of vitamin D in the prevention of coronavirus ... (Aging Clin. & Exper. Res.) |

    25-Hydroxyvitamin D Concentrations Are Lower in Patients with ... SARS-CoV-2 (Nutrients) |

    Vitamin D deficiency in COVID-19: Mixing up cause and consequence (Metabolism) |

    Low plasma 25(OH) vitamin D level... increased risk of COVID-19... (The FEBS J.) |

    The link between vitamin D deficiency and Covid-19... |

    SARS-CoV-2 positivity rates... with circulating 25-hydroxyvitamin D levels (PLOS One) |

    Vitamin D status and outcomes for... COVID-19 (Post. Med. J.) |

    Vitamin D Deficiency and Outcome of COVID-19... (Nutrients) |

    “Effect of calcifediol treatment...” (J. of Steroid Bio. Molec. Bio.) |

    Vitamin D and survival in COVID-19 patients... (J. of Steroid Bio. Molec. Bio.) |

    Effect of Vitamin D3 ... vs Placebo on Hospital Length of Stay...: A Multicenter, Double-blind, RCT |

    Short term, high-dose vitamin D... for COVID-19 disease: RCT [SHADE study] (Postgrad. Med. Journal) |

    Association of Vitamin D Status... With COVID-19 Test Results (JAMA Network Open) |

    Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (JCEM) |

    Vitamin D Fortification of Fluid Milk ... A Review (Nutrients) |

    Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients... (Scientific Reports from the Journal Nature) |

    MEDCRAM.COM

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    All coronavirus updates are at MedCram.com (including COVID-19 developments, cholecalciferol, vitamin d benefits, etc.) We offer videos on over 60 medical topics

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    #COVID19 #SARSCoV2 #VitaminD

  • x
  • Vitamin D, Immune System & SARS-CoV-2 | Mechanism of Vit D Immune Regulation & Overview

    12:33

    Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation, Overview of Evidence

    In this lesson, I discuss the vitamin D its immune system regulation, specifically with regards to how vitamin D can help protect against respiratory tract infections like SARS-CoV-2 (COVID-19).

    1) Brief Introduction to Vitamin D and SARS-CoV-2

    2) Vitamin D deficiency and increased risk of infections

    3) Vitamin D supplementation and protection against acute respiratory tract infections

    4) Vitamin D and Immune System Regulation (including cytokines like IL-6)

    5) Vitamin D and SARS-CoV-2 (COVID-19), comorbidities and associations

    3) Summary of some Remdesivir data in in-vitro and in-vivo (mice and rhesus monkeys) studies used in treatment of other coronaviruses like SARS-CoV and MERS-CoV

    ****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

    *DISCLAIMER* Although there has been a meta-analysis showing reduced risk of acute respiratory tract infections with daily/weekly recommended doses of Vitamin D, WE DON’T have enough evidence to say that Vitamin D is protective against SARS-CoV-2 (COVID-19) – WE ONLY HAVE ASSOCIATIONS/CORRELATIONS at this point.

    ***This video is merely here to PRESENT INFORMATION from the studies quoted in this video - if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors****

    I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel – all of your support is greatly appreciated!
    JJ

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    **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

    Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

    *Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

  • x
  • Does Supplemental Vitamin D Help Prevent Covid-19?

    5:25

    Ah, Vitamin D, back again. We’ve made our case on how unnecessary Vitamin D supplements are for outcomes like diabetes, cardiovascular and musculoskeletal health, and overall mortality. But what about its effect on viral infections like Covid-19? Can it reduce symptom severity, or perhaps even reduce your odds of becoming infected in the first place?

    Sources:









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    #healthcaretriage #covid-19 #vitaminD

  • Should you take vitamin D for Coronavirus? Which? investigates

    5:14

    Experts agree vitamin D is the one vitamin we should be taking, but can it prevent you catching Coronavirus and help your body fight it?

    In this video we cover how vitamin D works and the dosage you should take, and Which? video reporter Lucia Ariano speaks with Martin Hewison, Professor of Endocrinology at the University of Birmingham and specialist in vitamin D research to find out how vitamin D can help you fight colds, flu and Covid-19.

    Chapters
    00:00 What is vitamin D and how does it help your immune system?
    01:37 Does vitamin D protect against coronavirus?
    02:52 How much vitamin D should you take?
    04:23 Do you need to take anything else with vitamin D?

    Read more:

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  • If You Get COVID 19: Optimize Immune System

    39:55

    Professor Roger Seheult, MD gives practical strategies if you test positive for COVID-19 (or are in contact with someone who tests positive) including:
    0:00 Video Intro
    1:11 Use of a pulse oximeter at home to monitor oxygen saturation and possible COVID pneumonia
    3:02 How to choose a pulse oximeter
    3:34 Tips for using a pulse oximeter
    5:35 Who qualifies for monoclonal antibodies (bamlanivimab, casirivimab, and imdevimab from Lily and Regeneron), how they work, and how effective are they?
    11:11 The varying level of data/study strength for different strategies
    12:55 Vitamins that may boost immune function: Vitamin D, NAC, Vitamin C, Quercetin, Zinc, Vitamin K-2, Magnesium
    18:27 The importance of adequate sleep (Melatonin discussed)
    21:57 Core body temperature elevation (the data on hydrotherapy and sauna use)
    35:11 Isolation strategies at home: ventilation, HEPA filtration, mask-wearing
    37:32 Summary of strategies to consider if testing positive for COVID 19

    Roger Seheult, MD is the co-founder and lead professor at
    He is an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine
    Dr. Seheult is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine

    Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com

    REFERENCES:

    The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications (Anesth Analg) |

    The mystery of the pandemic's ‘happy hypoxia’ (Science) |
    Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (JCEM) |

    SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19 (NEJM) |

    An EUA for Bamlanivimab—A Monoclonal Antibody for COVID-19 (JAMA Network) |

    Short term, high-dose vitamin D... for COVID-19 disease: RCT [SHADE study] (Postgrad. Med. Journal) |

    The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review (Int J Endocrinol) |

    Vitamin D and COVID 19: The Evidence for Prevention and Treatment of SARS-CoV-2 |

    Thinking About Getting a COVID-19 Vaccine? CDC Weighs In (Contagion Live) | 

    Monoclonal Antibody Successful in Clearing Viral Load for Mild COVID-19 Patients (Contagion Live) | 

    Some home-based hydrotherapy techniques:

    Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations (SAGE) | 

    Ventilation in Buildings (CDC) | 

    Coronavirus Update 59: Dr. Roger Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) |

    The Coronavirus Pandemic: Airborne Transmission, Ventilation and School and Workplace Reopening (Harvard T.H. Chan School of Public Health) | 


    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:

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    #COVID19 #SARSCoV2 #stopthespread

  • Can vitamin D help prevent COVID-19?

    1:51

    Dr. Jen Ashton has the latest information on the potential benefits of vitamin D.

  • x
  • COVID-19 and Vitamin D | Association Between Vitamin D Deficiency and COVID-19

    1:2:02

    Ninja Nerds,
    #COVID #VitaminD #coronavirus
    In this lecture, Zach Murphy, PA-C will present on the association between Vitamin D levels and COVID-19. We will be presenting on all of the current evidence that is available on the association between Vitamin D deficiency and COVID-19. Please scroll down to the bottom of our description box to review all of our references on the association between Vitamin D deficiency and COVID-19. Please enjoy this lecture and be sure to check out all of our social media pages and ways to donate below!

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    REFERENCES
    1) Decreased Vitamin D associated with increased mortality in hospitalized COVID-19 patient's.
    2) Decreased Vitamin D associated with increased ventilation requirements in COVID-19 patient's.
    a)
    b)
    c)
    d)
    e)
    f)

    3) Decreased Vitamin D associated with increased SARS-CoV-2 positive PCR's.
    a)
    b)
    c)
    d)

    4) Decreased Vitamin D is associated with increased CRP, fibrinogen, and D-dimer levels in COVID-19 patient's.
    a)
    b)

    5) Decreased Vitamin D is associated with decreased clearance of SARS-CoV-2.
    a)
    b)
    c)
    d)

    6) Decreased Vitamin D is associated in elderly, African Americans, hispanics, and obesity.
    a)
    b)
    c)

    7) Decreased Vitamin D is associated with worsening of conditions such as CHF, CAD, DM, and HTN.
    a)
    b)
    c)
    d)

    8) Vitamin D has been shown to be effective against viral respiratory tract infections.
    a)

    Vitamin D Dosage:


    Vitamin D Toxicity:

    Vitamin D Immunology:
    a. Cathelicidins:

    b. Beta Defensins:

    c. Vitamin D and Cytokines:


    d. Vitamin D Metabolic Pathway: Lehninger's Principles of Biochemistry Textbook

  • Coronavirus Update 111: Masks; New Vitamin D Data and COVID 19; n acetylcysteine

    13:59

    Professor Roger Seheult, MD discusses important COVID 19 Updates including:
    - A new study on oxygenation levels when wearing masks
    - New data on vitamin D levels and COVID-19 infections
    - The results of a recent study of hospitalized patients using NAC (N Acetylcysteine)
    - An overview of recent coronavirus data from the United States, United Kingdom, Spain, Canada, India, Hawaii, and more (This video was recorded on October 9, 2020).

