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Your Brain on Psilocybin

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  • 2-Minute Neuroscience: Psilocybin

    2:01

    Psilocybin is a substance found in a number of mushroom species that can be ingested to cause psychoactive effects. Although psilocybin itself is thought to have very little (if any) psychoactive effects, upon ingestion it is rapidly metabolized into a highly psychoactive substance called psilocin. In this video, I discuss our understanding of psilocin’s effects on the brain.

    TRANSCRIPT:

    Psilocybin is a substance found in a number of mushroom species that can be ingested to cause psychoactive effects. It is considered a psychedelic or hallucinogenic drug with some similarities to LSD in terms of effects.

    Psilocybin itself is not thought to be very psychoactive, but soon after it is ingested it is metabolized into a substance called psilocin, which is highly psychoactive. Psilocybin is thus considered a prodrug, or a substance that is inactive until converted into an active drug after administration. Although we have some understanding of the activity of psilocin in the brain, it is not fully understood how this activity leads to the subjective experiences people have while taking psilocybin. Regardless, it is thought that psilocin’s activity at a subtype of serotonin receptor known as the 5-HT2A receptor is critical to the drug’s psychedelic effects. Psilocin is thought to act as a partial agonist at the 5-HT2A receptor, which means that it binds to the 5-HT2A receptor and causes a response that is a fraction of what the natural ligand, serotonin, does. Psilocin also interacts with other targets, like other serotonin receptor subtypes, some subtypes of dopamine, histamine, and adrenergic receptors, and the serotonin transporter. The role of these other targets in the effects of psilocybin, however, is not very clear.

    Like many other psychedelic drugs, repeated administration of psilocybin over multiple days leads to rapid tolerance and substantially reduced effectiveness. This tolerance is thought to be associated with the down-regulation, or decrease in number, of 5-HT2A serotonin receptors. Psilocybin also exhibits cross-tolerance with LSD, meaning that if someone develops tolerance to one of these drugs, they may display tolerance to the other---regardless of their history with the other drug. Psilocybin, however, is not generally considered to be addictive and is thought to be safe in terms of its effects on the body.

    References:

    Geiger HA, Wurst MG, Daniels RN. DARK Classics in Chemical Neuroscience: Psilocybin. ACS Chem Neurosci. 2018 Oct 17;9(10):2438-2447. doi: 10.1021/acschemneuro.8b00186. Epub 2018 Jul 16.

    Nichols DE.Psychedelics. Pharmacol Rev. 2016 Apr;68(2):264-355. doi: 10.1124/pr.115.011478.

    Rickli A, Moning OD, Hoener MC, Liechti ME. Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. Eur Neuropsychopharmacol. 2016 Aug;26(8):1327-37. doi: 10.1016/j.euroneuro.2016.05.001. Epub 2016 May 20.

    Tylš F, Páleníček T, Horáček J. Psilocybin--summary of knowledge and new perspectives. Eur Neuropsychopharmacol. 2014 Mar;24(3):342-56. doi: 10.1016/j.euroneuro.2013.12.006. Epub 2013 Dec 17.

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  • Psilocybin may ‘reset’ the brain to help manage treatment-resistant depression

    2:19

    Freely access the full article here:

    Robin L Carhart-Harris, Leor Roseman, Mark Bolstridge, Lysia Demetriou, J Nienke Pannekoek, Matthew B Wall, Mark Tanner, Mendel Kaelen, John McGonigle, Kevin Murphy, Robert Leech, H Valerie Curran & David J Nutt Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Scientific Reports 2017.



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  • Your Brain on Psychedelics | Katrin Preller | TEDxMarin

    6:59

    What does the latest research show about the role these molecules might play in emotional and social cognition? Dr. Preller is a recipient of the Pfizer Research Award and the Swiss Society for Biological Psychiatry Young investigators award. Her group’s research focus is centered on the neurobiology and pharmacology of cognitive and emotional processes in health and disease using multi-modal behavioral, electrophysiological and neuroimaging techniques, the development of novel treatment approaches, and the interaction between pharmacological and non-pharmacological treatments. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at

  • This Is Your Brain On Shrooms

    19:21

    Psychedelics like magic mushrooms have huge effects on the brain. But what are they doing up there?

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    More than 180 species of magic mushrooms produce the psychoactive compound psilocybin. And ingesting it triggers some pretty trippy changes in the brain. Shrooms and many of these other psychedelic drugs show real promise for treating mental health issues and may result in breakthrough medications for psychiatric disorders.

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    Chapters:
    0:00 An introduction
    1:54 Psychedelics and their effects
    3:21 The promise of psychedelics
    4:28 A brief history of shroooms
    7:00 The neuroscience of psychedelics
    12:15 What makes them trippy
    14:30 How dangerous are they
    17:36 What the future looks like
    18:25 Buy our book

    If you're looking for citations for this video, they are too long to fit in the description, but I can shoot you a comment with any of the studies referenced.

