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Vitamins to Prevent COVID???

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  • Vitamins to Prevent COVID???

    14:41

    Dr. Christy looks at the data on several vitamins, minerals and supplements and provides recommendations on all.

    REFERENCES:
    EVMS/Dr. Marik COVID Protocols:




    VITAMIN C:


    1. Douglas RM, Hemilä H, Chalker E, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007;(3):CD000980. [PubMed abstract]
    Vitamin D:
    BMJ Article:



    Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583.
    Zhou YF, Luo BA, Qin LL. The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies. Medicine (Baltimore). 2019;98:e17252.


    ZINC:






    B VITAMINS:




    MELATONIN:

    Reiter RJ, Abreu-Gonzalez P, Marik PE, Dominguez-Rodriguez A. Therapeutic algorithm for use of melatonin in patients with COVID-19. Front Med 2020; 7:226.

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  • Vitamin D, Vitamin C, Zinc and COVID - Prevention of COVID

    12:41

    Vitamin D, Vitamin C, Zinc and COVID - Prevention of COVID

    Does colder temperature make you more prone to getting a cold Or COVID?
    Most health experts agree that people spend more time indoors and close contact with other people when it’s cold, which likely increases germs spread.
    Also, experts believe that our immune system may be more active when our body is warmer, as in during the summer months.

    ⏩ Prevention of COVID Timestamps
    00:00 - Introduction
    00:38 - Do Colder Temperatures make you more prone to getting COVID?
    02:52 - Why are COVID more likely to cause infections in winter?
    03:20 - Vitamin D and COVID
    07:20 - Vitamin C and COVID
    09:47 - Zinc and COVID

    This is the Vitamin D that I take:


    Back in 2007, there was this study…

    - In this one particular study looking at the spread of the influenza virus, they put guinea pigs together in a chamber and carried out different environmental experiments on them. They found that low relative humidities of 20%–35% were most favorable for infection, while the transmission was completely blocked at high humidity of 80%.
    They also found that when guinea pigs were kept at 5 °C, transmission occurred with greater frequency than at 20 °C, while at 30 °C, no transmission was detected.
    The authors concluded that low relative humidities produced by indoor heating and cold
    temperatures favored the spread of the influenza virus.

    I also want to add that cold weather, by itself, can cause a runny nose without necessarily
    having a cold allows for the virus to be carried in those secretions, which probably facilitates transmission.
    40% of common colds are caused by rhinoviruses. The second most common cause of cold is the coronavirus, the normal one, not this covid.
    Its been shown that the rhinovirus reproduces more quickly at cooler temperatures means you might catch a cold more quickly if you’re chilly.

    And this probably applies to the coronavirus as well.

    It's likely that with the combination of all of these 5 factors, meaning cooler temp, lower humidity, people staying indoors more often in winter months, cold weather causing runny noses, and our immune system is more active when it's warmer, these combinations of factors likely explain why colds, flu, and COVID are more likely to cause infections in the winter months.
    But there is likely a 6th factor as well. And that is vitamin D. Our bodies don’t normally make vitamin D unless we get sunlight. In the winter months, for most of us in this world, we don’t get enough sunlight to make enough vitamin D. Unless you live warm, maybe you are the exception. So if you aren’t getting enough sunlight in the winter months, that means you have to get enough vitamin D in your diet. And if you don’t do that, you will have low vitamin D levels. Vitamin D helps regulate or Calcium levels and is important for bone and muscle health. It also plays a role in regulating our immune system, but its exact role is not known.

    Why is this important for the common cold, flu, and perhaps with this novel, the coronavirus that’s causing COVID? Well, vitamin D doesn’t affect these viruses themselves. Instead, it affects our immune systems.

    So what is my recommendation for taking Vitamin D?
    The best thing to do is check with your doctor to see if you might have low vitamin D, and if it is low, you’ll def need to get more vitamin D, especially during the winter months.

    Vitamin C is a water-soluble vitamin. It is vital to white blood cells that help to fight infections and overall immune system health. Vitamin C is also important for iron absorption, and being deficient in iron can make you more vulnerable to infections in general.
    The normal, recommended daily intake of vitamin C for adults from the diet and/or supplements is 75 to 120 mg. In addition, you can get about 80 to 90 mg from a cup of orange juice or sliced orange, or even more from kiwi fruit or a cup of sweet peppers.

    Zinc has become one of the most popular suggestions for reducing symptoms of COVID.
    Some studies showed that zinc reduces the duration of a cold by half, while others showed no effect. Another study found that the type of zinc taken determined the result—zinc gluconate lozenges that provided 13.3 milligrams (mg) of zinc lessened the duration of colds, but zinc acetate lozenges that provided 5 mg or 11.5 mg of zinc did not.

    Note: Please watch the whole video to get the proper details. I couldn't provide the whole details for the youtube description character limitations, so I suggest watching the whole video.

    Doctor Mike Hansen, MD
    Internal Medicine | Pulmonary Disease | Critical Care Medicine
    Website:
    IG Account:

    #vitamind #vitaminc #covid

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  • Does Supplemental Vitamin D Help Prevent Covid-19?

    5:25

    Ah, Vitamin D, back again. We’ve made our case on how unnecessary Vitamin D supplements are for outcomes like diabetes, cardiovascular and musculoskeletal health, and overall mortality. But what about its effect on viral infections like Covid-19? Can it reduce symptom severity, or perhaps even reduce your odds of becoming infected in the first place?

    Sources:









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    Acetaminophen, Risk-Taking, and Covid-19:

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    #healthcaretriage #covid-19 #vitaminD

  • Coronavirus Update 59: Dr. Roger Seheults Daily Regimen

    18:33

    COVID-19 Update 59 with Roger Seheult, MD of

    We recorded this video in response to your comments asking what Dr. Seheult's daily regimen is - to optimize his immune system and minimize COVID-19 risk. In the absence of good clinical data that is specific to SARS-CoV-2, Dr. Seheult discusses supplements, sleep, and his daily disinfection routine when removing PPE, getting in his car, and returning home from the hospital. We look forward to more randomized, blinded, placebo-control studies in the future that will build upon the current body of evidence as it relates to immunity and specifically coronaviruses such as SARS-CoV-2.

    Links referenced in this video:

    Johns Hopkins -

    Nutrients -

    Healthline -

    BMJ -

    Trinity College Dublin -

    Eur Respit J -



    Hydrotherapy -






    Some previous videos from this series (visit MedCram.com for the full series):
    - Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?
    - Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses?
    - Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV:
    - Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?:
    - Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?:
    - Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?:
    - Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia:
    - Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19:
    - Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes):
    - Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials:
    - Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu:
    -Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine
    - Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention
    - Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful?
    - How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:

    Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, coronavirus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Sleep, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19) and other medical topics (ECG Interpretation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com

    Speaker: Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

    MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

    Media Contact: customers@medcram.com
    Media contact info:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #Coronavirus

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  • Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus

    1:24

    Professor Roger Seheult, MD explains the important role Vitamin D may have in the prevention and treatment of COVID-19. Dr. Seheult is the lead professor at
    Dr. Seheult illustrates how Vitamin D works, summarizes the best available data and clinical trials on vitamin D, and discusses vitamin D dosage recommendations.

    Roger Seheult, MD is Co-Founder of MedCram and an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine. He is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, & Sleep Medicine

    Interviewer: Kyle Allred, Producer & Co-Founder of MedCram.com

    REFERENCES:

    The National Human Activity Pattern Survey (NHAPS)... (J. of Exposure A. and Env. Epidem.) |

    Aging decreases the capacity of human skin to produce vitamin D3 (The J. of Clin. Invest.) |

    Racial differences in the relationship between vitamin D... (Osteoporosis Int.) |

    Decreased bioavailability of vitamin D in obesity (The American J of Clin. Nutrition) |

    Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases ... (Nutrients) |

    Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis... (BMJ) |

    Randomized trial of vitamin D supplementation to prevent seasonal influenza A... (The American J.of Clin. Nutrition) |

    Vitamin D and SARS-CoV-2 infection... (Irish J. of Med. Sci.) |

    Factors associated with COVID-19-related death... (Nature) |

    Editorial: low population mortality from COVID-19 ... (Alimentary Pharm. & Therap.) |

    The role of vitamin D in the prevention of coronavirus ... (Aging Clin. & Exper. Res.) |

    25-Hydroxyvitamin D Concentrations Are Lower in Patients with ... SARS-CoV-2 (Nutrients) |

    Vitamin D deficiency in COVID-19: Mixing up cause and consequence (Metabolism) |

    Low plasma 25(OH) vitamin D level... increased risk of COVID-19... (The FEBS J.) |

    The link between vitamin D deficiency and Covid-19... |

    SARS-CoV-2 positivity rates... with circulating 25-hydroxyvitamin D levels (PLOS One) |

    Vitamin D status and outcomes for... COVID-19 (Post. Med. J.) |

    Vitamin D Deficiency and Outcome of COVID-19... (Nutrients) |

    “Effect of calcifediol treatment...” (J. of Steroid Bio. Molec. Bio.) |

    Vitamin D and survival in COVID-19 patients... (J. of Steroid Bio. Molec. Bio.) |

    Effect of Vitamin D3 ... vs Placebo on Hospital Length of Stay...: A Multicenter, Double-blind, RCT |

    Short term, high-dose vitamin D... for COVID-19 disease: RCT [SHADE study] (Postgrad. Med. Journal) |

    Association of Vitamin D Status... With COVID-19 Test Results (JAMA Network Open) |

    Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (JCEM) |

    Vitamin D Fortification of Fluid Milk ... A Review (Nutrients) |

    Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients... (Scientific Reports from the Journal Nature) |

    MEDCRAM.COM

    Visit us for videos on over 60 medical topics and CME / CEs for clinicians:
    All coronavirus updates are at MedCram.com (COVID-19 developments, cholecalciferol, vitamin d benefits, vitamin D biochemistry, vitamin B12 etc.)