    Dr. Seheult is the co-founder and lead instructor at

    LINKS / REFERENCES:

    Johns Hopkins Tracker |

    Worldometer |

    Effect of Face Masks on Gas Exchange in Healthy Persons and Patients with COPD |

    SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels |

    Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19 (Clinical Infectious Diseases) |


    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


    SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:


    Get notified of new videos by hitting the bell icon:


    RECENT PREVIOUS COVID-19 UPDATES:

    Please visit MedCram.com for the full series:
    - Coronavirus Pandemic Update 110: Trump's Risk Factors and COVID-19 Prognosis; Interferon
    - Coronavirus Pandemic Update 109: New Data From Europe As COVID 19 Infections Rise
    - Coronavirus Pandemic Update 108: High Risk COVID 19 Behaviors; Cases Rise in Europe
    - Coronavirus Pandemic Update 107: Monoclonal Antibodies for COVID 19 Treatment and Prevention?
    - COVID 19 Update Update 106: Comorbidities and Excess Deaths; Bradykinin and Coronavirus
    - Coronavirus Pandemic Update 105: FDA Authorized Treatments; COVID 19 Vaccine Update
    - Coronavirus Pandemic Update 104: COVID 19 Reinfection & Immunity
    - Coronavirus Pandemic Update 103: Convalescent Plasma Treatment & the FDA; College Campuses Close
    - At Home, Cheap, COVID-19 Tests with Results in 15 Minutes: How to Fix Testing with Dr. Michael Mina

    All coronavirus updates are at MedCram.com (including COVID 19 diagnosis, prevention, treatment, vaccine COVID 19, vitamin D and COVID 19, covid 19 prevention, vitamin d covid 19, vitamin d deficiency, NAC (N acetylcysteine), surgical mask vs N95 mask vs cloth mas efficacy, interferon, remdesivir, restaurants and COVID 19, and more).
    We offer many other medical topics (ECG Interpretation, thrombosis, pulmonary embolism, myocardial infarction, hypertension, DKA, influenza, measles, mechanical ventilation, etc.) on our website.


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    MEDIA CONTACT:

    Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
    Associate Professor at the University of California, Riverside School of Medicine

    Media Contact: customers@medcram.com
    Media contact info:

    Video Produced by Kyle Allred

    FOLLOW US ON SOCIAL MEDIA:






    DISCLAIMER:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #VitaminD

  • Can vitamin D help fight COVID-19?

    6:24

    Former trauma surgeon Dr. L. Ray Matthews discusses research looking into the potential impact of vitamin D in the fight against the coronavirus.

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  • Vitamin D might just save you from getting Covid-19

    2:24

    There may be a cheap and effective way to help prevent getting infected with Covid-19 and fighting it if you’ve already been infected. Taha Meli Arvas explains, In Brief.

    All other episodes of ‘In Brief’
    ????

    #Covid19 #VitaminD #Coronavirus

  • COVID-19 and Zinc

    22:21

    President Trump taking zinc (WSJ)



    Low zinc levels at clinical admission associates with poor outcomes in COVID-19, (11th October)



    Zinc balances immune responses and also has a proven direct antiviral action against some viruses.

    Zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases

    Increased intracellular zinc concentrations efficiently impair replication

    Resulting in a lower number of viruses

    Retrospective analysis

    Patients admitted in Barcelona

    15th March to 30th April 2020

    Clinical severity of COVID-19 and PMH assessed

    Fasting plasma zinc levels measured routinely at admission

    N = 611

    Mean age, 63 years

    Male 332, (55%)

    Total mortality was 87 patients (14%) during study time

    But

    249 of 611 patients studied

    Of the 249, 21 (8%) died

    Baseline zinc levels

    Died, (21 people) mean plasma zinc = 43 μg/dl

    Survived, (228 people) mean plasma zinc = 63.1 μg/dl

    Higher zinc levels, associated with lower maximum levels of interleukin-6 during the period of active infection

    Zinc level lower than 50 μg/dl at admission, 2.3 times increased risk of in-hospital death

    Compared with those of 50 μg/dl or higher

    Lower zinc levels at admission correlate with higher inflammation in the course of infection and poorer outcome

    Low plasma zinc levels at admission are associated with mortality in COVID-19 in our study

    Further studies are needed to assess the therapeutic impact of this association

    COVID-19: Poor outcomes in patients with zinc deficiency (International Journal of Infectious Diseases, November 2020)

    Chennai, India

    Prospective study of fasting zinc levels in COVID-19 patients at the time of hospitalization

    Healthy controls median 105.8 μg/dl



    Zinc is a trace element with potent immunoregulatory and antiviral properties

    Is utilized in the treatment of coronavirus disease 2019 (COVID-19)

    Patients with serious COVID-19 had significantly low zinc levels in comparison to healthy controls

    Zinc deficient COVID patients developed more complications

    Zinc deficient patients 70.4% developed complications

    Non zinc deficient patients, 30.0% developed complications, (p = 0.009)

    Acute respiratory distress syndrome

    More need of steroids

    Increased mortality

    Zinc deficient COVID patients had a prolonged hospital stay

    Zinc deficient patients, 7.9 days

    Non zinc deficient patients, 5.7 days, (p = 0.048)

    In vitro studies

    Reduced zinc levels increase SARS-CoV-2 virus receptor interactions

    Increased zinc levels inhibit ACE2 expression




    What zinc does

    Catalytic activity of approximately 100 enzymes

    Plays a role in immune function

    Protein synthesis

    Wound healing

    DNA synthesis

    Cell division

    Normal growth and development, pregnancy, childhood, adolescence

    Required for sense of taste and smell

    Zinc and immunity

    Severe zinc deficiency depresses immune function

    Even mild to moderate degrees of zinc deficiency can impair macrophage and neutrophil functions, natural killer cell activity, and complement activity

    Body requires zinc to develop and activate T-lymphocytes

    Low zinc levels have shown reduced lymphocyte proliferation

    …. that can be corrected by zinc supplementation

    Low zinc status has been associated with increased susceptibility to pneumonia and other infections in children in developing countries and the elderly

    Foods
    Oysters
    Sea food
    Beef
    Pork
    Baked beans
    Fortified cereals
    Pumpkin seeds
    Yogurt
    Cashew nuts
    Chickpeas
    Oats
    Almonds

    Vitamin D and zinc can be made in bulk for essentially nothing

  • New Study - Vitamin D High Dose and COVID-19

    44:53

    New Study - Vitamin D High Dose and COVID-19

    More lectures on drbeen.com

    Looking to support my educational work? Donate here:



    2% of the patients taking high dose calcifediol were admitted to ICU.
    50% of the patients not taking calcifediol were admitted to ICU.

    Effect of calcifidiol (25(OH)D) on severity and disease progress of COVID-19


    Effect of vitamin D receptor activation


    Vitamin D deficiency in the US population


    Obesity and vitamin d deficiency. A study of their relationship


    What is cholecalciferol?


    What is calcifediol?


    Active Vitamin D synthesis pathway


    Should you always take calcium and vitamin K2 with vitamin D?


    Cathelicidins

  • Vitamins to Prevent COVID???

    14:41

    Dr. Christy looks at the data on several vitamins, minerals and supplements and provides recommendations on all.

    REFERENCES:
    EVMS/Dr. Marik COVID Protocols:




    VITAMIN C:


    1. Douglas RM, Hemilä H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007;(3):CD000980. [PubMed abstract]
    Vitamin D:
    BMJ Article:



    Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583.
    Zhou YF, Luo BA, Qin LL. The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies. Medicine (Baltimore). 2019;98:e17252.


    ZINC:






    B VITAMINS:




    MELATONIN:

    Reiter RJ, Abreu-Gonzalez P, Marik PE, Dominguez-Rodriguez A. Therapeutic algorithm for use of melatonin in patients with COVID-19. Front Med 2020; 7:226.

  • How Does Vitamin D Help Us Fight COVID?

    4:21

    Dr. David Meltzer from the University of Chicago joins to share about the findings of his recent study, which found that patients who were vitamin D deficient were about 77% more likely to test positive for COVID than patients who weren’t. There are many ways to get vitamin D, including the sun, vitamin D fortified foods, and supplements.

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    About The Doctors:
    The Doctors is an Emmy award-winning daytime talk show hosted by Dr. Ian Smith. The Doctors helps you understand the latest health headlines, delivers exclusive interviews with celebrities dealing with health issues, debates and investigates health and safety claims, explains the latest viral videos and how you can avoid emergency situations, and serves up celebrity chefs to share the hottest and healthiest recipes and foods.

  • Coronavirus Update 59: Dr. Roger Seheults Daily Regimen

    18:33

    COVID-19 Update 59 with Roger Seheult, MD of

    We recorded this video in response to your comments asking what Dr. Seheult's daily regimen is - to optimize his immune system and minimize COVID-19 risk. In the absence of good clinical data that is specific to SARS-CoV-2, Dr. Seheult discusses supplements, sleep, and his daily disinfection routine when removing PPE, getting in his car, and returning home from the hospital. We look forward to more randomized, blinded, placebo-control studies in the future that will build upon the current body of evidence as it relates to immunity and specifically coronaviruses such as SARS-CoV-2.

    Links referenced in this video:

    Johns Hopkins -

    Nutrients -

    Healthline -

    BMJ -

    Trinity College Dublin -

    Eur Respit J -



    Hydrotherapy -






    Some previous videos from this series (visit MedCram.com for the full series):
    - Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?
    - Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses?
    - Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV:
    - Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?:
    - Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?:
    - Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?:
    - Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia:
    - Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19:
    - Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes):
    - Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials:
    - Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu:
    -Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine
    - Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention
    - Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful?
    - How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

    Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, coronavirus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Sleep, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19) and other medical topics (ECG Interpretation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com

    Speaker: Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

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    #COVID19 #SARSCoV2 #Coronavirus

  • Coronavirus Pandemic Update 97: Vitamin D & COVID-19 Immunity, The Endothelium, & Deficiencies

    13:31

    The role of vitamin D in preventing viral infections, including COVID-19, is gaining attention as more studies are released. In this video, Dr. Seheult of discusses a recent vitamin D review article published in the peer-reviewed journal Nutrients which has compelling implications for COVID-19 and overall vascular and endothelial health. (This video was recorded July 16, 2020).