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  • Psychedelics: effects on the human brain and physiology | Simeon Keremedchiev | TEDxVarna

    26:56

    The talk looks at modern research on how psychedelics affect the human brain and consciousness. It focuses on the psilocybin mushroom and examines key scientific findings on its effects on humans. The talk goes into a degree of detail about the short- and long-term effects of psychedelic substances, and seeks to outline the potential these substances have in medicine and self-development.

    Simeon Keremedchiev comes from a legal background, but his interest in different scientific disciplines and human consciousness led him to attaining a degree in Psychology. He is currently
    involved in the development and launch of a comprehensive online informational platform, directed at self-development, human consciousness and conscious living. Simeon's work gravitates around the genetic potential which lies within the human genome and our innate ability to unlock it.

    This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at

  • What magic mushrooms do to your brain and body

    1:08

    Magic mushrooms have been around for a long time, but two studies are shedding new light on how they affect your mind and what they can be used for.

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  • Psilocybin side effects - Intro to Psychology

    3:59

    This video is part of an online course, Intro to Psychology. Check out the course here:

  • How do psychedelic drugs work on the brain?

    49:53

    Dr Robin Carhart-Harris talks about his scientific research
    into the effects and potential therapeutic uses of psychedelic drugs. Join him as he discusses brain imaging work involving psilocybin, the active ingredient of magic mushrooms, and explains how the drug works in the brain.

    For more information please visit

  • Psilocybin Induces Long Lasting Modifications to Brain Connections

    7:14

    A recent study investigated the effects of psilocybin, the active ingredient in magic mushrooms, in mice and demonstrated its long lasting effects on the growth and structure of dendritic spines. The authors suggest these changes may underlie the putative rapid and sustained antidepressant effects of psychedelic drugs. In this video, I will give a brief overview of these very interesting results!

    I'd be happy to hear your thoughts about this study and continue the discussion down below in the comments section.

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    Also check out my video on Psilocybin and 5HT2A receptors:


    Original study
    Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
    Ling-Xiao Shao, Clara Liao, Ian Gregg, Pasha A Davoudian, Neil K Savalia, Kristina Delagarza, Alex C Kwan
    PMID: 34228959 DOI: 10.1016/j.neuron.2021.06.008

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  • How Magic Mushrooms Work in the Brain | The Neuroscience of Psilocybin

    7:22

    In honour of our wonderful fungal comrades and the fact that 9/20 was this past weekend (9/20 is the magic mushroom version of cannabis' 4/20), here's a video going over all the main brain imaging findings with psilocybin (the active compound in magic mushrooms) over the past decade.

    The video should be accessible to all, but if you have zero background in brain networks or the default mode network, I highly recommend watching my video 'fMRI Brain Networks in 10 minutes' prior to this one. Enjoy!

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    More info about the host:

    Manesh Girn is a Neuroscience PhD student at McGill University and has been lead or co-author on over a dozen scientific publications and book chapters on topics including psychedelics, meditation, daydreaming, and brain networks.

    Manesh currently has ongoing collaborations with Robin Carhart-Harris and others at the Imperial College Center for Psychedelic Research and is investigating the brain changes underlying psilocybin, LSD, and DMT.


  • Neurohacking: rewiring your brain | Don Vaughn | TEDxUCLA

    20:02

    We've all heard of the phrase life hack. But have you heard of something called a brain hack? Don Vaughn gives us the inside scoop on the amazing powers of the human brain.

    Don Vaughn is a UCLA PhD Student and DJ.

    This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at

  • Brain Imaging Studies with Psilocybin and MDMA - Robin Carhart-Harris

    58:45




    Brain Imaging Studies with Psilocybin and MDMA

    Robin Carhart-Harris, PhD

    Abstract: Highlighting the results of two fMRI studies and one MEG study with psilocybin and an fMRI study with MDMA, Carhart-Harris will report the effects of both drugs on regional brain activity and brain network organization. Additionally, he will report the effects of both drugs on brain and subjective responses to personal autobiographical memory cues. A general theory will be presented on how psychedelics alter brain activity to alter consciousness and the implications of these brain imaging results for therapeutic applications of psychedelics will be discussed.

    A general theory will be presented on how psychedelics alter brain activity to alter consciousness and the implications of these brain imaging results for therapeutic applications of psychedelics will be discussed.