    Media contact:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #VitaminD

  • Vitamin C and Zinc Studies Report - COVID Update

    8:43

    Vitamin C and Zinc Studies Report - COVID Update

    Welcome to another COVID Update, based on a recent study that looked at giving vitamin C and Zinc for mild COVID illness. Zinc gluconate and vitamin C, aka ascorbic acid, are commonly available over-the-counter supplements that people often take to treat viral illnesses. Zinc is known to play a role in our immune function by helping to produce antibodies, in addition to enhancing our white blood cell's ability to fight infection, especially when it comes to neutrophils, a type of white blood cell. There is also some evidence that zinc deficiency increases pro-inflammatory cytokines.

    Studies done on the first SARS virus have shown that zinc might inhibit its ribonucleic acid polymerase that's the enzyme that allows the virus to replicate its RNA. But the biological activity of zinc against viruses may require ionophores like Pyrithione to accomplish this. Vitamin C is an antioxidant that may play a role in our immune system’s ability to fight infection. In vitro and in vivo studies in chicks have shown that they could be protective against coronavirus. Human trials have found that it may decrease susceptibility to viral respiratory infections. When it comes to the common cold, there is limited evidence to suggest that high doses of oral vitamin C and zinc might reduce the duration of symptoms and decrease the severity of symptoms.

    But what does that mean for zinc in real life?
    Based on a review of 13 studies, if zinc is taken within 24 hours of the first signs of a cold, it might reduce a mean length by a day. And with vitamin C, some research suggests that it can shorten colds by 8% in adults and 14% in kids, but it doesn't appear helpful if taken after the symptoms start. Vitamin C in the INTRAVENOUS form has also been looked at for non-COVID patients is variable. A meta-analysis review investigated its use in critically ill patients. It failed to show a significant association with mortality but inconsistent associations with secondary endpoints, including duration of patients requiring a breathing tube with a ventilator and length of stay in the hospital.
    But what about zinc and vitamin C for the treatment of COVID?
    The COVID A to Z study was a prospective randomized clinical open-label trial at multiple hospitals within a single health system, involving sites in Ohio and Florida. Enrolled participants remained in their own home settings, and all study visits and/or procedures were conducted virtually via telephone, email, computer, or laptop. So we are not talking about hospitalized COVID patients. We're talking about patients with mild, perhaps moderate illness here. A total of 214 patients were randomized, 132 women, 82 men, and 45.

    Patients were randomized in a 1:1:1:1 ratio, meaning 1/4th received vitamin C, 1/4th received zinc, 1/4th received both vitamin C and zinc, and 1/4th received neither, just standard of care, which is nothing more than rest, hydration, and maybe some Tylenol or ibuprofen, but no supplements. The vitamin C group received 10 days of 8,000 mg vitamin C after being diagnosed with COVID based on PCR testing. The zinc group received 50 mg of zinc gluconate at bedtime. The zinc and vitamin C group received 8,000 mg of vitamin C and 50 mg of zinc.

    So we are talking big doses here, much more than what most people take. Patients then tracked their symptoms daily, including potential side effects from vitamin c and zinc. During the course of study, patients admitted to the hospital were considered treatment failures and were no longer required to continue study supplementation or track their daily symptoms. The trial's primary endpoint was the number of days required to reach a 50% reduction in symptom severity score from peak symptom score. Secondary endpoints were the number of days required to get a total symptom severity score of 0, cumulative severity score at day 5, hospitalizations, deaths, adjunctive prescribed medications, and adverse effects of vitamin C and Zinc.

    Based on statistical analysis, there was no significant difference in the primary outcome of days required to reach a 50% reduction in symptoms among the 4 study groups. Patients who received usual care without supplementation achieved a 50% reduction in symptoms on average 4.4 days compared with 3.7 for the vitamin C group, compared to 4.9 days for the zing group, and 3.4 days for the group that received both.

    Doctor Mike Hansen, MD
    Internal Medicine | Pulmonary Disease | Critical Care Medicine
    Website:
    IG Account:
    FB Page:

    #vitaminc #covid #zinc

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  • Medication, Supplements, Vitamins, and COVID-19 | National Kidney Foundation

    2:07

    Donate to support our mission today:
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    Learn about kidney health, kidney disease, and related conditions:

    This video is for: Anyone looking to learn more about using vitamins, supplements, medication, or other methods for the prevention or treatment COVID-19.

    Concepts: National Kidney Foundation, Kidney, Chronic Kidney Disease, Kidney disease, Kidneys, CKD, NKF, COVID-19 Prevention, COVID-19 Treatment, COVID-19 Medication, COVID-19 Vitamins, Coronavirus Vitamin C, Coronavirus Vitamin D, COVID-19 supplements, DIY COVID-19 Treatment, DIY COVID-19 Prevention, Natural COVID-19 Treatment

    About the National Kidney Foundation:
    Fueled by passion and urgency, National Kidney Foundation is a lifeline for all people affected by kidney disease. As pioneers of scientific research and innovation, NKF focuses on the whole patient through the lens of kidney health. Relentless in our work, we enhance lives through action, education and accelerating change.

    Follow NKF at:




    #kidneys #kidneystrong #kidneyhealth #heartyourkidneys #mykidneysmylife

  • Can Vitamin C help prevent COVID-19?

    2:26

    Vitamin C has lately been of interest to researchers in the fight against the COVID-19 pandemic. Large doses of intravenous Vitamin C are being tried in COVID-19 critical patients on ventilators in China.
    Australian researchers reported that they did not find any benefit in using Vitamin C. But the U.S. is planning to try a combination of Vitamin C, Vitamin D, Zinc and hydroxychloroquine for COVID-19 prevention.
    There is still no evidence to prove consuming a high amount of vitamin C is effective against coronavirus. According to Chennai-based Nephrologist Dr. Rajan Ravichandran, caution is required in consuming mega doses of vitamins without prescriptions, especially for long periods.
    Vitamin C or Ascorbic acid is a water-soluble essential nutrient. Being water-soluble, it is not stored in the body and requires daily intake.
    It is a powerful antioxidant with an important role in controlling infections and promoting healing of wounds. Its many functions include synthesis of collagen, chemical messengers in the brain and hormones.
    The source of Vitamin C is fruits and vegetables like oranges and lemons. After consumption, the absorbed Vitamin C is metabolised in the body to oxalate and is removed by the kidneys. 
    Large doses of Vitamin C have been used to improve the immunity and promote wound healing. Normally the body can cope with this high dose by reducing the absorption and increasing the oxalate loss in urine. But in some people, the oxalate can get deposited in the kidneys resulting in kidney failure. This is likely in patients with intestinal disorders and pre-existing kidney disease.
    The daily requirement of Vitamin C is 90mg in adult males, 75mg for females which increases to 120 mg during pregnancy. 
    Deficiency of Vitamin C is rare and but when it occurs, it is called scurvy. The deficiency can manifest with bleeding gums, delayed wound healing, skin spots, hair loss and anaemia.

  • Can vitamin D help prevent COVID-19?

    1:51

    Dr. Jen Ashton has the latest information on the potential benefits of vitamin D.

  • x
  • Vitamin D, Immune System & SARS-CoV-2 | Mechanism of Vit D Immune Regulation & Overview

    12:33

    Vitamin D, Immune System & SARS-CoV-2 (COVID-19) | Mechanism of Vit D Immune Regulation, Overview of Evidence

    In this lesson, I discuss the vitamin D its immune system regulation, specifically with regards to how vitamin D can help protect against respiratory tract infections like SARS-CoV-2 (COVID-19).

    1) Brief Introduction to Vitamin D and SARS-CoV-2

    2) Vitamin D deficiency and increased risk of infections

    3) Vitamin D supplementation and protection against acute respiratory tract infections

    4) Vitamin D and Immune System Regulation (including cytokines like IL-6)

    5) Vitamin D and SARS-CoV-2 (COVID-19), comorbidities and associations

    3) Summary of some Remdesivir data in in-vitro and in-vivo (mice and rhesus monkeys) studies used in treatment of other coronaviruses like SARS-CoV and MERS-CoV

    ****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

    *DISCLAIMER* Although there has been a meta-analysis showing reduced risk of acute respiratory tract infections with daily/weekly recommended doses of Vitamin D, WE DON’T have enough evidence to say that Vitamin D is protective against SARS-CoV-2 (COVID-19) – WE ONLY HAVE ASSOCIATIONS/CORRELATIONS at this point.

    ***This video is merely here to PRESENT INFORMATION from the studies quoted in this video - if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors****

    I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel – all of your support is greatly appreciated!
    JJ

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    **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

    Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

    *Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

  • COVID-19 and Zinc

    22:21

    President Trump taking zinc (WSJ)



    Low zinc levels at clinical admission associates with poor outcomes in COVID-19, (11th October)



    Zinc balances immune responses and also has a proven direct antiviral action against some viruses.

    Zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases

    Increased intracellular zinc concentrations efficiently impair replication

    Resulting in a lower number of viruses

    Retrospective analysis

    Patients admitted in Barcelona

    15th March to 30th April 2020

    Clinical severity of COVID-19 and PMH assessed

    Fasting plasma zinc levels measured routinely at admission

    N = 611

    Mean age, 63 years

    Male 332, (55%)

    Total mortality was 87 patients (14%) during study time

    But

    249 of 611 patients studied

    Of the 249, 21 (8%) died

    Baseline zinc levels

    Died, (21 people) mean plasma zinc = 43 μg/dl

    Survived, (228 people) mean plasma zinc = 63.1 μg/dl

    Higher zinc levels, associated with lower maximum levels of interleukin-6 during the period of active infection

    Zinc level lower than 50 μg/dl at admission, 2.3 times increased risk of in-hospital death

    Compared with those of 50 μg/dl or higher

    Lower zinc levels at admission correlate with higher inflammation in the course of infection and poorer outcome

    Low plasma zinc levels at admission are associated with mortality in COVID-19 in our study

    Further studies are needed to assess the therapeutic impact of this association

    COVID-19: Poor outcomes in patients with zinc deficiency (International Journal of Infectious Diseases, November 2020)

    Chennai, India

    Prospective study of fasting zinc levels in COVID-19 patients at the time of hospitalization

    Healthy controls median 105.8 μg/dl



    Zinc is a trace element with potent immunoregulatory and antiviral properties

    Is utilized in the treatment of coronavirus disease 2019 (COVID-19)

    Patients with serious COVID-19 had significantly low zinc levels in comparison to healthy controls

    Zinc deficient COVID patients developed more complications

    Zinc deficient patients 70.4% developed complications

    Non zinc deficient patients, 30.0% developed complications, (p = 0.009)

    Acute respiratory distress syndrome

    More need of steroids

    Increased mortality

    Zinc deficient COVID patients had a prolonged hospital stay

    Zinc deficient patients, 7.9 days

    Non zinc deficient patients, 5.7 days, (p = 0.048)

    In vitro studies

    Reduced zinc levels increase SARS-CoV-2 virus receptor interactions

    Increased zinc levels inhibit ACE2 expression




    What zinc does

    Catalytic activity of approximately 100 enzymes

    Plays a role in immune function

    Protein synthesis

    Wound healing

    DNA synthesis

    Cell division

    Normal growth and development, pregnancy, childhood, adolescence

    Required for sense of taste and smell

    Zinc and immunity

    Severe zinc deficiency depresses immune function

    Even mild to moderate degrees of zinc deficiency can impair macrophage and neutrophil functions, natural killer cell activity, and complement activity

    Body requires zinc to develop and activate T-lymphocytes

    Low zinc levels have shown reduced lymphocyte proliferation

    …. that can be corrected by zinc supplementation

    Low zinc status has been associated with increased susceptibility to pneumonia and other infections in children in developing countries and the elderly

    Foods
    Oysters
    Sea food
    Beef
    Pork
    Baked beans
    Fortified cereals
    Pumpkin seeds
    Yogurt
    Cashew nuts
    Chickpeas
    Oats
    Almonds

    Vitamin D and zinc can be made in bulk for essentially nothing

  • Best Supplements for COVID 19? Boost Natural Immunity?

    16:38

    Best Supplements for COVID 19? Boost Natural Immunity?

    5 Vitamins and Supplements for Boosting immunity
    Big question these days is how to improve our immunity without having to take medication and something we can do easily at home. Well recently this past week there was a new article talking specifically about zinc and vitamin C by the end of the video-----and we're going to
    Why is evidence important???


    Vit C
    Vit D
    N Acetyl Cysteine
    Melatonin
    Zinc

  • TOP 5 VITAMINS TO BOOST IMMUNITY - How to strengthen IMMUNE SYSTEM

    6:05

    TOP 5 VITAMINS TO BOOST IMMUNITY - How to strengthen IMMUNE SYSTEM.

    Support Us on Patreon :

    If you fall sick very often or frequently suffer from flu, sore throat and skin infections, it’s possible your body needs vitamins to boost the immune system. The best way to increase your vitamin intake is by having a healthy and balanced diet, but sometimes our bodies need an extra boost.
    Most of the time, the immune system does its job to keep us healthy. However if the system sometimes fails to defend us, it can result in illness, infection, or diseases. This is where the body needs reinforcements in the form of vitamins and other immune-boosting nutrients.
    In this video we will look at the Top 5 important vitamins that you need to include in your diet to boost your immune system and fight off infections.

  • New Study - Vitamin D High Dose and COVID-19

    44:53

    New Study - Vitamin D High Dose and COVID-19

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    2% of the patients taking high dose calcifediol were admitted to ICU.
    50% of the patients not taking calcifediol were admitted to ICU.

    Effect of calcifidiol (25(OH)D) on severity and disease progress of COVID-19


    Effect of vitamin D receptor activation


    Vitamin D deficiency in the US population


    Obesity and vitamin d deficiency. A study of their relationship


    What is cholecalciferol?


    What is calcifediol?


    Active Vitamin D synthesis pathway


    Should you always take calcium and vitamin K2 with vitamin D?


    Cathelicidins

  • Vitamin D and COVID NEW Studies - Evidence for a Protective Role of Vitamin D in COVID

    15:47

    Vitamin D and COVID NEW Studies - Evidence for a Protective Role of Vitamin D in COVID

    Vitamin D Supplements in COVID, how much proof do we need?
    Vitamin D has been maligned and praised throughout 2020 and into 2021.

    As a cheap supplement that nearly everyone has access to, why is it getting so much attention?
    Many studies show a strong association between vitamin D deficiency and increased numbers and severity of respiratory infections. These studies show a relationship between vitamin D supplements and COVID, not that vitamin D deficiency causes COVID. This distinction is important because a third variable may actually be responsible for the effect. Imagine you are studying 100 people who have double the number of respiratory infections per year compared to the baseline population. They all have low levels of vitamin D.

    Is having low levels of vitamin D cause their increased risk of respiratory infections?
    Maybe they live in a crowded, understaffed nursing home. They do not get outside and eat a poor diet. These factors could explain the increased risk for infection and the low vitamin D levels. But you would not know that unless you were looking for it or structured your study to remove the effect of other variables that are not measured. Here are five studies that support the relationship between vitamin D deficiency and more severe respiratory diseases.

    Researchers in Germany followed 9548 adults aged 50-75 for 15 years to evaluate their respiratory disease mortality. Among study participants, 44 percent had low vitamin D levels, and 15 percent were deficient. Overall, after adjusting for sex, age, the season of blood draw, school education, BMI, physical activity, and fish consumption, 41 percent of respiratory disease mortality was statistically because of low vitamin D levels. A meta-analysis published in the British Medical Journal in 2017 reviewed 25 randomized, double-blind, controlled trials with 11,321 participants. Vitamin D supplements reduced each individual's risk by at least one respiratory infection. When all the results were averaged together, there was a slight protective effect. While daily and weekly doses of vitamin D reduced risk, single large doses of vitamin D did not. Protective effects of vitamin D were greatest in those with the lowest vitamin D levels.

    In a retrospective study in 2020, Quest Diagnostics in the U.S. looked at the labs for vitamin D levels and SARS-CoV-2 positivity for 191,779 de-identified participants. The authors found a strong inverse relationship between vitamin D levels and SARS positivity that persisted across latitudes, races/ethnicities., sexes, and age ranges. They found the risk of being positive for SARS-CoV-2 was 1.6% lower with each vitamin D increase by 1 ng/ml. A previous study showed that for every 4ng/ml increase in vitamin D, there was a 7% decrease in risk for seasonal respiratory infections.

    When researchers at the University of Chicago Medicine reviewed the health records of 489 patients who had vitamin D testing within the previous year, they found that the relative risk for testing positive for COVID was 1.77 times greater for vitamin D deficient patients when compared to those who were not. In addition, two-thirds of the study participants were non-white, and 47 percent had a BMI greater than or equal to 30 (obese). Though the results were significant, the authors point out that this was a retrospective study. Thus, there may be unknown confounding variables that increase the risk for both vitamin D deficiency and COVID.

    What is my recommendation for taking Vitamin D?
    The best thing to do is check with your doctor to see if you might have low vitamin D, and if it is low, you’ll def need to get more vitamin D, especially during the winter months.

    A common question is, How much Vitamin D should I take a day?
    Personally, I take 1,000 IU per day. I know that I’m not going to run anywhere near toxic levels of vitamin D with that dose, while at the same time, I know that I won’t be vitamin D deficient.

    Doctor Mike Hansen, MD
    Internal Medicine | Pulmonary Disease | Critical Care Medicine
    Website:
    IG Account:
    FB Page:

    #covid #vitamind #covid

  • Vitamin D and immunity

    20:21

    Vit D




  • COVID and Vitamin D | Vitamin D for SEVERE COVID?

    5:57

    COVID and Vitamin D | Vitamin D for SEVERE COVID?

    2020 Is finally coming to an end. But the virus won't be anytime soon. Especially if people don't get the vaccine. December 2020 was the worst pandemic month. And January will be even worse.
    Ivermectin for COVID?
    Vitamin D for Covid? (SEVERE Covid)
    Let's talk.

    ⏩ Timestamps
    00:00 - Intro
    00:11 - January The Worst
    02:38 - COVID Vaccine Allergic Reaction Issues
    04:32 - Ivermectin for COVID (latest update)
    04:51 - Vitamin D for COVID (latest update)

    More people traveled through US airports this past Sunday than any other day this pandemic, about 1.3 million. Simultaneously, more Americans were hospitalized this past week than any other week of the pandemic.

    This past week, about 40% of all ICU patients in the US had Covid, according to data published Monday by the US Department of Health and Human Services. That's up from 16% in late September, 22% in late October, and 35% in late November. More than 63,000 Americans have already died so far this month, which is the worst month of this entire pandemic. And next month is only going to be worse.
    Three big reasons;
    One, because of holiday travel and indoor gatherings.
    Two, because of colder temperatures.
    And three, that new coronavirus variant B.1.1.7 is more contagious, more transmissible. It's nowhere in the US, first identified in a Colorado man.
    So I think that January is going to be the worst month of this entire pandemic.

    Of course, the way we fight this is with distancing and masks, and the more people do this, the better the numbers will be. And the more people who get the vaccine, the higher the likelihood of bringing this pandemic to an end. Most experts believe that about 80% of the population needs to be vaccinated to reach herd immunity. Most polls show that about 60% of Americans want the covid vaccine. Based on my YT poll, 10,000 of you voted. And 47% want the vaccine. 37% don’t want it. And 16% are still undecided.