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    Please visit MedCram.com for the full series:
    - Coronavirus Pandemic Update 96: RNA Vaccine; Ivermectin; von Willebrand Factor and COVID-19
    - Coronavirus Pandemic Update 95: Widespread Clotting on Autopsy; New COVID-19 Prognostic Data
    - Coronavirus Pandemic Update 94: Inhaled Steroids COVID-19 Treatment; New Pneumonia in Kazakhstan?
    - Coronavirus Pandemic Update 93: Antibodies, Immunity, & Prevalence of COVID-19 - New Data from Spain
    - Coronavirus Pandemic Update 92: Blood Clots & COVID-19 - New Research & Potential Role of NAC
    - Coronavirus Pandemic Update 91: Remdesivir Pricing & Disparities in Drug Availability
    - Coronavirus Pandemic Update 90: Assess The Quality of COVID-19 Info With A Validated Research Tool
    - Coronavirus Pandemic Update 89: COVID 19 Infections Rising in Many States; Dexamethasone Cautions
    - Coronavirus Pandemic Update 88: Dexamethasone History & Mortality Benefit Data Released From UK
    - Coronavirus Pandemic Update 87: More on Dexamethasone; Do COVID-19 antibodies last?
    - Coronavirus Pandemic Update 86: COVID-19 Testing & Cases Increasing but Daily Deaths Decreasing
    - Coronavirus Pandemic Update 85: Dexamethasone and Key Questions to Ask if in The Hospital (Part 2)
    - Coronavirus Pandemic Update 84: Key Questions to Ask if in the Hospital for COVID-19 (Part 1 of 2)
    - Coronavirus Pandemic Update 83: High Fructose, Vitamin D, & Oxidative Stress in COVID-19
    - Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D
    - Coronavirus Pandemic Update 81: New Data on Hydroxychloroquine Side Effects & Prevention of COVID-19

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  • Vitamin C, Zinc, Vitamin D and COVID 19 - Prevention of COVID

    12:41

    Vitamin C, Zinc, Vitamin D, and COVID 19 - Prevention of COVID

    Does colder temperature make you more prone to getting a cold Or COVID 19?
    Most health experts agree that people spend more time indoors and in close contact with other people when it’s cold, which likely increases germs spread.
    Also, experts believe that our immune system may be more active when our body is warmer, as in during the summer months.

    ⏩ Timestamps, click to skip ahead!
    00:00 - Introduction
    00:38 - Do Colder Temperatures make you more prone to getting COVID 19?
    02:52 - Why are COVID more likely to cause infections in winter?
    03:20 - Vitamin D and COVID 19
    07:20 - Vitamin C and COVID 19
    09:47 - Zinc and COVID 19

    This is the Vitamin D that I take:


    Back in 2007, there was this study…

    - In this one particular study looking at the spread of the influenza virus, they put guinea pigs together in a chamber and carried out different environmental experiments on them. They found that low relative humidities of 20%–35% were most favorable for infection, while the transmission was completely blocked at high humidity of 80%.
    They also found that when guinea pigs were kept at 5 °C, transmission occurred with greater frequency than at 20 °C, while at 30 °C, no transmission was detected.
    The authors concluded that low relative humidities produced by indoor heating and cold
    temperatures favored the spread of the influenza virus.

    I also want to add that cold weather, by itself, can cause a runny nose without necessarily
    having a cold allows for the virus to be carried in those secretions, which probably facilitates transmission.
    40% of common colds are caused by rhinoviruses. The second most common cause of cold is the coronavirus, the normal one, not this covid 19.
    Its been shown that the rhinovirus reproduces more quickly at cooler temperatures means you might catch a cold more quickly if you’re chilly.

    And this probably applies to the coronavirus as well.

    It's likely that with the combination of all of these 5 factors, meaning cooler temp, lower humidity, people staying indoors more often in winter months, cold weather causing runny noses, and our immune system is more active when it's warmer, these combinations of factors likely explain why colds, flu, and COVID 19 are more likely to cause infections in the winter months.
    But there is likely a 6th factor as well. And that is vitamin D. Our bodies don’t normally make vitamin D unless we get sunlight. In the winter months, for most of us in this world, we don’t get enough sunlight to make enough vitamin D. Unless you live in a warm, maybe you are the exception. So if you aren’t getting enough sunlight in the winter months, that means you have to get enough vitamin D in your diet. And if you don’t do that, you will have low vitamin D levels. Vitamin D helps regulate or Calcium levels and is important for bone and muscle health. It also plays a role in regulating our immune system, but its exact role is not known.

    Why is this important for the common cold, flu, and perhaps with this novel, the coronavirus that’s causing COVID 19? Well, vitamin D doesn’t affect these viruses themselves. Instead, it affects our immune systems.

    So what is my recommendation for taking Vitamin D?
    The best thing to do is check with your doctor to see if you might have low vitamin D, and if it is low, you’ll def need to get more vitamin D, especially during the winter months.

    Vitamin C is a water-soluble vitamin. It is vital to white blood cells that help to fight infections and overall immune system health. Vitamin C is also important for iron absorption, and being deficient in iron can make you more vulnerable to infections in general.
    The normal, recommended daily intake of vitamin C for adults from the diet and/or supplements is 75 to 120 mg. You can get about 80 to 90 mg from a cup of orange juice or sliced orange, or even more from kiwi fruit or a cup of sweet peppers.

    Zinc has become one of the most popular suggestions for reducing symptoms of COVID 19.
    Some studies showed that zinc reduces the duration of a cold by half, while others showed no effect. Another study found that the type of zinc taken determined the result—zinc gluconate lozenges that provided 13.3 milligrams (mg) of zinc lessened the duration of colds, but zinc acetate lozenges that provided 5 mg or 11.5 mg of zinc did not.

    Note: Please watch the whole video to get the proper details. For the youtube description character limitations, I couldn't provide the whole details, so I suggest watching the whole video.

    Doctor Mike Hansen, MD
    Internal Medicine | Pulmonary Disease | Critical Care Medicine
    Website:
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    #covid19 #vitaminc #vitamind

  • Does VITAMIN D Protect Against COVID-19? | Doctor ER

    4:52

    Does VITAMIN D Protect Against COVID-19? | Doctor ER. Vitamin D and COVID 19: Board-Certified Emergency Medicine Physician, Dr. Jordan Wagner explains the latest COVID news and the important role vitamin D may have in the prevention and treatment of coronavirus. What is the link between COVID-19 and vitamin D? Vitamin D deficiency has been associated with rickets, however, 120 health, science, and medical experts from the United States and Europe say there is scientific evidence that vitamin D reduces infections, hospitalizations, and deaths during the COVID-19 pandemic. Can I take any vitamins or supplements to prevent COVID-19? Is vitamin D important for the immune system? What is the best way to reduce the spread of COVID-19? The role of vitamin D in preventing viral infections, including COVID-19, is gaining attention as more studies are released. A new study that looked at 216 people with COVID-19 found that 80% did not have adequate levels of vitamin D (vitamin D3) in their blood. Doctor Jordan Wagner is always sharing his experience coping with the COVID-19 pandemic and what he's learned first hand treating COVID-19 patients. If you have any medical questions, COVID-19 questions, or even a funny quarantine vlog, send it my way! Thanks so much for watching. Stay healthy, my friends!

    OTHER VIDEOS ABOUT VITAMIN D AND COVID-19:

    @MedCram - Medical Lectures Explained CLEARLY - Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)


    @Doctor Mike Hansen - COVID 19: Should you take Vitamin C and Vitamin D to fight COVID


    @Doctor Mike - Doctor Reacts To Simpsons Medical Scenes


    @The Daily Show with Trevor Noah - The Best of Michael Kosta in the Field | The Daily Social Distancing Show


    @TODAY - Officials Fear ‘Surge’ In COVID-19 Cases After Christmas | TODAY


    @Doctor Mike Hansen - Vitamin D for SEVERE Covid 19? (And other final 2020 Thoughts)


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    Coronavirus Disease 2019 (COVID-19) | CDC


    Coronavirus disease (COVID-19) - World Health Organization (WHO)


    Coronavirus Disease 2019 (COVID-19) | coronavirus.gov


    Coronavirus (COVID-19) Response | FEMA.gov


    Coronavirus Disease 2019 (COVID-19) | FDA


    Vitamin D and SARS-CoV-2 infection—evolution of evidence supporting clinical practice and policy development | Irish Journal of Medical Science


    The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality | Aging Clinical & Experimental Research


    25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2 |
    Nutrients


    The link between vitamin D deficiency and Covid-19 in a large population


    Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study) | Postgraduate Medical Journal


    ** WARNING** If you feel like you are actually experiencing a real-life medical emergency, immediately stop watching and call 9-11 or contact a medical professional. The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace an appointment with your own personal doctor/mental health professional!

  • Vitamin D and COVID 19 || Vitamin D for SEVERE COVID 19?

    5:57

    Vitamin D and COVID 19 || Vitamin D for SEVERE COVID 19?

    2020 Is finally coming to an end. But the virus won't be anytime soon. Especially if people don't get the vaccine. December 2020 was the worst pandemic month. And January will be even worse.
    Ivermectin for COVID 19?
    Vitamin D for Covid 19? (SEVERE Covid 19)
    Let's talk.

    ⏩ Timestamps, click to skip ahead!
    00:00 - Intro
    00:11 - January The Worst
    02:38 - COVID Vaccine Allergic Reaction Issues
    04:32 - Ivermectin for COVID 19 (latest update)
    04:51 - Vitamin D for COVID 19 (latest update)

    More people traveled through US airports this past Sunday than any other day this pandemic, about 1.3 million. Simultaneously, more Americans were hospitalized this past week than any other week of the pandemic.

    This past week, about 40% of all ICU patients in the US had Covid 19, according to data published Monday by the US Department of Health and Human Services. That's up from 16% in late September, 22% in late October, and 35% in late November. More than 63,000 Americans have already died so far this month, which is the worst month of this entire pandemic. And next month is only going to be worse.
    Three big reasons;
    One, because of holiday travel and indoor gatherings.
    Two, because of colder temperatures.
    And three, that new coronavirus variant B.1.1.7 is more contagious, more transmissible. It's nowhere in the US, first identified in a Colorado man.
    So I think that January is going to be the worst month of this entire pandemic.