    Robin Carhart-Harris completed his doctorate in psychopharmacology at the University of Bristol in 2009 after which he moved to Imperial College London to continue his fMRI research with the classic psychedelic drug psilocybin. In the last few years, Carhart-Harris & Professor David Nutt have built up a programme of research with psychedelics that includes fMRI and MEG imaging with psilocybin, fMRI with MDMA and soon an MRC-sponsored clinical trial to assess the efficacy of psilocybin as a treatment for major depression. Carhart-Harris has a review article published in Brain on the neurobiology of Freudian constructs and his work with psilocybin is now published in PNAS, the British Journal of Psychiatry, and Schizophrenia Bulletin. Carhart-Harris has been supported by the Beckley Foundation, the Neuropsychoanalysis Foundation, the Heffter Foundation, and MAPS.

    More videos available at

    At Psychedelic Science 2013, over 100 of the world's leading researchers and more than 1,900 international attendees gathered to share recent findings on the benefits and risks of LSD, psilocybin, MDMA, ayahuasca, ibogaine, 2C-B, ketamine, DMT, marijuana, and more, over three days of conference presentations, and two days of pre- and post-conference workshops.

  • Man’s Life Changed by a Weekly Dose of ‘Magic Mushrooms’?

    4:13

    Ryan Munevar joins The Doctors with psycho-pharmacologist Dr. Benjamin Malcom and psychologist and chemical dependency specialist Dr. Megan Marcum to share his personal experience of microdosing psilocybin weekly, which he credits for making several positive changes in his life. Could this treatment be something doctors to put in their arsenal in the future?

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    The Doctors helps you understand the latest health headlines, delivers exclusive interviews with celebrities dealing with health issues, debates and investigates health and safety claims, explains the latest viral videos and how you can avoid emergency situations, and serves up celebrity chefs to share the hottest and healthiest recipes and foods.

  • Can Magic Mushrooms Unlock Depression? | Rosalind Watts | TEDxOxford

    13:37

    A clinical psychologist from Imperial College describes how Magic Mushrooms (Psilocybin), when used in a therapeutic setting, have been found to be a very effective treatment for depression. In this talk she draws on her experiences as working as a therapist on the groundbreaking Psilocybin for Depression study, and introduces us to some of the patients and their stories of transformation.


    Dr Rosalind Watts completed her clinical psychology training at University College London. After six years of practicing psychotherapy in the NHS, she joined a clinical trial at Imperial College, investigating psilocybin (magic mushrooms) as a treatment for depression. Her research explores patients' positive views of this intriguing therapy.


    This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at

  • Dr. Oz Tells Us the Truth About Magic Mushrooms | Elvis Duran Show

    37:50

    Dr. Oz teaches us an incredible amount of information. We learn why dark liquor is more likely to give you a bad hangover, the truth about magic mushrooms and intermittent fasting, and how he became the Dr. Oz we know today!

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  • Can Magic Mushrooms cure Depression? | Research evidence

    4:31

    The Magic Mushroom Compounds (Psilocybin & Psilocin) outperformed the Standard Depression Medications (SSRI, Escitalopram) in a recent clinical trial which was published in the New England Journal of Medicine. The new developments suggest that Psychedelic drugs like Psilocybin could be a potential cure for depression in the near future. This would be a welcome news for millions of people suffering from severe and treatment resistant depression.
    Here I have animated research findings including the followings.
    • Benefits of magic mushrooms such as being a fast antidepressant, profound experiences, provision of insight, beneficial ancillary effects (mood, self-esteem, sex, motivation, expression of emotions).
    • Side effects of Magic Mushrooms including Visual and Auditory Hallucinations
    • Mechanism of Action of Psilocybin (How it interacts with Serotonin- 5-HTA2 receptors in the cerebral cortex)
    • The potential of being a cure/treatment for Patients with Depression.
    Interested in the clinical trials?
    The New England Journal of Medicine research:
    Johns Hopkins University Research:

    Summary:
    a) Psilocybin is faster than the standard Selective Serotonin Reuptake inhibitors (SSRI) in the market
    b) Magic Mushroom provides better insight into the depression and have better secondary effects.
    c) Side effects found to be similar in both drugs (SSRI & Psilocybin) in the study. (at the proper dosing)
    d) Psilocybin could be used as a potential treatment drug for Depression in future as monotherapy or together with other antidepressants.

  • Magic mushrooms: A magical cure for depression?

    3:31

    Psilocybin (magic) mushrooms have recently gained popularity in the scientific community after many years of being illegal. This video summarizes the history of this drug as well as the recent research on psilocybin mushrooms for the treatment of depression.

    This video was made by McMaster Demystifying Medicine students Hasna Sultan, Christina Kang, Dusan Kovacevic and Sydney McIntyre.

    Copyright McMaster University 2020

    References:

    Al-Harbi, S. K (2012). Treatment-resistant depression: therapeutic trends, challenges, and future directions. Dove Press, 6, 369–388.