    So this virus will not be extinguished anytime soon unless these numbers change. The soonest I expect this pandemic to be over would be by next fall. But people need to get the covid vaccine to make this happen. I’m glad that I was able to get my Pfizer vaccine back on Dec 15th. Other than some arm soreness in the first 24 hours or so, I didn’t have any side effects. So, I feel great. And I’m going to get by the second shot of the Pfizer vaccine a week from now. With the second shot, the chances of developing side effects are slightly higher than the first shot, so we’ll see, and I’ll keep you posted.

    One concern with these covid vaccines is the potential for allergic reactions. Reactions to vaccines, in general, are rare. The American College of Allergy, Asthma, and Immunology (ACAAI) has updated its advice regarding allergic reactions to these new mRNA vaccines. They say that anyone with a severe allergic reaction to the first shot should not get the second shot. People with allergies to medications, foods, insects, and latex are no more likely than the general public to be allergic to these covid vaccines.

    It's still unclear whether having had an allergic reaction to an older type of vaccine means people will react badly to the mRNA vaccines. People who have had a previous allergic reaction to a specific component of the new vaccine, such as propylene glycol or lipid nanoparticles, should hold off on getting the vaccine. Regardless, these people should discuss the covid vaccine's benefits and risks with their health care providers, ideally, an allergist. These are the latest recommendations at the time of this video, and they are subject to change.

    Now, with this new coronavirus variant, which scientific experts are saying is more contagious.
    Does that mean the covid vaccine will be less effective to new coronavirus variants?
    This is still unknown at this point.
    And if the vaccine is less effective against this new variant, how much so?
    Again, an unknown. Most scientists think that the vaccine will remain effective against it.

    A lot of people are also talking about the parasitic drug Ivermectin. Is it useful against COVID? Too early to tell.
    Some weak studies show it might help against COVID, but nothing conclusive so far. We will need a large RCT to know if it works or not, and that hasn’t happened yet.

    What did just come out, though, is an RCT for giving Vitamin D to patients with severe COVID from Brazil? We know that vitamin d deficiency is linked with a higher risk for severe COVID. Still, when vitamin D was given to critically ill COVID patients with lower vitamin D levels, it did not shorten their length of stay in the hospital or decrease mortality. The way that I look at it, it's important not to be vitamin D deficient in the first place, as getting a large dose of vitamin D when you are critically ill is not going to save you.

    Doctor Mike Hansen
    Internal Medicine | Pulmonary Disease | Critical Care Medicine

    #covid #vitd #vaccine

  • Could Vitamin D Help Protect You From The Virus? | This Morning

    7:27

    As the forecast turns towards scorching sunshine, new reports this week have suggested a link between vitamin D deficiency and the severity of the Coronavirus. Dr Chris separates fact from fiction when it comes to this important vitamin, and gives his advice on how to make sure you’re getting the right amount.
    Broadcast on 20/05/20
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  • Could Vitamin D Help Fight COVID-19?

    50:29

    My opinion is that you keep the correct levels of vitamin D in your body. Now a days, due to staying indoors, it is possible that you will develop the deficiency of vitamin D. Get this checked by your doctor and use the correct dose to stay healthy.

    Looking to support my work? Here is the link to donate:

    Here are my notes:
    Daily 10 microgram or 400 IU/Day

    Lippincott’s Biochemistry Review 4th Edition. Page 388
    Daily 5 mg of cholecalciferol or 200 IU of Vitamin D.

    However, 800 IU/Day is shown to reduce the incidence of osteoporotic fractures.
    800 IU/Day recommended by the Institute of Medicine to maintain bone health.

    Frank deficiency is when the levels of 25-hydroxycholecalciferol (25OHD) is less than 20 ng/mL (50 mmol/L)


    No consensus that the oral vitamin D supplements are helpful

    Ergocalciferol from plants is called Vitamin D2
    Cholecalciferol from the animal tissue is called Vitamin D3

    7 deidro-cholesterol to (UV light) to cholecalciferol (D3) to 25 hydroxylase in liver to 25 OH D to -hydroxycholecalciferol 1-hydroxylase in kidney to 1,25 DiOH D3




    Vitamin D Receptors are abbreviated to VDR in the notes. These are cytosolic receptors.


    Deficiency of vitamin D makes people more susceptible to respiratory tract infections.
    Vitamin D supplement can reduce these infections by 12%
    Keep in mind, this is for those who are deficient in this vitamin. If you are not deficient, then it will not make a difference. Because, you are already good.
    Evidence is not sufficient to say that vitamin D helps prevent respiratory infections.

    2018 Study

    People with autoimmune diseases commonly have hypovitaminosis D

    What are cathelicidins?


    What are beta defensins?



    2011 Study


    Activation of TLR and PAMPs on macrophages increases the production of 1, alpha hydroxylase and the VDR. This in turn causes more production of cathelicidine and beta defensins 4.

    Vitamin D also affects monocytes to reduce production of IL1, IL6, IL8, IL12, and TNF. Regulating the immune response.

    Vitamin D acts on the dendritic cells to inhibit/reduce their differentiation and maturation. It reduces their MHCII expression, co-stimulatory molecules like CD40, CD80, CD86, decreased production of IL-12 etc.

    2013 Study

    Vitamin D improves immune system by helping produce cathelicidine and by helping modulate inflammatory cascade. Especially for the respiratory infections.
    It also helps produce NFk-B (nuclear factor kappa light chain for activated B cells.)

    (
    Notes about the NFkB

    Helps with cytokine production and cell survival.
    NFk-B factor becomes active when T and B cell receptors become active. Its activation causes the gene expressions that allow T cell development, maturation, and proliferation.
    T and B cells have Vitamin D receptors that help them produce NFk-B
    )

    Continuing the notes from the study:
    In pulmonary infections. Lung epithelial cells are able to convert inactive vitamin D to its active form. This active Vitamin D then helps produce cathelicidine. Which helps kill the pathogens.

    Vitamin D seems to favor TH2 and TH17 cell activation which is anti-inflammatory profile.
    Vitamin D seems to reduce the activation of TH1 cells which are pro inflammatory by their IFN-gamma action.
    A deficiency of vitamin D may dysregulate the inflammatory response of the body.

    Vitamin B also increases the IkBa. This leads to inhibition of NFkB. This helps reduce the production of IL6 and IL8 by inhibiting the production of NFkB.

  • Vitamin D for respiratory infections: Coronavirus Pandemic—Daily Report with Rishi Desai, MD, MPH

    8:28

    For more info and resources:

    #RaiseTheLine #FlattenTheCurve

    Stay on top of the latest COVID-19 news with the Osmosis Coronavirus Pandemic Daily Report. In each report, Osmosis Chief Medical Officer Rishi Desai, MD, MPH, will deliver a short, focused explanation of a specific COVID-19 topic, and provide updates on the current status of the pandemic, both within the US and globally.

    Today's update focuses on COVID-19 and the use of Vitamin D for respiratory infections.

    For more on today's episode please refer to:





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  • Does Vitamin D help with Immunity? | Vitamin D and Covid

    13:05

    Does Vitamin D help with Immunity? | Vitamin D and Covid

    Hopefully, YT does not take this video down, as it's all based on medical studies. However, if they keep doing this, I will have to upload my videos to a different website.

    The Vitamin D supplement that I take:


    Mentioned Video:
    Vitamin D3 (Cholecalciferol) and Vitamin D2 (Ergocalciferol) and Calcitriol
    Video Link:

    So what does not having enough vitamin D have to do with COVID? And IF insufficient vitamin D levels CAUSE more severe disease, why is that? Well, I have to first clarify that it's not proven that insufficient vitamin D levels lead to worse outcomes. But while it hasn’t been proven, it also certainly hasn’t been disproven. And there is more and more compelling evidence suggesting that lower levels lead to worse outcomes. And there’s no question that vitamin D plays an important role in our immune system. More and more studies are coming out that are sorting out its exact role in this capacity. But the link between insufficient vitamin D status and the risk of certain infections remains cloudy. For example, in 2017, a meta-analysis study consisted of 25 separate randomized trials with about 11,000 patients in total, evaluating the incidence of acute respiratory disease.

    Vitamin D supplementation reduced the percentage of patients experiencing an acute respiratory tract infection. The incidence of URTI in the vitamin D group was 40.3%, compared to 42.2% in the placebo group. In a subgroup analysis, vitamin D supplementation was most effective in patients with less than 10 ng/mL and those treated daily or weekly with smaller doses instead of a huge single dose. The takeaway from this meta-analysis study is that being vitamin d deficient probably makes people more prone to getting upper respiratory infections and should take supplemental vitamin D. But people who have low levels should be taking supplemental vitamin D regardless. Vitamin D has major effects on nearly all our immune system cells, including dendritic cells, macrophages, and T and B lymphocytes. These immune cells have a receptor that binds to vitamin D, called the vitamin D receptor, or VDR.

    Here are some questions we still need answers to:
    1) what level of vitamin D is adequate to protect against or minimize the impact of COVID?
    2) What level of vitamin D is considered too high
    3) should more and more people get their vitamin D levels checked, especially during this pandemic, when fewer and fewer people are physically going to the doctor?
    4) should people just supplement themselves? If so, how much?

    These are all tough questions to answer, mainly because we won’t have RCT results for vitamin D anytime soon. However, given that low dose vitamin D is pretty darn safe, it seems quite reasonable for people to take a low dose supplement, especially if they think they might not be getting enough from sunlight or their diet. Of course, ideally, you want to have a discussion with your doctor if possible.

    A common question is, How much Vitamin D should I take a day?
    Personally, I take 1,000 IU per day. I know that I’m not going to run anywhere near toxic levels of vitamin D with that dose, while at the same time, I know that I won’t be vitamin D deficient.