    Of course, the way we fight this is with distancing and masks, and the more people do this, the better the numbers will be. And the more people who get the vaccine, the higher the likelihood of bringing this pandemic to an end. Most experts believe that about 80% of the population needs to be vaccinated to reach herd immunity. Most polls show that about 60% of Americans want the covid vaccine. Based on my YT poll, 10,000 of you voted. And 47% want the vaccine. 37% don’t want it. And 16% are still undecided.

    So this virus will not be extinguished anytime soon unless these numbers change. The soonest I expect this pandemic to be over would be by next fall. But people need to get the covid vaccine to make this happen. I’m glad that I was able to get my Pfizer vaccine back on Dec 15th. Other than some arm soreness in the first 24 hours or so, I didn’t have any side effects. So, I feel great. And I’m going to get by the second shot of the Pfizer vaccine a week from now. With the second shot, the chances of developing side effects are slightly higher than the first shot, so we’ll see, and I’ll keep you posted.

    One concern with these covid vaccines is the potential for allergic reactions. Reactions to vaccines, in general, are rare. The American College of Allergy, Asthma, and Immunology (ACAAI) has updated its advice regarding allergic reactions to these new mRNA vaccines. They say that anyone with a severe allergic reaction to the first shot should not get the second shot. People with allergies to medications, foods, insects, and latex are no more likely than the general public to be allergic to these covid vaccines.

    It's still unclear whether having had an allergic reaction to an older type of vaccine means people will react badly to the mRNA vaccines. People who have had a previous allergic reaction to a specific component of the new vaccine, such as propylene glycol or lipid nanoparticles, should hold off on getting the vaccine. Regardless, these people should discuss the covid vaccine's benefits and risks with their health care providers, ideally, an allergist. These are the latest recommendations at the time of this video, and they are subject to change.

    Now, with this new coronavirus variant, which scientific experts are saying is more contagious.
    Does that mean the covid vaccine will be less effective to new coronavirus variants?
    This is still an unknown at this point.
    And if the vaccine is less effective against this new variant, how much so?
    Again, an unknown. Most scientists think that the vaccine will remain effective against it.

    A lot of people are also talking about the parasitic drug Ivermectin. Is it useful against COVID 19? Too early to tell.
    Some weak studies show it might help against COVID 19, but nothing conclusive so far. We will need a large RCT to know if it works or not, and that hasn’t happened yet.

    What did just come out, though, from Brazil, is an RCT for giving Vitamin D to patients with severe COVID 19? We know that vitamin d deficiency is linked with a higher risk for severe COVID 19. Still, when vitamin D was given to critically ill COVID 19 patients who had lower vitamin D levels, it did not shorten their length of stay in the hospital or decrease mortality. The way that I look at it, it's important not to be vitamin D deficient in the first place, as getting a large dose of vitamin D when you are critically ill is not going to save you.

    - Doctor Mike Hansen

    #covid19

  • Vitamin D & COVID-19: Dr. David Meltzer discusses benefits

    4:01

    Dr. David Meltzer of the University of Chicago joins WGN Evening News to discuss how a proper Vitamin D level can help play a role in reducing one's risk to COVID-19.

  • x
  • Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D

    19:51

    COVID-19 Update 82 with Roger Seheult, MD of
    There is an increasing amount of data that suggests that Black, Asian, and other minority ethnic groups are at an increased risk of COVID-19 deaths in the United States, England, and other European Countries. Dr. Seheult discusses how Vitamin D deficiency may play a role in this disparity. (This video was recorded June 10, 2020).
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    Worldometer

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    Springer -

    Nutra -

    MDPI -

    Vitamin D Illustration -

    -------------------------------------------

    Some previous videos from this series (visit MedCram.com for the full series):
    - Coronavirus Pandemic Update 81: New Data on Hydroxychloroquine Side Effects & Prevention of COVID-19
    - Coronavirus Pandemic Update 80: COVID-19 Retractions & Data (Hydroxychloroquine, ACE Inhibitors)
    - Coronavirus Pandemic Update 79: COVID-19 Vaccines to Keep an Eye On - mRNA, Antigen, Others:
    - Coronavirus Pandemic Update 78: Mask Controversy; Vaccine Update for COVID-19
    - Coronavirus Pandemic Update 77: Remdesivir Update; COVID-19 in Mexico
    - Coronavirus Pandemic Update 76: Antibody Testing False Positives in COVID-19
    - Coronavirus Pandemic Update 75: COVID-19 Lung Autopsies - New Data
    - Coronavirus Pandemic Update 74: Vitamin D & COVID 19; Academic Censorship
    - Coronavirus Pandemic Update 73: Relapse, Reinfections, & Re-Positives - The Likely Explanation
    - Coronavirus Pandemic Update 72: Dentists; Diabetes; Sensitivity of COVID-19 Antibody Tests:
    - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine +
    Azithromycin:
    - Coronavirus Pandemic Update 70: Glutathione Deficiency, Oxidative Stress, and COVID 19
    - Coronavirus Pandemic Update 69: NAC Supplementation and COVID-19 (N-Acetylcysteine)
    - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19:
    - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor
    - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19

    All coronavirus updates are at MedCram.com (including a discussion of the diagnosis, prevention, treatment, and vaccines for COVID-19 - including mRNA vaccines, randomized controlled trials, and recent journal retractions related to ACE inhibitors, ARBs, coronavirus second wave, vitamin D, and race and ethnic differences in COVID-19 data) and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.).

    -------------------------------------------

    Speaker: Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
    Associate Professor at the University of California, Riverside School of Medicine

    MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

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    #COVID19 #SARSCoV2 #FOAMed

  • Vitamin D and COVID-19 Study

    1:48

    UCSF Fresno studies the effects of vitamin D on patients fighting the coronavirus. Rheumatologist Anna Kazaryan explains.

  • NKF Renal Roundtable: COVID-19 and Vitamin D

    59:06

    Donate to support our mission today:
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    The NKF hosted a Renal Roundtable on COVID-19 and Vitamin D.

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  • Could Vitamin D Help Fight COVID-19?

    50:29

    My opinion is that you keep the correct levels of vitamin D in your body. Now a days, due to staying indoors, it is possible that you will develop the deficiency of vitamin D. Get this checked by your doctor and use the correct dose to stay healthy.

    Looking to support my work? Here is the link to donate:

    Here are my notes:
    Daily 10 microgram or 400 IU/Day

    Lippincott’s Biochemistry Review 4th Edition. Page 388
    Daily 5 mg of cholecalciferol or 200 IU of Vitamin D.

    However, 800 IU/Day is shown to reduce the incidence of osteoporotic fractures.
    800 IU/Day recommended by the Institute of Medicine to maintain bone health.

    Frank deficiency is when the levels of 25-hydroxycholecalciferol (25OHD) is less than 20 ng/mL (50 mmol/L)


    No consensus that the oral vitamin D supplements are helpful

    Ergocalciferol from plants is called Vitamin D2
    Cholecalciferol from the animal tissue is called Vitamin D3

    7 deidro-cholesterol to (UV light) to cholecalciferol (D3) to 25 hydroxylase in liver to 25 OH D to -hydroxycholecalciferol 1-hydroxylase in kidney to 1,25 DiOH D3




    Vitamin D Receptors are abbreviated to VDR in the notes. These are cytosolic receptors.


    Deficiency of vitamin D makes people more susceptible to respiratory tract infections.
    Vitamin D supplement can reduce these infections by 12%
    Keep in mind, this is for those who are deficient in this vitamin. If you are not deficient, then it will not make a difference. Because, you are already good.
    Evidence is not sufficient to say that vitamin D helps prevent respiratory infections.

    2018 Study

    People with autoimmune diseases commonly have hypovitaminosis D

    What are cathelicidins?


    What are beta defensins?



    2011 Study


    Activation of TLR and PAMPs on macrophages increases the production of 1, alpha hydroxylase and the VDR. This in turn causes more production of cathelicidine and beta defensins 4.

    Vitamin D also affects monocytes to reduce production of IL1, IL6, IL8, IL12, and TNF. Regulating the immune response.

    Vitamin D acts on the dendritic cells to inhibit/reduce their differentiation and maturation. It reduces their MHCII expression, co-stimulatory molecules like CD40, CD80, CD86, decreased production of IL-12 etc.

    2013 Study

    Vitamin D improves immune system by helping produce cathelicidine and by helping modulate inflammatory cascade. Especially for the respiratory infections.
    It also helps produce NFk-B (nuclear factor kappa light chain for activated B cells.)

    (
    Notes about the NFkB

    Helps with cytokine production and cell survival.
    NFk-B factor becomes active when T and B cell receptors become active. Its activation causes the gene expressions that allow T cell development, maturation, and proliferation.
    T and B cells have Vitamin D receptors that help them produce NFk-B
    )

    Continuing the notes from the study:
    In pulmonary infections. Lung epithelial cells are able to convert inactive vitamin D to its active form. This active Vitamin D then helps produce cathelicidine. Which helps kill the pathogens.

    Vitamin D seems to favor TH2 and TH17 cell activation which is anti-inflammatory profile.
    Vitamin D seems to reduce the activation of TH1 cells which are pro inflammatory by their IFN-gamma action.
    A deficiency of vitamin D may dysregulate the inflammatory response of the body.

    Vitamin B also increases the IkBa. This leads to inhibition of NFkB. This helps reduce the production of IL6 and IL8 by inhibiting the production of NFkB.

  • Vitamin D and COVID-19 || Could Vitamin D Help with COVID-19

    29:03

  • Does Vitamin D Play A Role In Preventing COVID-19? Dr. Natalie Azar Weighs In | TODAY

    4:29

    NBC News medical contributor Dr. Natalie Azar breaks down emerging research in the fight against COVID-19 and news regarding variants of the virus. She also talks about distribution of the vaccine and explains that rollout plans will differ state-by-state.
    » Subscribe to TODAY:
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    #VitaminD #NatalieAzar #TodayShow

    Does Vitamin D Play A Role In Preventing COVID-19? Dr. Natalie Azar Weighs In | TODAY

  • Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention

    12:41

    Coronavirus (COVID-19) Update 30 with pulmonologist Dr. Seheult of

    Topics include a variety of growing international coronavirus epidemics including Australia, Norway, Iceland, Iran, Italy, Poland, India, Belgium, South Korea, Canada, and the United States (Los Angeles). Dr. Seheult also discusses compelling evidence about the possible role of Vitamin D (in proper dosage) in fighting acute respiratory infections like COVID-19.