    Beckley Foundation (2017). Psilocybin for Depression Study. Retrieved March 14, 2020, from:

    Carhart-Harris, L. R., Bolstridge, M., Rucker, J., Day, M. J. C., Erritzoe, D.,
    Kaelen, M. et al. (2016). Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry, 3(7), 619-627.

    Dinis-Oliveira RJ. Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance. Drug Metabolism Reviews. 2017;49(1):84-91. doi:10.1080/03602532.2016.1278228

    Freeman, S & Chandler, N. (2020, March 17). A Brief History of Magic Mushrooms. Retrieved from

    Goldberg, J. (2019). Depression Medicines. Retrieved March 14, 2020, from

    Griffiths, R., Richards, W., Johnson, M., McCann, U., & Jesse, R. (2008). Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. Journal of psychopharmacology (Oxford, England), 22(6), 621–632.

    Harvard Library. (2002). R. Gordon Wasson (1898-1986). Retrieved from

    Kroeger, P. (2019, March 9). A Brief History of Magic Mushrooms in BC. Vancouver Mycological Society. Retrieved from

    Roseman L, Nutt DJ, Carhart-Harris RL. Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression. Front Pharmacol. 2018;8. doi:10.3389/fphar.2017.00974

    World Health Organization. (2017). Depression and other common mental disorders: Global health estimates. Retrieved March 14, 2020, from:

  • Inside the Trippers Brain | National Geographic

    4:22

    Psychedelics over-stimulate serotonin receptors in the brain, resulting in a blissful experience or a horrifying one.
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  • EXCLUSIVE: Could magic mushrooms treat depression? BBC Newsnight

    7:23

    Could the magic element of magic mushrooms - psilocybin - treat people with severe depression? Researchers at Imperial College have just published the results of a trial looking at exactly this. Newsnight had exclusive access to this controversial drugs trial. James Clayton reports. The film was produced and directed by David Fuller.

    Newsnight is the BBC's flagship news and current affairs TV programme - with analysis, debate, exclusives, and robust interviews.

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  • The Strange Reason You Can Hallucinate

    4:53

    Hallucinations explain where your consciousness comes from.
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    Your brain is a complex organ that makes you...YOU! Your consciousness is controlled by a variety of molecules and receptors in your brain which are studied while hallucinating. New research places participants in an fMRI machine to study their brains while hallucinating, it shows a decrease in the default mode network. The default mode network is a brain region that controls worrying, reason, motivation, reflecting on your past and planning your future. It is the part of the brain that builds the story of you! Your consciousness, fear of mortality, obsession with the ego starts to dissolve when you hallucinate, and your brain starts to add information and use the neurology of your brain in different ways to cope leading to a hallucination. All of this research is leading to breakthroughs in addiction therapy, end of life therapy and most importantly, a clear picture of where your consciousness comes from.

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    How To Change Your Mind by Michael Pollan




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  • Heres Why You Want To Know About Mushrooms and Depression

    8:13

    Psilocybin is a compound found in mushrooms that has psychedelic properties. Psychedelic means it makes you hallucinate. Psilocybin works in the brain by activating the 5-HT2A receptor on the neuron to increase serotonin.

    **Do you have your 2020 Self-Improvement Calendar? You can get it on Amazon here:


    Psilocybin has been used recreationally for years and is known to broaden your thinking, relax you and amplify your emotions.

    There have been studies that have shown that after only two doses of psilocybin, the person was more mentally flexible and less uptight about things. These attitude changes 7-12 months after the 1-2 doses.

    There’s a real race to get this to market. The FDA granted breakthrough therapy designation in 2018 to Compass Pathways for treatment resistant depression using a range of doses. Then in November 2019, the FDA granted the designation to the company Usona Institute to treat regular depression (not treatment resistant) using a single dose.

    Depression inside of bipolar disorder is different from unipolar depression. Psilocybin is being studied for the treatment of unipolar depression. We don't know what affect it will have on possibly triggering mania or psychosis. This doesn't mean that it can't help with the depression that comes with bipolar disorder, though. We’ll first have to see what side effects are associated with the drug once they have completed the trials to anticipate how it may affect bipolar disorder.

    References
    Erritzoe D, Roseman L, Nour MM, et al. Effects of psilocybin therapy on personality structure. Acta Psychiatr Scand. 2018;138(5):368–378.

    Lyons T, Carhart-Harris RL. Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression. J Psychopharmacol. 2018;32(7):811–819.

    Interested in the clinical trials?
    Usona Institute for major depression


    Compass Pathways for treatment resistant depression



    Want to know more about mental health and self-improvement? On this channel I discuss topics such as bipolar disorder, major depression, anxiety disorders, attention deficit disorder (ADHD), relationships and personal development/self-improvement. I upload weekly. If you don’t want to miss a video, click here to subscribe.

    Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.