    Doctor Mike Hansen, MD
    Internal Medicine | Pulmonary Disease | Critical Care Medicine
    Website:
    IG Account:
    FB Page:

    #covid #covid19 #coronavirus

  • If You Get COVID 19: Optimize Immune System

    39:55

    Professor Roger Seheult, MD gives practical strategies if you test positive for COVID-19 (or are in contact with someone who tests positive) including:
    0:00 Video Intro
    1:11 Use of a pulse oximeter at home to monitor oxygen saturation and possible COVID pneumonia
    3:02 How to choose a pulse oximeter
    3:34 Tips for using a pulse oximeter
    5:35 Who qualifies for monoclonal antibodies (bamlanivimab, casirivimab, and imdevimab from Lily and Regeneron), how they work, and how effective are they?
    11:11 The varying level of data/study strength for different strategies
    12:55 Vitamins that may boost immune function: Vitamin D, NAC, Vitamin C, Quercetin, Zinc, Vitamin K-2, Magnesium
    18:27 The importance of adequate sleep (Melatonin discussed)
    21:57 Core body temperature elevation (the data on hydrotherapy and sauna use)
    35:11 Isolation strategies at home: ventilation, HEPA filtration, mask-wearing
    37:32 Summary of strategies to consider if testing positive for COVID 19

    Roger Seheult, MD is the co-founder and lead professor at
    He is an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine
    Dr. Seheult is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine

    Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com

    REFERENCES:

    The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications (Anesth Analg) |

    The mystery of the pandemic's ‘happy hypoxia’ (Science) |
    Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline (JCEM) |

    SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19 (NEJM) |

    An EUA for Bamlanivimab—A Monoclonal Antibody for COVID-19 (JAMA Network) |

    Short term, high-dose vitamin D... for COVID-19 disease: RCT [SHADE study] (Postgrad. Med. Journal) |

    The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review (Int J Endocrinol) |

    Vitamin D and COVID 19: The Evidence for Prevention and Treatment of SARS-CoV-2 |

    Thinking About Getting a COVID-19 Vaccine? CDC Weighs In (Contagion Live) | 

    Monoclonal Antibody Successful in Clearing Viral Load for Mild COVID-19 Patients (Contagion Live) | 

    Some home-based hydrotherapy techniques:

    Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations (SAGE) | 

    Ventilation in Buildings (CDC) | 

    Coronavirus Update 59: Dr. Roger Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) |

    The Coronavirus Pandemic: Airborne Transmission, Ventilation and School and Workplace Reopening (Harvard T.H. Chan School of Public Health) | 


    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:

    All coronavirus updates are at MedCram.com (including COVID-19 developments, monoclonal antibodies (bamlanivimab, casirivimab, and imdevimab from Lily and Regeneron), pulse oximter use, possible vitamin d benefits, quercetin COVID, HEPA filters, melatonin, Vitamin C, Zine, Ventilation etc.)


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    #COVID19 #SARSCoV2 #stopthespread

  • 5 Covid-19 Supplements You Should be Taking

    7:13

    IG: dr.sam.md


    Hey Fam, Dr. Sam here. I hope you guys are keeping safe, socially distancing, donning masks as much as possible, and washing your hands frequently.

    In this video I talk about 5 supplements you can take to help your body fight and protect against covid-19. I have included references and time stamps below. These recommendations have been adapted from our practices at my hospital, as well as from the Marik Covid-19 Protocol. Because Covid-19 is so new the research to support the use of these supplements are largely from lab or in vitro studies, studies done on previous iterations of Coronavirus (SARS and MERS were caused by Coronavirus), and research regarding the intrinsic anti-viral properties found within these supplements. I will include references below.

    Before making any sort of decision, its important to do a cost/benefit analysis: these supplements are cheap, readily available, safe (if taken the recommended amount), and will likely confer some benefit, therefore I would remiss to not recommend.

    Speak to your Primary Care Doctor before staring any new supplement!

    Time Stamps:
    Zinc 2:16 (50mg Daily)
    Vitamin C 3:10 (1000mg Daily)
    Melatonin 4:03 (0.3mg In The Evening)
    Quercetin 4:50 (500mg Daily)
    Vitamin D 5:21(1000 iu Daily)


    References and Discussion:

    Marik Covid-19 Protocol:


    Zinc:
    Zinc has been to shown to inhibit Coronavirus RNA Polymerase, and in doing so, serves as an impediment to Coronavirus replication.



    Additionally Zinc has been shown to reduce the duration of colds by approximately 1 day, see the systematic review, linked below.



    Only take the recommended amount because too much zinc can lead to zinc toxicity, furthermore, zinc in large amounts can interfere with your body's ability to use copper.

    Vitamin C:
    Vitamin C has intrinsic Anti-Viral properties and is an essential cofactor in the proper functioning of the immune system!



    Additionally Vitamin C is water soluble, and so it is less resistant to overdose (excess can dissolve in water and your body can pee it out). For more information on which vitamins you can over dose on either head over to my instagram @dr.sam.md (

    Or check out the Vitamin Overdose video on my youtube channel.



    If you have a propensity to form Kidney Stones, be careful, because excess vitamin C can increase chance of getting kidney stones.

    Melatonin:
    Melatonin is a well known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS (Acute Lung Injury/Acute Respiratory Distress Syndrome) caused by viral and other pathogens.



    Melatonin can interact with some blood pressure medications and some blood thinners - although the interaction is not strong, it should be considered.

    Quercetin:
    Quercetin is a dietary flavonoid found in fruits and vegetables including apples, black, green and buckwheat tea, onions, red grapes, cherries, raspberries, and citrus fruits. It has anti-inflammatory and antioxidant properties. It was found to be an efficacious compound in the treatment of SARS which was caused by a previous iteration of Coronavirus. It did this by inhibiting protease which is an enzyme the virus uses to dock onto cells.





    Vitamin D:
    Vitamin D has been shown to induce proteins called defensins that sit wedged within the cell wall and help to defend that cell wall against bacteria and viruses! Check this article titled, Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths



    Additionally, Vitamin D is fat soluble and therefore has a higher potential for overdose. Bear that in mind. If you would like more information on which vitamins you can over dose on check out my Instagram or the other video posted on my channel.

    instagram @dr.sam.md (

    If you have any questions please feel free to email me at Askdrsammd@gmail.com or message me on instagram!

  • Can Supplements Prevent and Treat COVID 19 | Vitamin D, Vitamin C, and Zinc

    7:37

    Can supplements prevent or treat COVID 19? I review current data on Vitamin C, Zinc, and Vitamin D. Unfortunately for two of these, data is lacking in supporting their use for prevention or treatment. Vitamin D however does show some potential. More studies are needed before making any definitive claims however.

    In full disclosure, I do take vitamin C and Vitamin D daily. They can't hurt right? As long as you don't take too much that is.

    Studies mentioned in this video:

    Vitamin C:
    Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection
    The COVID A to Z Randomized Clinical Trial -

    Zinc:
    Low zinc levels at clinical admission associates with poor outcomes in COVID-19 -

    Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection
    The COVID A to Z Randomized Clinical Trial -

    Vitamin D:
    Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study -

    Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study -

    No significant association between vitamin D and COVID-19. A retrospective study from a northern Italian hospital -

    Is there a link between vitamin D status, SARS‐CoV‐2 infection risk and COVID‐19 severity? -

    Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy -

    Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results -

    Vitamin D concentrations and COVID-19 infection in UK Biobank -

    0:00 Intro
    1:00 Vitamin C and Zinc
    3:20 Vitamin D
    5:45 Supplement Dose

    ------------------------------------
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    This video is for educational purposes only. It is not intended to diagnose or treat any condition in any way. Always consult a medical professional for matters concerning your personal health.

    #covid19 #supplementsforCOVID #vitaminsforCOVID

  • How To Boost Your Immune System Against Coronavirus | TODAY

    2:27

    Dr. Mehmet Oz of “The Dr. Oz Show” tells TODAY that there are proactive steps you can take against the coronavirus, such as boosting your immune system with fruits and vegetables, vitamin D3 and a flu shot. He says to avoid shaking hands and touching your face and to wash your hands frequently.
    » Subscribe to TODAY:
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    How To Boost Your Immune System Against Coronavirus | TODAY

  • Coronavirus Pandemic Update 97: Vitamin D & COVID-19 Immunity, The Endothelium, & Deficiencies

    13:31

    The role of vitamin D in preventing viral infections, including COVID-19, is gaining attention as more studies are released. In this video, Dr. Seheult of discusses a recent vitamin D review article published in the peer-reviewed journal Nutrients which has compelling implications for COVID-19 and overall vascular and endothelial health. (This video was recorded July 16, 2020).