    PLEASE NOTE: This video was recorded on March 4, 2020. Our more recent COVID-19 updates can be accessed free at our website or here on YouTube:

    We've produced each COVID-19 video with the best information we could access at the time of recording. Naturally, some videos will contain information that has become outdated or replaced by better information or research.

    That said, we believe each video contains concepts that have enduring value and reviewing how the response to COVID-19 has progressed over time may be of interest to you as well.


    Previous videos from this series:

    - Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran:

    - Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate:

    - Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases:

    - Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic?

    - Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends:

    - Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms:

    - Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats:

    - Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing:

    - Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?:

    - Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins:

    - Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials:

    - Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips:

    - Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19):

    - Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19):

    - Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19)

    - Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks:

    - Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada:

    - Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV:

    - Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine):

    - Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV):

    - Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate:

    - How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

    -----------------------------------------------------------
    LINKS for references from this video:

















    -----------------------------------------------------------

    Speaker: Roger Seheult, MD
    Produced by Kyle Allred, PA

    Note: MedCram medical videos are for medical education and exam preparation, and not intended to replace recommendations by your doctor.
    #Coronavirus #COVID19 #SARSCoV2

  • Vitamin D and Zinc’s impact on COVID-19

    1:45

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  • Coronavirus Pandemic Update 74: Vitamin D & COVID 19; Academic Censorship

    8:54

    COVID-19 Update 74 with Roger Seheult, MD. All coronavirus updates available free at our website
    In this video, Dr. Seheult reviews a new article from the Lancet discusses the potential benefit and role of Vitamin D in preventing and reducing the severity of COVID-19. The censorship of academic discussion about studies and peer-reviewed journal articles has become an area of significant concern for medical professionals and those seeking evidence-based information during a pandemic. Dr. Seheult shares his opinion on this type of censorship, and also shares resources for dental professionals preparing to open their practices. (This video was recorded on May 22, 2020)
    -------------------------------------------

    Links referenced in this video:

    Johns Hopkins Tracker -

    Worldometer

    Lancet Article on Vitamin D -

    TILDA Study -

    Australian Dental Association -

    ADA Center for Professional Success -

    CNN -

    60 Minutes -

    -------------------------------------------

    Some previous videos from this series (visit MedCram.com for the full series):
    - Coronavirus Pandemic Update 73: Relapse, Reinfections, & Re-Positives - The Likely Explanation
    - Coronavirus Pandemic Update 72: Dentists; Diabetes; Sensitivity of COVID-19 Antibody Tests:
    - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine +
    Azithromycin:
    - Coronavirus Pandemic Update 70: Glutathione Deficiency, Oxidative Stress, and COVID 19
    - Coronavirus Pandemic Update 69: NAC Supplementation and COVID-19 (N-Acetylcysteine)
    - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19:
    - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor
    - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19
    - Coronavirus Pandemic Update 65: COVID-19 and Oxidative Stress (Prevention & Risk Factors)
    - Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update
    - Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?
    - Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)?
    - Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress
    - Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19?
    - Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
    - Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID 19 (V/Q vs Shunt vs Diffusion)
    - Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?

    All coronavirus updates are at MedCram.com (including a discussion of that data for coronavirus UK, coronavirus NYC, COVID 19 testing and reinfections) and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.).

    -------------------------------------------

    Speaker: Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

    MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

    Media Contact: customers@medcram.com
    Media contact info:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #FOAMed

  • Winter Vitamin D Update

    27:44

    Vitamin D
    Essential role in immunomodulation
    Innate and adaptive immune systems
    Enhances innate immunity, immune peptides, anti-viral effects, disrupt viral envelopes
    Suppressing the excessive expression of proinflammatory cytokines
    Regulating the expression of ACE2 receptors
    Epidemiological and clinical evidence, incidence, severity and mortality
    Low levels
    Hypertension, diabetes, cancer, cardiovascular diseases

    Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study





    50 patients treated with calcifediol

    One required admission to the ICU (2%)

    No deaths

    All discharged, without complications

    26 untreated patients

    13 required ICU (50 %)

    2 died

    Calcifediol clinical trial, 1,000 patients, 15 hospitals



    Vitamin D Status in Hospitalized Patients With SARS-CoV-2 Infection

    The Journal of Clinical Endocrinology & Metabolism (Accepted, 27th October 2020)



    To assess serum 25-hydroxyvitamin D (25OHD) levels in hospitalized patients with COVID-19

    Analyze the possible influence of vitamin D status on disease severity

    Retrospective

    Case-control

    216 COVID-19 patients

    197 population-based controls

    Results

    Vitamin D deficiency was defined as serum 25OHD levels less than 20 ng/ml (50 nmol/L)

    COVID patients group

    Mean levels 13.8 ng/ml. (34.5 nmol/L)

    82.2% vitamin D deficient

    Community control group

    Mean levels 20.9 ng/ml (52.25 nmol/L) (p less than 0.0001)

    47.2% vitamin D deficient

    Blood levels lower in men than in women


    Evidence of protective role of Ultraviolet-B (UVB) radiation in reducing COVID-19 deaths (Nature scientific reports, 19th October 2020)



    Ultraviolet-B (UVB) radiation, mediated by vitamin D synthesis

    Dataset of 152 countries over 108 days (n = 6,524)

    A permanent unit increase in UVI is associated with a 1.2 percentage points decline in daily growth rates of cumulative COVID-19 deaths

    and a 1.0 percentage points decline in the CFR daily growth rate

    Globally
    Minus 12% of cumulative COVID-19 deaths

    Minus 38% on CFR

    We find a significant negative association between UVI and COVID-19 deaths

    indicating evidence of the protective role of UVB in mitigating COVID-19 deaths

    If confirmed via clinical studies, then the possibility of mitigating COVID-19 deaths via sensible sunlight exposure or vitamin D intervention would be very attractive


    Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection



    Association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes

    n = 235

    Results

    Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and 32.8% were vitamin D sufficient.

    Vitamin D sufficiency

    25(OH)D less than 30 ng/ml. (75 nmol/L)

    Reduction in clinical severity

    Inpatient mortality

    Serum levels of C-reactive protein (CRP)

    Increase in lymphocyte percentage

    Vitamin D insufficiency in southern Arizona (American Journal of Clinical Nutrition)



    Population 26.1 ng/ml (65.25 nmol/L)

    Below 20 ng/ml (50 nmol/L)

    Blacks 55%

    Hispanics 37.6%

    Whites 22.7%

    Also more obesity in first two groups

    Adult Health Status Among Native American Families Participating in the Growing Resilience Home Garden Study (CDC August 22, 2019)



    Northern Arapaho and Eastern Shoshone tribes sharing the Wind River Indian Reservation (WRIR) in Wyoming reportedly die 30 years earlier than whites in the state

    Nearly 80% of adults had deficient vitamin D levels ( less than 20 ng/mL; n = 167) (50 nmol/L)

    Obesity

    Waist circumference, associated with higher risk of obesity-related disease

    Women 95%

    Men 80%

    Hypertension

    Diabetes

    EVMS CRITICAL CARE COVID-19 MANAGEMENT PROTOCOL



    If you would like to donate to John's educational projects, please use the following link, thank you,

  • Coronavirus Update 124: California and New York Variants

    15:25

    Dr. Seheult illustrates what we know about the coronavirus variants first discovered in California and New York. Will these SARS-CoV-2 variants be more transmissible or cause more severe COVID 19 disease? Learn what the research and experts say so far about these coronavirus mutations (This video was recorded on February 28, 2021).

    Roger Seheult, MD is the co-founder and lead professor at
    He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.


    LINKS / REFERENCES:

    Pfizer and BioNTech Submit COVID-19 Vaccine Stability Data at Standard Freezer Temperature to the U.S. FDA (Pfizer) |

    Moderna Says Covid-19 Vaccine for South Africa Strain Is Ready for Human Testing (WSJ) |

    California coronavirus variant is resistant to antibodies, but vaccines should still work (San Francisco Chronicle) |

    New research shows California coronavirus variant is more transmissible (Washington Post) |

    California’s coronavirus strain looks increasingly dangerous: ‘The devil is already here’ (Los Angeles Times) |

    A New Coronavirus Variant Is Spreading in New York, Researchers Report (NYT) |

    SARS-CoV-2 lineage B.1.526 emerging in the New York region detected by software utility created to query the spike mutational landscape (bioRxiv) |

    A Novel SARS-CoV-2 Variant of Concern, B.1.526, Identified in New York (medRxiv) |

    Researchers found more evidence that the variant from South Africa can evade antibodies. (NYT) |

    Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 (bioRxiv) |


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    Please visit MedCram.com for the full series:
    - COVID 19 Travel Tips: Safety, Restrictions, Flying During Pandemic
    - Coronavirus Update 123: COVID 19 Vaccines vs. Variants
    - Coronavirus Update 122: The Research So Far on COVID-19 and Vaccines vs. Pregnancy
    - Coronavirus Update 121: Johnson and Johnson Vaccine - Efficacy and Safety vs. Pfizer & Moderna
    - Coronavirus Update 120: Anticoagulants (Blood Thinners) Improve Hospital Outcomes (Full Dose)
    - Coronavirus Update 119: Pfizer BioNTech COVID Vaccine (Clinical Considerations)
    - Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2)
    - Coronavirus Update 118: AstraZeneca DNA COVID 19 Vaccine Explained (vs. Pfizer / BioNTech, Moderna mRNA vaccines)

    All coronavirus updates are at MedCram.com (including more discussion on COVID variants, COVID mutations, and more).