  • Can Psilocybin Help Treat OCD? A Conversation with Prof. David Nutt and Sean Fletcher

    57:10

    We've teamed up with our friends at Orchard OCD for another livestream hosted by journalist and advocate, Sean Fletcher, and Professor of Neuropharmacology and Director of the Neuropharmacology Unit of Brain Sciences at Imperial College, Professor David Nutt.

    Tune in to hear Sean and Prof. Nutt discuss the science behind OCD, and why psilocybin is a potential treatment method. He'll overview his upcoming study into the drug, and explain what he hopes to uncover.

    - Learn more or contribute to Orchard's crowdfunding campaign here:
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  • The Pros and Cons of the ‘Magic’ Drug Psilocybin

    3:09

    Joined by psycho-pharmacologist Dr. Benjamin Malcom and psychologist and chemical dependency specialist Dr. Megan Marcum, The Doctors debate whether or not magic mushrooms should be legalized. ER physician Dr. Travis Stork shares what can happen on the drug, and also what can go wrong.

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    The Doctors is an Emmy award-winning daytime talk show hosted by ER physician Dr. Travis Stork and co-hosted by plastic surgeon Dr. Andrew Ordon, along with dermatologist Dr. Sonia Batra, OB-GYN Dr. Nita Landry, and neuropsychologist Dr. Judy Ho.

    The Doctors helps you understand the latest health headlines, delivers exclusive interviews with celebrities dealing with health issues, debates and investigates health and safety claims, explains the latest viral videos and how you can avoid emergency situations, and serves up celebrity chefs to share the hottest and healthiest recipes and foods.

  • ‘Magic Mushrooms as Medicine? Psychedelics Could Be Used to Fight Alcohol Dependence, PTSD | NBCLA

    4:14

    There is a growing body of evidence that the psychedelic fungus has therapeutic effectiveness for a number of conditions. Patrick Healy reported on NBC4 News on Monday, March 22, 2021.
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  • Expert Answers Psychedelics Questions From Twitter | Tech Support | WIRED

    15:12

    Michael Pollan, author of This Is Your Mind On Plants, answers the internet's burning questions about psychedelics. How does LSD work? What is ego death? How are psychedelics used for addiction therapy? Why are psychedelics so frowned upon? Michael answers all these questions and much more.

    For more on the pharmacology of plants, read Michael Pollan's latest book THIS IS YOUR MIND ON PLANTS -

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    Expert Answers Psychedelics Questions From Twitter (ft. Michael Pollan) | Tech Support | WIRED

  • How To Hack Your Brain - Top 6 Nootropics

    12:24

    These 6 of my favorite nootropics for enhancing my cognitive performance.
    Get 20% Off Your Entire Order At Natural Stacks:


    Disclaimer:

    I want to clarify that there is no magic pill. This isn't the movie Limitless where you can take a pill and suddenly you can calculate physics equations off the top of your head. I also do not support self-medicating with drugs such as Adderall (without a doctors prescription) to enhance your performance. Drugs like this help you for a short period of time, but the side effects and the toll it takes on your body is not worth it.

    The term “Nootropics” simply refers to the wide range of synthetic and natural compounds that are thought to improve your brains function. Things such focus, motivation, memory, and even mental clarity. In order for something to be a Nootropic there should be no serious side effect, this rule means that most Nootropics will only offer you a slight edge. Not some crazy 4 hour high. The only nootropics you should look into are the ones with decades of research backing them up. It is your responsibility to conduct further research on these supplements before you start taking them. You should also consult with your doctor.

    If you are interested in coaching:
    Email me at ImprovementPill@gmail.com

  • Psychedelic Medicine: From Tradition to Science

    2:56:44

    Researchers in neuroscience, psychiatry, and clinical practice join other leaders in psychedelic medicine to discuss this rapidly emerging field.

    Schedule

    Lecture: The Therapeutic Mechanisms of Psychedelic Medicine
    by Robin Carhart-Harris, PhD

    Panel Discussion:
    Michael Pollan
    Rick Doblin, PhD
    Anja Loizaga-Velder, PhD
    Robin Carhart-Harris, PhD
    Matthew Johnson, PhD
    Franklin King, MD

    Moderated by Julie Holland, MD

    Sponsors: The Grof Holotropic Foundation, The Harvard Brain Science Initiative, Harvard Medical School (Programs in Neuroscience & Education), The Broad Institute, and the Multidisciplinary Association for Psychedelic Studies (MAPS).

  • Your brain hallucinates your conscious reality | Anil Seth

    17:01

    Visit to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more.

    Right now, billions of neurons in your brain are working together to generate a conscious experience -- and not just any conscious experience, your experience of the world around you and of yourself within it. How does this happen? According to neuroscientist Anil Seth, we're all hallucinating all the time; when we agree about our hallucinations, we call it reality. Join Seth for a delightfully disorienting talk that may leave you questioning the very nature of your existence.