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    LINKS / REFERENCES:

    JCEM Journal |

    Nutrients Review of Vitamin D |

    Johns Hopkins Tracker |

    Simple Vitamin D Pathway |


    PREVIOUS COVID-19 UPDATES:

    Please visit MedCram.com for the full series:
    - Coronavirus Pandemic Update 96: RNA Vaccine; Ivermectin; von Willebrand Factor and COVID-19
    - Coronavirus Pandemic Update 95: Widespread Clotting on Autopsy; New COVID-19 Prognostic Data
    - Coronavirus Pandemic Update 94: Inhaled Steroids COVID-19 Treatment; New Pneumonia in Kazakhstan?
    - Coronavirus Pandemic Update 93: Antibodies, Immunity, & Prevalence of COVID-19 - New Data from Spain
    - Coronavirus Pandemic Update 92: Blood Clots & COVID-19 - New Research & Potential Role of NAC
    - Coronavirus Pandemic Update 91: Remdesivir Pricing & Disparities in Drug Availability
    - Coronavirus Pandemic Update 90: Assess The Quality of COVID-19 Info With A Validated Research Tool
    - Coronavirus Pandemic Update 89: COVID 19 Infections Rising in Many States; Dexamethasone Cautions
    - Coronavirus Pandemic Update 88: Dexamethasone History & Mortality Benefit Data Released From UK
    - Coronavirus Pandemic Update 87: More on Dexamethasone; Do COVID-19 antibodies last?
    - Coronavirus Pandemic Update 86: COVID-19 Testing & Cases Increasing but Daily Deaths Decreasing
    - Coronavirus Pandemic Update 85: Dexamethasone and Key Questions to Ask if in The Hospital (Part 2)
    - Coronavirus Pandemic Update 84: Key Questions to Ask if in the Hospital for COVID-19 (Part 1 of 2)
    - Coronavirus Pandemic Update 83: High Fructose, Vitamin D, & Oxidative Stress in COVID-19
    - Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D
    - Coronavirus Pandemic Update 81: New Data on Hydroxychloroquine Side Effects & Prevention of COVID-19

    All coronavirus updates are at MedCram.com (including the diagnosis, prevention, treatment, vaccine developments, dexamethasone, inhaled steroids, vitamin D and the endothelium, SARS-CoV-2 antibody tests, coronavirus misinformation, infodemic, peer-reviewed research, and more).
    We offer many other medical topics (ECG Interpretation, thrombosis, pulmonary embolism, myocardial infarction, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at our website.


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    #COVID19 #SARSCoV2 #FOAMed

  • Melatonin, Zinc, and Vitamins for Coronavirus: Its Pascals Wager All Over Again

    4:47

    As you're here on YouTube, you may want to watch How Social Media Hacks Your Brain --~--
    “It’s safe, why not try it?” is a good argument for any ONE drug. But it falls apart quickly.

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  • Vitamin D and Immunity, Lots of Evidence

    30:26

    Public Health England
    Vitamin D recommendations


    Vit D and COVID


    Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.

    Prevalence and correlates of vitamin D deficiency in US adults





    About 42% of the US population is vitamin D deficient. However, this rate rises to 82% in black people and 70% in Hispanics

    Vit D deficiency in Ireland

    Vitamin D is essential for bone and muscle health


    Arizona University





  • COVID-19 and Vitamin D | Association Between Vitamin D Deficiency and COVID-19

    1:2:02

    Ninja Nerds,
    #COVID #VitaminD #coronavirus
    In this lecture, Zach Murphy, PA-C will present on the association between Vitamin D levels and COVID-19. We will be presenting on all of the current evidence that is available on the association between Vitamin D deficiency and COVID-19. Please scroll down to the bottom of our description box to review all of our references on the association between Vitamin D deficiency and COVID-19. Please enjoy this lecture and be sure to check out all of our social media pages and ways to donate below!

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    REFERENCES
    1) Decreased Vitamin D associated with increased mortality in hospitalized COVID-19 patient's.
    2) Decreased Vitamin D associated with increased ventilation requirements in COVID-19 patient's.
    a)
    b)
    c)
    d)
    e)
    f)

    3) Decreased Vitamin D associated with increased SARS-CoV-2 positive PCR's.
    a)
    b)
    c)
    d)

    4) Decreased Vitamin D is associated with increased CRP, fibrinogen, and D-dimer levels in COVID-19 patient's.
    a)
    b)

    5) Decreased Vitamin D is associated with decreased clearance of SARS-CoV-2.
    a)
    b)
    c)
    d)

    6) Decreased Vitamin D is associated in elderly, African Americans, hispanics, and obesity.
    a)
    b)
    c)

    7) Decreased Vitamin D is associated with worsening of conditions such as CHF, CAD, DM, and HTN.
    a)
    b)
    c)
    d)

    8) Vitamin D has been shown to be effective against viral respiratory tract infections.
    a)

    Vitamin D Dosage:


    Vitamin D Toxicity:

    Vitamin D Immunology:
    a. Cathelicidins:

    b. Beta Defensins:

    c. Vitamin D and Cytokines:


    d. Vitamin D Metabolic Pathway: Lehninger's Principles of Biochemistry Textbook

  • Vitamin D deficiency in the UK

    28:46

    1st October, Vitamin D, news and science


    16th September, Vitamin D and pandemic science


    12th September, Vitamin D, Large scale studies


    6th September, Vitamin D, Frist clinical trial


    27th July, Vitamin D, Science


    20th June, Vitamin D hits the media


    10th June, Vitamin D update


    18th May, Dr Shelton, Part 1, Reports from New Zealand


    21st May, Dr Shelton, Part 2, Vitamin D


    10th May, Vitamin D dose


    15th April, Vitamin D and Immunity, Lots of evidence


    9th March, Vitamin D and immunity


    There is not enough evidence that vitamin D supplements protect people against Covid-19, an expert panel says.



    Institute for Health and Care Excellence

    Public Health England

    Scientific Advisory Committee on Nutrition

    More research needed

    Insufficient evidence

    Advised to take a daily supplement this winter to keep bones and muscles healthy

    10 micrograms (400 international units)

    Nobel prize, 1928, Adolf Windaus

    Dr Paul Chrisp

    We are continuing to monitor evidence as it is published and will review and update the guidance if necessary

    Determinants of vitamin D deficiency in the UK (Clinical Nutrition)

    University of South Australia (16th December)







    Using UK Biobank data



    Severe vitamin D deficiency remains an issue throughout the UK

    Cross-ethnic analyses on the prevalence and determinants of vitamin D deficiency

    25(OH)D equal to or less than 25 nmol/L Calcifediol

    10 ng/ml

    Data from 440,581 UK Biobank participants

    415,903 identified as White European

    7,880 Asian

    7,602 Black African

    1,383 Chinese

    6,473 of mixed ancestry

    Prevalence of vitamin D deficiency

    Asian ancestry

    57.2% in winter or spring

    50.8% in summer or autumn

    Black African ancestry

    38.5% in winter and spring

    30.8% in summer or autumn

    Mixed ancestry

    36.5% in winter and spring

    22.5% in summer or autumn

    Chinese ancestry

    33.1% in winter and spring

    20.7% in summer or autumn

    White European ancestry

    17.5% in winter and spring

    5.9% in summer or autumn

    Participants with higher socioeconomic deprivation

    More likely to have 25(OH)D deficiency compared to less deprived participants (P = less than 1 × 10 −300)

    This pattern was more apparent among those of White European ancestry

    Regular consumption of oily fish was associated with reduced odds of vitamin D deficiency across all ethnicities

    Asians are less likely to eat fish or use vitamin D supplements compared to other ethnicities

    Outdoor-time in summer was less effective for Black Africans than White Europeans

    Other risk factors

    Living further north

    Indoor employment

    Computer time and games

    Professor Elina Hypponen (SA)

    The severity of vitamin D deficiency is concerning

    especially with the high rates of COVID-19 infections in Europe and elsewhere in the northern hemisphere this winter

    Clinical trials have shown that vitamin D supplements are beneficial in the prevention of respiratory infections and even mortality

    Vitamin D is not expensive and the doses which have shown the greatest benefits are those that we can all acquire over the counter from the local pharmacy

    Given the COVID-19 pandemic, now is really the time for all who may be affected to take action

  • Covid-19 News: Vitamin C, Zinc Safe But Should Not Be Taken For A Long Time - AIIMS Chief

    1:13

    Covid-19 News: AIIMS chief Dr Randeep Guleria made an important clarification on use of immunity boosters like multivitamins and zinc supplements, saying they do no harm, but should not be taken for prolonged periods. He advised people to eat healthy and get them from natural sources.

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    #Coronavirus

  • Coronavirus Update 111: Masks; New Vitamin D Data and COVID 19; n acetylcysteine

    13:59

    Professor Roger Seheult, MD discusses important COVID 19 Updates including:
    - A new study on oxygenation levels when wearing masks
    - New data on vitamin D levels and COVID-19 infections
    - The results of a recent study of hospitalized patients using NAC (N Acetylcysteine)
    - An overview of recent coronavirus data from the United States, United Kingdom, Spain, Canada, India, Hawaii, and more (This video was recorded on October 9, 2020).

    Dr. Seheult is the co-founder and lead instructor at

    LINKS / REFERENCES:

    Johns Hopkins Tracker |

    Worldometer |

    Effect of Face Masks on Gas Exchange in Healthy Persons and Patients with COPD |

    SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels |

    Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19 (Clinical Infectious Diseases) |


    THE MEDCRAM WEBSITE:

    Visit us for videos on over 60 medical topics and CME / CEs for medical professionals:


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    RECENT PREVIOUS COVID-19 UPDATES:

    Please visit MedCram.com for the full series:
    - Coronavirus Pandemic Update 110: Trump's Risk Factors and COVID-19 Prognosis; Interferon
    - Coronavirus Pandemic Update 109: New Data From Europe As COVID 19 Infections Rise
    - Coronavirus Pandemic Update 108: High Risk COVID 19 Behaviors; Cases Rise in Europe
    - Coronavirus Pandemic Update 107: Monoclonal Antibodies for COVID 19 Treatment and Prevention?
    - COVID 19 Update Update 106: Comorbidities and Excess Deaths; Bradykinin and Coronavirus
    - Coronavirus Pandemic Update 105: FDA Authorized Treatments; COVID 19 Vaccine Update
    - Coronavirus Pandemic Update 104: COVID 19 Reinfection & Immunity
    - Coronavirus Pandemic Update 103: Convalescent Plasma Treatment & the FDA; College Campuses Close
    - At Home, Cheap, COVID-19 Tests with Results in 15 Minutes: How to Fix Testing with Dr. Michael Mina

    All coronavirus updates are at MedCram.com (including COVID 19 diagnosis, prevention, treatment, vaccine COVID 19, vitamin D and COVID 19, covid 19 prevention, vitamin d covid 19, vitamin d deficiency, NAC (N acetylcysteine), surgical mask vs N95 mask vs cloth mas efficacy, interferon, remdesivir, restaurants and COVID 19, and more).
    We offer many other medical topics (ECG Interpretation, thrombosis, pulmonary embolism, myocardial infarction, hypertension, DKA, influenza, measles, mechanical ventilation, etc.) on our website.