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    #COVID19 #SARSCoV2

  • Should Zinc Be Added To Treatment Protocols For Covid-19 Patients?

    11:15

    Should Zinc Be Added To Treatment Protocols For Covid-19 Patients?

    Watch more on The Dr. Oz Show:
    Subscribe to Dr. Oz's official YouTube channel:
    Like Dr. Oz on Facebook:
    Follow Dr. Oz on Instagram:
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  • COVID-19 und Vitamin D - Eine evidenzbasierte Analyse - Spitzen-Gespräch Prof. Jörg Spitz & Gröber

    23:35

    In der Spitzen-Eventreihe Vitamin D mit dem Untertitel Gemeinsam gesund durch die sonnenlose Zeit liefern wir einen umfangreichen Überblick über alles Wissenswerte zum Thema Vitamin D. Melden Sie sich jetzt kostenfrei an unter ???????? ????
    -------------------------------------------------------------------------------------
    Wieder einmal ist es an der Zeit, den versierten Mikronährstoff-Experten Uwe Gröber zum Spitzen-Gespräch zu empfangen. Der Grund: Immer mehr aktuelle Interventionsstudien belegen einen positiven Effekt von Vitamin D auf das Immunsystem im Allgemeinen und so auch bei SARS-CoV-2-Infektionen. Gleichzeitig muss jedoch festgehalten werden: 96 Prozent aller COVID-19-Patienten leiden an einem Vitamin-D-Mangel. Zum einen sind vor allem die vulnerablen Gruppen qua definitionem von diesem Defizit betroffen, zum anderen führen bestimmte Pandemie-Maßnahmen, wie beispielsweise vermehrte Tätigkeiten im Homeoffice, zu immer geringerer Sonnenexposition in der Gesamtbevölkerung.

    Gemeinsam mit Prof. Dr. Jörg Spitz blickt der Leiter der Akademie für Mikronährstoffmedizin, Uwe Gröber, auf die neuesten Forschungsergebnisse, erklärt, warum die Bundesregierung diese Erkenntnisse bei ihrer Pandemie-Strategie berücksichtigen sollte und beantwortet die Frage, was dies alles mit Thomas Manns Roman „Der Zauberberg“ zu tun hat.

    Denn ebenfalls gilt: An sich ist ein Vitamin-D-Mangel sehr einfach und kostengünstig zu beheben.
    -------------------------------------------------------------------------------------
    Uwe Gröber ist Gründer und Leiter der Akademie für Mikronährstoffmedizin in Essen. Neben der publizistischen Arbeit, u.a. als Herausgeber der „Zeitschrift für Orthomolekulare Medizin“, widmet sich der Apotheker auch der Aus- und Fortbildung von Apothekern, Ärzten und Ernährungswissenschaftlern. Gröber zählt zu den führenden Mikronährstoffexperten im deutschsprachigen Raum.
    -------------------------------------------------------------------------------------
    ???? Bücher von Uwe Gröber: ????
    - Die wichtigsten Nahrungsergänzungsmittel: Das Plus für Ihre Gesundheit - Die kleine Bibel der Nahrungsergänzungsmittel: ????????
    - Arzneimittel als Mikronährstoff-Räuber: Was Ihr Arzt und Apotheker Ihnen sagen sollten: ????????
    - Mikronährstoff-Beratung: Ein Arbeitsbuch: ????????
    - Mikronährstoffe: Metabolic Tuning-Prävention-Therapie (Für die Kitteltasche): ????????
    - Orthomolekulare Medizin: Ein Leitfaden für Apotheker und Ärzte: ????????
    - Vitamin D - Die Heilkraft des Sonnenvitamins: ????????
    - Corona, Influenza & Co. - wie stärke ich mein Immunsystem? - Patientenratgeber: ????????
    -------------------------------------------------------------------------------------
    ???? Hier können Sie sich für den Newsletter bei der Akademie für menschliche Medizin registrieren


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    #Corona #COVID #VitaminD

  • Vitamin D, Large scale studies

    27:14

    Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study (Federation of European Biochemical Societies Journal)



    Vitamin D deficiency is a worldwide pandemic

    To evaluate associations of plasma 25(OH)D levels with the likelihood of coronavirus disease infection and hospitalization

    N = 7, 807

    February 1st to April 30th, 2020

    Participants had one previous blood test for the plasma 25(OH)D level

    Suboptimal’ or ‘low’ plasma 25(OH)D. Below 30 ng/mL

    Sufficiency more than 30 ng/ml. (75 nmol/L)

    Insufficiency, 20 – 29 ng/ml

    Deficiency less than 20 ng/ml (50 nmol/L)

    7, 807 individuals

    Risk by age and sex were as expected

    Obesity not significantly associated with increased risk for COVID‐19 infection or hospitalization

    Sufficient vitamin D levels

    7, 025 tested negative

    Low vitamin D levels

    782 tested positive

    Increased likelihood of COVID‐19 infection
    Odds ratio (OR) of 1.45

    Increased likelihood of hospitalisation
    OR of 1.95

    We concluded that low plasma 25(OH)D levels appear to be an independent risk factor for COVID‐19 infection and hospitalization.

    The link between vitamin D deficiency and Covid-19 in a large population



    52, 405 infected patients

    524, 050 controls

    Greater incidence of COVID-19 with lower vitamin D levels

    Highest infection prevalence with lowest vitamin D levels

    A significant protective effect in those who had supplemented over the previous 4 months

    Joint Guidance on Vitamin D in the Era of COVID-19 from the ASBMR, AACE, Endocrine Society, ECTS, NOF, and IOF



    Spend at least 15-30 minutes with direct sun exposure each day

    Most older and younger adults can safely take 400-1000 IU daily

    Vitamin-D and COVID-19: do deficient risk a poorer outcome? (Lancet)



    Comparing data across nations, mortality from COVID-19 is clearly higher in some countries than in others

    Relative vitamin D status of populations

    Vitamin D supplementation could be especially important for older people

    Functions

    Calcium and phosphate balance

    Affecting bone growth and turnover

    Low vitamin D status

    Associated with increased susceptibility to infectious disease

    Notably, upper respiratory tract infections

    Treating the lowest levels gives most percentage benefit

    Vitamin D and COVID-19

    Virus emerged and started its spread in the northern hemisphere at the end of 2019

    When levels of 25-hydroxyvitamin D are lowest

    COVID-19 mortality was significantly associated with vitamin D status in different populations

    Nordic countries, widespread fortification of foods

    Italy and Spain, prevalence of vitamin D deficiency, surprisingly common

    Black and minority ethnic people

    UK, more than four times more likely to die from COVID-19

    In COVID

    Vitamin D supports production of antimicrobial peptides in the respiratory epithelium

    Might help to reduce the inflammatory response

    Vitamin D is known to interact angiotensin- converting enzyme 2

    SARS-CoV-2 down regulates expression of ACE2

    Vitamin D promotes expression of this gene

    Rose Anne Kenny

    Trinity College Dublin

    Lead investigator of the Irish Longitudinal Study on Ageing

    The circumstantial evidence is very strong

    we don’t have randomised controlled trial evidence, but how long do you want to wait in the context of such a crisis?

    We know vitamin D is important for musculoskeletal function, so people should be taking it anyway

    Vitamin D supplements should normally be given to care home residents unless there is an extremely good reason not to do so.

    Adrian Martineau

    Queen Mary University of London

    At best vitamin D deficiency will only be one of many factors involved in determining outcome of COVID-19

    but it’s a problem that could be corrected safely and cheaply

    there is no downside to speak of, and good reason to think there might be a benefit

    Vitamin D dose

    IU mcg
    400 10mcg
    800 20mcg
    1,000 25mcg
    2,000 50mcg
    4,000 100mcg

  • Second Vitamin D clinical trial, positive results

    21:15

    Download my two educational text books for free using this link: Influenza


    Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)




    It has been observed that vitamin D-deficient individuals
    have increased COVID-19 risk and mortality

    Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA 2020;323:1824–36. doi: 10.1001/jama.2020.6019

    The role of vitamin D in the prevention of coronavirus disease infection and mortality.

    Aging Clin Exp Res 2020;32:1195–8. doi: 10.1007/s40520-020-01570-8

    Association of vitamin D status and other clinical characteristics with COVID-19 test results.

    JAMA Netw Open 2020;3:e2019722. (Published 3 Sep 2020).doi: 10.1001/jamanetworkopen.2020.19722

    Immunomodulatory role and protective effect of vitamin D against other viral infections

    Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;15:356:i6583. doi: 10.1136/bmj.i6583

    An intervention study with calcifediol noticed a reduction in requirement for intensive care among hospitalised patients for COVID19

    Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study.

    J Steroid Biochem Mol Biol 2020;203:105751. doi: 10.1016/j.jsbmb.2020.105751

    50 patients treated with calcifediol, one required admission to the ICU (2%), no deaths

    26 untreated patients, 13 required admission (50 %) to the ICU, 2 deaths

    Immune-modulatory effect of vitamin D is likely to be observed at 25(OH)D levels, which are considered higher than that required for its skeletal effects

    Vitamin D to prevent COVID-19: recommendations for the design of clinical trials. Febs J2020;287:3689–92. doi: 10.1111/febs.15534

    Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults.

    BMC Res Notes 2012;5:575. doi: 10.1186/1756-0500-5-575

    Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection.

    PLoS One 2020;15:e0239799.doi: 10.1371/journal.pone.0239799

    Aim



    Effect of high dose, oral cholecalciferol supplementation on SARS-CoV-2 viral clearance

    First cholecalciferol intervention study for asymptomatic and mildly symptomatic SARS-CoV-2 positive individuals


    Design

    Randomised, placebo-controlled.