    The TED Talks channel features the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and more. You're welcome to link to or embed these videos, forward them to others and share these ideas with people you know.

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  • Psychedelics Are Fueling a Mental Health Revolution

    11:43

    Once deemed dangerous and illegal, psychedelic compounds have been rediscovered by the scientific, medical and psychiatric communities as research reveals their capacity to help patients with a range of maladies. With investors beginning to flood this new market with capital, will Big Pharma join in, or try to squash a nascent revolution of the mind?

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  • Mushrooms as Medicine with Paul Stamets at Exponential Medicine

    31:55

    Leading mycologist Paul Stamets shares his work exploring the diverse role medicinal mushrooms may have in activating our immune systems and helping treat cancer, to new data supporting the role of fungi in biosecurity and the health of the bees that pollinate our planet.

    Exponential Medicine ( is unique cross-disciplinary program exploring the cutting edge of health, medicine and technology. The next xMed program will be held November 4-7th 2019 at the Hotel del Coronado.

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  • Does microdosing LSD make you smarter? | WIRED Explains

    7:05

    Microdosing psychedelics refers to the practice of taking tiny amounts of drugs such as LSD or magic mushrooms. Some people claim that microdosing brings them benefits such as improved mood, focus or creativity. But there’s very little scientific evidence to show which effects microdosing actually has – or if it has any at all.

    Now, several groups of researchers are running placebo-controlled studies to explore what microdosing does. They ask participants to take either microdoses or placebos, without telling them which they are getting, then have them complete tasks testing things like cognitive function and psychological wellbeing. Having a placebo control is particularly important, as otherwise the reported effects of microdosing could be down to a placebo response rather than a physiological effect of the drug.

    #microdosing #lsd #psychedelics

  • Tinnitus: Ringing in the Brain | Josef Rauschecker | TEDxCharlottesville

    18:01

    In this talk Josef Rauschecker illuminates the science behind tinnitus as well as the current state of treatment options.

    Josef Rauschecker has 35 years of experience in systems and cognitive neuroscience, more than 25 years of experience in animal electrophysiology, and upwards of 15 years of experience with functional magnetic resonance imaging (fMRI). At Georgetown University Medical Center, he helped create the first human fMRI research facility. He has also held visiting appointments at several institutions, including Harvard Medical School, and has been the recipient of a Humboldt Award and a Finland Distinguished Professorship.

    This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at

  • History of Magic Mushrooms

    4:11

    How did an ancient Aztec ritual make its way to Phish concerts across America? What is it about magic mushrooms that make them so magical? Studies show they can be used for medicinal purposes, so why are they still illegal throughout most of the world?

    Slink back into your chair because on this week’s episode, we’re going on a wild trip and taking a look at the history of ‘shrooms.


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  • MDMA - Respect Your Brain

    50

    See how MDMA affects the brain. MDMA (ecstasy) boosts the feel-good chemicals in your brain but any amount is risky and the more you take, the more often, the more damage you can do.
    For more information on the developing brain and alcohol, cannabis and MDMA visit

  • Psilocybin, love and the meaning of life | Mary Cosimano | TEDxKC

    14:51

    Johns Hopkins Researcher Mary Cosimano shares promising results from clinical trials of guided psilocybin sessions being utilized in the treatment of addiction, depression, and cancer/end-of-life. The impressive results offer much hope for an effective treatment to heal “hearts and minds.” One of Mary’s key observations is the importance of love and connection — it seems, love is literally part of the answer. Mary Cosimano, MSW, has been working with the Johns Hopkins Center for Psychedelic and Consciousness Research since 2000 when they began research with psilocybin. In her role as Director of Guide/Facilitator Services she is responsible for training and supervising Session Facilitators. She has served as Session Facilitator and research coordinator involved with all the psilocybin studies and has conducted over 450 study sessions. In addition to her work with the psilocybin studies, she has worked with the Club Drug Studies including Salvia Divinorum and Dextromethorphan. She taught individual and group meditation to breast cancer patients in a Johns Hopkins research study, and taught at California Institute to Integral Studies (CIIS) for their Psychedelic-Assisted Therapies and Research program. In 2003 she started and has maintained a meditation group for employees in her department. She also has 15 years of experience with direct patient care as a hospice volunteer. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at

  • Psychedelics: Treating Addiction, Depression and Anxiety with Dr. Roland Griffiths

    1:1:21

    Psychedelics were the subject of serious medical research in the 1940s to the 1960s, when many scientists believed some of the mind-bending compounds held tremendous therapeutic promise for treating a number of conditions including severe mental health problems and alcohol addiction. By the mid-60s, research into psychedelics was shut down for decades.