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    MEDIA CONTACT:

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    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
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    #COVID19 #SARSCoV2 #VitaminD

  • Vitamins and Supplements: An Evidence-Based Approach

    1:27:58

    (2:50 - Main Presentation) Dr. Jeffrey Tice, UCSF Department of Medicine, looks at vitamin use and the benefits and harms from these dietary supplements. [11/2013] [Show ID: 25642]

    More from: Eating for Health (and Pleasure): The UCSF Guide to Good Nutrition
    (

    Explore More Health & Medicine on UCTV
    (
    UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.

    UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
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  • Vitamins D and K2

    40:22

    Download my two educational text books for free using this link:

    Hard copy of the Physiology Notes text book on ebay,

    Hard copy of the Pathophysiology text book,

    Latest on Vitamin D


    Basically, consider 400 units (10 mcg) per day

    But, NHS mid Essex



    Routine screening of vitamin D levels and prescribing of Vitamin D is not advisable.

    Both clinical symptoms and risk factors must be present before measuring Vitamin D levels (25OHD).

    As yet there is no clear evidence to prove the risks from non-symptomatic Vitamin D deficiency.

    Adults

    Vitamin D levels less than 30nmol/L (12ng / ml)

    Oral capsules, 40,000 units (1,000 mcg or 1 mg) colecalciferol weekly for 7 weeks

    (400 units per day = 2,800 units per week)

    Vitamin D levels 30 – 50 nmol/L (12 – 20 ng / ml)

    Buy your own, 400 units per day

    Vitamin D levels more than 50 nmol/L (20 ng / ml)

    Buy your own, consider, 400 units per day

    Vitamin K1

    Phylloquinone

    Involved in blood coagulation (1929)

    Found in plant foods like leafy greens

    Vitamin K2







    Menaquinones

    Mostly bacterial origin

    Animal-based and fermented foods

    Adult vitamin K Adequate Intakes, 90 -120 mcg

    Fermented foods

    Sauerkraut

    Natto

    High fat dairy from grass fed cows

    Eggs

    Animal organs

    Gut bacteria

    Antibiotics

    Vitamin K might play a role, osteoporosis and coronary heart disease

    Vitamin K-dependent proteins



    Vitamin K2 supplements may improve bone and heart health, while vitamin K1 has no significant benefits



    Promotes bone calcification

    Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women



    May prevent tissue calcification

    Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats



    Vitamin K2 (MK-4) reduced blood vessel calcification whereas vitamin K1 did not



    Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study



    K2 may help with dental health



    Especially with vitamin D



    Links with liver cancer



    Links with preventing advanced prostate cancer

    Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)



    Synergistic effect with vitamin D

    Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy



    Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice



    Determine the concentrations of 25-OH-vitamin D at which the risk of hypercalcemia

    N = 25,567

    Hypervitaminosis D was defined at serum 25-OH-vitamin D more than160 nmol/L (64 ng / ml)

    Results:

    382 samples were identified as the first record of hypervitaminosis D

    39 presented hypercalcemia (10.2%)

    Some had 25-OH-vitamin D levels between 161 and 375 nmol/L.

    (most subjects presented hypercalcemia at serum concentrations of 25-OH-vitamin D less than 375 nmol/L, 150 ng / ml)

    In 15 subjects, hypercalcemia could be directly attributed to vitamin D

    In no case, serum calcium achieved concentrations considered as critical values (more than13 mg/dl).

    Conclusion

    Hypercalcemia due to vitamin D represented less than 4% of the total hypervitaminosis D detected

    Less than 0.1% of the tests performed.

    Healthline



    No strong evidence proves that moderate amounts of vitamin D are harmful without an adequate intake of vitamin K. However, research is ongoing, and the picture might become clearer in the near future.

  • Does immune protection play any part in COVID-19 severity? | COVID-19 Special

    11:46

    In times of the coronavirus pandemic, it's important to stay as healthy as possible. Having a balanced diet can help. The World Health Organization suggests:
    #1 Eating a variety of foods from different nutritional groups
    #2 including plenty of fruit and vegetables.
    #3 The WHO also recommends eating a diet rich in whole grains and nuts
    #4 limiting your intake of sugar, salt and fat.
    #5 Practising good food hygiene to avoid becoming sick of food-borne disease.
    #6 Limiting your consumption of alcohol.

    Research shows improving nutrition helps support optimal immune function. So if you catch Covid-19, your immune system may be better equipped to fight it.

    Subscribe:

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    #Coronavirus #Covid19 #ImmuneSystem

  • COVID-19 Insights: Could Vitamin C Help with COVID-19?

    28:46

    Here are the references and my notes
    Vitamin C (Ascorbic Acid)

    Found in plants, citrus fruits, tomatoes, and green vegetables
    Water soluble hence extra dose is peed out.
    Deficiency causes scurvy
    Large doses cause diarrhea


    Reason that people looked into it was that the people with vitamin C deficiency had more occurrences of pneumonia.

    Normal dose is 90 mg/day. Add 30 mg/day for pregnant women, and 35 mg/day for smokers.

    Functions:
    Antioxidant
    Neutralize reactive oxygen species or free radicals.
    Needed in procollagen hydroxylation during the collagen synthesis.

    COVID-19 related
    It helps shorten the flu duration by about 8% in adults and 14% in children
    Helped prevent the occurrence of flu in people with rigorous physical activity when given in megadoses IV.
    It has helped reduce the seriousness and ventilation need by patients.
    A study is on going in China that will conclude in September.



    Is useful in megadose

    Claims that megadoses caused 85% reduction in reporting of the flu and cold symptoms.


    Mixed results

    Protective for the skin (collagen synthesis.)

    Needed by the phagocytic cells when they are performing oxidative burst. NADPH is used to produce reactive oxygen species.

    Some evidence that it reduces lung inflammation during the flu infection.


    Study in Chinese language


    Need to study the effects


    Study that vitamin c is marginally useful in people engaged in rigorous activities.


    Marginally helpful.


    Maybe helpful


    Helpful for the immune cells


    Helpful during infections

  • Coronavirus Pandemic Update 83: High Fructose, Vitamin D, & Oxidative Stress in COVID-19

    22:02

    COVID-19 Update 83 with Roger Seheult, MD of
    Oxidative stress may play a key role in the severity of COVID-19 infection. A variety of studies have demonstrated how high sugar intake (and fructose in particular - such as high fructose corn syrup) contributes not only to oxidative stress but to the inactivation of a usable form of vitamin D as well. Join Dr. Seheult for illustrations of how these pathways work.
    (This video was recorded June 12, 2020).
    -----------------------------------------
    Visit us at our website for videos on over 60 medical topics:

    Get notified of new videos by subscribing to MedCram:
    -------------------------------------------

    Links referenced in this video:

    Johns Hopkins Tracker -

    Worldometer

    Nutrients -

    HHS -

    Plos One -

    American Journal of Physiology, Endocrinology and Metabolism -

    Global Public Health -

    IJMS -

    Univ. of Washington -

    Glucose Illustration -

    -------------------------------------------

    Some previous videos from this series (visit MedCram.com for the full series):
    - Coronavirus Pandemic Update 82: Racial Disparities with COVID-19 & Vitamin D
    - Coronavirus Pandemic Update 81: New Data on Hydroxychloroquine Side Effects & Prevention of COVID-19
    - Coronavirus Pandemic Update 80: COVID-19 Retractions & Data (Hydroxychloroquine, ACE Inhibitors)
    - Coronavirus Pandemic Update 79: COVID-19 Vaccines to Keep an Eye On - mRNA, Antigen, Others:
    - Coronavirus Pandemic Update 78: Mask Controversy; Vaccine Update for COVID-19
    - Coronavirus Pandemic Update 77: Remdesivir Update; COVID-19 in Mexico
    - Coronavirus Pandemic Update 76: Antibody Testing False Positives in COVID-19
    - Coronavirus Pandemic Update 75: COVID-19 Lung Autopsies - New Data
    - Coronavirus Pandemic Update 74: Vitamin D & COVID 19; Academic Censorship
    - Coronavirus Pandemic Update 73: Relapse, Reinfections, & Re-Positives - The Likely Explanation
    - Coronavirus Pandemic Update 72: Dentists; Diabetes; Sensitivity of COVID-19 Antibody Tests:
    - Coronavirus Pandemic Update 71: New Data on Adding Zinc to Hydroxychloroquine +
    Azithromycin:
    - Coronavirus Pandemic Update 70: Glutathione Deficiency, Oxidative Stress, and COVID 19
    - Coronavirus Pandemic Update 69: NAC Supplementation and COVID-19 (N-Acetylcysteine)
    - Coronavirus Pandemic Update 68: Kawasaki Disease; Minority Groups & COVID-19:
    - Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor
    - Coronavirus Pandemic Update 66: ACE-Inhibitors and ARBs - Hypertension Medications with COVID-19

    All coronavirus updates are at MedCram.com (including a discussion of the diagnosis, prevention, treatment, and vaccines for COVID-19 - including mRNA vaccines, randomized controlled trials, and recent journal retractions related to ACE inhibitors, ARBs, coronavirus second wave, fructose, high fructose corn syrup, oxidative stress, and vitamin D) and we offer many other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.).