    Participants

    Asymptomatic or mildly symptomatic SARS-CoV-2

    RNA positive vitamin D deficient (25(OH) D less than 20 ng/ml)

    Calcifediol, calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3

    Pre intervention baseline serum 25(OH) D

    Intervention group, 8.6 ng/ml

    Control group, 9.54 ng/ml (p=0.730)

    10 out of 16 patients could achieve 25(OH)D more than 50 ng/ml by
    day-7

    Another two by day-14

    Outcome measure

    Proportion of patients with SARS-CoV-2 RNA negative before day-21

    Change in inflammatory markers

    Intervention group (n=16)

    60 000 IU of cholecalciferol (oral nano-liquid droplets) for 7 days

    Therapeutic target 25(OH)D more than 50 ng/ml

    Cholecalciferol supplementation was continued for those with 25(OH)D less than 50 ng/ml

    Fibrinogen levels significantly decreased with cholecalciferol supplementation

    10 (62.5%) participants became SARS-CoV-2 RNA negative

    Control group (n=24)

    Placebo

    5 (20.8%) participants became SARS-CoV-2 RNA negative (p less than 0.018)

    Both groups

    Patients requiring invasive ventilation or with significant comorbidities were excluded

    25(OH)D levels were assessed at day 7

    Regular measurements of: SARS-CoV-2 RNA, fibrinogen, D-dimer, procalcitonin, CRP, ferritin

    Improvements

    Calcifediol would have been better

    Little and often for prevention

  • Coronavirus Pandemic Update 83: High Fructose, Vitamin D, & Oxidative Stress in COVID-19

    22:02

    COVID-19 Update 83 with Roger Seheult, MD of
    Oxidative stress may play a key role in the severity of COVID-19 infection. A variety of studies have demonstrated how high sugar intake (and fructose in particular - such as high fructose corn syrup) contributes not only to oxidative stress but to the inactivation of a usable form of vitamin D as well. Join Dr. Seheult for illustrations of how these pathways work.
    (This video was recorded June 12, 2020).
    -----------------------------------------
    Visit us at our website for videos on over 60 medical topics:

    Get notified of new videos by subscribing to MedCram:
    -------------------------------------------

    Links referenced in this video:

    Johns Hopkins Tracker -

    Worldometer

    Nutrients -

    HHS -

    Plos One -

    American Journal of Physiology, Endocrinology and Metabolism -

    Global Public Health -

    IJMS -

    Univ. of Washington -

    Glucose Illustration -

    -------------------------------------------

    Some previous videos from this series (visit MedCram.com for the full series):
    - Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D
    - Coronavirus Pandemic Update 81: New Data on Hydroxychloroquine Side Effects & Prevention of COVID-19
    - Coronavirus Pandemic Update 80: COVID-19 Retractions & Data (Hydroxychloroquine, ACE Inhibitors)
    - Coronavirus Pandemic Update 79: COVID-19 Vaccines to Keep an Eye On - mRNA, Antigen, Others:
    - Coronavirus Pandemic Update 78: Mask Controversy; Vaccine Update for COVID-19
    - Coronavirus Pandemic Update 77: Remdesivir Update; COVID-19 in Mexico
    - Coronavirus Pandemic Update 76: Antibody Testing False Positives in COVID-19
    - Coronavirus Pandemic Update 75: COVID-19 Lung Autopsies - New Data
    - Coronavirus Pandemic Update 74: Vitamin D & COVID 19; Academic Censorship
    - Coronavirus Pandemic Update 73: Relapse, Reinfections, & Re-Positives - The Likely Explanation
    - Coronavirus Pandemic Update 72: Dentists; Diabetes; Sensitivity of COVID-19 Antibody Tests:
    - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine +
    Azithromycin:
    - Coronavirus Pandemic Update 70: Glutathione Deficiency, Oxidative Stress, and COVID 19
    - Coronavirus Pandemic Update 69: NAC Supplementation and COVID-19 (N-Acetylcysteine)
    - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19:
    - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor
    - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19

    All coronavirus updates are at MedCram.com (including a discussion of the diagnosis, prevention, treatment, and vaccines for COVID-19 - including mRNA vaccines, randomized controlled trials, and recent journal retractions related to ACE inhibitors, ARBs, coronavirus second wave, fructose, high fructose corn syrup, oxidative stress, and vitamin D) and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.).

    -------------------------------------------

    Speaker: Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
    Associate Professor at the University of California, Riverside School of Medicine

    MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

    Media Contact: customers@medcram.com
    Media contact info:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #FOAMed

  • Vitamin D: Evidence-Based Health Information Related to COVID-19

    14:21

    By Stefanie A. Stramel, PharmD, BCIDP, MS
    Published: 9/17/2020
    Current as of: 9/5/2020

    DISCLAIMER:
    This presentation is posted on behalf of the Society of Infectious Diseases Pharmacists (SIDP), which is a non-profit organization of 1500+ pharmacists specializing in infectious diseases pharmacotherapy. Please note the following regarding this educational video:
    1) The presenter is a vetted expert in infectious diseases pharmacotherapy and qualified to give this presentation based on training and practice experience.
    2) The information in this presentation is not intended to provide medical advice. We advise that patients always consult with a licensed healthcare provider before making individual decisions regarding their healthcare, or the use of any agents or therapies described in this presentation.
    3) The information in this presentation is intended to educate healthcare providers regarding appropriate use of this agent, specifically in the context of considered treatment of COVID-19 infection. Providers should always consider the benefits and risks for each individual patient before making patient-specific healthcare decisions.
    4) All information provided in this presentation is cited from published medical evidence or other verifiable sources. Any expert opinion is identified as such within the presentation for purposes of transparency.
    5) The information in this presentation is not intended to endorse or promote the use of any specific commercial product. Providers should always consider the risks and benefits associated with any particular product prior to making patient-specific decisions.
    To learn more about SIDP and our COVID-19 Resources, please visit sidp.org/covid19/ and/or follow our verified social media account, @SIDPharm, on Twitter.

  • Vitamin D, First clinical trial

    27:43

    Please share this video around, this message needs to get out there, thank you, John


    About 42% of the US population is vitamin D deficient

    82% in black people

    70% in Hispanics

    Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results, (JAMA Open, 3rd September, Chicago)



    Cohort study of 489

    Patients who had a vitamin D level measured in the year before COVID-19
    testing

    Relative risk of testing positive for COVID-19 was 1.77 times

    First clinical trial on vitamin D and COVID

    Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study (Spain, Journal of steroid biochemistry and molecular biology)



    Objective

    Vitamin D decreases Acute Respiratory Distress Syndrome

    Effect of calcifediol treatment

    Calcifediol can rapidly increase serum 25OHD concentration

    25-hydroxyvitamin D

    Intensive Care Unit Admission and Mortality

    Spanish patients hospitalized for COVID-19.

    Design

    Parallel pilot, randomized, double-masked clinical trial

    Setting

    Reina Sofia University Hospital, Córdoba, Spain

    Participants

    76 consecutive patients hospitalized with COVID-19 infection

    Clinical picture of acute respiratory infection

    Confirmed by a radiographic pattern of viral pneumonia

    Positive SARS-CoV-2 PCR

    Procedures

    All hospitalized patients received as best available therapy

    Hydroxychloroquine and azithromycin

    Allocated at a 2 calcifediol:1

    Oral calcifediol (0.532 mg), or not

    Oral calcifediol (0.266 mg) on day 3 and 7

    Then weekly until discharge

    End points, ICU admission and deaths.

    Results

    50 patients treated with calcifediol

    One required admission to the ICU (2%),

    Of 26 untreated patients, 13 required admission (50%)

    p  less than 0.001

    Of the patients treated with calcifediol, none died, and all were discharged, without complications

    Of the patients not treated, 2 died

    Conclusion

    Calcifediol seems to be able to reduce severity of the disease

    Larger trials with groups properly matched will be required to show a definitive answer

    Rationale, activation of the vitamin D receptor (VDR) signalling pathway

    Reduced ARDS

    Cytokine/chemokine storm

    Regulating the renin angiotensin system

    Modulating neutrophil activity

    Maintaining the integrity of the pulmonary epithelial barrier

    Stimulating epithelial repair

    Tapering down the increased coagulability


    Ventilate

    Don't abdicate
    Dilute that virus
    So you stay great
    Ventilate
    Don't complicate,
    Complain or whine
    You'll acclimate
    Contemplate
    When you congregate
    Does the air here circulate
    Instigate, Nominate
    Educate, Motivate
    I hope this message will resonate
    That when we populate
    Instead of isolate
    Ventilate
    Don't abdicate
    Dilute that virus
    So you stay great

  • Researchers examine whether vitamin D could help treat COVID-19

    1:58

    Several clinical trials are trying to determine whether vitamin D could be effective in helping to treat or prevent COVID-19, while a new study shows many patients in a Spanish hospital had a vitamin D deficiency.

    Watch The National live on YouTube Sunday-Friday at 9 p.m. ET

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    The National is CBC's flagship nightly news program, featuring the day's top stories with in-depth and original journalism, with hosts Adrienne Arsenault and Andrew Chang in Toronto, Ian Hanomansing in Vancouver and the CBC's chief political correspondent, Rosemary Barton in Ottawa.

  • Vitamin D and Immunity, Lots of Evidence

    30:26

    Public Health England
    Vitamin D recommendations


    Vit D and COVID


    Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.