    After the blackout ended, the doctor we have on the podcast today was among the first to initiate a new series of studies on psilocybin—the psychoactive compound in “magic” mushrooms.

    On today’s Broken Brain Podcast, our host, Dhru, talks to Dr. Roland Griffiths, a Professor in the Departments of Psychiatry and Neurosciences at Johns Hopkins University School of Medicine. He has conducted extensive research with sedative-hypnotics, caffeine, and novel mood-altering drugs. In 1999, he initiated a research program at Johns Hopkins investigating the effects of the classic hallucinogen psilocybin that includes studies of psilocybin-occasioned mystical-type experiences in healthy volunteers, psilocybin-facilitated treatment of psychological distress in cancer patients, psilocybin-facilitated treatment of cigarette smoking cessation, psilocybin effects in beginning and long-term meditators, and psilocybin effects in religious leaders.

    In this episode, Dhru and Dr. Griffiths talk about his extensive research with psilocybin in the treatment of psychological distress in cancer patients and cigarette smoking cessation. They discuss the connection between psilocybin, spirituality, and consciousness. They also talk about psychedelics and their potential for treating conditions ranging from drug and alcohol dependence to depression and post-traumatic stress disorder.

    In this episode, we dive into:

    - The connection between psychedelics, spirituality, and consciousness (7:48)
    - The history of psychedelic research (8:28)
    - The reintroduction of psychedelic research by Dr. Roland Griffiths and others (12:27)
    - Why research participants rated their psychedelic experience as one of their most meaningful (16:36)
    - What is happening in the brain when using psychedelics (23:39)
    - How psychedelics can help us understand altered states of consciousness (29:09)
    - The therapeutic benefits of psilocybin for the treatment of addiction (40:16)
    - How a single dose of psilocybin substantially diminished depression and anxiety in cancer patients (44:52)
    - The future of psychedelics (48:07)
    - The downside and risks of psychedelics (56:14)
    - Learn more about Dr. Roland Griffiths and his work (1:00:24)

    For more on Dr. Roland Griffiths and his research on psychedelics check out his website

  • Paul Stamets – Psilocybin Mushroom Medicines: A Paradigm Shift in Global Consciousness

    20:29

    Psilocybin mushrooms have been used for millennia by several cultures from Europe to Mesoamerica. More than 116 species have been identified thus far in the genus Psilocybe alone. New scientific evidence is pointing to the fact that, not only can they be psycho-spiritually transformative, but they are capable of stimulating neurogenesis, i.e. the growth of nervous system tissue.

    These recent discoveries show psilocybin’s potential for helping address such conditions as depression and anxiety, but perhaps as well to help prevent dementia, Alzheimer’s and other neuropathies. In fact, they may increase intelligence. But these exciting new findings have generated a rush of investors seeking to corner medicalized psilocybin, which raises the question: Should psilocybin mushrooms come to market as People’s Medicine or Profit Medicine?

    Paul Stamets, one of the world’s leading authors, inventors, educators and entrepreneurs in the field of mycology, and very possibly the planet’s foremost expert on psilocybin mushrooms, shares his thoughts on the latest research and the rapidly evolving landscape of psychedelic medicine.

    Paul Stamets delivered this talk at the 2020 Bioneers Conference, introduced by Kenny Ausubel. Watch more conference videos at

    Paul Stamets, speaker, author, award-winning mycologist, medical researcher, groundbreaking mycological entrepreneur, and a visionary thought leader in the study of fungi and their uses in promoting human health, ecological restoration, and detoxification of the environment, is the author of six books, including: Mycelium Running: How Mushrooms Can Help Save The World, Growing Gourmet and Medicinal Mushrooms, and Psilocybin Mushrooms of the World. Paul has discovered and named numerous new species of psilocybin mushrooms and is the founder and owner of Fungi Perfecti, LLC, makers of the Host Defense Mushrooms supplement line. And Paul’s work has now entered mainstream popular culture. The new Star Trek: Discovery series features a Lt. Paul Stamets, Science Officer and Astromycologist(!).

    Learn more about Paul and his work at his website:

  • Fire Up Your Brain with these 5 Nootropics

    8:57

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    Fire Up Your Brain with these 5 Nootropics- Thomas DeLauer

    This video covers the 5 best foods that will light up your brain to give you laser focus! Enjoy, and I'll see you in the comments!

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  • What’s In Your Brain? | Compilation

    36:56

    Ever stop to ponder how your brain ponders its own complexities? How does it know to tell your limbs to stop moving and have a think? Fear not, because we have answers to many questions about those wrinkly sponges!

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  • Why Does LSD Do Amazing & Terrible Things To Your Brain?

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  • How Do Magic Mushrooms Expand Your Mind?