    -------------------------------------------

    Speaker: Roger Seheult, MD
    Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
    Associate Professor at the University of California, Riverside School of Medicine

    MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

    Media Contact: customers@medcram.com
    Media contact info:

    MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
    #COVID19 #SARSCoV2 #FOAMed

  • Vitamin D: Mayo Clinic Radio

    9:26

    Dr. Sundeep Khosla, an endocrinologist at Mayo Clinic, explains the importance of vitamin D. This interview originally aired July 15, 2017.

  • 5 Food Nutrients to Supercharge Your Immune System

    6:35

    ►???????????????? ???????????????? ???????????????????????????? ???????? ???????????? ???????????????????????? ???????? ???????????????????? :-

    ►???????????????????????????????? ???????????? ???????????????????????????? ???????????? ???????????????????? ???????????? ???????????????????? ???????????????? ???????????????? ???????????????????????????????? ????????????????
    ►???????????????????????????? :-

    ???????????????????????????? ???????? ???????????????????????????????????? :-


    5 Food Nutrients to Supercharge Your Immune System

    Certain foods may be helpful for boosting the immune system and preventing colds and the flu. Here's a look at five types of nutrients that your immune system needs to perform and which foods to find them in.


    Vitamin C
    ---------------
    An essential nutrient, vitamin C acts as an antioxidant. Antioxidants help fight free radicals, a type of unstable molecule known to damage the immune system.1 There's some evidence that vitamin C may be particularly helpful in boosting the immune systems of people under major stress. To increase your vitamin C intake, add these foods to your diet:
    citrus fruits and juices (such as orange and grapefruit)
    kiwi fruit
    red and green peppers
    broccoli
    strawberries


    Vitamin E
    ----------------
    Like vitamin C, vitamin E is a powerful antioxidant. Research suggests maintaining ample levels of vitamin E is crucial for maintaining a healthy immune system, especially among older people. To get your fill of vitamin E, look to these foods:
    wheat germ oil
    almonds
    sunflower seeds
    hazelnuts
    peanut butter


    Zinc
    --------
    Zinc is an essential mineral involved in the production of certain immune cells. The National Institutes of Health (NIH) caution that even mildly low levels of zinc may impair your immune function.2 Here are some top food sources of zinc:
    oysters
    baked beans
    cashews
    raisin bran
    chickpeas


    Carotenoids
    --------------------
    Another type of antioxidant, carotenoids are a class of pigments found naturally in a number of plants. When consumed, carotenoids are converted into vitamin A (a nutrient that helps regulate the immune system).3 Carotenoids are better absorbed when cooked or eaten with fat.
    Look to these foods to boost your carotenoids:
    carrots
    kale
    apricots
    papaya
    mango
    sweet potato
    spinach
    collard greens


    Omega-3 Fatty Acids
    ------------------------------------
    Omega-3 fatty acids are a type of essential fatty acid known to suppress inflammation and keep the immune system in check.4 Although it's not known whether omega-3s can help fight off infections (such as the common cold), research suggests that omega-3s can protect against autoimmune disorders like Crohn's disease, ulcerative colitis, and rheumatoid arthritis. Try these omega-3-rich foods:
    oily fish (including mackerel, tuna, salmon, sardines, herring, and trout)
    flaxseed
    walnuts
    chia seeds


    Taking Supplements to Boost Your Immune System
    Although supplements containing high doses of antioxidants and other nutrients found in whole foods are often touted as natural immune-boosters, some research indicates that taking dietary supplements may have limited benefits for the immune system. Additionally, these nutrients are better obtained from foods than supplements. If you're still considering taking them, it's a good idea to consult your healthcare provider first to weigh the pros and cons.


    #foodstoboostimmunesystem #immunesystemboosters #foodstoimproveimmunity #immunity #improveimmunity #vitaminc #zincmineral #zinc #carotenoids #vitaminE #omega3fattyacids #omegafattyacids #covid19 #coronavirusimmunity #covid19immunity #foodsforcovid19 #coronavirusdisease

  • Vitamin D reduces hospital risk

    13:59

    Vitamin D deficiency is associated with higher hospitalisation risk from COVID-19: a retrospective case-control study (June 2021)

    Not funded





    Large scale, retrospective case-control study

    North West of England

    Two hospital groups

    Lancaster and Tameside and Glossop

    Objective

    Is hospitalisation with COVID-19 more prevalent with lower vitamin D levels

    Individuals with results of serum 25-hydroxyvitamin D (25[OH]D)

    1st April 2020 and 29th January 2021

    Deficient = less than 25 nmol/L (10 ng/ml)

    Insufficient = 25-50 nmol/L (10 to 20 ng/ml)

    N = 80,670

    1,808 were admitted to hospital with COVID-19

    670 died

    Primary cohort, n = 58,368

    Median vitamin D levels in participants not hospitalised

    50 nmol/L (20ng/ml)

    (interquartile range, IQR 34.0-66.7 nmol/L)

    Median vitamin D levels in participants hospitalised

    35.0 nmol/L (14 ng/ml)

    (interquartile range, 21.0-57.0nmol/L)

    p less than 0.005

    Similar findings in a validation cohort, n = 21,234

    Non-hospitalised = 47.1 nmol/L (IQR 31.8-64.7 nmol/L)

    Hospitalised patients = 33.0 (IQR 19.4-54.1 nmol/L)

    p less than 0.005

    Adjusted odds ratios

    Age, sex, seasonal variation- for hospital admission

    OR = 2.3-2.4 times higher, 25(OH)D less than 50 nmol/L

    OR for validation cohort, adjusted, = 2.33

    No association between low vitamin D levels and in-patient hospital mortality from COVID-

    19 in either cohort.

    Conclusions

    Vitamin D deficiency is associated with higher risk of COVID-19 hospitalisation.

    Widespread measurement of serum 25(OH)D and treating any unmasked insufficiency or deficiency through testing may reduce this risk

    We have clearly demonstrated that vitamin D insufficiency and deficiency exponentially increase the risk of the disease by a factor of 2.3 to 3.6, even after adjustments for age and sex.

    Vitamin D is anti-inflammatory, and it has been shown to modulate the immune system

    With its effect on macrophage function and innate immunity, vitamin D may alter the disease manifestations of COVID-19

    Vitamin D supplementation should be an important consideration for deficient populations at risk

  • Second Vitamin D clinical trial, positive results

    21:15

    Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)




    It has been observed that vitamin D-deficient individuals
    have increased COVID-19 risk and mortality

    Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA 2020;323:1824–36. doi: 10.1001/jama.2020.6019

    The role of vitamin D in the prevention of coronavirus disease infection and mortality.

    Aging Clin Exp Res 2020;32:1195–8. doi: 10.1007/s40520-020-01570-8

    Association of vitamin D status and other clinical characteristics with COVID-19 test results.

    JAMA Netw Open 2020;3:e2019722. (Published 3 Sep 2020).doi: 10.1001/jamanetworkopen.2020.19722

    Immunomodulatory role and protective effect of vitamin D against other viral infections

    Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;15:356:i6583. doi: 10.1136/bmj.i6583

    An intervention study with calcifediol noticed a reduction in requirement for intensive care among hospitalised patients for COVID19

    Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study.

    J Steroid Biochem Mol Biol 2020;203:105751. doi: 10.1016/j.jsbmb.2020.105751

    50 patients treated with calcifediol, one required admission to the ICU (2%), no deaths

    26 untreated patients, 13 required admission (50 %) to the ICU, 2 deaths

    Immune-modulatory effect of vitamin D is likely to be observed at 25(OH)D levels, which are considered higher than that required for its skeletal effects

    Vitamin D to prevent COVID-19: recommendations for the design of clinical trials. Febs J2020;287:3689–92. doi: 10.1111/febs.15534

    Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults.

    BMC Res Notes 2012;5:575. doi: 10.1186/1756-0500-5-575

    Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection.

    PLoS One 2020;15:e0239799.doi: 10.1371/journal.pone.0239799

    Aim



    Effect of high dose, oral cholecalciferol supplementation on SARS-CoV-2 viral clearance

    First cholecalciferol intervention study for asymptomatic and mildly symptomatic SARS-CoV-2 positive individuals


    Design

    Randomised, placebo-controlled.

    Participants

    Asymptomatic or mildly symptomatic SARS-CoV-2

    RNA positive vitamin D deficient (25(OH) D less than 20 ng/ml)

    Calcifediol, calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3

    Pre intervention baseline serum 25(OH) D

    Intervention group, 8.6 ng/ml

    Control group, 9.54 ng/ml (p=0.730)

    10 out of 16 patients could achieve 25(OH)D more than 50 ng/ml by
    day-7

    Another two by day-14

    Outcome measure

    Proportion of patients with SARS-CoV-2 RNA negative before day-21

    Change in inflammatory markers

    Intervention group (n=16)

    60 000 IU of cholecalciferol (oral nano-liquid droplets) for 7 days

    Therapeutic target 25(OH)D more than 50 ng/ml

    Cholecalciferol supplementation was continued for those with 25(OH)D less than 50 ng/ml

    Fibrinogen levels significantly decreased with cholecalciferol supplementation

    10 (62.5%) participants became SARS-CoV-2 RNA negative

    Control group (n=24)

    Placebo

    5 (20.8%) participants became SARS-CoV-2 RNA negative (p less than 0.018)

    Both groups

    Patients requiring invasive ventilation or with significant comorbidities were excluded

    25(OH)D levels were assessed at day 7

    Regular measurements of: SARS-CoV-2 RNA, fibrinogen, D-dimer, procalcitonin, CRP, ferritin

    Improvements

    Calcifediol would have been better

    Little and often for prevention

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    About The Doctors: The Doctors is an Emmy award-winning daytime talk show in its 13th season. The Doctors helps you understand the latest health headlines, delivers exclusive interviews with celebrities dealing with health issues, debates and investigates health and safety claims, explains the latest viral videos and how you can avoid emergency situations, and serves up celebrity chefs to share the hottest and healthiest recipes and foods.

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