    Prevalence and correlates of vitamin D deficiency in US adults





    About 42% of the US population is vitamin D deficient. However, this rate rises to 82% in black people and 70% in Hispanics

    Vit D deficiency in Ireland

    Vitamin D is essential for bone and muscle health


    Arizona University





  • Vitamin D in the times of Covid 19

    1:1:43

    Understand the nuances of vitamin D and its role in COVID 19.
    Dr. Anurag Bajpai, MD, FRACP, SCE, Pediatric Endocrinologist,
    Depura Talkies, Sanofi Aventis Webinar
    MedEClasses Online Course in Pediatric Endocrinology

  • Vitamin D studies confirm correlations

    26:58

    Download my two educational text books for free using this link:

    Hard copy of the Physiology Notes text book on ebay,

    Hard copy of the Pathophysiology text book,

    Vitamin D

    UK biobank



    Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank (29th January, 2021)



    The American Journal of Clinical Nutrition

    Background

    Vitamin D supplementation, lower risk of acute respiratory tract infection

    Emerging evidence, vitamin D insufficiency is related to a higher risk of coronavirus infection and disease

    Objectives

    To investigate the prospective association between habitual use of vitamin D supplements and risk of COVID- 19 infection

    Associations according to levels of circulating and genetically predicted vitamin D

    Methods

    N = 8,297 adults

    Records of COVID-19 test results from UK Biobank

    16 March 2020 to 29 June 2020

    Results

    Of the 8,297 adults, 1,374 (16.6%) tested positive

    Vit D users, n = 363

    Non-vit D users, n = 7,934

    Unadjusted model

    OR 0.78 (p = 0.105)

    Adjustment for covariates

    Age, sex, race, origin (outpatient or inpatient), blood-type, years of education, TDI, smoking, moderate drinking, physical activity, healthy diet score, use of any other supplements

    Inverse association emerged

    Between habitual use of vitamin D supplements and risk of COVID-19 infection

    OR, 0.66, (P = 0.038)

    Habitual use of vitamin D supplements was significantly associated with a 34% lower risk of COVID-19 infection

    No association with baseline blood vitamin D levels and risk of COVID-19 infection

    Associations between the risk of COVID-19 infection and habitual use of other individual supplements

    Vitamin A, vitamin B, vitamin C, vitamin E, folic acid, a
    multivitamin,

    Calcium, zinc, iron, selenium, glucosamine, fish
    Oil

    Vitamin D Deficiency and Outcome of COVID-19 Patients

    Medical University Hospital Heidelberg, (September 2020)



    Identification of modifiable prognostic factors may help to improve outcomes

    N = 185, diagnosed and treated in Heidelberg

    Median Vitamin D level was 16.6 ng/ml

    Associations of vitamin D status with disease severity and survival

    Vitamin D status assessed at first presentation

    Deficient

    25-hydroxyvitamin D (Calcifediol)
    level less than 12 ng/mL ( less than 30 nM)

    N = 41 (22%)

    Median IL-6 levels at hospitalization were significantly higher

    70.5 versus 29.7 pg/mL

    Insufficiency

    Less than 20 ng/mL (less than 50 nM)

    N = 118 (64%)

    Higher levels

    N = 26

    Median Vitamin D level was significantly lower in the inpatient versus the outpatient subgroup

    Results

    Median observation period of 66 days

    93 (50%) patients required hospitalization

    28 patients required ventilation

    Including 16 deaths

    Adjusting for age, sex, comorbidities

    Deficiency was associated with higher risk of ventilation and death

    Mechanical ventilation

    HR 6.12

    p less than 0.001

    Death

    HR 14.73

    p less than 0.001

    Other hazard ratios

    Male, 1.69 2.5

    Over 60, 3.2 7.7

    Comorbidity, 2.7 5.3

    Need for interventional studies

    Cholecalciferol

    Calcifediol

    Active form of vitamin D3, 1, 25-dihydroxyvitamin D3 (1,25D3), calcitriol, is
    pluripotent hormone and important modulator of both innate and adaptive immunity

  • Vitamin D and COVID-19

    2:11

    Does vitamin D affect susceptibility to COVID-19?

  • Vitamin D und CoVID-19 - aktuelle Studien und Publikationen!

    6:03

    Aktuell existieren 14 Studien und Publikationen, die sich mit Vitamin D und dem CoVID-19 befassen oder zumindest damit in Vebindung gebracht werden können. In dem heutigen Beitrag werden 2 daraus vorgestellt, der Rest ist unter den folgenden Links ersichtlich:

    1. Pattern of Covid-19 Mortality and Vitamin D: An indonesian study:


    2. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with coronavirus-2019 (COVID-19):


    3. The role of Vitamin D in the prevention of coronavirus disease 2019- infection and mortality:


    4. High dose Vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial:


    5. Vitamin D for influenza:


    6. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS):


    7. Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system:


    8. Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial:


    9. Cationic host defence peptides: potential as antiviral therapeutics:


    10. Effect of cholecalciferol supplementation on vitamin D status and cathelicidin levels in sepsis: A randomized, placebo-controlled trial:


    11. Vitamin-D-Status in Deutschland:


    12. Vitamin D - der aktuelle D-A-CH-Referenzwert aus Sicht der Risikobewertung:


    13. Ausgewählte Fragen und Antworten zu Vitamin D. Deutsche Gesellschaft für Ernährung e.V.:


    14. D-vitamin kan skydda mot svår infektion vid covid-19:




    Weitere Infos unter:


    Schauen Sie auch ins Newsletterarchiv, nutzen Sie die Suchfunktion. Wenn Sie sich in den Newsletter eintragen, bekommen Sie regelmäßig wertvolle Informationen rund um die Gesundheit.Bitte beachten Sie:Die hier dargebotenen Informationen und Empfehlungen dienen ausschließlich der allgemeinen Information und haben weder werbenden, noch beratenden Charakter. Sie ersetzen in keinem Fall den individuellen, persönlichen Rat eines Arztes und sind auch keine medizinische Hilfe. Von einer Behandlung ohne Absprache mit einem Arzt in diesem Fachgebiet - insbesondere bei bekannten Vorerkrankungen und unklaren Beschwerden - wird dringend abgeraten.

  • Vitamin D-Mangel und Infektionskrankheiten: COVID 19 | Priv.-Doz. Dr. Karin Amrein

    7:38



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  • Ist Vitamin D das Wundermittel gegen Corona? Wir haben die Antwort! | maintower

    2:55

    Was ist dran wirklich dran: Hilft uns Vitamin D tatsächlich beim Kampf gegen Covid 19? Wir checken mit Internist Tilo Hanfstingl die Fakten.

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    #Coronavirus #Covid19 #VitaminD

  • Impact of Vitamin D on COVID-19

    2:27

  • Connect the Dots: COVID-19 & Vitamin D

    52

    It's called the sunshine vitamin and new research shows Vitamin D's impact on our odds of getting COVID-19.

  • Vitamin D Supplementation in Hospitalized COVID-19 Patients: Saving Lives Podcast

    8:32

    Providing Calcifediol (25-hydroxyvitamin D3) to COVID patients in this Pilot Study showed that it decreased the need for transfer to the intensive care unit. Let's take a look at why we shouldn't exactly put it in the water... yet.

    Show Notes:

    Although great care has been taken to ensure that the information in this podcast are accurate, eddyjoe, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

    My website:
    Instagram:
    Twitter:
    Facebook:
    Podcast:
    My Amazon store for resources you may find helpful:

    Citation:
    Castillo ME, Entrenas Costa LM, Vaquero Barrios JM, et al. Effect of Calcifediol Treatment and best Available Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study [published online ahead of print, 2020 Aug 29]. J Steroid Biochem Mol Biol. 2020;105751. doi:10.1016/j.jsbmb.2020.105751

  • Vitamin D & Coronavirus ???? Schützt uns das Sonnenvitamin vor Viren, Covid-19 & Atemwegsinfektionen?

    22:03

    ⏩ Jetzt meinem neuen Ratgeber bestellen: Welche Nahrungsergänzungsmittel Ihr Herz & Herz-Kreislauf-System stärken: ✅
    ❎ 100 % unabhängig ❎ 100 % studienbasiert ❎ 100 % medizinisch korrekt
    Wollen Sie mehr über Vitamin D erfahren? Hier weitere Videos zum Thema Vitamin D ????:
    ⏩ Vitamin D Mangel - Diese Personen sind besonders betroffen:
    ⏩ Hilft Vitamin D bei Krebs - eine wissenschaftliche Bestandsaufnahme:
    ⏩ Hochdosistherapie von Vitamin D - Was nutzt das Coimbra Protokoll?:
    #vitamind #vitamind2 #coronavirus #covid19
    In den vergangenen Jahren intensivierte sich die Forschung um das „Sonnenvitamin“, gerade weil es stellenweise immer wieder Hinweise darauf gibt, dass eine Supplementierung sogar einen präventiven Effekt in Bezug auf Infektionen der Atemwege haben könnte, z.B. einen Schutz bei Influenza. Durch Covid-19 ist das Thema jetzt natürlich extrem relevant und es stellen sich zwei (Haupt-)Fragen:
    1. Schützt Vitamin D vor der Atemwegsinfektion Covid-19?
    2. Verbessert Vitamin D den Heilungsprozess bei Covid-19-Patienten?

    Dass Vitamin D sehr wichtig für uns ist, lässt sich nicht bestreiten. Es ist an verschiedenen Stoffwechselprozessen beteiligt, vor allem am Knochenstoffwechsel. Ein nachgewiesener Mangel sollte unbedingt ausgeglichen werden. Die Entstehung eines solchen Mangels kann durch viele Faktoren begünstigt werden, u.a. ein hohes Alter, die Hautfarbe, das Körpergewicht, wenig Aufenthalt im Freien und dadurch auch wenig Sonnenexposition. Auch verschiedene chronische Erkrankungen von bspw. Magen, Darm, Leber, Nieren sowie bestimmte Medikamente können potenziell zu einem Mangel führen.

    ???? Daher mein Tipp: Checken Sie unbedingt einmal bei Ihrem Hausarzt/Hausärztin Ihren Vitamin D Spiegel

    Im Video gehe ich in Teil 1 auf den Zusammenhang von Atemwegsinfektionen, wie eine Lungenentzündung und Kindern ein, im Anschluß auf die Situation bei Erwachsenen. Dazu schaue ich mir insgesamt 12 Studien an.















    Gliederung des Videos:
    3:20 ⏩ Was ist Vitamin D?
    4:30 ⏩ Risikogruppen für einen Vitamin D Mangel
    6:00 ⏩ Vitamin D bei Atemwegsinfektionen: Kinder
    11:25 ⏩ Vitamin D bei Atemwegsinfektionen: Erwachsene

    Mehr dazu aber jetzt im Video ????✅

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