    2:54

    Psychedelic mushrooms have been around for thousands of years, and have been used for research purposes and in religious ceremonies! How do these magic mushrooms work? Tara takes a look at this history of these mushrooms, and also explains how they expand one's mind.

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    Magic mushrooms expand your mind and amplify your brain's dreaming areas - here's how

    Psychedelic drugs alter consciousness in a profound and novel way that increases the breadth and fluency of cognition.

    Enhanced repertoire of brain dynamical states during the psychedelic experience

    The study of rapid changes in brain dynamics and functional connectivity (FC) is of increasing interest in neuroimaging. Brain states departing from normal waking consciousness are expected to be accompanied by alterations in the aforementioned dynamics.

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  • Science of Drugs: What Do Magic Mushrooms Do To Your Brain?

    2:06

    Why did the mushroom get invited to all the parties? 'Cuz he's a fungi!

    Magic mushrooms have been used to achieve oneness with the universe and mingle with rainbow striped elephants for over 9,000 years. But scientists are only just starting to figure out exactly how these funky fungi work. Join us as we dive into the science of Shrooms.

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  • Are Magic Mushrooms Healthy? An In-Depth Look at the Research

    15:56

    A look at over a dozen studies including shocking studies on depression, how it works, overdose risk, and beyond.
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  • My Brain on Shrooms | Painting Big Abstract Canvas

    8:01

    Painting while high on magic mushrooms. Fun art experience in my atelier, much movement captured. Canvas is available for collectors on my website.


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  • Magic Mushrooms and Mental Health

    16:36

    What role can psychedelics play in the mental health of cancer patients? And how does mental health impact quality of life? Alyson Moadel-Robblee, Director of Psychosocial Oncology Program and Founding Director of Bronx Oncology Living Daily Program, Montefiore Einstein Center for Cancer Care, and Stephen Ross, Director of NYU Addictive Disorders and Experimental Therapeutics Research Laboratory and Co-Director of NYU Psychedelic Research Group, joined The Atlantic’s Olga Khazan to discuss.

  • Tomas Palenicek: Psilocybin´s Effect on Perception, Cognition and Brain Activity

    42:43

    Recorded on the occasion of Colloquium on Psychedelic Psychiatry, 2018. Organized by Nätverket för psykedelisk vetenskap

    A high quality, 2-day international academic seminar on psychedelic science, with a special focus on the use of psychedelics in psychiatry

  • Your Brain on Psilocybin | Ep. 1 Highlight | The Grow Pod

    4:19

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  • 5 Mind-Blowing FACTS About PSILOCYBIN MUSHROOMS

    7:01

    These are 5 scientific facts about psilocybin mushrooms that I personally find to be very interesting.

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    Griffiths, R.R., Richards, W.A., McCann, U. et al. Psychopharmacology (2006) 187: 268. doi:10.1007/s00213-006-0457-5

    Charles S. Grob, MD; Alicia L. Danforth, MA; Gurpreet S. Chopra, MD; et al. Arch Gen Psychiatry. 2011;68(1):71-78. doi:10.1001/archgenpsychiatry.2010.116

    Catlow, B.J., Song, S., Paredes, D.A. et al. Exp Brain Res (2013) 228: 481. doi:10.1007/s00221-013-3579-0

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  • The effect of psilocybin on personality in patients with major depression -David Erritzoe

    24:10

    Over the last few years, a number of clinical pilot studies have examined the therapeutic potential of psilocybin for a variety of mental health conditions; including anxiety, OCD, smoking and alcohol dependence. David Erritzoe et al have recently
    completed a similar feasibility study in treatment-resistant major depression. Based on previous observations in healthy psychedelic naïve volunteers of long-lasting increases in the personality trait “openness” after a single high-dose of psilocybin, Dr. Erritzoe et al speculated that similar changes in personality may occur in patients with major depression after their treatment with psilocybin. This talk will report on a clinical trial involving 19 pa-
    tients with treatment-resistant depression who received two doses of psilocybin in an open label pilot study. Significant changes in personality traits, as assessed with pre- and post-treatment personality measurements using the full 240-item NEO-PIR, were observed. These data and their relationships with treatment response will be presented in this talk.

    BIOGRAPHY

    David Erritzoe is a medical doctor and clinical psychiatrist. After finishing medical school at Copenhagen University, he obtained his PhD on serotonergic neurotransmission in the Center for Integrated Molecular Brain Imaging (CIMBI) in Copenhagen. He is post-doctoral researcher at Imperial College London under the mentorship of Professors Anne Lingford-Hughes and David Nutt. There, he investigates dopaminergic and opioid neurotransmission in addiction. Additionally, he is part of a research programme together with Professor Nutt and Dr Carhart-Harris conducting research in the neurobiology and the treatment potential of MDMA and classic psychedelics.

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